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Extended therapy duration for therapy-refractory hepatitis C patients with genotype 2

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World Journal of Gastroenterology 2013年第34期19卷 5754-5758页

作者： Ken Sato Masatoshi Yanagisawa Hiroaki Hashizume Yuichi Yamazaki Norio Horiguchi Satoru Kakizaki Masatomo Mori Department of medicine and molecular Science Gunma University Graduate School of Medicine

We devised an extended 72-wk peginterferon--2a/ribavirin therapy regimen for the retreatment of highly intractable cases,i.e.,48-wk peginterferon--2b/ribavirin therapy-intractable *** 2 cases achieved a rapid virological response to 72-wk peginterferon--2a/ribavirin therapy,1 case failed to achieve a sustained virological *** the reason for this difference in the effectiveness of 72-wk peginterferon--2a/ribavirin therapy between the cases was unclear,the rebound phenomenon of serum transaminase after48-wk peginterferon--2b/ribavirin therapy and the resultant lower viral load compared to that before 48-wk peginterferon--2b/ribavirin therapy might have influenced the treatment ***,it may be beneficial to consider the rebound phenomenon of serum transaminase and the changes in viral load resulting from previous interferon-based therapy and then cau-tiously determine the indication and the timing of the administration of 72-wk peginterferon--2a/ribavirin in highly intractable *** studies should be performed to confirm this strategy.

关键词： Hepatitis C Genotype 2 and high viral loads Interferon-based therapy Highly intractable case Extended therapy duration

Concurrent infections of dengue viruses serotype 2 and 3 in patient with severe dengue from Jakarta, Indonesia

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Asian Pacific Journal of tropical medicine 2016年第2期9卷 130-135页

作者： Soroy Lardo Yaldiera Utami Benediktus Yohan Seri MMU Tarigan Widayat Djoko Santoso Leonard Nainggolan R Tedjo Sasmono Division of tropical medicine and Infectious Diseases Department of Internal Medicine Gatot Soebroto Central Army Hospital Department of Internal medicine Faculty of Medicine University of Indonesia Eijkman Institute for molecular Biology Division of tropical medicine and Infectious Diseases Department of Internal Medicine Cipto Mangunkusumo National Central Hospital

Objective: To describe the clinical manifestation of patient with severe dengue, to identify the serotypes and genotypes of dengue viruses(DENV) which concurrently infecting the patient, and to explore the possible relationship of severe dengue with the concurrent infection of DENV. Methods: Dengue diagnosis was performed using NS1 antigen detection and Ig G/Ig M ELISA. Standard clinical and laboratory examinations were performed to obtain the clinical and hematological data. DENV concurrent infections were detected and confirmed using RT-PCR and DENV Envelope gene sequencing. Phylogenetic analyses were performed to determine the genotypes of the viruses. Results: The patient was classified as having severe dengue characterized by severe plasma leakage, hemorrhage, and organ damage involving lung, liver, and kidney. Concurrent infection of DENV serotype 2 and 3 was observed. The infecting DENV-2 virus was grouped into Cosmopolitan genotype while DENV-3 virus was classified into Genotype Ⅰ. Both viruses were closely related to isolates that were endemic in Jakarta. Viremia measurement was conducted and revealed a significantly higher virus titer of DENV-3 compared to DENV-2. Conclusions: The occurrence of multi-serotype DENV infections was presented in a patient with severe clinical manifestation in Indonesia. The hyperendemicity of dengue in Indonesia may contribute to the DENV concurrent infections cases and may underlie the severity of the disease.

关键词： Severe dengue Concurrent infections DENV-2 DENV-3

Detection of non-typhoid Salmonella infection by citrus and citrus extracts in Lao PDR

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Asian Pacific Journal of tropical medicine 2010年第12期3卷 939-942页

作者： Yutaka Midorikawa Satoshi Nakamura Rattanaphone Phetsouvanh Manivanh Vongsouvaht Kaoru Midorikawa Suzuka University Medical Science Research Institute of National Center for Global Health and Medicine Wellcome Trust-Mahosot Hospital Oxford University Tropical Medicine Research Collaboration Department of Environmental and molecular medicine Mie University Graduate School of Medicine

Objective:To know the current state of non-typhoid Salmonella infection in *** examine the usefulness of new screening methods for Salmonella using ***:Non-typhoid Salmonella infection of person in Lao PDR was studied in this research(2004-2009).The site was Vientiane capital city in *** from rural villages locating suburb of Vientiane during 2005-2008 was carried *** villages in Attapu province where ethnic minorities were living was searched for this study in *** this research,to detect Salmonella strain, a new method using citrus and citrus extract named MY phenomenon that observing black ring (MIDO ring) on DHL agar was *** slice lemon and lime were used for this trial in 2004. After 2005,disk of ascorbic acid and citric acid were used for the device instead of citrus fruits ***:During this research,65 of 272 human samples(23.9%) were infected with non- typhoid ***:During this study,the method using citrus and citrus extracts was accepted for the detection of *** study shows that with citrus and citrus extract, detection of Salmonella is possible using only DHL *** suggest that infectious rate of non-typhoid Salmonella was high.

关键词： Non-typhoid Salmonella Citrus MY phenomenon MIDO ring Lao PDR

Efficacy of combined albendazol and praziquntel and their loaded solid lipid nanoparticles components in chemoprophylaxis of experimental hydatidosis

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Asian Pacific Journal of tropical Biomedicine 2017年第6期7卷 549-554页

作者： Ali Jelowdar Abdollah Rafiei Mohammad Reza Abbaspour Iran Rashidi Mahmood Rahdar Department of parasitology School of MedicineAhvaz Jundishapur University of Medical Sciences Health Research Institute Infectious and Tropical Diseases Research CenterFaculty of MedicineAhvaz Jundishapur University of Medical Sciences Targeted Drug Delivery Research Center School of PharmacyMashhad University of Medical Sciences Department of Pathology School of MedicineAhvaz Jundishapur University of Medical Sciences

Objective:To evaluate the efficacy of combined ABZ and PZQ and their solid lipid nanoparticles in chemoprophylaxis of cystic echinococcosis(CE).Methods:ABZ and PZQ loaded solid lipid nanoparticles(SLNs) were prepared by high shear homogenization and microemulsion congealing techniques with some minor *** average size,polydispersity index(PDI),and particle size distribution were determined by scanning electron microscopy(SEM) and photon correlation *** females BALB/c were experimentally infected by protoscoleces(PSC) and randomly divided into four equal groups of 10 *** the end of the 3 months treatment period and 2 months rest,mice were sacrificed and the peritoneal cavity was opened for removal,counting,measuring,and histological analysis of hydatid ***:The results indicated that ABZ and PZQ chemoprophylaxis treatment reduced the wet weight and size of developed cysts 77.3% and 79%,*** corresponding result for the ABZ and PZQ loaded SLNs was 83% and 85%,***:This study for the first time demonstrated that ABZ and PZQ loaded SLNs is superior to free ABZ and PZQ for the chemoprophylaxis of CE in mice.

关键词： Echinococcosis Albendazole Praziquantel High pressure homogenization Solid lipid nanoparticles(SLNs)

A case report of pulmonary coinfection of Strongyloides stercoralis and Pneumocystis jiroveci

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Asian Pacific Journal of tropical Biomedicine 2011年第4期1卷 334-336页

作者： Bava AJ Romero MM Prieto R Troncoso A Laboratory of parasitology Infectious Diseases HospitalBuenos AiresArgentina Respiratory Unit of Intensive Care Infectious Diseases HospitalBuenos AiresArgentina Department of Microbiology ParasitologyInfectious Diseases and Tropical MedicineSchool of MedicineBuenos Aires UniversityArgentina

A case of pulmonary coinfection by Strongyloides stercoralis and Pneumocystis jiroveci has been detected in an AIDS patient treated in the Respiratory Intensive Care Unit of the Muniz *** diagnosis,the patient presented cough with mucopurulent expectoration,dyspnea,fever,bilateral pulmonary infiltrates on the chest X-ray,negative bacilloscopy for acid fast bacteria and a CD4^+ T lymphocytes count of 52 cells/μ *** microbiological diagnosis was achieved by microscopic observation of the respiratory secretions obtained by bronchoalveolar lavage,while the wet mount examination revealed rhabditiform and filariform larvae of the nematode and foamy exudates,pathognomonic of the pulmonary *** was the unique case of this association among about 3 000 samples performed in our laboratory in the last 10 years and diagnosed by *** complementary stains(a rapid modification of Grocott,Kinyoun and Giemsa) were applied to the smears after the diagnosis of mycotic and parasitary infections achieved by fresh *** physicians and microbiologists should take into account the possible coexistence of respiratory pathogens in immunocompromised patients,such as those with AIDS.

关键词： Strongyloides stercoralis Pneumocystis jiroveci Pulmonary coinfection AIDS Bronchoalveolar lavage Wet mout examination Pulmonary pneumocystosis

Zoonotic transmission of hepatitis E:Implications for public health worldwide

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Asian Pacific Journal of tropical medicine 2009年第4期2卷 77-82页

作者： Analia Paiva Victoria Rebagliati Alcides Troncoso Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineUniversity of Buenos AiresArgentina

Since the year 1982,the Hepatitis E virus(HEV),enteric transmission,has been widely spread in many tropical and subtropical *** has multiple routes of transmission,such as food or water contaminated with faecal matter,person-to-person transmission or by the ingestion of raw or undercooked *** is important to consider the significance of zoonotic infections propagation,both in endemic areas as well as in developed countries,where there have been some sporadic *** article summarizes the research conducted to date,which supports the zoonotic transmission of HEV,its risks and how they are often underestimated.

关键词： Human zoonosis HEV Public health

Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第01期 329-336页

作者： Yuzhu Li Yumeng Gao Feng Tian Yu Wang Yuan Yao Shaoliang Lin Xiang Ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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Identification of necrophagous fly species from 12 different cities in China using ISSR and SCAR markers

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Asian Pacific Journal of tropical medicine 2010年第7期3卷 510-514页

作者： Xueli Zheng Jialin Hu Santhosh Puthiya Kunnon Chen Xiaoguang Department of Pathogenic Biology school of Public Health and tropical medicine Southern Medical University

Objective:To identify necrophagous fly speies from different regions in China using inter simple sequenc repeat(ISSR) and sequence-characterized amplified region(SCAR) melocular markers and to analyze their gene difference and genetic ***:Five carrion fly species were collected from 12 cities and regions in China,including Musca domestica(***), Lucilia sericata(***),Chrysomya megacephala(***),Helicophagella melanura(***),Boethcherisca peregrina,and they were studied using ISSR and SCAR ***:Eight ISSR primers were used for amplification of 121 samples.679 clear and stable bands were identified,of which 516 bands were *** species-specific ISSR fragment were cloned and sequenced as an initial effort to derive the SCAR *** *** SCAR specific primers,SCAR-PCR amplification was performed for 8 *** population sample DNA from different regions in China as well as L sericata,***, *** and Lucillia *** result showed only *** produced specificalty 600 bp fragment,but L sericata,***,*** and Lucillia cupirina did not produce the same specific *** analysis showed clustering of most flies of M. domestica,*** and L *** samples from different regions in China yielded different banding ***:Application of ISSR-PCR and SCAR markers to identify necrophagous fly species from 12 cities and regions in China is first ***-PCR and SCAR markers provide a quick reliable molecular marker technique for the identification of different species of necrophagous fly.

关键词： Forensic insects Necrophagous flies Different population molecular markers Inter-simple sequence repeat Sequence-characterized amplified region

Nucleic acid detection in the diagnosis and prevention of schistosomiasis

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Infectious Diseases of Poverty 2016年第1期5卷 230-240页

作者： Ping He Lan-gui Song Hui Xie Jin-yi Liang Dong-ya Yuan Zhong-dao Wu Zhi-yue Lv Department of parasitology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Key Laboratory of tropical Disease Control Ministry of EducationGuangzhou 510080China Department of Pathogenic Biology Medical SchoolXizang Minzu UniversityXianyang 712082China

Schistosomiasis is an important zoonotic parasitic disease that causes serious harms to humans and *** and diagnosis play key roles in schistosomiasis control,however,current techniques for surveillance and diagnosis of the disease have *** genome data for parasites are increasing,novel techniques for detection incorporating nucleotide sequences are receiving widespread *** sensitive,specific,and rapid detection methods are particularly important in the diagnosis of low-grade and early infections,and may prove to have clinical *** paper reviews the progress of nucleic acid detection in the diagnosis and prevention of schistosomiasis,including such aspects as the selection of target genes,and development and application of nucleic acid detection methods.

关键词： Schistosoma japonicum S.mansoni S.haematobium Diagnosis Nucleic acid detection