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EjGASA6 promotes flowering and root elongation by enhancing gibberellin biosynthesis

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Journal of Integrative Agriculture 2024年第5期23卷 1568-1579页

作者： Qian Chen Shunyuan Yong Fan Xu Hao Fu Jiangbo Dang Qiao He Danlong Jing Di Wu Guolu Liang Qigao Guo Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education)/College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China State Cultivation Base of Crop Stress Biology for Southern Mountainous Land of Southwest University/Academy of Agricultural Sciences of Southwest University Chongqing 400715China College of Agronomy and biotechnology Southwest UniversityChongqing 400715China

The Gibberellic Acid-stimulated Arabidopsis(GASA)gene family is involved in the regulation of gene expression and plant growth,development,and stress responses.To investigate the function of loquat GASA genes in the growth and developmental regulation of plants,a loquat EjGASA6 gene homologous to Arabidopsis AtGASA6 was cloned.EjGASA6 expression was induced by gibberellin,and ectopic transgenic plants containing this gene exhibited earlier bloom and longer primary roots since these phenotypic characteristics are related to higher gibberellin content.Transcriptome analysis and qRT-PCR results showed that the expression levels of GA3ox1 and GA20ox1,which encode key enzymes in gibberellin biosynthesis,were significantly increased.Furthermore,we confirmed that EjGASA6 could promote the expression of GA20ox1 via the luciferase reporter system.Overall,our results suggest that EjGASA6 promotes blooming and main-root elongation by positively regulating gibberellin biosynthesis.These findings broaden our understanding of the role of GASAs in plant development and growth,and lay the groundwork for future research into the functions of EjGASA6 in regulating loquat growth and development.

关键词： loquat EjGASA6 gibberellin synthesis biological function

Structure and sequence analysis of influenza A virus nucleoprotein

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Science China(Life Sciences) 2009年第5期52卷 439-449页

作者： NG Andy Ka-Leung SHAW Pang-Chui molecular biotechnology programme Department of Biochemistry and Centre for Protein Science and Crystallography The Chi-nese University of Hong Kong

Influenza A virus nucleoprotein (NP) forms homo-oligomers and multiple copies of NP wrap around genomic RNA, along with a trimeric polymerase making up ribonucleoprotein (RNP) complex. Sequence comparison of more than 2500 influenza A NP showed that this protein contains 30.1 % of polymorphic residues. NP is composed of a head and a body domain and a tail loop/ linker region. The head domain is more conserved than the body domain, as revealed from the structure-based sequence alignment. NP oligomerization is mediated by the insertion of the non-polymorphic and structurally conserved tail loop of one NP molecule to a groove of another NP. The different form of NP oligomers is due to the flexibility of the polymorphic linkers that join the tail loop to the rest of the protein. The RNA binding property of NP is known to involve the protruding element and the flexible basic loop between the head and body domains, both having high degree of primary sequence conservation. To bind RNA, NP may first capture the RNA by the flexible basic loop and then the RNA is clamped by the protruding element.

关键词： Influenza H5N1 nucleoprotein oligomerization RNA binding

Synergistic fluorescent hydrogel actuators with selective spatial shape/color-changing behaviors via interfacial supramolecular assembly

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SmartMat 2024年第2期5卷 93-102页

作者： Wei Lu Ruijia Wang Muqing Si Yi Zhang Shuangshuang Wu Ning Zhu Wenqin Wang Tao Chen Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina School of Chemical Sciences University of Chinese Academy of SciencesBeijingChina Faculty of Materials Science and Chemical Engineering Ningbo UniversityNingboChina College of biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjingJiangsuChina

Biomimetic intelligent polymeric hydrogel actuators with cooperative fluorescence-color switchable behaviors are expected to find great potential applications in soft robotics,visual detection/display,and camouflage applications.However,it remains challenging to realize the spatial manipulation of synergistic shape/color-changing behaviors.Herein,we report an interfacial supramolecular assembly(ISA)approach that enables the construction of robust fluorescent polymeric hydrogel actuators with spatially anisotropic structures.On the basis of this ISA approach,diverse 2D/3D soft fluorescent hydrogel actuators,including chameleon-and octopi-shaped ones with spatially anisotropic structures,were facilely assembled from two different fluorescent hydrogel building blocks sharing the same physically cross-linked agar network.Spatially control over synergistic shape/color-changing behaviors was then realized in one single anisotropic hydrogel actuator.The proposed ISA approach is universal and expected to open promising avenues for developing powerful bioinspired intelligent soft actuators/robotics with selective spatial shape/color-changing behaviors.

关键词： actuator anisotropic structure interfacial supramolecular assembly multicolor fluorescent hydrogels self-gluing

Dynamics of ecosystems and anthropogenic drivers in the Yellow Sea Large Marine Ecosystem

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Acta Oceanologica Sinica 2022年第6期41卷 1-3页

作者： Jun Sun Yinfeng Guo Gyung Soo Park Andrew Hudson Institute for Advanced Marine Research China University of GeosciencesGuangzhou 511462China National Marine Hazard Mitigation Service Ministry of Natural ResourcesBeijing 100194China Department of Marine biotechnology Anyang UniversityAnyang 14028R.O.Korea Bureau for Policy and programme Support United Nations Development ProgrammeNew York 10017USA

In the developed world,governance of marine ecological environment is the important part of the national ecological and economic outcome.The Yellow Sea is one of large marine ecosystems in the seas of East Asia,which is an extension of one of the largest continental shelf areas,and forms a huge but shallow sediment body in its south area which is geographically unique in the world.As a region with the most fragile natural environment,unparalleled global ecological significance and the most urgent protection needs,the Yellow Sea ecological zone is becoming a common concern of countries around the Yellow Sea and beyond,such as tidal flats and the staging migratory birds(Murray et al.,2015).

关键词： shallow tidal shelf

Mixed iridium-nickel oxides supported on antimony-doped tin oxide as highly efficient and stable acidic oxygen evolution catalysts

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Materials Futures

Materials Futures 2024年第1期3卷 165-180页

作者： Jonathan Ruiz Esquius Alec P LaGrow Haiyan Jin Zhipeng Yu Ana Araujo Rita Marques Adélio Mendes Lifeng Liu Clean Energy Cluster International Iberian Nanotechnology LaboratoryAv.Mestre JoséVeigaBraga 4715-330Portugal Carbon Science and Technology Institute INCAR-CSICFrancisco Pintado Fe 26Oviedo 33011Spain Scientific Imaging Section Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0412Japan Songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China Laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal.

Proton exchange membrane(PEM)water electrolysis represents a promising technology for green hydrogen production,but its widespread deployment is greatly hindered by the indispensable usage of platinum group metal catalysts,especially iridium(Ir)based materials for the energy-demanding oxygen evolution reaction(OER).Herein,we report a new sequential precipitation approach to the synthesis of mixed Ir-nickel(Ni)oxy-hydroxide supported on antimony-doped tin oxide(ATO)nanoparticles(IrNiyO_(x)/ATO,20 wt.%(Ir+Ni),y=0,1,2,and 3),aiming to reduce the utilisation of scarce and precious Ir while maintaining its good acidic OER performance.When tested in strongly acidic electrolyte(0.1 M HClO_(4)),the optimised IrNi1Ox/ATO shows a mass activity of 1.0 mAµgIr^(−1) and a large turnover frequency of 123 s^(−1) at an overpotential of 350 mV,as well as a comparatively small Tafel slope of 50 mV dec^(−1),better than the IrOx/ATO control,particularly with a markedly reduced Ir loading of only 19.7µgIr cm^(−2).Importantly,IrNi1O_(x)/ATO also exhibits substantially better catalytic stability than other reference catalysts,able to continuously catalyse acidic OER at 10 mA cm^(−2) for 15 h without obvious degradation.Our in-situ synchrotron-based x-ray absorption spectroscopy confirmed that the Ir^(3+)/Ir^(4+)species are the active sites for the acidic OER.Furthermore,the performance of IrNi1Ox/ATO was also preliminarily evaluated in a membrane electrode assembly,which shows better activity and stability than other reference catalysts.The IrNi1Ox/ATO reported in this work is a promising alternative to commercial IrO_(2) based catalysts for PEM electrolysis.

关键词： mixed oxides oxygen evolution reaction polymer electrolyte membrane antimony doped tin oxide membrane electrode assembly

Light-responsive nanomedicine for cancer immunotherapy

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药学学报:英文版 2023年第6期13卷 2346-2368页

作者： Weirong Kang Yuwei Liu Weiping Wang State Key Laboratory of Pharmaceutical biotechnology the University of Hong KongHong KongChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Laboratory of molecular Engineering and Nanomedicine Dr.Li Dak-Sum Research Centrethe University of Hong KongHong KongChina

Immunotherapy emerged as a paradigm shift in cancer treatments, which can effectively inhibit cancer progression by activating the immune system. Remarkable clinical outcomes have been achieved through recent advances in cancer immunotherapy, including checkpoint blockades, adoptive cellular therapy, cancer vaccine, and tumor microenvironment modulation. However, extending the application of immunotherapy in cancer patients has been limited by the low response rate and side effects such as autoimmune toxicities. With great progress being made in nanotechnology, nanomedicine has been exploited to overcome biological barriers for drug delivery. Given the spatiotemporal control,light-responsive nanomedicine is of great interest in designing precise modality for cancer immunotherapy. Herein, we summarized current research utilizing light-responsive nanoplatforms to enhance checkpoint blockade immunotherapy, facilitate targeted delivery of cancer vaccines, activate immune cell functions, and modulate tumor microenvironment. The clinical translation potential of those designs is highlighted and challenges for the next breakthrough in cancer immunotherapy are discussed.

关键词： Light-responsive nanoparticles Photodynamic therapy Photothermal therapy Nanomedicine Cancer therapy Immunotherapy Photopharmacology Light-triggered drug release

Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第11期2卷 910-915页

作者： Viswanadha Vijaya Padma Gurusamy Lalitha Nichokon Puthanveedu Shirony Rathinasamy Baskaran Animal tissue culture and molecular genetics Laboratory Department of BiotechnologySchool of Biotechnology and Genetic EngineeringBharathiar University Department of biotechnology PSG College of Arts and ScienceCoimbatoreTamilnaduIndia

Objective:To assess the effect of quercetin(flavonoid) against lindane induced alterations in lipid profile of wistar rats.Methods:Rats were administered orally with lindane(100 mg/kg body weight) and quercetin(10 mg/kg body weight) for 30 days.After the end of treatment period lipid profile was estimated in serum and tissue.Results:Elevated levels of serum cholesterol, triglycerides,low density lipoprotein(LDL),very Low Density Lipoprotein(VLDL) and tissue triglycerides,cholesterol with concomitant decrease in serum HDL and tissue phospholipids were decreased in lindane treated rats were found to be significantly decreased in the quercetin and lindane co-treated rats.Conclusions:Our study suggests that quercetin has hypolipidemic effect and offers protection against lindane induced toxicity in liver by restoring the altered levels of lipids.The quercetin cotreatment along with lindane for 30 days reversed these biochemical alterations in lipids induced by lindane.

关键词： Lindane Quercetin Oxidative stress Low density lipoprotein Very low density lipoprotein High density lipoprotein Triglycerides

What makes(hydroxy)chloroquine ineffective against COVID-19:insights from cell biology

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Journal of molecular Cell Biology 2021年第3期13卷 175-184页

作者： Dania Altulea Sjors Maassen Maksim V.Baranov G.van den Bogaart Department of molecular Immunology and Microbiology Groningen Biomolecular Sciences and Biotechnology InstituteUniversity of GroningenGroningenthe Netherlands Department of Tumor Immunology Radboud Institute for Molecular Life SciencesRadboud University Medical CenterNijmegenthe Netherlands

Since chloroquine(CQ)and hydroxychloroquine(HCQ)can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in cultured cells,the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease(COVID-19).However,despite promising preliminary findings,many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19.Here,we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.

关键词： coronavirus COVID-19 SARS-CoV-2 chloroquine hydroxychloroquine

Overcoming mitochondrial dysfunction in neurodegenerative diseases

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Neural Regeneration Research 2023年第7期18卷 1486-1488页

作者： João Pessoa Ana I.Duarte CNC-Center for Neuroscience and Cell Biology CIBB-Center for Innovative Biomedicine and BiotechnologyUniversity of CoimbraCoimbraPortugal

Due to their intense electrical activity,neurons have high energy demands.This requirement makes them particularly sensitive to mitochondrial dysfunction.Like all eukaryotic cells,neurons have intrinsic mechanisms to mitigate the impact of mitochondrial dysfunction and its consequent production of toxic substances.Among such(neuro)protective mechanisms,mitochondrial autophagy(mitophagy)is responsible for the removal of dysfunctional mitochondria.Pathological inhibition of mitophagy,together with insufficient mitochondrial activity,results in a shortage of adenosine triphosphate(ATP)and the accumulation of reactive oxygen species(ROS)(Simmons et al.,2020).

关键词： protective dysfunction intense