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国际医学放射学杂志 2018年第3期 357-358页

作者： S.A.Kwee L.Wong O.T.M.Chan S.Kalathil N.Tsai 孙鹤 Hamamatsu/Queen’s pet Imaging center The Queen’s Medical Center

摘要目的探讨肝癌肝叶切除术的Child-Pugh A、B级的慢性肝病病人在联合术前pet/CT的F荧光胆碱摄取与慢性肝病组织病理学特征的关系。材料与方法 48例可切除

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Determination of Synthetic Impurities and Metabolic Products of F-ADAM, a Positron Emission Tomography Imaging Agent for Serotonin Transporter (SERT) Using HPLC-Tandem Mass Spectrometry

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Pharmacology & Pharmacy 2020年第10期11卷 282-298页

作者： Wei-Hsi Chen Chyng-Yann Shiue Chemistry Division Institute of Nuclear Energy Research Taiwan pet center Department of Nuclear Medicine National Taiwan University Hospital Taiwan pet center Department of Nuclear Medicine Tri-Service General Hospital Taiwan

A high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) analytical method was developed to determine the identity of impurities resulting from the synthesis of N,N-dimethyl-2-(2-amino-4-fluorophenylthio)benzyl-amine (F-ADAM), as well as its metabolic products by rat liver microsomes. 18F-ADAM is an important positive electron emission ligand commonly employed as a radio-imaging agent for serotonin transporter (SERT) in the brain. F-ADAM and its derivatives were separated using HPLC on a C4-phenyl column with an ammonium formate aqueous buffer/acetonitrile programmed mobile phase. Synthetic contaminants and metabolic products were identified using fragmentation spectra obtained by tandem mass spectrometry. We show that F-ADAM is unstable in methanol, and propose the use of acetonitrile to generate optimal chromatogram. A Cl-substituted species was found to be the major impurity resulting from the F-ADAM synthetic process. The metabolic products of F-ADAM by rat liver microsomes were characterized by oxidization of the sulfur moiety to sulfoxide, demethylation of the dimethylamine moiety, and oxidative defluorination/deamination. These results elucidate the by-products of F-ADAM synthetic and metabolic processes, and provide direction for the application of this imaging agent to biosystems properly.

关键词： Liver Microsomes Metabolites Impurities F-ADAM Serotonin Transporter

Infuence of Gender on Tau Precipitation in Alzheimer’s Disease According to ATN Research Framework

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Phenomics 2023年第6期3卷 565-575页

作者： Ying Zhang Jiaying Lu Min Wang Chuantao Zuo Jiehui Jiang School of Communication and Information Engineering Shanghai UniversityShanghai 200444China pet center and National Research center for Agingand Medicine and National center for NeurologicalDisorders Huashan HospitalFudan UniversityShanghai 201206China Institute of Biomedical Engineering School of Life ScienceShanghai UniversityShanghai 200444China

Tau proteins accumulation and their spreading pattern were afected by gender in cognitive impairment patients,especially in the progression of Alzheimer’s disease(AD).However,it was unclear whether the gender efects for tau deposition infuenced by amyloid *** aim of this study was to investigate gender diferences for tau depositions in Aβpositive(A^(+))*** this study,tau and amyloid positron emission tomography images,structural magnetic resonance imaging images,and demographic information were collected from 179 subjects in Alzheimer’s Disease Neuroimaging Initiative(ADNI)database and 63 subjects from Huashan *** were classifed as T^(+)or T^(-)according to the presence or absence of tau(T)*** used two-sample t test and one-way analysis of variance test to analyze the efect of gender with adjusting for age,years of education,and Minimum Mental State *** the ADNI cohort,we found diferences in Tau deposition in fusiform gyrus,inferior temporal gyrus,middle temporal gyrus and parahippocampal gyrus between the female T^(+)(FT^(+))and male T^(+)(MT^(+))groups(p0.05).In the Huashan Hospital cohort,there was no diference in Tau deposition between FT^(+)and MT^(+)(p>0.05).The results show that tau depositions signifcantly increased in females in above brain *** fndings suggest that tau deposition is infuenced by gender in the A+*** result has important clinical implications for the development of gender-guided early interventions for patients with both Tau and Amyloid depositions.

关键词： Alzheimer’s disease Gender Amyloid positron emission computed tomography Tau positron emission computed tomography

Extrapulmonary benign and malignant lesions avid for 18F-fluoro-deoxyglucose by multivariate regression model identification

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Nuclear Science and Techniques 2013年第4期24卷 44-49页

作者： CHEN Yangchun XU Hao CHEN Ping Department of Nuclear Medicine in the First Affiliated Hospital of Jinan University pet/CT center in the First Affiliated Hospital of Guangzhou Medical College

Whether extrapulmonary lesions are avid for18F-fluorodeoxyglucose(18F-FDG) could help to differentiate the benign or malignant lung *** this trial,the 199 consecutive patients with newly diagnosed lung lesions(169 malignant and 36 benign lesions) were imaged by whole body18F-FDG pet/*** and clinic results served as the reference *** malignancy likelihood were conducted by CTscores;the maximum standardized uptake value(SUVmax) of lung lesions,and pet on FDG negative or positive,as well as metastasis index(MI),by pet combined with CT *** data were analyzed by stepwise logistic regression and *** malignancy predictive probability(P) was obtained by P =ex/(1+ex),where x= –1.16+0.87(CTscore) +0.15(SUVmax)+0.27(MI).The area under curve(AUC) for the fitted logistic model was 0.82±0.04,this was superior and significantly different from SUVmax(AUC,0.73±0.05) and CTscores(AUC,0.71±0.05).The fitted logistic model could improve the diagnostic *** MI could help for differential diagnosis.

关键词：恶性肿瘤脱氧葡萄糖病变肺部模型辨识多元回归氟代 Logistic模型

Quantification of the impact of TOF and PSF on pet images using the noise-matching concept: clinical and phantom study

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Nuclear Science and Techniques 2017年第11期28卷 258-265页

作者： M. Shekari P. Ghafarian S. Ahangari M. R. Ay Department of Medical Physics and Biomedical Engineering Tehran University of Medical Sciences Tehran Iran Research center for Molecular and Cellular Imaging Tehran University of Medical Sciences Tehran Iran Chronic Respiratory Diseases Research center National Research Institute of Tuberculosis and Lung Diseases(NRITLD) Shahid Beheshti University of Medical SciencesTehran Iran pet/CT and Cyclotron center Masih Daneshvari HospitalShahid Beheshti University of Medical Sciences Tehran Iran

This study was to assess quantitatively the accuracy of ^(18)F-FDG pet/CT images reconstructed by TOF+PSF and TOF only, considering the noise-matching concept to minimize probable bias in evaluating algorithm performance caused by noise. pet images of similar noise level were considered. Measurements were made on an inhouse phantom with hot inserts of Φ10–37 mm, and oncological images of 14 patients were analyzed. The pet images were reconstructed using the OSEM, OSEM+TOF and OSEM+TOF+PSF algorithms. Optimal reconstruction parameters including iteration, subset, and FWHM of post-smoothing filter were chosen for both the phantom and patient data. In terms of quantitative accuracy, the recovery coefficient(RC) was calculated for the phantom pet images. The signal-to-noise ratio(SNR),lesion-to-background ratio(LBR), and SUV_(max)were evaluated from the phantom and clinical data. The smallest hot insert(Ф10 mm) with 2:1 activity concentration ratio could be detected in the pet image reconstructed using the TOF and TOF+PSF algorithms, but not the OSEM algorithm. The relative difference for SNR between the TOF+PSF and OSEM showed significantly higher values for smaller sizes, while SNR change was smaller for Ф22–37 mm inserts both 2:1 and 4:1 activity concentration ratio. In the clinical study, SNR gains were 1.6 ± 0.53 and 2.7 ± 0.74 for the TOF and TOF+PSF, while the relative difference of contrast was 17 ± 1.05 and 41.5 ± 1.85% for the TOF only and TOF+PSF, respectively. The impact of TOF+PSF is more significant than that of TOF reconstruction, in smaller inserts with low activity concentration ratio. In the clinical pet/CT images, the use of the TOF+PSF algorithm resulted in better SNR and contrast for lesions, and the highest SUV_(max)was also seen for images reconstructed with the TOF+PSF algorithm.

关键词： Time of flight (TOF) Point spread function(PSF) Lesion detectability pet Quantification Image reconstruction SUV

Whole Body Positron Emission Tomography/Computed Tomography （pet/CT） in the Evaluation of Ophthalmic Tumors

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Current Medical Science 2018年第2期38卷 310-317页

作者： Ping JIANG Shan-shan LIAO Xiao-li LAN Fa-gang JIANG Department of Ophthalmology Union Hospital Tongii Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Nuclear Medicine and pet center Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

The clinical value of whole body positron emission tomography/computed tomography （pet/CT） as an imaging tool in diagnosis of ophthalmic tumors was investigated. The retrospective observational case series were performed on the patients with suspected ophthalmic tumors who underwent whole body pet/CT. The golden standard of diagnosis was the final pathological diagnosis or the results of long-term follow-up for patients without surgery/ biopsy. pet/CT findings were compared with the golden standard. The sensitivity, specificity, accuracy an^t positive likelihood ratio of pet/CT in the detection of ophthalmic tumors were calculated. The clinical application of pet/CT in different types of ophthalmic tumors was evaluated. The results showed that 30 patients （18 males and 12 females） with a mean age of 43.0 years （range 4-63 years） were collected. The mean sizes of orbital tumors and intraocular tumors were 26.8 mmxl7.8 mm and 11.2 minx6.1 mm, respectively. The overall sensitivity, specificity, accuracy and positive likelihood ratio of whole body pet/CT in ophthalmic tumors were 76.5%, 71.4%, 75.0% and 2.67, and were 62.5%, 100% and 70.0% in intraocular tumors, and those were 100%, 60.0% and 84.6% in orbital tumors, respectively. pet/CT findings were applied to help make appropriate treatment options in 27 out of 30 patients （90.0%）, and 12 （40.0%） patients changed the treatment strategy. False negative results in 4 cases and false positive results in 2 cases were observed in this series. It was suggested that pet/CT was an effective imaging modality in detecting, diagnosing and developing therapeutic schedule for patients with ophthalmic tumors. It was more sensitive and accurate for detecting orbital tumors than for detecting intraocular tumors.

关键词： positron emission tomography/computed tomography ophthalmic tumor orbital tumor ocular tumor

Improved preparation and chemical kinetics on fully automated synthesis of [^(18)F]-THK523,a pet imaging probe for Tau pathologies

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Nuclear Science and Techniques 2014年第4期25卷 28-35页

作者：孔艳艳司展曹国宪张政伟吴平薛方平杜富强朱建华李聪陈键管一晖 pet center Huashan HospitalFudan University Key Laboratory of Nuclear Medicine Ministry of HealthJiangsu Key Laboratory of Molecular Nuclear MedicineJiangsu Institute of Nuclear Medicine Key Laboratory of Smart Drug Delivery Ministry of Education & PLA.School of PharmacyFudan University

Extensive accumulation of neurofibrillary tangles(NFTs)consistently correlate with the degree of cognitive impairment and neuronal circuitry deterioration associated with Alzheimer's ***,no pet probe is currently available for selective detection of NFTs in the living human brain.[^(18)F]-THK523 was developed as a potential in vivo imaging probe for tau *** this paper,we report a new protected precursor,2-((2-(4-((tert-butoxycarbonyl)amino)phenyl)quinolin-6-yl)oxy)ethyl 4-methylbenzenesulfonate(THK-7),instead of2-((2-(4-aminophenyl)quinolin-6-yl)oxy)ethyl 4-methylbenzenesulfonate(BF241),and an improved automated radiosynfhesis of[^(18)F]-THK523 and the study on chemical kinetics of the labeling reaction of[^(18)F]-THK523,with high-yield(70±5%,n=6,decay-corrected to end of bombardment),and high radiochemical purity(>90%)and specific activity(2.5±0.5Ci/umol)from protected precursor on fully automated module at the end of radiosynthesis(45-55 min).The chemical kinetics for[^(18)F]-THK523 demonstrates that nucleophilic substitution can be carried out easily with protected precursor.

关键词： pet探测器化学动力学全自动化制备工艺合成成像放射化学纯度阿尔茨海默氏病

18F-FDG pet/CT对壶腹和十二指肠乳头疾病的术前表征或分期的获益

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国际医学放射学杂志 2020年第6期 747-748页

作者：刘晨 G.H.Wen J.M.Gu W.L.Zhou L.J.Wang Y.Tian Y.Dong Nanfang pet center Nanfang Hospital Southern Medical University

摘要目的壶腹部十二指肠乳头状癌（ADPC）的诊断具有挑战性。本研究探讨了18氟代脱氧葡萄糖正电子发射体层成像/CT(;F-FDG pet/CT)在肿瘤术前评估中的应用价值。

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^11C-methionine and ^18F-fluorodeoxyglucose positron emission tomography/CT in the evaluation of patients with suspected primary and residual/recurrent gliomas

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Chinese Medical Journal 2012年第1期000卷 91-96页

作者： LI Dong-li XU Yi-kai WANG Quan-shi WU Hu-bing LI Hong-sheng pet center Nanfang Hospital Southern Medical University Guangzhou Guangdong 510515 China Medical Imaging center Nanfang Hospital Southern Medical University Guangzhou Guangdong 510515 China

Background ^18F-fluorodeoxyglucose （FDG） is the most widely used radiotracer in tumor imaging,but its use for brain gliomas and recurrence is limited by the high ^18F-FDG uptake in normal brain tissue.^11C-methionine （MET） has low uptake in the normal brain tissue,providing potential advantages over ^*** aim of the study was to investigate the diagnostic value of ^11C-MET compared to ^18F-FDG positron emission tomography and computed tomography （pet/CT） in patients with suspected primary and residual/recurrent *** Eighty paired pet/CT scans using ^11C-MET and 18F-FDG were performed on 44 newly diagnosed patients with suspected gliomas and 36 post-operative patients with suspected residual/recurrent ***/CT results were evaluated by visual and semiquantitative *** sensitivity,specificity and accuracy for detection of gliomas and residual/recurrent tumors were calculated using visual *** to contralateral normal gray matter （T/G） ratio was calculated for semiquantitative *** Final pathology of the 44 newly diagnosed patients included 26 gliomas （14 high-grade and 12 low-grade tumors） and 18 non-glioma benign ***/recurrent gliomas were verified in 28 patients and excluded in 8/36 post-operative patients by subsequent histopathologic examination and/or clinical follow-up for more than six *** sensitivity,specificity and accuracy of 11C-MET pet/CT were 88.5%,83.3% and 86.4% for gliomas and 96.4%,87.5% and 94.4% for residual/recurrent gliomas,*** sensitivity,specificity and accuracy of 18F-FDG pet/CT were 50.0%,88.9% and 65.9% for gliomas and 46.4%,100.0% and 58.3% for residual/recurrent gliomas,respectively.11C-MET had a higher sensitivity than 18F-FDG （83.3% vs.33.3%,P=0.031） in low-grade gliomas,but had no significant difference in sensitivity from 18F-FDG for high-grade gliomas （92.9% vs.64.3%,P=0.219）.11C-MET T/G uptake ratios in high-grade gliomas,low-grade gliomas and benign

关键词： ^11 C-methionine glioma ^18 F-fluorodeoxyglucose positron emission tomography computed tomography

The role of ^(11)C-choline positron emission tomography-computed tomography and videomediastinoscopy in the evaluation of diseases of middle mediastinum

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Chinese Medical Journal 2006年第8期119卷 634-639页

作者： LIU Qi PENG Zhong-min LIU Qing-wei YAO Shu-zhan ZHANG Lin MENG Long CHEN Jing-han Department of Thoracic Surgery Shandong Provincial Hospital Jinan 250021 China pet-CT center Shandong Provincial Hospital Jinan 250021 China

Background Middle mediastinal masses comprise a wide variety of tumors but may also reflect lymphadenopathy, and thus remain an interesting diagnostic challenge. We performed positron emission tomography （pet） of mediastinal masses in order to evaluate the ability of pet to predict the malignancy of these tumors. We compared histologic findings, videomediastinoscopy, computed tomography （CT）, and pet-CT in patients with mediastinal disease. Methods Thirty-two patients were evaluated with CT, pet-CT and videomediastionoscopy, and all studies were performed within four weeks in each patient. ^11C-choline as a pet tracer was used to visualize masses. pet data were evaluated using the standardized uptake value （SUV） and were compared with pathologic data. Results There were 13 men and 19 women aged from 21 to 74 （mean 45.2） years. Among the patients with mediastinal diseases, sarcoidosis was diagnosed in 12 patients, tuberculosis in 5 patients, lymphoma in 5 patients, and noncaseating granulomata without classical ＂sarcoid＂ finding in 3 patients. N2 or N3 nodal metastasis was revealed in 6 of 7 patients who had non-small cell lung cancer or suspected lung cancer, and one was negative （the pathological diagnosis was reactive hyperplasia）. The accuracies for correctly diagnosing mediastinal masses for CT, pet-CT and videomediastinoscopy were 38% （12/32）, 63% （20/32）, and 91% （29/32） respectively. The diagnostic accuracy of videomediastinoscopy was superior to that of pet-CT （X^2=11.130, P〈0.001）. The SUVs were similar among these diseases. On the other hand, if the diagnostic classification was benign vs malignancy, the accuracies for CT, pet-CT and videomediastinoscopy were 53% （17/32）, 75% （24/32）, 100% （32/32） respectively. The diagnostic accuracy of videomediastinoscopy was superior to that of pet-CT （X^2=22.042, P〈0.001）. The SUV of malignant lesions （6.9, 3.2-9.8; n=11） appeared to be higher than that of benign lesions （4.9, 2.9-8.3; n=21）, however, this differenc

关键词： mediastionoscopy positron emission tomography mediastinal diseases lymph nodes mediastinum lung neoplasms