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Assessing the impact of booster vaccination on diphtheria transmission:Mathematical modeling and risk zone mapping

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Infectious disease modelling 2024年第1期9卷 245-262页

作者： Ilham Saiful Fauzi Nuning Nuraini Ade Maya Sari Imaniah Bazlina Wardani delsi Taurustiati Purnama Magdalena Simanullang Bony Wiem Lestari department of Accounting Politeknik Negeri MalangMalangIndonesia department of Mathematics Faculty of Mathematics and Natural SciencesInstitut Teknologi BandungBandungIndonesia center for Mathematical modeling and Simulation Institut Teknologi BandungBandungIndonesia Study Program of Biology Education Faculty of Education and Teacher TrainingUIN Kiai Haji Achmad Siddiq JemberJemberIndonesia West Java Provincial Health Office West JavaIndonesia department of Public Health Faculty of MedicineUniversitas PadjadjaranBandungIndonesia department of Internal Medicine Radboud Institute for Health SciencesRadboud University Medical CentreNijmegenthe Netherlands

The COVId-19 pandemic caused significant disruptions in the healthcare system,affecting vaccinations and the management of diphtheria *** a consequence of these disruptions,numerous countries have experienced a resurgence or an increase in diphtheria *** Java province in Indonesia is identified as one of the high-risk areas for diphtheria,experiencing an upward trend in cases from 2021 to *** analyze the situation,we developed an SIr model,which integrated dPT and booster vaccinations to determine the basic reproduction number,an essential parameter for infectious *** spatial analysis of geo-referenced data,we identified hotspots and explained diffusion in diphtheria case *** calculation of r0 resulted in an r0=1.17,indicating the potential for a diphtheria outbreak in West *** control the increasing cases,one possible approach is to raise the booster vaccination coverage from the current 64.84%to 75.15%,as suggested by simulation ***,the spatial analysis revealed that hot spot clusters were present in the western,central,and southern regions,posing a high risk not only in densely populated areas but also in rural *** diffusion pattern of diphtheria clusters displayed an expansion-contagious *** the rising trend of diphtheria cases and their geographic distribution can offer crucial insights for government and health authorities to manage the number of diphtheria cases and make informed decisions regarding the best prevention and intervention strategies.

关键词： diphtheria Vaccination Mathematical modeling SIr model Hot spot analysis

Understanding important features of deep learning models for segmentation of high-resolution transmission electron microscopy images

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npj Computational Materials 2020年第1期6卷 765-773页

作者： James P.Horwath dmitri N.Zakharov rémi Mégret Eric A.Stach department of Materials Science and Engineering University of PennsylvaniaPhiladelphiaPAUSA center for Functional Nanomaterials Brookhaven National LaboratoryUptonNYUSA department of Computer Science University of Puerto RicoRío PiedrasSan JuanPRUSA

Cutting edge deep learning techniques allow for image segmentation with great speed and ***,application to problems in materials science is often difficult since these complex models may have difficultly learning meaningful image features that would enable extension to new *** situ electron microscopy provides a clear platform for utilizing automated image *** this work,we consider the case of studying coarsening dynamics in supported nanoparticles,which is important for understanding,for example,the degradation of industrial *** systematically studying dataset preparation,neural network architecture,and accuracy evaluation,we describe important considerations in applying deep learning to physical applications,where generalizable and convincing models are *** a focus on unique challenges that arise in high-resolution images,we propose methods for optimizing performance of image segmentation using convolutional neural networks,critically examining the application of complex deep learning models in favor of motivating intentional process design.

关键词： neural networks image

Ablation strategies for arrhythmogenic right ventricular cardiomyopathy: a systematic review and meta-analysis

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Journal of Geriatric Cardiology 2020年第11期17卷 694-703页

作者： Li-Shui SHEN Li-Min LIU Li-Hui ZHENG Feng HU Zhi-Cheng HU Shang-Yu LIU Jin-rui GUO Kush Kumar Bhagat Yan YAO Arrhythmia center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Arrhythmia center Yunnan Fuwai Cardiovascular HospitalKunmingChina Eternal hospital JaipurRajasthanIndia

Background Catheter ablation for ventricular tachycardia(VT) in patients with arrhythmogenic right ventricular cardiomyopathy(ArVC) has significantly evolved over the past decade. However, different ablation strategies showed inconsistency in acute and long-term outcomes. Methods We searched the databases of Medline, Embase and Cochrane Library through October 17, 2019 for studies describing the clinical outcomes of VT ablation in ArVC. data including VT recurrence, all-cause mortality, acute procedural efficacy and major procedural complications were extracted. A meta-analysis with trial sequential analysis was further performed in comparative studies of endo-epicardial versus endocardial-only ablation. results A total of 24 studies with 717 participants were enrolled. The literatures of epicardial ablation were mainly published after 2010 with total ICd implantation of 73.7%, acute efficacy of 89.8%, major complication of 5.2%, follow-up of 28.9 months, VT freedom of 75.3%, all-cause mortality of 1.1% and heart transplantation of 0.6%. Meta-analysis of 10 comparative studies revealed that compared with endocardial-only approach, epicardial ablation significantly decreased VT recurrence(Or: 0.50;95% CI: 0.30–0.85;P = 0.010), but somehow increased major procedural complications(Or: 4.64;95% CI: 1.28–16.92;P = 0.02), with not evident improvement of acute efficacy(Or: 2.74;95% CI: 0.98–7.65;P = 0.051) or all-cause mortality(Or: 0.87;95% CI: 0.09–8.31;P = 0.90). Conclusion Catheter ablation for VT in ArVC is feasible and effective. Epicardial ablation is associated with better long-term VT freedom, but with more major complications and unremarkable survival or acute efficacy benefit.

关键词： Arrhythmogenic right ventricular cardiomyopathy Catheter ablation Ventricular tachycardia

Nanotechnological strategies for prostate cancer imaging and diagnosis

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Science China Chemistry 2022年第8期65卷 1498-1514页

作者： Thecla Trinity Wheeler Pei Cao Muhammad daniyal Ghouri Tianjiao Ji Guangjun Nie Yuliang Zhao CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The high incidence rates and complicated subtypes of prostate cancer(PCa)call for the demand of the precise diagnostic and therapeutic *** clinical imaging techniques,such as MrI,CT,and ultrasonography are difficult to accurately detect the early-stage tumor lesions,and biochemical assays or biopsies are invasive and cannot provide sufficient information for the PCa staging and *** has the potential to improve the accuracy of current diagnosis strategies by targeting specific PCa biomarkers and/or integrating multiple imaging *** this review,we briefly introduce current clinical PCa imaging strategies and their major limitations,and highlight representative works on nanoparticle-mediated multimode imaging *** also discuss the challenges of nanotechnology-based PCa diagnosis,and come up with suggestions and perspectives.

关键词： prostate cancer diagnosis nanotechnology targeting multi-mode imaging

Lung cancer risk score for ever and never smokers in China

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Cancer Communications 2023年第8期43卷 877-895页

作者： Zhimin Ma Jun Lv Meng Zhu Canqing Yu Hongxia Ma Guangfu Jin Yu Guo Zheng Bian Ling Yang Yiping Chen Zhengming Chen Zhibin Hu Liming Li Hongbing Shen department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuP.R.China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsuP.R.China department of Epidemiology School of Public HealthSoutheast UniversityNanjingJiangsuP.R.China department of Epidemiology&Biostatistics School of Public HealthPeking UniversityBeijingP.R.China Ministry of Education Key Laboratory of Molecular Cardiovascular Sciences(Peking University)BeijingP.R.China Chinese Academy of Medical Sciences BeijingP.R.China Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxfordOxfordshireUK research Units of Cohort Study on Cardiovascular diseases and Cancers Chinese Academy of Medical SciencesBeijingP.R.China

Background:Most lung cancer risk prediction models were developed in European and North-American cohorts of smokers aged≥55 years,while less is known about risk profiles in Asia,especially for never smokers or individuals agedd to develop and validate a lung cancer risk estimate tool for ever and never smokers across a wide age ***:Based on the China Kadoorie Biobank cohort,we first systematically selected the predictors and explored the nonlinear association of predictors with lung cancer risk using restricted cubic ***,we separately developed risk prediction models to construct a lung cancer risk score(LCrS)in 159,715 ever smokers and 336,526 never *** LCrS was further validated in an independent cohort over a median follow-up of 13.6 years,consisting of 14,153 never smokers and 5,890 ever ***:A total of 13 and 9 routinely available predictors were identified for ever and never smokers,*** these predictors,cigarettes per day and quit years showed nonlinear associations with lung cancer risk(Pnon-linearrve of lung cancer incidence increased rapidly above 20 cigarettes per day and then was relatively flat until approximately 30 cigarettes per *** also observed that lung cancer risk declined sharplywithin the first 5 years of quitting,and then continued to decrease but at a slower rate in the subsequent *** 6-year area under the receiver operating curve for the ever and never smokers’models were respectively 0.778 and 0.733 in the derivation cohort,and 0.774 and 0.759 in the validation *** the validation cohort,the 10-year cumulative incidence of lung cancerwas 0.39%and 2.57%for ever smokers with low(d intermediate-high LCrS(≥166.2),*** smokers with a high LCrS(≥21.2)had a higher 10-year cumulative incidence rate than those with a low LCrS(risk evaluation tool(LCKEY;http://***/lckey/web)was develope

关键词： early-onset cancer lung cancer screening lung cancer never smokers prediction model

Growth simulation and yield prediction for perennial jujube fruit tree by integrating age into the WOFOST model

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Journal of Integrative Agriculture 2020年第3期19卷 721-734页

作者： BAI Tie-cheng WANG Tao ZHANG Nan-nan CHEN You-qi Benoit MErCATOrIS TErrA Teaching and research Centre Gembloux Agro-Bio TechLiège UniversityGembloux 5030Belgium Southern Xinjiang research center for Information Technology in Agriculture/College of Information Engineering Tarim UniversityAlaer 843300P.R.China Institute of Agricultural resources and regional Planning Chinese Academy of Agricultural SciencesBeijing 100081P.R.China

Mathematical models have been widely employed for the simulation of growth dynamics of annual crops,thereby performing yield prediction,but not for fruit tree species such as jujube tree(Zizyphus jujuba).The objectives of this study were to investigate the potential use of a modified WOFOST model for predicting jujube yield by introducing tree age as a key *** model was established using data collected from dedicated field experiments performed in *** growth dynamics of dry weights of leaves,stems,fruits,total biomass and leaf area index(LAI) agreed well with measured values,showing root mean square error(rMSE) values of 0.143,0.333,0.366,0.624 t ha^-1 and 0.19,and r2 values of 0.947,0.976,0.985,0.986 and 0.95,*** phenological development stages for emergence,anthesis and maturity were 2,3 and 3 days earlier than the observed values,*** addition,in order to predict the yields of trees with different ages,the weight of new organs(initial buds and roots) in each growing season was introduced as the initial total dry weight(TdWI),which was calculated as averaged,fitted and optimized values of trees with the same *** results showed the evolution of the simulated LAI and yields profiled in response to the changes in *** modelling performance was significantly improved when it considered TdWI integrated with tree age,showing good global(r2≥0.856,rMSE≤0.68 t ha^-1) and local accuracies(mean r2≥0.43,rMSE≤0.70 t ha^-1).Furthermore,the optimized TdWI exhibited the highest precision,with globally validated r2 of 0.891 and rMSE of 0.591 t ha^-1,and local mean r2 of 0.57 and rMSE of 0.66 t ha^-1,*** proposed model was not only verified with the confidence to accurately predict yields of jujube,but it can also provide a fundamental strategy for simulating the growth of other fruit trees.

关键词： fruit tree growth simulation yield forecasting crop model tree age

Printing High-resolution Micro-patterns by Solution Processes

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Chemical research in Chinese Universities 2021年第5期37卷 1008-1018页

作者： ZHANG Kejie ZHANG Min LIU Huan Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringInternational Research Institute for Multidisciplinary ScienceBeihang UniversityBeijing100191P.R.China

The preparation of high-resolution micro-patterns is urgently demanded for developing opto-/electric-devices in various ***,solution processes have been commonly used for fabricating micro-patterned surfaces for its mild operation conditions,facile operability and *** this contribution,we reviewed recent processes on preparing micro-/nano-patterns using solution processes based the viewpoint of resolution,including inkjet printing,photolithography,micro-contact printing.

关键词： resolution preparing viewpoint

High-dimensional quantum information processing on programmable integrated photonic chips

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Science China(Information Sciences) 2023年第8期66卷 5-22页

作者： Yulin CHI Yue YU Qihuang GONG Jianwei WANG State Key Laboratory for Mesoscopic Physics School of Physics Peking University Frontiers Science center for Nano-optoelectronics and Collaborative Innovation center of Quantum Matter Peking University Peking University Yangtze delta Institute of Optoelectronics Collaborative Innovation center of Extreme Optics Shanxi University Hefei National Laboratory

This study reviews the recent progress of high-dimensional quantum information processing with photons. We first introduce the basic language of high-dimensional quantum information, including the representation of quantum dits(qudits), unitary operations of qudit states, and the general format of quantum algorithms with qudits. We discuss experimental implementations of high-dimensional quantum information processing and quantum computing in photonic systems, particularly in integrated quantum photonic platforms. We also discuss how qudit-based quantum photonic devices and systems can be adopted for further improving qubit-based quantum computation and quantum simulation.

关键词： high-dimensional quantum information processing quantum computation integrated quantum photonics

On the Edge-forwarding Indices of Frobenius Graphs

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1735-1744页

作者： Yan WANG Xin Gui FANG d. F. HSU department of Mathematics Yantai University Yantai 264005 P. R. China LMAM & department of Mathematics Peking University Beijing 100871 P. R. China department of Computer & Information Sciences Fordham University New York 10023 USA dIMA CS center Rutgers University 96 Frelinghuysen Road Piscataway New Jersey 08854 USA

A G-Frobenius graph F, as defined by Fang, Li, and Praeger, is a connected orbital graph of a Frobenius group G = K × H with Frobenius kernel K and Frobenius complement H. F is also shown to be a Cayley graph, F = Cay（K, S） for K and some subset S of the group K. On the other hand, a network N with a routing function r, written as （N, r）, is an undirected graph N together with a routing r which consists of a collection of simple paths connecting every pair of vertices in the graph. The edge-forwarding index π（N） of a network （N, r）, defined by Heydemann, Meyer, and Sotteau, is a parameter to describe tile maximum load of edges of N. In this paper, we study the edge-forwarding indices of Frobenius graphs. In particular, we obtain the edge-forwarding index of a G-Frobenius graph F with rank（G） ≤ 50.

关键词： Frobenius graph networks edge-forwarding index