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Graphene-calcium carbonate coating to improve the degradation resistance and mechanical integrity of a biodegradable implant

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Journal of Magnesium and Alloys 2024年第1期12卷 394-404页

作者： Lokesh Choudhary Parama Chakraborty Banerjee R.K.Singh Raman Derrek E.Lobo Christopher D.Easton Mainak Majumder Frank Witte Jörg F.Löffler Department of Mechanical and Aerospace Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Department of Chemical and Biological Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Nanoscale Science and Engineering Laboratory(NSEL) Bldg 37Monash UniversityClayton CampusMelbourneVIC 3800Australia CSIRO Materials Science and Engineering Bayview AvenueClaytonVIC 3168Australia Julius Wolff Institute and Berlin Brandenburg Center for Regenerative Therapies Charité–Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany Laboratory of Metal Physics and Technology Department of MaterialsETH Zurich8093 ZurichSwitzerland

Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body *** necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical *** this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RGO)-calcium carbonate(CaCO_(3))composite *** analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.

关键词： Graphene coating Biodegradable implant Hydroxyapatite Corrosion Magnesium alloy

变废为宝:“蓝色循环”海洋塑料废物管理新策略

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Science Bulletin 2024年第8期69卷 993-996页

作者：余灏轩 Izni Zahidi Chow Ming Fai 梁东方 DagØivind Madsen Department of Civil Engineering School of EngineeringMonash University MalaysiaBandar Sunway 47500Malaysia monash Climate-Resilient Infrastructure Research Hub(M-CRInfra) School of EngineeringMonash University MalaysiaBandar Sunway 47500Malaysia Department of Engineering University of CambridgeCambridge CB21PZUK Davis School of Business Colorado Mesa UniversityGrand Junction 81501-3122USA

The"Blue Circle"vision,initiated by Zhejiang Province in China,represents a groundbreaking advancement in addressing marine plastic *** more than just an innovative concept,it embodies a future-forward approach to managing marine plastic waste,revealing the untapped potential in what was previously considered mere *** initiative,marrying scientific innovation with advanced technology,has been rightfully acknowledged with the prestigious2023 United Nations"Champions of the Earth"award,recognizing its innovative strategy in environmental stewardship(https://***/a/202310/31/***).

关键词： breaking debris initiated

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 945-997页

作者： Jian Sheng Loh Wen Qi Mak Li Kar Stella Tan Chu Xin Ng Hong Hao Chan Shiau Hueh Yeow Jhi Biau Foo Yong Sze Ong Chee Wun How Kooi Yeong Khaw School of Pharmacy Monash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia School of Pharmacy Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia Digital Health&Medical Advancements Taylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia School of Biosciences Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia UCL School of Pharmacy University College London29-39 Brunswick SquareLondon WC1N 1AXUK

The human gastrointestinal tract is populated with a diverse microbial *** vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology,including health maintenance,development,aging,and *** advent of new sequencing technologies and culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations to shed light on microbiome–host *** has unveiled the bidirectional communication between the gut microbiome and the central nervous system,referred to as the“microbiota–gut–brain axis”.The microbiota–gut–brain axis represents an important regulator of glial functions,making it an actionable target to ameliorate the development and progression of neurodegenerative *** this review,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative *** the gut microbiome provides essential cues to microglia,astrocytes,and oligodendrocytes,we examine the communications between gut microbiota and these glial cells during healthy states and neurodegenerative ***,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative diseases using a metabolite-centric approach,while also examining the role of gut microbiota-related neurotransmitters and gut ***,we examine the potential of targeting the intestinal barrier,blood–brain barrier,meninges,and peripheral immune system to counteract glial dysfunction in ***,we conclude by assessing the pre-clinical and clinical evidence of probiotics,prebiotics,and fecal microbiota transplantation in neurodegenerative diseases.A thorough comprehension of the microbiota–gut–brain axis will foster the development of effective therapeutic interventions for the management of neurodegenerative diseases.

关键词： degenerative therapeutic diseases

Multifunctional, Sustainable, and Biological Non-Ureolytic Self-Healing Systems for Cement-Based Materials

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Engineering 2022年第6期8卷 217-237页

作者： Mohammad Fahimizadeh Pooria Pasbakhsh Lee Sui Mae Joash Ban Lee Tan R.K.Singh Raman School of Engineering Monash University MalaysiaBandar Sunway 47500Malaysia School of Science Monash University MalaysiaBandar Sunway 47500Malaysia Tropical Medicine and Biology Multidisciplinary Platform Monash University MalaysiaBandar Sunway 47500Malaysia Department of Chemical Engineering&Department of Mechanical and Aerospace Engineering Monash UniversityClaytonVIC 3168Australia

Microbially induced calcium carbonate(CaCO_(3))precipitation(MICP)has been investigated as a sustain-able alternative to conventional concrete remediation methods for improving the mechanical properties and durability of concrete *** date,urea-dependent MICP is the most widely employed MICP pathway in biological self-healing concrete research as its use has resulted in efficient CaCO_(3) precipita-tion ***_(3) is a byproduct of ureolysis,and can be hazardous to cementitious structures and the health of various ***,non-ureolytic bacterial concrete self-healing systems have been developed as eco-friendly alternatives to urea-dependent self-healing ***-ureolytic pathways can improve the physical properties of concrete samples and incorporate the use of waste materials;they have the potential to be cost-effective and ***,they can be applied in terrestrial and marine *** date,research on non-ureolytic concrete self-healing systems has been scarce compared to that on ureolytic *** article discusses the advances and challenges in non-ureolytic bacterial concrete self-healing studies and highlights the directions for future research.

关键词： Self-healing concrete Mechanical properties Durability Non-ureolytic pathways Cement composite Sustainability

A review on current and future advancements for commercialized microalgae species

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Food Science and Human Wellness 2022年第5期11卷 1156-1170页

作者： Jia Fei Wong Hui Jing Hong Su Chern Foo Michelle Khai Khun Yap Ji Wei Tan School of Science Monash University MalaysiaBandar Sunway 47500Malaysia

Microalgae are unicellular photosynthetic microorganisms that are commonly found in saline or freshwater *** the years,microalgae represent promising sources of sustainable bioactivities with past literatures reflecting a growing interest in algae-based dietary supplements in the form of whole ***,the bioactive molecules that can be identified and extracted in microalgae have scientifically proven to contain therapeutic properties which can be beneficial to human *** the increasing occurrence of global health threats such as antimicrobial resistance and cancer,this has resulted in considerable attention for microalgae study especially in the medicinal *** studies have proved the therapeutic potentials of high-value bioproducts in microalgae,however,there is still room to understand their potential therapeutic properties on humans’health,discovering novel microalgae-derived bioactive compounds,as well as translating the lab-based evidence to clinical trial *** review will focus on accessing the biochemical compositions of commercialised microalgae species from 2007 to 2020,and the activity of their biologically active molecules in eliciting selected therapeutic potentials which are anti-oxidative,anti-inflammatory,anti-microbial and anti-cancer *** review article will also be looking at the research gaps in addition to the above four major selected therapeutic potentials,and future prospective.

关键词： Commercialized microalgae Antioxidant Anti-inflammation Antimicrobial Anticancer

Microbial and heavy metal contamination in commonly consumed traditional Chinese herbal medicines

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Journal of Traditional Chinese Medicine 2013年第1期33卷 119-124页

作者： Adelinesuyien Ting Yiingyng Chow Weishang Tan School of Science Monash University Sunway Campus Jalan Lagoon Selatan Bandar Sunway 46150 Petaling Jaya Selangor Malaysia

OBJECTIVE: The increasing popularity and widespread use of traditional Chinese herbs as alternative medicine have sparked an interest in understanding their biosafety, especially in decoctions that are consumed. This study aimed to assess the level of microbial and heavy metal contamination in commonly consumed herbal medicine in Malaysia and the effects of boiling on these contamination levels. METHODS: Four commonly consumed Chinese herbal medicine in Malaysia-"Eight Treasure Herba Tea", "Herbal Tea", Xiyangshen (Radix Panacis Quinquefolii) and Dangshen (Radix Codonopsis) were evaluated in this study. Herbal medicines were prepared as boiled and non-boiled decoctions, and their microbial enumeration and heavy metal detection were conducted with plate assay and atomic absorption spectroscopy, respectively. RESULTS: Findings revealed that herbal medicines generally had 6 log10cfu/mL microbial cells and that boiling had significantly reduced microbial contam-inants, where no Bacillus spp., Staphylococcus spp. and Clostridium spp. were recovered. Heavy metals such as Mn, Cu, Cd, Pb, Fe and Zn were also detected from all the samples, generally in low concentrations (<1 mg/L) except for Mn (18.545 mg/L). All decoctions (after boiling) have reduced concentrations of Cu, while others were not significantly different. Comparisons between samples with single and multi-herbs suggest level of microbial and metal contamination is not influenced by number of herbs in sample. CONCLUSION: Herbal medicines generally have microbial and heavy metal contaminants. However, the boiling process to generate decoctions was able to successfully reduce the number of microbes and Cu, ensuring safety of herbal medicines for consumption.

关键词：重金属污染物微生物细胞安全食用中草药中国传统梭状芽孢杆菌重金属检测

On complete and micropolar-based incomplete strain gradient theories for periodic lattice structures

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Applied Mathematics and Mechanics(English Edition) 2023年第10期44卷 1651-1674页

作者： Zeyang CHI Jinxing LIU A.K.SOH Faculty of Civil Engineering and Mechanics Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina School of Engineering Monash University MalaysiaJalan Lagoon SelatanBandar SunwaySelangor Darul Ehsan 47500Malaysia

The micropolar(MP) and strain gradient(SG) continua have been generally adopted to investigate the relations between the macroscopic elastic constants and the microstructural geometric parameters. Owing to the fact that the microrotation in the MP theory can be expressed in terms of the displacement gradient components, we may regard the MP theory as a particular incomplete SG theory called the MPSG theory,compared with the existing SG theories which are deemed complete since all the SGs are included. Taking the triangular lattice comprising zigzag beams as an example, it is found that as the angle of the zigzag beams increases, the bending of the beams plays a more important role in the total strain energy, and the difference between the results by the two theories gradually decreases. Finally, the models are verified with the pure bending and simple shear of lattices by comparing with the results obtained by the finite element method(FEM)-based structure analyses.

关键词： periodic lattice metamaterial energy principle homogenization micropolar(MP) strain gradient(SG)theory

Strategies to assemble therapeutic and imaging molecules into inorganic nanocarriers

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Frontiers of Materials Science 2022年第3期16卷 101-144页

作者： Sheikh Tanzina HAQUE Mark M.BANASZAK HOLL Ezharul Hoque CHOWDHURY Jeffrey Cheah School of Medicine and Health Sciences Monash University MalaysiaJalan Lagoon SelatanBandar Sunway47500 Subang JayaSelangorMalaysia Department of Chemical and Biological Engineering Monash UniversityClaytonVictoria 3800Australia Health and Wellbeing Cluster Global Asia in the 21st Century(GA21)PlatformJeffrey Cheah School of Medicine and Health SciencesMonash University MalaysiaJalan Lagoon SelatanBandar Sunway47500 Subang JayaSelangorMalaysia

Inorganic nanocarriers are potent candidates for delivering conventional anticancer drugs,nucleic acid-based therapeutics,and imaging agents,influencing their blood half-lives,tumor targetability,and *** addition to the high surface area-to-volume ratio,they exhibit excellent scalability in synthesis,controllable shape and size,facile surface modification,inertness,stability,and unique optical and magnetic ***,only a limited number of inorganic nanocarriers have been so far approved for clinical applications due to burst drug release,poor target specificity,and *** overcome these barriers,understanding the principles involved in loading therapeutic and imaging molecules into these nanoparticles(NPs)and the strategies employed in enhancing sustainability and targetability of the resultant complexes and ensuring the release of the payloads in extracellular and intracellular compartments of the target site is of paramount ***,we will shed light on various loading mechanisms harnessed for different inorganic NPs,particularly involving physical entrapment into porous/hollow nanostructures,ionic interactions with native and surface-modified NPs,covalent bonding to surface-functionalized nanomaterials,hydrophobic binding,affinity-based interactions,and intercalation through co-precipitation or anion exchange reaction.

关键词： inorganic nanoparticle cancer ionic interaction covalent bonding affinity interaction intercalation

Clustering Indoor Location Data for Social Distancing and Human Mobility to Combat COVID-19

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Computers, Materials & Continua 2022年第4期71卷 907-924页

作者： Yuan Ai Ho Chee Keong Tan Yin Hoe Ng School of Information Technology Monash University MalaysiaJalan Lagoon SelatanBandar Sunway47500Selangor Darul EhsanMalaysia Faculty of Engineering Multimedia UniversityPersiaran MultimediaCyberjaya63100Selangor Darul EhsanMalaysia

The world is experiencing the unprecedented time of a pandemic caused by the coronavirus disease(i.e.,COVID-19).As a countermeasure,contact tracing and social distancing are essential to prevent the transmission of the virus,which can be achieved using indoor location *** on the indoor location analytics,the human mobility on a site can be monitored and planned to minimize human’s contact and enforce social distancing to contain the transmission of *** the indoor location data,the clustering can be applied to cluster spatial data,spatio-temporal data and movement behavior features for proximity detection or contact tracing *** specifically,we propose the Coherent Moving Cluster(CMC)algorithm for contact tracing,the density-based clustering(DBScan)algorithm for identification of hotspots and the trajectory clustering(TRACLUS)algorithm for clustering indoor *** feature extraction mechanism is then developed to extract useful and valuable features that can assist the proposed system to construct the network of users based on the similarity of the movement behaviors of the *** network of users is used to model an optimization problem to manage the human mobility on a *** objective function is formulated to minimize the probability of contact between the users and the optimization problem is solved using the proposed effective scheduling solution based on *** simulation results show that the proposed indoor location analytics system outperforms the existing clustering methods by about 30%in terms of accuracy of clustering *** adopting this system for human mobility management,the count of close contacts among the users within a confined area can be reduced by 80%in the scenario where all users are allowed to access the site.

关键词： Indoor location analytics COVID-19 contact tracing social distancing spatial-temporal dimensions human mobility