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Journal of Chinese Pharmaceutical Sciences 2020年第1期29卷 1-12页

作者： Eric Wei Chiang Chan Chen Wai Wong Siu Kuin Wong Yew Woh Hui Joash Ban Lee Tan Faculty of Applied Sciences UCSI University56000 CherasKuala LumpurMalaysia Xiamen university Malaysia Bandar Sunsuria43900 SepangSelangorMalaysia School of Science Monash University MalaysiaBandar Sunway47500 Subang JayaSelangorMalaysia

Emodin and shikonin are quinones that are commonly found in the roots of plant species of the families Polygonaceae and Boraginceae,*** have a wide spectrum of bioactivities,including anti-cancer *** overview on the cytotoxic properties of emodin and shikonin is focused on lung cancer,the leading cause of cancer death in the *** emodin,the-OH groups at C1 and C3 positions,while in shikonin,the-OH groups of the naphthazarin moiety and chiral side-chain,are important for their anti-tumour *** have shown that emodin and shikonin inhibit the growth of lung cancer cells by inducing apoptosis,autophagy,necrosis and early senescence,and by inhibiting proliferation,invasion,migration and *** cytotoxic activities are involved multiple molecular targets and signalling pathways.A clinical trial using shikonin to treat patients with late-stage lung cancer has been *** future perspectives and research needs are *** of information are from Google Scholar,Pub Med,Science Direct,J-Stage,Pub Chem and CNKI.

关键词： Quinones Emodin Shikonin Lung cancer cells Clinical trial

Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence

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Acta Pharmaceutica Sinica B 2021年第10期11卷 3286-3296页

作者： Xiu Han Xiang Xu Ziheng Wu Zhenghong Wu Xiaole Qi Key Laboratory of Modern Chinese Medicines China Pharmaceutical UniversityNanjing 210009China Medical School of Nanjing university Nanjing UniversityNanjing 210093China Parkville campus Monash UniversityVIC 3052Australia

The functionality of DNA biomacromolecules has been widely excavated,as therapeutic drugs,carriers,and functionalized modification *** this study,we developed a series of DNA tetrahedron nanocages(Td),via synchronous conjugating different numbers of i-(X)and therapeutic siRNA on four vertexes of tetrahedral DNA nanocage(aX-Td@bsiRNA,a+b=4).This i-motif-conjugated Td exhibited good endosomal escape behaviours in A549 tumor cells,and the escape efficiency was affected by the number of ***,the downregulating mRNA and protein expression level of epidermal growth factor receptor(EGFR)caused by this siRNA embedded Td were verified in A549 *** tumor growth inhibition efficiency of the 2X-Td@2siRNA treated group in tumorbearing mice was significantly higher than that of non-i-motif-conjugated Td@2siRNA(3.14-fold)and free siRNA(3.63-fold).These results demonstrate a general strategy for endowing DNA nanostructures with endosomal escape behaviours to achieve effective in vivo gene delivery and therapy.

关键词： i-motif siRNA Gene delivery DNA tetrahedron Endosomal escape Cancer Gene silence Biocompatibility

Distribution Patterns of Medicinal Plants along an Elevational Gradient in Central Himalaya,Nepal

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Journal of Mountain Science 2012年第2期9卷 201-213页

作者： Maan B.ROKAYA Zuzana MÜNZBERGOVÁ Mani R.SHRESTHA Binu TIMSINA Institute of Botany Academy of Sciences of the Czech Republic Department of Botany Faculty of SciencesCharles University School of Biological Sciences Monash UniversityClayton Campus Institute for Environmental Studies Faculty of ScienceCharles University

This study aimed to compare the distribution patterns and trends of plant parts used among different groups of medicinal plants, geographical regions,and between medicinal plants and all vascular *** used the published sources for elevation records of 2,331 medicinal plant species to interpolate presence between minimum and maximum elevations and estimated medicinal plant richness for each 100-m elevational band. Monte Carlo simulations were used to test whether differences in elevational distribution between different groups of medicinal plants were significant. Total number of medicinal plants as well as different groups showed unimodal relationship with elevation. The elevational distributions of medicinal plants significantly differ between regions and between medicinal plant *** comparing the richness of all medicinal plants to all vascular plants,Monte Carlo simulations indicated that the numbers of medicinal plants are higher than expected at low *** highest richness of medicinal plants at low elevation could be possibly due to favorable environmental factors such as high temperature, rainfall,sunlight or due to higher density of human population and thus higher pressure on use of any plants in lower elevations.

关键词：药用植物海拔梯度分布格局喜马拉雅山尼泊尔蒙特卡罗模拟低海拔地区维管束植物

用于制备优质单壁碳纳米管管束的MgO负载Fe_3O_4纳米粒子的合成(英文)

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新型炭材料 2011年第4期26卷 255-261页

作者： Wei-Wen Liu Azizan Aziz Siang-Piao Chai Abdul Rahman Mohamed Ching-Thian Tye School of Materials and Mineral Resources Engineering Engineering Campus 14300 Nibong Tebal Seberang Peral Selatan MalaysiaUniversiti Sains Malaysia School of Engineering Monash University Jalan Lagoon Selatan 46150 Bandar Sunway Selangor Malaysia School of Chemical Engineering Engineering Campus Universiti Sains Malaysia 14300 Nibong Tebal S eberang Perai Selatan Malaysia

采用沉淀方法制备了直径分布狭窄的均匀Fe3O4纳米颗粒。Fe3O4纳粒形体几近一致,平均粒径为10.33nm±2.99nm(平均粒径±标准偏差)。在超声作用下将MgO纳米颗粒分散在一定量Fe3O4纳米颗粒的水溶液中获得MgO负载Fe3O4的纳米颗粒。以甲烷为... 详细信息

采用沉淀方法制备了直径分布狭窄的均匀Fe3O4纳米颗粒。Fe3O4纳粒形体几近一致,平均粒径为10.33nm±2.99nm(平均粒径±标准偏差)。在超声作用下将MgO纳米颗粒分散在一定量Fe3O4纳米颗粒的水溶液中获得MgO负载Fe3O4的纳米颗粒。以甲烷为碳源,Fe3O4/MgO为催化剂,经化学气相沉积,在Fe3O4纳粒上制得了大量直径近乎均匀的单壁碳纳米管(SWCNTs)束。TEM显示:SWCNTs的平均直径1.22nm。热重分析显示:样品在400℃～600℃温度区间失重量约19%。拉曼光谱显示:SWCNTs的ID/IG的强度比为0.03,表明采用Fe3O4/MgO催化剂可制得高石墨化程度的单壁碳纳米管。

关键词：单壁碳纳米管化学气相沉积电子显微镜拉曼光谱

Challenges against CO_(2) abatement strategies in cement industry: A review

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Journal of Environmental Sciences 2021年第6期33卷 84-101页

作者： Emad Benhelal Ezzatollah Shamsaei Muhammad Imran Rashid Department of Chemical Engineering The University of NewcastleNew South Wales 2287Australia Department of Civil Engineering Monash UniversityClayton 3800VictoriaAustralia Chemical Polymer and Composite Materials Engineering DepartmentUniversity of Engineering and TechnologyLahore(New Campus)39021Pakistan

Cement industry is an intensive source of fuel consumption and greenhouse gases(GHGs) emissions. This industry is responsible for 5% of GHGs emissions and is among the top industrial sources of carbon dioxide(CO_(2)) emissions. Therefore, CO_(2) emissions reduction from cement production process has been always an appealing subject for researches in universities and industry. Various efforts have been carried out to mitigate the huge mass of CO_(2) emissions from the cement industry. Although, majority of these strategies are technically viable, due to various barriers, the level of CO_(2) mitigation in cement industry is still not satisfactory. Among numerous researches on this topic, only a few have tried to answer why CO_(2) abatement strategies are not globally practiced yet. This work aims to highlight the challenges and barriers against widespread and effective implementation of CO_(2) mitigation strategies in the cement industry and to propose practical solutions to overcome such barriers.

关键词： CO_(2)emissions CO_(2)mitigation Cement industry Challenges of CO_(2)reduction

A synopsis on flavonoids from the roots of Scutellaria baicalensis with some insights on baicalein and its anti-cancer properties

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Journal of Chinese Pharmaceutical Sciences 2019年第4期28卷 217-228页

作者： Eric Wei Chiang Chan Siu Kuin Wong Joseph Tangah Tomomi Inoue Hung Tuck Chan Faculty of Applied Sciences UCSI University School of Science Monash University Sunway Forest Research Centre Sabah Forestry Department Centre for Environmental Biology and Ecosystem Studies National Institute for Environmental Studies(NIES) Secretariat of the International Society for Mangrove Ecosystems Faculty of Agriculture University of the Ryukyus

Flavones are the most dominant type of flavonoids isolated from the roots of Scutellaria baicalensis(Radix Scutellariae), which is a traditional medicinal plant in East Asian countries, including China, Japan and *** of the flavones are derivatives with methoxyl and hydroxyl groups, and they include baicalein, baicalin, chrysin, norwogonin, oroxylin A and *** possesses anti-cancer activities against a wide spectrum of human cancer cells by inducing apoptosis and cell cycle arrest, and by inhibiting angiogenesis, metastasis and *** examples of the effects of baicalein on apoptosis, cell cycle arrest and metastasis are presented with discussion on the molecular targets and *** on the structure-activity relationships of flavonoid cytotoxicity towards human cancer cells show that the potent cytotoxic activities of baicalein can be attributed to its-OH groupsat C5, C6 and C7(triple hydroxylation) of ring A, carbonyl group at C4 of ring C, and C2–C3 double bond of ring *** on structural modifications of baicalein have shown that the configurations at C6 of ring A are critical factors influencing its anti-proliferative *** the remarkable anti-cancer properties, the future prospects for developing baicalein into an anti-cancer drug are promising.

关键词： Radix Scutellariae Baicalein Flavones Structure-activity relationships

A trigger-tube tracer dilution technique for determining Darcy and apparent velocities of groundwater in dug wells: A case study on phreatic aquiferous formation in Bamenda-Cameroon

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Journal of Groundwater Science and Engineering 2019年第2期7卷 182-194页

作者： Akoanung Ayaba ABENDONG ENDENE Emmanuel Enoh Jeanot FONGOH AKOACHERE Richard Ayuk II NJENG Napoleon Ngenge Faculty of Science Department of Geology University of Buea Cameroon Civil Engineering Discipline School of Engineering Monash University Malaysia Jalan Lagoon Selatan 47500 Bandar Sunway Selangor Malaysia Ministry of Scientific Research and Innovation Yaoundd-Cameroon

The need to understand flow within aquiferous formations for a complete evaluation of groundwater resource and quality control prompts the determination of groundwater velocities through well dilution technique. Well dilution techniques utilize tracer solutions after establishing an initial homogenous condition to monitor the flow rate of ambient groundwater into the wells. Application of dilution techniques in wells makes it feasible to determine the velocities of groundwater in the aquiferous formation surrounding the well. In this study, a simple trigger-tube tracer dilution technique was employed to determine the Darcy and apparent velocities of groundwater in the phreatic aquiferous formation in Bamenda, Cameroon. Eighteen (18) hand dug-wells at different locations within Bamenda were sampled by utilizing sodium chloride (NaCl) as the conservative tracer. Field estimates of groundwater flow velocities in the phreatic aquiferous formation in Bamenda reveal Darcy's groundwater velocity in the range of 0.39 m/d at Nacho to 130.64 m/d at Foncha Street and apparent velocity in the range of 0.78 m/d at Nacho to 277.86 m/d at Foncha Street. The immense variations in the velocities of groundwater indicate that the groundwater flows at different rates and directions within the aquiferous formation in Bamenda, possibly due to variations in their hydraulic conductivities. Moreover, the spatial variations in the formation types, facies changes, thickness, and layering of the aquiferous formation also contribute to the variation of velocities. Areas with low groundwater velocities are associated with a lower contaminant transport rate when compared to areas with high groundwater velocities. The findings of this study are important for assessing the rates of pollutant movement in the subsurface, as well as the effectiveness and efficacy of the trigger-tube technique in evaluating the hydraulic properties of aquiferous formations.

关键词： Trigger-tube Groundwater Darcy velocity Apparent velocity Bamenda- Cameroon

Cerbera are coastal trees with promising anticancer properties but lethal toxicity： A short review

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Journal of Chinese Pharmaceutical Sciences 2016年第3期25卷 161-169页

作者： Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan Shigeyuki Baba Mio Kezuka Faculty of Applied Sciences UCSI University 56000 Cheras Kuala Lumpur Malaysia School of Science Monash University Sunway 46150 Petaling Jaya Selangor Malaysia Secretariat International Society for Mangrove Ecosystems c/o Faculty of Agriculture University of the Ryukyus Okinawa903-0129 Japan

In this short review, the current knowledge on the chemical constituents and anticancer properties of Cerbera odollam and Cerbera manghas is updated with some description of their botany and uses. Although these two closely-related coastal tree species have overlapping geographical distribution, they can be distinguished by the eye colour of flowers and the shape of fruits. Chemical constituents of C. odollam and C. manghas include lignans, iridoids, terpenoids, cardiac glycosides(cardenolides), flavonoids, phenolic acids and steroids. Cardiac glycosides of cerberin, dehydrocerberin, neriifolin, tanghinin, deacetyltanghinin and tanghinigenin possess promising anticancer properties with apoptotic activities. However, these cardiac glycosides are also cardiotoxic. Fatal cases of suicides by ingesting Cerbera fruits or seeds have been reported in India and Sri Lanka. In two suicide cases, one in Taiwan and another in the United States, the patients recovered completely. In New Caledonia, four death-threatening cases of poisoning(two were fatal) occurred through consuming toxic coconut crabs. Taken together, both C. odollam and C. manghas are endowed with cardiac glycosides, which have useful pharmacological properties but lethal toxicity.

关键词： Sea mango Phytochemistry Pharmacology Cytotoxic Apoptosis Suicides

Alpinia zerumbet, a ginger plant with a multitude of medicinal properties： An update on its research findings

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Journal of Chinese Pharmaceutical Sciences 2017年第11期26卷 775-788页

作者： Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan Faculty of Applied Sciences UCSI University Cheras 56000 Kuala Lumpur Malaysia School of Science Monash University Sunway Petaling Jaya 46150 Selangor Malaysia Secretariat International Society for Mangrove Ecosystems c/o Faculty of Agriculture University of the Ryukyus 903-0129 Okinawa Japan

In this review, the botany and uses of Alpinia zerumbet(yan shan jiang) are described, and the current knowledge of its phytochemistry, pharmacological properties, and clinical trials is summarized. An important ginger crop in East Asia, A. zerumbet has many uses, both medicinal and non-medicinal. Leaves are used to produce essential oils and herbal teas. Rhizomes are consumed as spices, and stem fibers are made into paper, fabrics, and handicrafts. In Brazil, tea from A. zerumbet leaves is believed to have hypotensive, diuretic, and anti-ulcerogenic properties. This species possesses many medicinal properties due to its chemical constituents, including flavonoids, phenolic acids, phenylpropanoids, kava pyrones, sterols, and terpenoids. Extracts of A. zerumbet display antioxidant, antimicrobial, insecticidal, anthelmintic, tyrosinase and melanogenesis inhibitory, anti-atherogenic, anti-aging, anti-glycation, integrase and neuraminidase inhibitory, lifespan prolongation, hair growth promotion, anticancer, antidepressant, anxiolytic, anti-obesity, analgesic, anti-inflammatory, hypolipidemic, anti-ulcerogenic, anti-platelet, osteoblastic, osteogenic, thrombolytic, and cardiac arrhythmogenic activities. Essential oils of A. zerumbet leaves have antimicrobial, larvicidal, antinociceptive, hypotensive, vasorelaxant, myorelaxant, antispasmodic, antidepressant, anxiolytic, anti-neuraminidase, anti-atherogenic, anti-aging, anti-melanogenic, anti-tyrosinase, cytoprotective, cardiodepressive, antipsychotic, analgesic, anti-inflammatory, and tissue healing activities. Clinical trials conducted in Brazil showed that extracts of A. zerumbet have hypotensive and diuretic effects whereas topical application of the essential oil has positive therapeutic effects on patients with fibromyalgia. Spanning two continents of Asia and South America, A. zerumbet is truly a multi-purpose ginger plant with promising medicinal properties.

关键词： Alpinia zerumbet Shell ginger Phytochemistry Pharmacology Clinical trials

挤压参数对生物植入应用镁合金降解性能的影响:综述

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Transactions of Nonferrous Metals Society of China 2022年第9期32卷 2787-2813页

作者： Mahdi SHIRI Hassan JAFARI Raman SINGH Materials Engineering Department Faculty of Materials Engineering and Interdisciplinary SciencesShahid Rajaee Teacher Training University(SRTTU)16785-136 TehranIran Department of Mechanical&Aerospace Engineering and Department of Chemical Engineering 17 College Walk(Bldg 31)Monash University-Clayton Campus(Melbourne)Vic 3800Australia

作为新一代临时生物材料,镁合金具有良好的生物相容性和生物可降解性,也有助于损伤骨组织的修复。但是,其在人体体液中不具备所要求的耐腐蚀性能。挤压等热机械加工对镁合金的力学性能和生物腐蚀行为均有影响。本文综述挤压参数(挤压比... 详细信息

作为新一代临时生物材料,镁合金具有良好的生物相容性和生物可降解性,也有助于损伤骨组织的修复。但是,其在人体体液中不具备所要求的耐腐蚀性能。挤压等热机械加工对镁合金的力学性能和生物腐蚀行为均有影响。本文综述挤压参数(挤压比和温度)对镁合金生物腐蚀性能的影响。它们的影响主要归因于挤压合金显微组织的改变,包括最终的晶粒尺寸和均匀度、织构以及第二相的尺寸、分布和体积分数。挤压过程中的动态再结晶和晶粒细化使组织更均匀,并导致基面织构的形成,从而提高镁合金的强度和耐腐蚀性能。挤压温度和挤压比是影响降解的重要因素。随着挤压比的增加和/或挤压温度的降低,镁合金的晶粒尺寸减小,与挤压方向平行的样品两侧的基面织构增强,析出相体积分数降低,晶粒尺寸减小,这些都有助于提高镁合金植入物的耐腐蚀性能。

关键词：镁合金挤压温度挤压比生物降解显微组织

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