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World Journal of Gastroenterology 2016年第18期22卷 4515-4528页

作者： Fang Peng Ying Huang Mao-Yu Li Guo-Qing Li Hui-Chao Huang Rui Guan Zhu-Chu Chen Song-Ping Liang Yong-Heng Chen Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of education College of Life Sciences Hunan Normal University Changsha 410081 Hunan Province China Key Laboratory of Cancer Proteomics of Chinese Ministry of Health Xiang Ya Hospital Central South University Changsha 410008 Hunan Province China Maternal and Child Health Hospital of hunan province Changsha 410008 Hunan Province China Department of Biology School of Pharmacy and Life Science University of South China Hengyang 421001 Hunan Province China experimental Medicine center Hunan Cancer Hospital Changsha 410013 Hunan Province China collaborative innovation center for Cancer Medicine Guangzhou 510000 Guangdong Province China

AIM: To discover novel biomarkers for early diagnosis, prognosis or treatment of human colorectal cancer. MeTHODS: i TRAQ 2D LC-MS/MS analysis was used to identify differentially expressed proteins(DePs) in the human colonic epithelial carcinogenic process using laser capture microdissection-purified colonic epithelial cells from normal colon, adenoma, carcinoma in situ and invasive carcinoma tissues. ReSULTS: A total of 326 DePs were identified, and four DePs(DMBT1, S100A9, Galectin-10, and S100A8) with progressive alteration in the carcinogenic process were further validated by immunohistochemistry. The DePs were involved in multiple biological processes including cell cycle, cell adhesion, translation, m RNA processing, and protein synthesis. Some of the DePs involved in cellular process such as "translation" and "m RNA splicing" were progressively up-regulated, while some DePs involved in other processes such as "metabolism" and "cell response to stress" was progressively downregulated. Other proteins with up- or down-regulation at certain stages of carcinogenesis may play various roles at different stages of the colorectal carcinogenic process. CONCLUSION: These findings give insights into our understanding of the mechanisms of colorectal carcinogenesis and provide clues for further investigation of carcinogenesis and identification of biomarkers.

关键词： Colorectal Cancer Proteome Biomarker Carcinogenesis

Personalized News Recommendation Based on the Text and Image Integration

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Computers, Materials & Continua 2020年第7期64卷 557-570页

作者： Kehua Yang Shaosong Long Wei Zhang Jiqing Yao Jing Liu College of Computer Science and electronic engineering and Key Laboratory for embedded and Network Computing of hunan province Hunan UniversityChangsha410082China Oath Verizon Company New York10007USA

The personalized news recommendation has been very popular in the news recommendation *** most research,the picture information in the news is ignored,but the information conveyed to the users through pictures is more intuitive and more likely to affect the users’reading interests than the one in the textual ***,in this paper,a model that combines images and texts in the news is *** this model,the new tags are extracted from the images and texts in the news,and based on these new tags,an adaptive tag(AT)algorithm is *** AT algorithm selects the tags the user is interested in based on the user *** particular,the AT algorithm can predict tags that a user may be interested in with the help of the tag correlation graph without any user *** proposed AT algorithm is verified by *** experimental results verified the AT algorithm regarding three evaluation indexes F1-score(F1),area under curve(AUC)and mean reciprocal rank(MRR).The recommended effect of the proposed algorithm is found to be better than those of the various baseline algorithms on real-world datasets.

关键词： News recommendation F1 AUC MRR feedback correlation graph

Removal of Metallic Impurities from Off-Grade Copper Concentrate in Alkaline Solution

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International Journal of Nonferrous Metallurgy 2018年第2期7卷 9-23页

作者： Zhi-xiong Liu Lin Sun Liang-dong Tang Jie Hu Yang Xiao Yi-guang Chen Zhou-lan Yin College of Physics and Mechanical & electrical engineering Jishou University Jishou China The collaborative innovation center of Manganese-Zinc-Vanadium Industrial Technology (the 2011 Plan of hunan province) Jishou University Jishou China Key Laboratory of Mineral Cleaner Production and exploit of Green Functional Materials in hunan province Jishou University Jishou China College of Biology and environmental Sciences Jishou University Jishou China School of Chemistry and Chemical engineering Central South University Changsha China

The removal of metallic impurities from off-grade copper concentrate was investigated in alkaline solution with H2O2. The analysis results of XRD and SeM-eDS revealed the oxidative mechanisms of all sulfides. The influence of various parameters of alkaline leaching were investigated including concentrations of sodium hydroxide and hydrogen peroxide, liquid to solid ratio, leaching time and temperature. The results showed that the removal rate of Mo, As and Zn were increased with increasing leaching time and H2O2 concentration, and that the removal rate of Mo, As and Zn were firstly increased and then slightly decreased with increasing liquid to solid ratio, temperature and NaOH concentration, respectively. More than 95% Mo, 94% As, and 94 % Zn are removed from the off-grade concentrate under the optimum conditions, while only 1.7% Cu is dissolved. These optimum conditions were sodium hydroxide 1.5 mol/L, hydrogen peroxide 1.0 mol/L, temperature 50°C, liquid to solid ratio 5/1 mL/g and leaching time 5 h.

关键词： Copper Concentrate Impurities Removal Alkaline Leaching Hydrogen Peroxide

Non-conjugated polymers as thickness-insensitive electron transport materials in high-performance inverted organic solar cells

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Journal of energy Chemistry 2020年第8期29卷 196-202,I0007页

作者： Zhiquan Zhang Zheling Zhang Yufu Yu Bin Zhao Sheng Li Jian Zhang Songting Tan Key Laboratory for Green Organic Synthesis and Application of hunan province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan 411105HunanChina College of Material Science&engineering Guangxi Key Laboratory of Information MaterialsGuilin University of Electrical TechnologyGuilin 541004GuangxiChina hunan Research Institute of Light Industry Changsha 410015HunanChina

Two non-conjugated polymers PeIe-DBO and PeIe-DCO, prepared by quaternization of polyethyleneimine ethoxylate by 1,8-dibromooctane and 1,8-dichlorooctane respectively, are developed as electron transport layer(eTL) in high-performance inverted organic solar cells(OSCs), and the effects of halide ions on polymeric photoelectric performance are fully investigated. PeIe-DBO possesses higher electron mobility(3.68×10-4 cm2 V-1s-1), higher conductivity and more efficient exciton dissociation and electron extraction, attributed to its lower work function(3.94 eV) than that of PeIe-DCO, which results in better photovoltaic performance in OSCs. The inverted OSCs with PTB7-Th: PC71BM as photoactive layer and PeIe-DBO as eTL exhibit higher PCe of 10.52%, 9.45% and 9.09% at the thickness of 9, 35 and 50 nm,respectively. To our knowledge, PeIe-DBO possesses the best thickness-insensitive performance in polymeric eTLs of inverted fullerene-based OSCs. Furthermore, PeIe-DBO was used to fabricate the inverted non-fullerene OSCs(PM6:Y6) and obtained a high PCe of 15.74%, which indicates that PeIe-DBO is effective both in fullerene-based OSCs and fullerene-free OSCs.

关键词： Organic solar cells electron transport materials Thickness-insensitive Non-conjugated polymer

electrically driven motion, destruction, and chirality change of polar vortices in oxide superlattices

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Science China(Physics,Mechanics & Astronomy) 2022年第3期65卷 77-84页

作者： Pan Chen Congbing Tan Zhexin Jiang Peng Gao Yuanwei Sun Lifen Wang Xiaomei Li Ruixue Zhu Lei Liao Xu Hou Ke Qu Ning Li Xiaomin Li Zhi Xu Kaihui Liu Wenlong Wang Jinbin Wang Xiaoping Ouyang Xiangli Zhong Jie Wang Xuedong Bai Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China International center for Quantum Materials Electron Microscopy LaboratorySchool of PhysicsPeking UniversityBeijing 100871China hunan Provincial Key Laboratory of Intelligent Sensors and Advanced Sensor Materials School of Physics and ElectronicsHunan University of Science and TechnologyXiangtan 411201China Department of engineering Mechanics Zhejiang UniversityHangzhou 310027China collaborative innovation center of Quantum Matter Beijing 100871China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China State Key Laboratory for Artificial Microstructure&Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China School of Materials Science and engineering Xiangtan UniversityXiangtan 411105China Key Laboratory of Soft Machines and Smart Devices of Zhejiang province Zhejiang UniversityHangzhou 310027China

Topological polar vortices, which are electric analogs of magnetic objects, present great potential in applications of future nanoelectronics because of their nanometer size, anomalous dielectric response, and chirality. To enable the functionalities, it is prerequisite to manipulate the polar states and chirality by using external stimuli. Here, we probe the evolutions of polar state and chirality evolutions of topological polar vortices in Pb TiO;/Sr TiO;superlattices under an electric field by using atomically resolved in situ scanning transmission electron microscopy and phase-field simulations. We find that, under electric field, the chiral vortex cores can be moved laterally to form close-pair structures, transform into a/c domain stripes, and finally become a nonchiral c-domain. Such transition is reversible and spontaneous after bias removal. Interestingly, during switching and backswitching events, the vortex rotation can be changed, offering a potential strategy to manipulate vortex chirality. The revealed dynamic behavior of individual polar vortices at the atomic scale provides fundamentals for future device applications.

关键词： chirality polar vortex ferroelectrics in situ transmission electron microscopy phase-field simulations

Octacosanol and health benefits:Biological functions and mechanisms of action

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Food Bioscience 2022年第3期47卷 1-16页

作者： Yaping Zhou Fuliang Cao Feijun Luo Qinlu Lin National engineering Laboratory for Deep Process of Rice and Byproducts Hunan Key Laboratory of Grain-oil Deep Process and Quality ControlHunan Key Laboratory of Processed Food for Special Medical PurposeCollege of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha410004HunanChina Co-innovation center for the Sustainable Forestry in Southern China College of ForestryNanjing Forestry UniversityNanjing210037JiangsuChina

Octacosanol is a widely distributed natural higher aliphatic alcohol that can be isolated and purified from rice bran,sugarcane,beeswax,insect wax,*** exerts various biological effects,including anti-fatigue,anti-hypoxia,antioxidant,anti-inflammatory,antitumor,***,it has the effects of regulating the body's immune function and energy metabolism and has potential benefits for cardiovascular disease,cerebrovascular disorders,diabetes,Parkinson's disease,and *** is primarily responsible for regulating multiple signaling pathways,such as AMPK,PI3K/Akt,and MAPK/NF-κB,to achieve different physiological *** review systemically summarized the progress in characterization,extraction and purification,biological functions,molecular mechanisms,and bioavailability of *** study will provide a reference for many investigators to further explore the physiological functions of higher aliphatic alcohols and apply them as supplements in functional foods.

关键词： Octacosanol Phytochemical extraction and purification Biological functions Molecular mechanisms Bioavailability

Wire-in-Wire TiO_(2)/C Nanofibers Free-Standing Anodes for Li-Ion and K-Ion Batteries with Long Cycling Stability and High Capacity

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Nano-Micro Letters 2021年第7期13卷 91-104页

作者： Die Su Yi Pei Li Liu Zhixiao Liu Junfang Liu Min Yang Jiaxing Wen Jing Dai Huiqiu Deng Guozhong Cao National Base for International Science and Technology Cooperation National Local Joint Engineering Laboratory for Key Materials of New Energy Storage BatteryHunan Province Key Laboratory of Electrochemical Energy Storage and ConversionSchool of ChemistryXiangtan UniversityXiangtan 411105People’s Republic of China Department of Materials Science and engineering University of WashingtonSeattleWA 98195-2120USA College of Materials Science and engineering Hunan UniversityChangsha 410082People’s Republic of China School of Physics and electronics Hunan UniversityChangsha 410082People’s Republic of China

Wearable and portable mobile phones play a critical role in the market, and one of the key technologies is the flexible electrode with high specific capacity and excellent mechanical flexibility. Herein, a wire-in-wire TiO_(2)/C nanofibers (TiO_(2) ww/CN) film is synthesized via electrospinning with selenium as a structural inducer. The interconnected carbon network and unique wire- in-wire nanostructure cannot only improve electronic conductivity and induce effective charge transports, but also bring a superior mechanic flexibility. Ulti-mately, TiO_(2) ww/CN film shows outstanding electrochemical performance as free-standing electrodes in Li/K ion batteries. It shows a discharge capacity as high as 303 mAh g^(−1) at 5 A g^(−1) after 6000 cycles in Li half-cells, and the unique structure is well-reserved after long-term cycling. Moreover, even TiO_(2) has a large diffusion barrier of K^(+), TiO_(2) ww/CN film demonstrates excellent perfor-mance (259 mAh g^(−1) at 0.05 A g^(−1) after 1000 cycles) in K half-cells owing to extraordinary pseudocapacitive contribution. The Li/K full cells consisted of TiO_(2) ww/CN film anode and LiFePO_(4)/Perylene-3,4,9,10-tetracarboxylic dianhydride cathode possess outstanding cycling stability and demonstrate practical application from lighting at least 19 LeDs. It is, therefore, expected that this material will find broad applications in portable and wearable Li/K-ion batteries.

关键词： Free-standing TiO_(2)/C nanofiber Li-ion battery K-ion battery First-principles calculation Full cells

Sulfur-promoted,one-pot,and metal-free conversion of aromatic aldehydes to nitriles using an inorganic ammonium salt as the nitrogen source

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绿色合成与催化(英文) 2023年第1期4卷 46-53页

作者： Jiawen Yin Xia Meng Changqun Cai Lingyun Wang Hang Gong The Key Laboratory for Green Organic Synthesis and Application of hunan province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan 411105China School of Material and Chemical engineering Hunan Institute of TechnologyHengyang 421002China

A simple protocol for the sulfur-promoted conversion of aromatic aldehydes to aromatic nitriles has been *** strategy enables the one-pot conversion of inexpensive and readily available aromatic aldehydes into highly valuable aromatic nitriles using a cheap inorganic ammonium salt as the nitrogen source in the absence of ***,a broad scope of substrates was explored using this strategy,and various groups,including alkyl,alkoxyl,alkylthiol,hydroxyl,amino,aryl,alkenyl,cyano,carboxyl,and borate ester groups were tolerated,and good to excellent yields were achieved in most ***,polycyclic aromatic aldehydes and heteroaromatic aldehydes also could be converted to the corre-sponding nitriles with satisfactory *** method can be utilized as a powerful tool for the cyanation of complex molecules.

关键词： Synthetic methodology Transition-metal free Nitriles Aldehydes One-step reaction

Synthesis of benzisothiazoles by a three-component reaction using elemental sulfur and ammonium as heteroatom components under transition metal-free conditions

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Green Synthesis and Catalysis 2022年第2期3卷 168-174页

作者： Min Wang Xia Meng Changqun Cai Lingyun Wang Hang Gong The Key Laboratory for Green Organic Synthesis and Application of hunan province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan 411105China School of Material and Chemical engineering Hunan Institute of TechnologyHengyang 421002China

A strategy for the synthesis of benzisothiazoles by a three-component reaction was developed using elemental sulfur and ammonium as heteroatom components under transition metal-free *** reaction is preferably based on pyridine or quinoline ring substrate,and good to excellent yields can be ***,this reaction has been applied to the gram-scale synthesis of bioactive molecules.

关键词： Synthetic methodology Three-component reaction Transition-metal free Sulfur Benzisothiazole