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Current status and challenges for cell-cultured milk technology: a systematic review

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Journal of Animal Science and biotechnology 2024年第5期15卷 1778-1792页

作者： Hyuk Cheol Kwon Hyun Su Jung Vahinika Kothuri Sung Gu Han Department of Food Science and biotechnology of Animal Resources Konkuk UniversitySeoulRepublic of Korea

Cellular agriculture is an innovative technology for manufacturing sustainable agricultural products as an alternative to traditional *** most cellular agriculture is predominantly centered on the production of cultured meat,there is a growing demand for an understanding of the production techniques involved in dairy products within cellular *** review focuses on the current status of cellular agriculture in the dairy sector and technical challenges for cell-cultured milk *** agriculture technology in the dairy sector has been classified into fermentation-based and animal cell culture-based cellular ***,various companies synthesize milk components through precision fermentation ***,several startup companies are pursuing animal cell-based technology,driven by public concerns regarding genetically modified organisms in precision fermentation ***,this review offers an up-to-date exploration of animal cell-based cellular agriculture to produce milk components,specifically emphasizing the structural,functional,and productive aspects of mammary epithelial cells,providing new information for industry and academia.

关键词： Cell culture system Cell-cultured milk Mammary epithelial cells Precision fermentation

A transferrin receptor targeting dual-modal MR/NIR fluorescent imaging probe for glioblastoma diagnosis

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Regenerative Biomaterials 2024年第3期3卷 122-133页

作者： Jiaqi Hao Huawei Cai Lei Gu Yiqi Ma Yan Li Beibei Liu Hongyan Zhu Fanxin Zeng Min Wu Department of Radiology and Huaxi MR research Center(HMRRC) Functional and Molecular Imaging Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduSichuan 610041China research unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610041China Department of Nuclear Medicine&Laboratory of Clinical Nuclear Medicine West China HospitalSichuan UniversityChengduSichuan 610041China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China Department of Clinical research Center Dazhou Central HospitalDazhouSichuan 635000China

The prognosis of glioblastoma(GBM)remains challenging,primarily due to the lack of a precise,effective imaging technique for comprehensively *** GBM diagnostic challenges,our study introduces an innovative dual-modal imaging that merges near-infrared(NIR)fluorescent imaging with magnetic resonance imaging(MR).This method employs superparamagnetic iron oxide nanoparticies coated with NIR fluorescent dyes,specifically Cyanine 7,and targeted *** synthetic probe facilitates MRI functionality through superparamagnetic iron oxide nanoparticles,provides NIR imaging capability via Cyanine 7 and enhances tumor targeting trough peptide interactions,offering a comprehensive diagnostic tool for ***,the probe traverses the blood-brain barrier,targeting GBM in vivo via peptides,producing clear and discermible images in both *** and histopathology assessments confirm the probe's favorable safet *** findings suggest that the dual-modal MRINIR fluorescent imaging probe could revolutionize GBM prognosis and survival rate which can also be extended to other tumors type.

关键词： glioblastoma magnetic resonance imaging dual-modal probes near-infrared fluorescent targeting peptides

Effect of sample temperature on femtosecond laser ablation of copper

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Chinese Physics B 2024年第2期33卷 377-385页

作者：党伟杰陈雨桐陈安民金明星 Institute of Atomic and molecular Physics Jilin UniversityChangchun 130012China Jilin Provincial Key Laboratory of Applied Atomic and molecular Spectroscopy Jilin UniversityChangchun 130012China

We conduct an experimental study supported by theoretical analysis of single laser ablating copper to investigate the interactions between laser and material at different sample temperatures,and predict the changes of ablation morphology and lattice *** investigating the effect of sample temperature on femtosecond laser processing,we conduct experiments on and simulate the thermal behavior of femtosecond laser irradiating copper by using a two-temperature *** simulation results show that both electron peak temperature and the relaxation time needed to reach equilibrium increase as initial sample temperature *** the sample temperature rises from 300 K to 600 K,the maximum lattice temperature of the copper surface increases by about 6500 K under femtosecond laser irradiation,and the ablation depth increases by 20%.The simulated ablation depths follow the same general trend as the experimental *** work provides some theoretical basis and technical support for developing femtosecond laser processing in the field of metal materials.

关键词： femtosecond laser two-temperature model sample temperature ablation depth

Design,synthesis,and biological evaluation of 1,2,4-triazole derivatives as potent antitubercular agents

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Chinese Chemical Letters 2024年第3期35卷 326-331页

作者： Yu Wen Shichun Lun Yuxue Jiao Wei Zhang Tianyu Hu Ting Liu Fan Yang Jie Tang Bing Zhang William R.Bishai Li-Fang Yu Shanghai Engineering research Center of molecular Therapeutics and New Drug Development School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Center for Tuberculosis research Department of MedicineDivision of Infectious DiseaseJohns Hopkins School of MedicineBaltimoreMD21231-1044United States Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China

Inhibition of mycobacterial membrane protein large 3(MmpL3)thereby affecting the mycolic acid biosynthetic pathway has been proven to be an effective strategy for developing antitubercular *** on the X-ray crystal structure of MmpL3 inhibitor complexes,a series of novel 1,2,4-triazole derivatives were designed,synthesized and evaluated antitubercular activity against Mtb strain *** structure–activity relationship exploration resulted in the identification of compounds 21 and 28,which possess potent antitubercular activity against Mtb strain H37Rv[minimum inhibitory concentration(MIC)=0.03–0.13μg/mL]and the clinical isolates of multidrug resistance(MDR)and extensive drug resistance(XDR)tuberculosis(MIC=0.06–1.0μg/mL).Moreover,compounds 21 and 28 showed neglectable cytotoxicity(IC_(50)≥32μg/mL)to the mammalian Vero cells and favorable physicochemical and pharmacokinetic properties according to the in silico absorption,distribution,metabolism and excretion(ADME)***,the potential target of representative 1,2,4-triazole 28 was identified to be MmpL3 using a microscale thermophoresis(MST)assay.

关键词： Tuberculosis MDR and XDR-TB MmpL3 inhibitor 1 2 4-Triazole Structure-based drug design

RIOK1 synergizes with TRIP13 by regulating the E2F-Rb signaling pathway to promote the proliferation of esophageal cancer cells

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Genes & Diseases 2024年第3期11卷 55-58页

作者： Chengyu Li Deyuan Pan Wan Lin Danxia Deng Yingxin Zhou Hui Zhao Feng Pan Liyan Xu Enmin Li Lin Long The Key Laboratory of molecular Biology for High Cancer Incidence Coastal Chaoshan Area Department of Biochemistry and Molecular BiologyShantou University Medical CollegeShantouGuangdong 515041China Guangdong Provincial Key Laboratory of Infectious Diseases and molecular Immunopathology Institute of Oncologic PathologyShantou University Medical CollegeShantouGuangdong 515041China Institute of Basic Medical Science Cancer Research CenterShantou University Medical CollegeShantouGuangdong 515041China Clinical research Center Shantou Central HospitalShantouGuangdong 515041China

Esophageal cancer is one of the leading causes of cancer death in the world,with approximately half of the new cases occurring in China every year.^(1)Esophageal squamous cell carcinoma(ESCC)is the main subtype,accounting for more than 90%,and the five-year survival rate is less than 10%.Using large-scale genome analysis,many driver mutations and key pathways associated with ESCC have been ***,these genomic signatures have not improved the clinical management of EscC patients,or established effective targeted therapy.^(2)Esophageal cancer still lacks representative molecular markers.

关键词： cancer esophageal Esophageal

Natural hydrogel dressings in wound care: Design, advances, and perspectives

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Chinese Chemical Letters 2024年第10期35卷 28-38页

作者： Xiaoliu Liang Chunliu Huang Hui Liu Hu Chen Jiabao Shou Hongwei Cheng Gang Liu State Key Laboratory of Infectious Disease Vaccine Development Xiang An Biomedicine LaboratoryNational Innovation Platform for Industry-Education Integration in Vaccine ResearchState Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsCenter for Molecular Imaging and Translational MedicineSchoolofPublicHealthXiamenUniversityXiamen361102China Department of Burns and Plastics Surgery Liuzhou Worker's HospitalFourth Afliated Hospital of Guangxi Medical UniversityLiuzhou 545000China Institute of Applied Physics and Materials Engineering Zhuhai UM Science&Technology Research InstituteUniversity of MacaoMacao SAR 999078China

Natural hydrogels have emerged as a pivotal innovation in wound care,offering a unique combination of high absorbency,biocompatibility,and ***,due to the complexity of wound healing,the physiological state of the wound varies dynamically,and the mechanism of natural hydrogels that boost wound healing is still *** this review,we firstly provide a comprehensive introduction to the bio-logical process of wound healing,emphasizing the critical stages and factors affecting *** work concludes the composition and properties of natural hydrogels,including collagen,gelatin,hyaluronic acid,chitosan,alginates,cellulose,and fibroin,highlighting their biocompatibility and *** focus shifts to the various crosslinking strategies employed to enhance the structural integrity and functionality of natural *** review further investigates the biological effects of natural hydro-gels in wound healing,detailing their antibacterial,antioxidant,anti-inflammatory,adhesive,and hemo-static ***,we propose the challenges and future perspectives of natural hydrogels in practical *** review offers a comprehensive overview of the current state and poten-tial future advancements in natural hydrogel dressings for wound care,highlighting their critical role in addressing complex and hard-to-heal wounds.

关键词： Natural hydrogel Wound dressing Crosslinking strategy Antibacterial Anti-inflammation

Excitation and ionization of OCS molecules in strong UV and NIR laser fields

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Chinese Physics B 2024年第7期33卷 285-291页

作者：师慧军刘洋孙添吕航徐海峰 Institute of Atomic and molecular Physics Jilin UniversityChangchun 130012China

Rydberg state excitation(RSE) is a highly non-linear physical phenomenon that is induced by the ionization of atoms or molecules in strong femtosecond laser fields. Here we observe that both parent and fragments(S, C, OC) of the triatomic molecule carbonyl sulfide(OCS) can survive strong 800 nm or 400 nm laser fields in high Rydberg states. The dependence of parent and fragment RSE yields on laser intensity and ellipticity is investigated in both laser fields, and the results are compared with those for strong-field ionization. Distinctly different tendencies for laser intensity and ellipticity are observed for fragment RSE compared with the corresponding ions. The mechanisms of RSE and strong-field ionization of OCS molecules in different laser fields are discussed based on the experimental results. Our study sheds some light on the strong-field excitation and ionization of molecules irradiated by femtosecond NIR and UV laser fields.

关键词： Rydberg state excitation strong field carbonyl sulfide ionization

Earth's core-mantle boundary shaped by the crystallization of a hydrous terrestrial magma ocean

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National Science Review 2024年第7期11卷 73-75页

作者： Qingyang Hu Jie Deng Yukai Zhuang Zhenzhong Yang Rong Huang Center for High Pressure Science and Technology Advanced research(HPSTAR) Shanghai Advanced research in Physical Sciences(SHARPS) Department of Geosciences Princeton University Institute of Atomic and molecular Physics Sichuan University Key Laboratory of Polar Materials and Devices Department of Electronics East China Normal University

A water-rich global magma ocean(MO)likely existed in the early Hadean eon and subsequently cooled and *** water is an oxidant and is known to fundamentally affect liquid crystallization, the role of primordial water d... 详细信息

关键词： CROSSOVER MELT

Bright InP quantum dots by Ga-doping for red emitters

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Nano research 2024年第7期17卷 6721-6733页

作者： Kai-Zheng Song Xiao-Hang He Zhe-Yong Chen Ge Tang Jin-Zhao Huang Feng-Lei Jiang College of Chemistry and molecular Sciences Wuhan UniversityWuhan 430072China

Environment-friendly indium phosphide(InP)-based quantum dots(QDs)with efficient red-emitting properties are sufficiently needed to satisfy the requirement of burgeoning display and lighting ***,the syntheses of InP QDs using tris(trimethylsilyl)phosphine as the precursor are highly toxic and ***,we successfully introduced gallium(Ga)ions into tris(dimethylamino)phosphine-based red InP cores through thermally-promoted cation exchange,and the obtained Ga-doped InP cores exhibited significantly increased photoluminescence quantum yields(PLQY)of up to 26%.The existence of Ga was directly confirmed by energy-dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy,and the functions of Ga were systematically *** subsequent coating of Ga-doped InP cores with ZnSeS and ZnS shells,the resulting Ga-InP/ZnSeS/ZnS QDs achieved a high PLQY of 62%with an emission maximum at 640 *** contrast,without Ga-doping,the PLQY only attained 36%using the same synthetic *** indicated an approximate 1.7-fold increase in *** enhancement of photoluminescence was related to the Ga^(3+),as it not only passivated surface defects of InP cores but also reduced core–shell interface *** Ga-InP/ZnSeS/ZnS QDs exhibited good stability towards heat treatment and ultraviolet(UV)***,the red light-emitting diode(LED)based on Ga-InP/ZnSeS/ZnS QDs performed well in a wide injected current range of 2 to 200 mA,with a maximum power efficiency of 0.68 lm/*** work showcases Ga-doping through cation exchange as a promising strategy for enhancing the efficiency of InP-based red emitters.

关键词： indium phosphide gallium doping optical properties light emitting diode