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Cardiovascular risk burden,dementia risk and brain structural imaging markers:a study from UK Biobank

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General Psychiatry 2024年第1期37卷 94-102页

作者： Yaying Cao Gaohong Zhu Chengwu Feng Jing Chen Wei Gan Yuan Ma Yonghua Hu Klodian Dhana Trudy Voortman Jie Shen Ting Li Yan Zheng Changzheng Yuan Geng Zong Department of Food Nutrition and Health School of Medicine and HealthHarbin Institute of TechnologyHarbinHeilongjiangChina CAS Key laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina Department of Nuclear Medicine First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina Neurology Department Zhongshan Hospital Affliated with Fudan UniversityShanghaiChina Medical Research Council Population Health Research Unit University of OxfordOxfordUK Department of genetics Novo Nordisk Research Centre OxfordOxfordUK Harvard University T H Chan School of Public Health BostonMassachusettsUSA Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Internal Medicine Rush University Medical CenterChicagolinoisUSA Department of Epidemiology rasmus MCUniversity Medical Center RotterdamRotterdamThe Netherlands Division of Human Nutrition and Health Wageningen University&ResearchWageningenThe Netherlands School of Public Health the Second Afliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina First Afiliated Hospital of Kunming Medical University KunmingYunnanChina State Key laboratory of Genetic Engineering School f ife SCciencesFudan UniversityShanghaiChina ministry of education.Key laboratory of Public Health Safety School of Public HealthFudan UniversityShanghaiChina The Key laboratory of Inteligent Preventive Medicine of Zhejang Province HangzhouZhejiangChina Shanghai Jiao Tong University Affiliated Sixth People's Hospital ShanghaiChina

Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure,while the role of genetics and incident cardiovascular disease(CVD)remains *** To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample,and to explore the role of genetics and CVD *** A prospective study among 354 654 participants free of CVD and dementia(2006-2010,mean age 56.4 years)was conducted within the UK Biobank,with brain magnetic resonance imaging(MRl)measurement availablefor 15104participants since *** risk burden was evaluated by the Framingham General Cardiovascular Risk Score(FGCRS).Dementia diagnosis was ascertained from inpatient and death register *** Overamedian 12.0-yearfollow-up,3998 all-cause dementia cases were *** FGCRS was associated with increasedall-cause dementia risk after adjusting for demographic,major lifestyle,clinical factors and the polygenic risk score(PRS)of Alzheimer's *** the high versus low tertile of FGCRS,the odds ratios(ORs)and 95%confidence intervals(Cls)were 1.26(1.12 to 1.41)for all-cause dementia,1.67(1.33 to 2.09)for Alzheimer's disease and 1.53(1.07 to 2.16)for vascular dementia(all p_(treng)higher all-cause dementia risk comparing the high-high versus low-low FGCRS-PRS *** brain volumes,higher FGCRS was associated with greater log-transformed white matter hyperintensities,smaller cortical volume and smaller grey matter *** Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes.T

关键词： Cardiovascular diagnosis burden

Identification of four SNPs and association analysis with meat quality traits in the porcine Pitx2c gene

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Science China(Life Sciences) 2011年第5期54卷 426-433页

作者： WU WangJun ZUO Bo REN ZhuQing HAPSARI A.A.R LEI MingGang XU DeQuan LI FengE XIONG YuanZhu Key laboratory of Swine genetics and Breeding Ministry of Agriculture and Key Laboratory of Agriculture Animal Genetics Breeding and Reproduction Ministry of Education College of Animal Science Huazhong Agricultural University Wuhan 430070 China Faculty of Animal Agriculture Diponegoro University Tembalang Campus-Semarang 50275 Indonesia

The association of the porcine Pitx2c gene with meat quality traits was investigated in the present study. A total of eight single nucleotide polymorphisms （SNPs） were found. Allele frequencies of four SNPs were further detected in four commercial breeds and eight Chinese indigenous breeds. Single SNP and meat quality associations were analyzed in a YorkshirexMeishan F2 population. The SNPs c.474C〉T （P〈0.01） and c.636C〉T （P〈0.05） showed a significant association with meat color （MCV1）. The SNPs c,＊37G〉A and c.＊47G〉A were significantly associated with drip loss rate （DLR）, water holding capacity （WHC） and meat color value （MCV1） consistently （P〈0.05）. Linkage disequilibrium （LD） analysis revealed that the adjacent SNPs were in LD. Two major haplotypes were identified, and association analysis between haplotype combinations and meat quality indicated that the presence of two copies of haplotype 1 -CCGG- may improve meat quality.

关键词： association haplotype Pitx2c meat quafity pig

Asymmetric evolution and domestication in allotetraploid cotton (Gossypium hirsutum L.)

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The Crop Journal 2017年第2期5卷 159-165页

作者： Lei Fang Xueying Guan Tianzhen Zhang State Key laboratory of Crop genetics and Germplasm Enhancement Cotton Hybrid R&D Engineering Center (the Ministry of Education)Nanjing Agricultural University Nanjing 210095 China

Polyploidy plays a major role in genome evolution,which corresponds to environmental changes over millions of *** mechanisms of genome evolution,particularly during the process of domestication,are of broad interest in the fields of plant science and crop *** cotton is derived from the hybridization and polyploidization of its ancient A and D diploid *** a result,cotton is a model for polyploid genome evolution and crop *** explore the genomic mysteries of allopolyploid cotton,we investigated asymmetric evolution and domestication in the A and D ***,more structural rearrangements have been characterized in the A subgenome than in the D ***,more transposable elements,a greater number of lost and disrupted genes,and faster evolution have been identified in the A *** contrast,the centromeric retroelement(RT-domain related) sequence of tetraploid cotton derived from the D subgenome progenitor was found to have invaded the A subgenome centromeres after allotetrapolyploid *** there is no genome-wide expression bias between the subgenomes,as with expression-level alterations,gene expression bias of homoeologous gene pairs is widespread and varies from tissue to ***,there are more positively selected genes for fiber yield and quality in the A subgenome and more for stress tolerance in the D subgenome,indicating asymmetric *** review highlights the asymmetric subgenomic evolution and domestication of allotetraploid cotton,providing valuable genomic resources for cotton research and enhancing our understanding of the basis of many other allopolyploids.

关键词： Polyploidy Allotetraploid cotton Asymmetric evolution Asymmetric domestication

Molecular Cloning and Characterization of Three Novel Genes Related to Fatty Acid Degradation and Their Responses to Abiotic Stresses in Gossypium hirsutum L.

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Journal of Integrative Agriculture 2013年第4期12卷 582-588页

作者： DONG Jia WEI Li-bin HU Yan GUO Wang-zhen State Key laboratory of Crop genetics & Germplasm Enhancement Hybrid Cotton R&D Engineering Research Center Ministry of Education/College of Agriculture Nanjing Agricultural University

Fatty acid metabolism is responsible not only for oilseed metabolism but also for plant responses to abiotic stresses. In this study, three novel genes related to fatty acid degradation designated GhACX, Gh4CL, and GhMFP, respectively, were isolated from Gossypium hirsutum acc. TM-1. The phylogenetic analysis revealed that amino acid sequences of GhACXand GhMFP have the highest homology with those from Vitis vinifera, and Gh4CL has a closer genetic relationship with that from Camellia sinensis. Tissue- and organ-specific analysis showed that the three genes expressed widely in all the tested tissues, including ovules and fiber at different developing stages, with expressed preferentially in some organs. Among them, GhACX showed the most abundant transcripts in seeds at 25 d post anthesis （DPA）, however, GhMFP and Gh4CL have the strongest expression level in ovules on the day of anthesis. Based on real-time quantitative RT-PCR, the three genes were differentially regulated when induced under wounding, methyl jasmonate （MeJA）, cold, and abscisic acid （ABA） treatments. The characterization and expression pattern of three novel fatty acid degradation related genes will aid both to understand the roles of fatty acid degradation related genes as precursor in stress stimuli and to elucidate the physiological function in cotton oilseed metabolism.

关键词： genes related to fatty acid degradation molecular cloning expression analysis abiotic stress cotton( Gossypium hirsutum L.)

Molecular Cloning and Characterization of an Allene Oxide Cyclase Gene Associated with Fiber Strength in Cotton

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Journal of Integrative Agriculture 2014年第10期13卷 2113-2121页

作者： WANG Li-man ZHU You-min TONG Xiang-chao HU Wen-jing CAI Cai-ping GUO Wang-zhen State Key laboratory of Crop genetics & Germplasm Enhancement Hybrid Cotton R&D Engineering Research CenterMinistry of Education/College of AgricultureNanjing Agricultural University

Allene oxide cyclase （AOC） is one of the most important enzymes in the biosynthetic pathway of the plant hormone jasmonic acid （JA）. AOC catalyzes the conversion ofallene oxide into 12-oxo-phytodienoic acid （OPDA）, a precursor of JA. Using 28K cotton genome array hybridization, an expressed sequence tag （EST; GenBank accession no. ES792958） was investigated that exhibited significant expression differences between lintless-fuzzless XinWX and linted-fuzzless XinFLM isogenic lines during fiber initiation stages. The EST was used to search the Gossypium EST database （http：//***/） for corresponding cDNA sequences encoding full-length open reading frames （ORFs）. Identified ORFs were confirmed using transcriptional and genomic data. As a result, a novel gene encoding AOC in cotton （Gossypium hirsutum AOC; GenBank accession no. KF383427） was cloned and characterized. The 741-bp GhAOC gene comprises three exons and two introns and encodes a polypeptide of 246 amino acids. Two homologous copies were identified in the tetraploid cotton species G. hirsutum acc. TM-1 and G. barbadense cv. Hai7124, and one copy in the diploid cotton species G. herbaceum and G. raimondii, qRT-PCR showed that the GhAOC transcript was abundant in cotton fiber tissues from 8 to 23 days post anthesis （DPA）, and the expression profiles were similar in the two cultivated tetraploid cotton species G. hirsutum acc. TM- 1 and G. barbadense cv. Hai7124, with a higher level of transcription in the former. One copy of GhAOC in tetraploid cotton was localized to chromosome 24 （Chr. D8） using the subgenome-specific single nucleotide polymorphism （SNP） marker analysis, which co-localized GhAOC to within 10 cM of a fiber strength quantitative trait locus （QTL） reported previously. GhAOC was highly correlated with fiber quality and strength （P=0.014） in an association analysis, suggesting a possible role in cotton fiber development, especially in secondary cell wall thickening.

关键词： allene oxide cyclase structure expression pattern fiber development association analysis cotton

Exploring the influences of education.intelligence and income on mental disorders

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General Psychiatry 2024年第1期37卷 64-72页

作者： Ancha Baranova Hongbao Cao Fuquan Zhan George Mason University FairfaxVirginiaUSA Research Centre for Medical genetics MoscowRussia Nanjing Medical University Affiliated Brain Hospital NanjingZhejiangChina

Background Previous studies have shown that education.l attainment(EA),intelligence and income are key factors associated with mental ***,the direct effects of each factor on major mental disorders are *** We aimed to evaluate the overall and independent causal effects of the three psychosocial factors on common mental *** Using genome-wide association study summary datasets,we performed Mendelian randomisation(MR)and multivariable MR(MVMR)analyses to assess potential associations between the 3 factors(EA,N=766345;household income,N=392422;intelligence,N=146808)and 13 common mental disorders,with sample sizes ranging from 9907 to ***-variance weighting was employed as the main method in the MR *** Our MR analysis showed that(1)higher EA was a protective factor for eight mental disorders but contributed to anorexia nervosa,obsessive-compulsive disorder(OCD),bipolar disorder(BD)and autism spectrum disorder(ASD);(2)higher intelligence was a protective factor for five mental disorders but a risk factor for OCD and ASD;(3)higher household income protected against 10 mental disorders but confers risk for anorexia *** MVMR analysis showed that(1)higher EA was a direct protective factor for attention-deficit/hyperactivity disorder(ADHD)and insomnia but a direct risk factor for schizophrenia,BD and ASD;(2)higher intelligence was a direct protective factor for schizophrenia but a direct risk factor for major depressive disorder(MDD)and ASD;(3)higher income was a direct protective factor for seven mental disorders,including schizophrenia,BD,MDD,ASD,post-traumatic stress disorder,ADHD and anxiety *** Our study reveals that education.intelligence and income intertwine with each *** each factor,its independent effects on mental disorders present a more complex picture than its overall effects.

关键词： protective disorders income

RGB1 Regulates Rice Panicle Architecture and Grain Filling Through Monitoring Cytokinin Level in Inflorescence Meristem and Grain Abscisic Acid Level During Filling Stage

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Rice science 2021年第4期28卷 317-321,I0008-I0011页

作者： Zhang Dongping Zhang Minyan Wang Yuzhu Liang Jiansheng Key laboratory of Molecular Design for Plant Cell Factory of Guangdong higher education.Institute Department of BiologySouthern University of Science and TechnologyShenzhen 518055China Jiangsu Key laboratory of Crop genetics and Physiology/Co-Innovation Center for Modern Production Technology of Grain Crops Key Laboratory of Plant Functional Genomics of the Ministry of EducationYangzhou UniversityYangzhou 225009China

RGB1 regulated not only rice panicle architecture but also the grain filling *** of RGB1 expression resulted in a denser panicle and smaller grain size and weight,which was largely due to the lower endogenous cytokinin(CK)level caused by the increased expression of cytokinin oxidase genes in the inflorescence *** of RGB1 expression also significantly delayed the grain development and reduced the starch accumulation rate through reducing grain abscisic acid(ABA)accumulation during early filling *** ABA can partially rescue the detrimental effects of suppression of RGB1 expression on starch accumulation and grain *** conclusion,RGB1 regulated rice panicle architecture and grain filling through monitoring CK level in the inflorescence meristem and grain ABA level during filling stage.

关键词： panicle filling Grain

Clustered spikelets 4,encoding a putative cytochrome P450 protein CYP724B1,is essential for rice panicle development

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Chinese Science Bulletin 2014年第31期59卷 4050-4059页

作者： Min Guo Yi-Hao Yang Min Liu Qing-Cai Meng Xiu-Hong Zeng Ling-Xia Dong Shu-Zhu Tang Ming-Hong Gu Chang-Jie Yan Jiangsu Key laboratory of Crop genetics and Physiology/ Co-Innovation Center for Modern Production Technology of Grain Crops Key Laboratory of Plant Functional Genomics of the Ministry of EducationYangzhou University

Rice(Oryza sativa L.)inflorescence(panicle)architecture is an important agronomic trait,serving as one of the determinants of rice yield.A number of genes related to panicle development have been cloned and functionally characterized so ***,more information is needed for fully understanding of the mechanism underlying the panicle *** the present study,we identified a clustered spikelets 4(cl4)mutant in the 93-11 genetic *** to its wild-type 93-11,cl4 mutant has a typical clustered spikelets phenotype with all primary branches clustered on the base of the main rachis and 2–3abnormal spikelets clustered on the primary ***,cl4 mutant also shows shorter plant height than that of the wild ***-based cloning strategy is performed to clone the CL4 *** a result,CL4 is demonstrated to encode a putative cytochrome P450 protein CYP724B1,which is involved in brassinosteroid *** confirm our mapping result,the CL4 RNAi transgenic plants are *** the transgenic plants also show similar phenotype as the cl4 *** results provide strong evidence that CL4 plays an important role in rice panicle development as well as plant height regulation.

关键词：细胞色素P450 水稻产量小穗集群蛋白编码稻穗转基因植物

Distribution of Microbial Populations and Their Relationship with Environmental Variables in the North Yellow Sea,China

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Journal of Ocean University of China 2012年第1期11卷 75-85页

作者： BAI Xiaoge WANG Min LIANG Yantao ZHANG Zhifeng WANG Fang JIANG Xuejiao College of Marine Life Sciences Key Laboratory of Marine Genetics and BreedingMinistry of EducationOcean University of ChinaQingdao 266003P.R.China

In order to understand the large-scale spatial distribution characteristics of picoplankton,nanophytoplankton and virio-plankton and their relationship with environmental variables in coastal and offshore waters,flow cytometry(FCM) was used to ana-lyze microbial abundance of samples collected in summer from four depths at 36 stations in the North Yellow Sea(NYS).The data revealed spatial heterogeneity in microbial populations in the offshore and near-shore waters of the NYS during the *** the surface layer,picoeukaryotes were abundant in the near-shore waters,Synechococcus was abundant in the offshore areas,and bacte-rial and viral abundances were high in the near-shore waters around the Liaodong *** the near-shore waters,no significant vertical variation of picophytoplankton(0.2-2μm) abundance was ***,the nanophytoplankton abundance was higher in the upper layers(from the surface to 10 m depth) than in the bottom *** the offshore waters,both pico-and nanophytoplankton(2-20μm) abundance decreased sharply with depth in the North Yellow Sea Cold Water Mass(NYSCWM).But,for the vertical dis-tribution of virus and bacteria abundance,no significant variation was observed in both near-shore and offshore *** microbes were more sensitive to environmental change than heterotrophic microbes and *** showed a positive correla-tion with bacterial abundance,suggesting that the bacteriophage might be prominent for virioplankton(about 0.45μm) in summer in the NYS and that viral abundance might play an important role in microbial loop functions.

关键词： picoplankton nanophytoplankton bacterioplankton virioplankton the North Yellow Sea(NYS)