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Rapid Visible Improvements in Onychomycosis: An Open-Label Clinical Investigation of Kerasal Nail<sup>TM</sup>

Journal of Cosmetics, Dermatological Sciences and Applications 2017年第1期7卷 57-66页

作者： Jiun Yit Pan Chris Lixian Tan Anders Toft National Skin Centre Singapore City Singapore Division of Dermatology National University Hospital Singapore City Singapore moberg pharma ab Bromma Sweden

Traditional treatments for onychomycosis, a fungal disease primarily affecting the toenails, are associated with poor tolerability or inadequate efficacy. Moreover, because many patients find onychomycosis embarrassing, achieving rapid cosmetic improvements is desirable. Kerasal NailTM is a marketed topical treatment containing propylene glycol, urea and lactic acid. The ability of Kerasal Nail to improve the appearance of an affected nail was investigated in a 4-week open-label study. Patients aged ≥21 years and with 25% to 75% of a big toenail or thumbnail (the “target” nail) affected by clinically suspected onychomycosis (n = 65) were instructed to apply Kerasal Nail to all their affected nails once daily for 4 weeks. After 1, 2 and 4 weeks of treatment, they assessed the appearance of the target nail on a 4-point scale, with a score of ≥2 indicating a minimum of some improvement. They also assessed the nail for improvements in thickening, discoloration, brittleness and softness. Adverse events (AEs) occurring between administration of the first dose of Kerasal Nail and the end of the 4-week treatment period were recorded. 85% of patients (95% confidence interval [CI] 74 to 92) achieved some improvement in the target nail at 4 weeks. Improvement of the target nail was reported by 65% of patients (95% CI 52 to 76) after 1 week of treatment and by 82% of patients (95% CI 70 to 90) after 2 weeks. 55% of patients achieved some improvement in discoloration in the first week of treatment. After 4 weeks of treatment, discoloration, thickening, brittleness and softness were each improved in more than half of patients. Treatment-related AEs were limited to two cases of administration site pain. Overall treatment compliance was 99%. In summary, Kerasal Nail produced very rapid improvements in nail appearance in patients with onychomycosis and was well tolerated.

关键词： Onychomycosis Kerasal Nail Asian Topical 4 Weeks

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Early and Visible Improvements after Application of K101 in the Appearance of Nails Discoloured and Deformed by Onychomycosis

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Journal of Cosmetics, Dermatological Sciences and Applications 2011年第3期1卷 59-63页

作者： Jan Faergemann Soren Gullstrand Kjell Rensfeldt Department of Dermatology Sahlgrenska University HospitalGothenburgSweden Mollevangens Huslakargrupp MalmoSweden moberg Derma ab BrommaSweden

Onychomycosis is a fungal infection of the nails of the fingers and toes and is difficult to cure. A previous 24-week, placebo-controlled study demonstrated that a solution containing propylene glycol, urea and lactic acid (K101) was well-tolerated and effective in the treatment of onychomycosis. Patients who received K101 judged that their condition had improved from Week 2 of treatment onwards. The aim of the current study was to further evaluate and document early visible effects on nail appearance after application of topical K101 in an 8-week baseline-controlled study in 75 patients. Patients graded the appearance of their nail compared with baseline using a four-point scale. Compared with baseline, 91.8% (67/73;95% confidence interval (CI): 83.0%, 96.9%) of the patients experienced at least some improvement in their target nail after 8 weeks of treatment. At Week 2, the proportion showing some improvement was 76.7% (56/73;95% CI: 65.4%, 85.8%) with this number increasing to 87.7% (64/73;95% CI: 77.9%, 94.2%) at Week 4. Proportions of patients reporting less thickened, less discoloured, less brittle and softer nails increased over the course of the study. No safety issues were identified. In conclusion, K101 provided early visible improvements in nails affected by onychomycosis.

关键词： K101 Onychomycosis Early Effects Topical

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用易经思维找到癌症有效疗法

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海峡科学 2012年第3期 135-137页

作者：罗正武瑞典NUSWE pharma ab生物科技公司

两千五百多年前西方医圣"希波克拉提斯"说过"不懂食物的人,不可能了解疾病。"又说"让食物成为你的药物"。中国则有一句名言:"医食同源","医食同源",这句话具体表达了中国传统的医学基本观念。医药的起源,原本和食物如出一辙;可惜的是后... 详细信息

两千五百多年前西方医圣"希波克拉提斯"说过"不懂食物的人,不可能了解疾病。"又说"让食物成为你的药物"。中国则有一句名言:"医食同源","医食同源",这句话具体表达了中国传统的医学基本观念。医药的起源,原本和食物如出一辙;可惜的是后世的全球医药从业人员,早就丢掉了食疗文化的精髓和正宗,把西医对抗疗法(Allopathy),即针对症状进行直接对抗治疗。如化疗杀癌细胞。

关键词：癌症有效疗法白细胞 SOD 雌蕊白血球大蕊花部形态超氧化物歧化酶胶原蛋白易经思维花粉管

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核糖体失活蛋白及其在黄瓜中的表达分析（英文）

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生物化学与生物物理进展 2017年第10期44卷 929-941页

作者：党刘毅 Pierre Rougé Els JM Van Damme Laboratory of Biochemistry and Glycobiology Department of Molecular Biotechnology Ghent University Ghent Belgium UMR 152 pharma-DEV Universitd de Toulouse Toulouse France

核糖体失活蛋白是一类具有高度特异性r RNA N-糖苷酶活性的蛋白,它们能够使原核或真核细胞的核糖体失活因而具有细胞毒性.由于其独特的生物学性质,核糖体失活蛋白被认为在农业和医学中都有着巨大的应用潜力.我们之前的研究表明,黄瓜的... 详细信息

核糖体失活蛋白是一类具有高度特异性r RNA N-糖苷酶活性的蛋白,它们能够使原核或真核细胞的核糖体失活因而具有细胞毒性.由于其独特的生物学性质,核糖体失活蛋白被认为在农业和医学中都有着巨大的应用潜力.我们之前的研究表明,黄瓜的基因组中共包含2个2类核糖体失活蛋白基因,分别命名为Cumsa ab1和Cumsa ab2.以蓖麻毒蛋白Ricin为代表,2类核糖体失活蛋白通常由2条二硫键连接的肽链组成:具有N-糖苷酶活性的A链与具有凝集素活性的B链.本文研究了黄瓜中核糖体失活蛋白的表达情况.亚细胞定位研究表明Cumsa ab1经过蛋白分泌通路表达于细胞外,这与蛋白质序列分析显示的Cumsa ab1包含一个信号肽而不含转膜区域相一致.对黄瓜的不同生长阶段的不同组织中的转录水平分析表明,Cumsa ab1在大部分组织中以极低的水平表达,而Cumsa ab2表达水平则明显更高,尤其在第一片真叶阶段和刚开花的植物中.最后,我们使用分子模拟对黄瓜中核糖体失活蛋白的结构及糖结合位点进行了分析.本研究对黄瓜中核糖体失活蛋白的亚细胞定位、表达水平和可能的蛋白质结构进行了研究,为其进一步的生物学功能研究提供了重要信息.

关键词：凝集素核糖体失活蛋白亚细胞定位表达分析

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