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Climatological Hydric Balance and the Trends Analysis Climatic in the Region of Machado in Minas Gerais State,Brazil

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American Journal of Climate Change 2018年第4期7卷 558-574页

作者： Gustavo Souza Rodrigues Fernando Ferrari Putti Antonio Carlos da Silva Alisson Souza de Oliveira Luís Roberto Almeida Gabriel Filho Jose rosário Vellano University(UNIFENAS) AlfenasBrazil Machado Higher Education and Research Center(CESEP) MachadoBrazil Paulista State University Júlio de Mesquita Filho(UNESP) BotucatuBrazil

Lately the planet’s climate has been constantly changing, caused mainly by global warming which has exposed a great deal of concern to the population over the years. In order to understand the possible impacts that such changes may have on the environment and society in general, the importance of the analysis of climate and hydrological events trends and their performance in a region is justified. The objective of the present work was to perform the climatic classification and to evaluate the behavior of the Climatological Hydric Balance—CHB, from the region of Machado state of Minas Gerais—MG, taking into account a historical series of 55 years of climatic season data of the National Institute of Meteorology—INMET;to verify the occurrence of climatic changes by the temporal trends of precipitation and the average temperature, using the Mann-Kendall and Pettitt method;and the influence of these possible climate changes on CHB behavior and on the region’s climate classification. Based on the results found it verified the increase in the water deficit between the months of June to September and a reduction in the water surplus from November to February. By means of the trend analysis, there was a positive trend of increase in the average temperature of 1.6°C until the year 2100. The continuity and occurrence of these trends may have impacts on the economy, agriculture, the hydrological cycle, and consequently on the fauna, the flora and the population.

关键词： Climatic Series Global Warming IPCC

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Climate Characterization of the Machado-Mg Region through Geotechnology Techniques and Tools

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American Journal of Climate Change 2018年第1期7卷 79-96页

作者： Gustavo Souza Rodrigues Antô nio Carlos da Silva Alisson Souza de Oliveira Luís Roberto Almeida Gabriel Filho Fernando Ferrari Putti Universidade José do rosário Vellano (UNIFENAS) Alfenas Brazil Fundaç ã o Educacional de Machado (FEM) Machado Brazil Universidade Estadual de Sã o Paulo (UNESP) Botucatu Brazil

The characteristics of a region and its environmental changes are directly associated with the characteristics of the climate and the changes that occur in it. The importance of the study of the climate of a region is widely known in agriculture, by the size of the impact that the climate has on the productivity and final quality of the products. From the studies of these spatial and temporal changes in climatic and environmental information, excellent results have been obtained in understanding the variability of atmospheric phenomena that occur throughout. The objective of the present work was to perform the climatic characterization of the Machado-MG region, analyzing data collected on the elements of the climate, applying methodologies that allow its spatialization, from geotechnology tools, more precisely, the techniques of interpolation and manipulation of spatial data in the Geographic Information Systems (GIS) environment. For this purpose, it has been used the climatic data obtained from meteorological stations of the National Institute of Meteorology-INMET, located in the state of Minas Gerais, referring to the monthly and annual averages of a historical series of 55 years (1961-2015). The results obtained allowed to characterize the climate of the municipality, which presented an average temperature around 15°C to 25°C and with average rainfall between 100 - 200 mm in the rainiest periods. The relative humidity of the air presents throughout the year values in the average of 60% to 80%. From the spatialization maps of temperature, precipitation and relative humidity of the air, it becomes possible to analyze the spatial behavior of the climatic elements and thus to have the perception of the climate dynamics in the region.

关键词： Agrometeorology Kriging Geographic Information Systems

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Functional Morphology of the Spermatogenesis of Gir Bulls

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Agricultural Sciences 2020年第11期11卷 1081-1094页

作者： Daniel F. M. Silva Fabio J. C. Faria Fernando H. G. Furtado Carlos A. C. Fernandes Juliana C. B. Silva Adriano Garcia Deiler S. Costa Federal University of Mato Grosso do Sul Campo Grande Brazil University José do rosário Vellano Alfenas Brazil Embrapa Pantanal Corumbá Brazil Brazilian Zebu Breeders Association ABCZ Campo Grande Brazil Nucleus of Animal Production and Reproduction (NUPRA) Campo Grande Brazil

The purpose of this study was to evaluate the functional morphology of the spermatogenesis of Gir bulls, with emphasis on the testicular biometry and testicular parenchyma histomorphometry. Testicular fragments from eight Gir bulls were used. The fragments were fixed by tissue perfusion with Karnovsck’s solution, and inclusion was subsequently performed using glycol methacrylate. Histological sections of 4 μm were made and stained with a 1% toluidine blue-sodium borate solution. The mean age of the bulls was 8.0 ± 1.3 years and the mean body weight was 467.5 ± 26.7 kg. Testicular weight was 289.2 ± 30.5 g on average, and the average gonadosomatic index was 0.12% ± 0.02%. The seminiferous tubules, Leydig cells, stroma, and intertubular tissue composed 80.9% ± 1.7%, 5.4% ± 1.3%, 13.7% ± 1.1%, and 19.1% ± 1.7% of the total testicular weight, respectively. The mean length of the seminiferous tubule per gram of testicle was 17 ± 0.8 m. Losses during spermatogonia mitosis averaged 75.5% ± 3.22%, while losses were 30.6% ± 8.17% during the meiotic phase, which resulted in an average total loss of 81.49% ± 2.58% of cells during the entire process of spermatogenesis. The average daily sperm production per gram of parenchyma was 28.0 × 106 cells. It was concluded that the histometric measurements of testicular parameters in the Gir breed are within the averages reported for other zebu cattle breeds.

关键词： Spermatogonia Leydig Sertoli Testicle

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Latent tuberculosis:Risk factors,screening and treatment in liver transplantation recipients from an endemic area

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World Journal of Transplantation 2021年第12期11卷 512-522页

作者： Isabela Dias Lauar Luciana Costa Faria Roberta Maia de Castro Romanelli Wanessa Trindade Clemente Medicine Department Universidade Josédo Rosário VellanoBelo Horizonte 31710030Minas GeraisBrazil Internal Medicine Department Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo Horizonte 30130100Minas GeraisBrazil Pediatrics Department Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo Horizonte 30130100Minas GeraisBrazil Department of Laboratory Medicine Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo Horizonte 30130100Minas GeraisBrazil

BACKGROUND Patients undergoing solid organ transplantation,particularly those who live or have lived in tuberculosis(TB)endemic areas,are at a high risk of developing *** majority of post-transplantation TB cases are associated with reactivation of latent TB infection(LTBI).Brazil is in a single position with overlapping areas of high TB endemicity and high transplant *** liver transplant(LT),one should be aware of the potential hepatotoxicity associated with the treatment regimens for *** To evaluate the frequency of LTBI in LT patients and treatment-related *** This was a retrospective analysis of a cohort of cirrhotic patients aged≥18 years,who underwent LT at a high-complexity teaching hospital from January 2005 to December *** Overall,429 patients underwent LT during the study *** these,213(49.7%)underwent the tuberculin skin test(TST)during the pre-transplant period,and 35(16.4%)of them had a positive *** treatment for LTBI was initiated after LT in 12(34.3%)of the TST-positive patients;in 3(25.0%),treatment was maintained for at least 6 *** The prevalence of LTBI was lower than *** and completion of LTBI treatment was limited by difficulties in the management of these special patients.

关键词： Latent tuberculosis Liver transplantation Tuberculosis Infection Transplantation Risk factors

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Relapsing polychondritis with p-ANCA associated vasculitis: Which triggers the other?

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World Journal of Clinical Cases 2014年第12期2卷 912-917页

作者： Ibolya File Csilla Trinn Zsolt Mátyus László Ujhelyi József Balla János Mátyus Institute of Internal Medicine University of Debrecen Clinical Centre H-4032 Debrecen Hungary Borsod-Abaúj-Zemplén County and University Teaching Hospital 2nd Department of Internal Medicine H-3526 Miskolc Hungary

Relapsing polychondritis(RP) is a rare autoimmune disease with chronic inflammatory/destructive lesions of the cartilaginous tissues. In one third of the cases it is associated with other autoimmune disorders, mostly with anti-neutrophil cytoplasmic antibody(ANCA) associated vasculitis(AAV). We report three cases of RP with p-ANCA positive AAV. In the first patient RP developed 1.5 years after the onset of AAV. In the others the signs of RP were present before the onset of severe crescent glomerulonephritis. Patients responded well on steroid and cyclophosphamide. In dialysis dependent cases plasmapheresis was also used successfully. During the 2 and 1.5 years of follow up, they were symptom-free, and had stable glomerular filtration rate. The first patient died after four years of follow-up due to the complications of sudden unset pancytopenia,which raises the possibility of associated hemophagocytic syndrome. In the setting of RP or AAV physicians should always be aware of the possibility of sudden or insidious appearance of the other disease.

关键词： Relapsing polychondritis Anti-neutrophil cytoplasmic antibody Anti-neutrophil cytoplasmic antibody-associated vasculitis Rapidly progressive glomerulonephritis Immunosuppressive treatment

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Anterior segment parameters associated with extramuscular manifestations in polymyositis and dermatomyositis

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1443-1450页

作者： Zoltan Griger Katalin Danko Gabor Nemeth Ziad Hassan Zsuzsa Aszalos Katalin Szabo Levente Bodoki Rudolf Gesztelyi Judit Zsuga Peter Szodoray Adam Kemeny-Beke Division of Clinical Immunology Faculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Ophthalmology Faculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Ophthalmology Borsod-Abauj-Zemplen County Hospital and University Teaching HospitalMiskolc 3526Hungary Orbi-Dent Refractive Surgery and Medical Center Debrecen 4032Hungary Department of Rheumatology Institute of MedicineFaculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Pharmacology and Pharmacotherapy Faculty of MedicineUniversity of DebrecenDebrecen 4032Hungary Department of Health Systems Management and Quality Management in Health Care Faculty of Public HealthUniversity of DebrecenDebrecen 4032Hungary Department of Immunology RikshospitaletOslo University HospitalOslo 0372Norway

AIM:To evaluate detailed anterior segment parameters of patients with idiopathic inflammatory myopathies(IIM),including polymyositis(PM),and dermatomyositis(DM),and to clarify the associations between these data and clinical variables of ***:Totally 57 PM,41 DM patients and 62 controls were enrolled in this cross-sectional,observational,case-control *** study participants underwent Pentacam *** investigations consisted of different antibody assays,while extramuscular clinical assessments included Raynaud’s phenomenon,dysphagia,interstitial lung disease,arthritis/arthralgia,and weight *** signs and subjective symptoms of dry eye disease(DED)were also ***:All pachymetric parameters[center,apex,thinnest and maximal keratometry(Kmax)]and corneal volume(CV)of both sides of PM patients proved to be significantly *** pachymetric data were also noticed as significantly decreased compared to those of *** significant differences were traced between anterior segment values and extramuscular manifestations of myositis,largely in case of arthritis/arthralgia and weight loss,whereas associations between anterior segment parameters and antibodies were *** clinical tests of DED were also significantly decreased in IIM ***:The results suggest that all IIM patients have thinner corneas compared with those of controls,and decreased corneal parameters are significantly associated with the occurrence of some extramuscular *** addition,IIM patients tend to develop objective signs of DED.

关键词： dry eye extramuscular manifestations dermatomyositis polymyositis Scheimpflug imaging

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Effect of aerobic and anaerobic exercises on glycemic control in type 1 diabetic youths

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World Journal of Diabetes 2015年第3期6卷 534-542页

作者： Andrea Lukács László Barkai Faculty of Health Care University of Miskolc Velkey László Center for Child Health

AIM:To evaluate the long-term effect of aerobic and/or anaerobic exercise on glycemic control in youths with type 1 ***:Literature review was performed in spring and summer 2014 using Pub Med/MEDLINE,Google Scholar,Scopus,and Science Direct with the following terms:aerobic,anaerobic,high-intensity,resistance,exercise/training,combined with glycemic/metabolic control,glycated haemoglobin A1c(Hb A1c) and type *** peer-reviewed articles in English were included published in the last 15 *** was selected from 1999 to *** control was measured with Hb A1 *** with an intervention lasting at least 12 wk were included if the Hb A1 c was measured before and after the ***:A total of nine articles were found,and they were published between the years of *** sample size was 401 diabetic youths(166 males and 235 females) with an age range of 10-19 years except one study,in which the age range was 13-30 *** participants were from Australia,Tunisia,Lithuania,Taiwan,Turkey,Brazilia,Belgium,Egypt and *** studies were aerobic-based,four were combined aerobic and anaerobic programs,and one compared aerobic exercise to anaerobic *** studies had insufficient evidence that any type of exercise or combined training would clearly improve the glycemic control in type 1 diabetic *** three(two aerobic-based and one combined) studies could provide a significant positive change in glycemic ***:The regular physical exercise has several other valuable physiological and health benefits that justify the inclusion of exercise in pediatric diabetes treatment and care.

关键词： Type 1 diabetes mellitus Glycemic control Exercise Aerobic Anaerobic

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ID7 Isolated from Bauhinia variegata Stem Inhibits Tumor Progression and Metastatic Mechanisms of Triple Negative Breast Cancer in Vivo

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 368-384页

作者： Kamilla Monteiro dos Santos Izabela Natalia Faria Gomes Renato JoséSilva Oliveira Fernanda E.Pinto Bruno Oliveira Fabrício P.Batista Rafael Cesar Russo Chagas Hélio B.Santos Ralph G.Thomé Wanderson Romao Rui Manuel Reis Maria Luiza Vilela Oliva rosy Iara Maciel de Azambuja Ribeiro Laboratory of Experimental Pathology Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Josédo rosário Vellano University UnifenasDivinópolisMGBrazil Molecular Oncology Research Center(CPOM) Barretos Cancer HospitalBarretosSPBrazil Petroleomic and Forensic Chemistry Laboratory Department of ChemistryFederal Institute of Espírito Santo(IFES)VitóriaESBrazil Chemistry Department Federal University of Sao PauloBrazil Tissue Processing Laboratory Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Life and Health Sciences Research Institute(ICVS) Medical SchoolUniversity of MinhoBragaPortugal 3ICVS/3B’s-PT Government Associate Laboratory GuimaraesBragaPortugal

Background:The breast cancer has been the most common form of cancer among *** triple negative subtype represents 20%of all breast cancer cases in the world and is standing out by affecting young women and being *** main cause of death of patients with cancer is due to metastasis,which can reach the liver and ***:The activities of ID7 fraction of the stems of Bauhinia variegata *** breast cancer,lung metastasis and liver inflammatory process were ***:ID7 was characterized by *** viability of murine mammary cells(4T1)treated with ID7 was assessed by MTT,trypan blue and fluorescence assay and viability of BT-20,MDA-MB-231 and MCF-7 human breast cancer tumor lines by *** cell migration,invasion using matrigel and adhesion were *** expression of cell death proteins was quanitified by western blot and the gelatinases by *** ID7 activity of the tumor(4T1)and metastatic progession in vivo was ***:ID7 reduced the 4T1 and MDA-MB-231viability and increased the late apoptosis,inhibited the 4T1 migration and invasion,increased the 4T1 adhesion and decreased the secreted active ***7 also increased the expression of PARP,caspase-7 and caspase-8,RIP and *** vivo,the ID7 decreased the volume and weight of the tumors and decreased lung metastasis and inflammation in the *** characterization showed mainly the presence of oleic acid,myricetin,quercetin and kaempferol in ***:Thus,it was found that ID7 fraction exhibits selective antitumor and on the mechanisms of breast cancer metastasis activity,preventing lung metastasis and inflammation in the *** is suggested that fatty acids and flavonoids are correlated with such activities.

关键词： 4T1 cells MDA-MB-231 medicinal plants kaempferol gelatinases apoptosis cell viabilty in vivo

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Influence of Saliva and Mucin on the Adhesion of <i>Candida</i>Oral Clinical Isolates

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Journal of Encapsulation and Adsorption Sciences 2015年第4期5卷 217-227页

作者： Catarina L. Seabra Cláudia M. Botelho Ana C. N. Oliveira Mariana Henriques Instituto de investigação e Inovação em Saúde University of Porto Porto Portugal Instituto de Engenharia Biomédica University of Porto Porto Portugal Instituto de Patologia e Imunologia Molecular da Universidade do Porto University of Porto Porto Portugal Instituto de Ciências Biomédicas Abel Salazar University of Porto Porto Portugal Centre of Biological Engineering (CEB) Laboratório de Investiga&ccedil&atildeo em Biofilmes Rosário Oliveira University of Minho Braga Portugal Centre of Physics (CFUM) Department of Physics University of Minho Braga Portugal Centre of Molecular and Environmental Biology (CBMA) Department of Biology University of Minho Braga Portugal

Objectives: This research work intends to clarify the role of artificial saliva, in particularly the role of mucin, a salivary protein, on the surface properties and adhesion ability of Candida spp. oral clinical isolates to abiotic surfaces. Methods: Four oral clinical isolates of Candida spp. were used: two Candida albicans strains (AC;AM) and two Candida parapsilosis strains (AD;AM2). The strains were isolated from patients using oral prosthesis. The microorganisms were cultured in the absence or presence of mucin and artificial saliva, and their adhesion to an abiotic surface (coated with mucin and artificial saliva) was evaluated. Results: The presence of mucin per se onto the abiotic surface decreased the adhesion of all strains, although the combination of mucin with artificial saliva had reduced this effect. No direct correlation between adhesion and the surface free energies of adhesion of the microorganisms was found. Significance: Candida spp. were human commensal microorganisms that became pathogenic when the host immune defenses were compromised. Medical devices were colonized by Candida spp. particularly, oral prostheses, which might lead to the degradation of the prostheses and systemic infections. The salivary secretions that constantly cover the oral cavity influenced Candida spp. adhesion process. Therefore, it was important to understand the interactions between Candida spp., salivary proteins and the characteristic of oral prosthesis when developing materials for oral prostheses.

关键词： Candida Artificial Saliva Mucin Oral Adhesion Surface Properties

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Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations

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World Journal of Gastroenterology 2005年第10期11卷 1489-1495页

作者： Peter Laszlo Lakatos Laszlo Lakatos Ferenc Szalay Claudia Willheim-Polli Christoph (O|¨)sterreicher Zsolt Tulassay Tamas Molnar Walter Reinisch Janos Papp Gyula Mozsik Hungarian IBD Study Group Peter Ferenci 1st Department of Medicine Laszlo Lakatos Department of Internal Medicine 4 2nd Department of Medicine Semmelweis University 2nd Department of MedicineSemmelweis UniversityBudapest:Laszlo PronaiAnnamaria NemethPal Miheller Erzsebet Hospital 1st Department of MedicineBudapest: Agota KovacsLaszlo Bene Szent Janos Hospital 1st Department of Medicine:Gyorgy Szekely University of Pecs 1st Department of MedicinePecs:Beata Gasztonyi University of Szeged 1st Department of MedicineSzeged:Ferenc NagyJanos Lonovics Semmelweis Hospital 1st Department of MedicineMiskolc:Laszlo Ujszaszy University of Debrecen 2nd Department of MedicineDebrecen:Istvan AltorjaiKaroly Palatka Kenezi Gy. County Hospital 2nd Department of MedicineDebrecen: Gyula G. Kiss County Hospital 2nd Department of MedicineZalaegerszeg Ferenc Tarnok Markusovszky Hospital2nd Department of MedicineSzombathely:Zoltan Dobronte Csolnoky F. County Hospital 1st Department of MedicineVeszprem:Zsuzsanna ErdelyiTunde PandurGabor Mester

AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with ***: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing highperformance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by ***: NOD2/CARD15 mutations were found in 185patients (35.1%) and in 33 controls (16.5%, P＜0.0001).SNP8/R702W (10.8% vs 6%, P = 0.02), SNP13/3020insC (19.4% vs 5%, P＜0.0001) and exon4 R703C (2.1% vs 0%, P = 0.02) mutations were more frequent in CD, while the frequency of SNP12/G908R was not increased. The frequency of TLR4 D299G was not different (CD: 9.9% vscontrols: 12.0%). Variant NOD2/CARD15 allele was associated with an increased risk for CD (ORhet = 1.71,95%CI = 1.12-2.6, P= 0.0001, ORtwo-riskalleles = 25.2,95%CI = 4.37- , P＜0.0001), early disease onset (carrier:26.4 years vs non-carrier: 29.8 years, P = 0.0006), ileal disease (81.9% vs 69.5%, OR = 1.99, 95%CI = 1.29-3.08,P = 0.02, presence of NOD2/CARD15 and TLR4: 86.7% vs64.8%), stricturing behavior (OR = 1.69, 95%CI = 1.13-2.55,P = 0.026) and increased need for resection (OR=1.71,95%CI: 1.13-2.62, P= 0.01), but not with duration, extraintestinal manifestations, familial disease or smoking. TLR4exhibited a modifier effect: age of onset in wt/TLR4 D299G carriers: 27.4 years vs NOD2mut/TLR D299G: 23 years (P= 0.06), in NOD2mut/wt: 26.7 ***: These results confirm that variant NOD2/CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease,stricturing disease behavior in Hungarian CD patients. In contrast, although the frequency of TLR4 D299G polymorphism was not different from controls, NOD2/TLR4mutation carriers tended to present at earlier age.

关键词：基因型基因多态性 NOD2/CARD15 基因突变克罗恩病肠炎

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