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Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi Li Kaifei Xu Guoqing Wang Feng Zhang International Research laboratory of Ethnomedicine of ministry of education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

Sulfur doping and oxygen vacancy in In2O3 nanotube co-regulate intermediates of CO2 electroreduction for efficient HCOOH production and rechargeable Zn-CO2 battery

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Journal of Energy Chemistry 2025年第2期101卷 474-484页

作者： Yu Li Zhengrong Xu Quanxin Guo Qin Li Rui Liu key laboratory of Advanced Civil Engineering Materials of ministry of education School of Materials Science and Engineering Tongji University

By manipulating the distribution of surface electrons,defect engineering enables effective control over the adsorption energy between adsorbates and active sites in the CO2reduction reaction（CO2RR）.Herein,we report a hollow indium oxide nanotube containing both oxygen vacancy and sulfur doping（V_o-Sx-In2O3） for improved CO2-to-HCOOH electroreduction and *** componential synergy significantly reduces the*OCHO formation barrier to expedite protonation process and creates a favorable electronic micro-environment for*HCOOH *** a result,the CO2RR performance of Vo-Sx-In2O3outperforms Pure-In2O3and V_o-In2O3,where V_o-S53-In2O3exhibits a maximal HCOOH Faradaic efficiency of 92.4% at-1,2 V *** hydrogen electrode（RHE） in H-cell and above 92%over a wide window potential with high current density(119.1 mA cm-2at-1.1 V ***) in flow ***,the rechargeable Zn-CO2battery utilizing V_o-S53-In2O3as cathode shows a high power density of 2.29 mW cm-2and a long-term stability during charge-discharge *** work provides a valuable perspective to elucidate co-defective catalysts in regulating the intermediates for efficient CO2RR.

关键词： CO2 electroreduction In2O3 Intermediate Oxygen vacancy Sulfur doping Zn-CO2 battery

Structuring MoO3-polyoxometalate hybrid superstructures to boost electrocatalytic hydrogen evolution reaction

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Chinese Chemical Letters 2025年第2期36卷 239-243页

作者： Bowen Li Ting Wang Ming Xu Yuqi Wang Zhaoxing Li Mei Liu Wenjing Zhang Ming Feng key laboratory of Functional Materials Physics and Chemistry of the ministry of education Jilin Normal University

Improving the surface atoms utilization efficiency of catalysts is extremely important for large-scale H2production by electrochemical water splitting,but it remains a great ***,we reported two kinds of Mo O3-polyoxometalate hybrid nanobelt superstructures (MoO3-POM HNSs,POM=PW12O40and Si W12O40) using a simple hydrothermal *** superstructure with highly uniform nanoparticles as building blocks can expose more surface atoms and emanate increased specific surface *** incorporated POMs generated abundant oxygen vacancies,improved the electronic mobility,and modulated the surface electronic structure of MoO3,allowing to optimize the H*adsorption/desorption and dehydrogenation kinetics of ***,the as-prepared MoO3-PW12O40HNSs electrodes not only displayed the low overpotentials of 108 mV at 10 mA/cm2current density in 0.5 mol/L H2SO4electrolyte but also displayed excellent long-term *** hydrogen evolution reaction （HER） performance of MoO3-POM superstructures is significantly better than that of corresponding bulk materials MoO3@PW12O40and Mo O3@Si W12O40,and the overpotentials are about 8.3 and 4.9 times lower than that of single Mo *** work opens an avenue for designing highly surface-exposed catalysts for electrocatalytic H2production and other electrochemical applications.

关键词： Electrocatalysis Hydrogen production Metal oxide Polyoxometalate Superstructure

Research progress on piperidine-containing compounds as agrochemicals

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Chinese Chemical Letters 2025年第1期36卷 58-67页

作者： Wei Sun Anjing Liao Li Lei Xu Tang Ya Wang Jian Wu State key laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China

Piperidine is a crucial pharmacophore and a special scaffold in the realm of drug *** flexibility increases the molecule’s capability to bind to the *** piperidine-containing compounds are distinguished by their remarkable activity,and are increasingly becoming a vital category of *** this review,the research progress of piperidines in the discovery of pesticides was updated according to their active *** structure-activity relationships(SARs),and mechanisms of action of piperidine-containing compounds were also *** article is meant to enable readers to quickly understand piperidines,while providing ideas for creating piperidines with novel structures and unique mechanisms of action.

关键词： Piperidine Agrochemicals Biological activity Structure-activity relationships Mechanism of action

Nitrogen addition promotes soil carbon accumulation globally

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Science China(Life Sciences) 2025年第1期68卷 284-293页

作者： Xuemei Yang Suhui Ma Erhan Huang Danhua Zhang Guoping Chen Jiangling Zhu Chengjun Ji Biao Zhu Lingli Liu Jingyun Fang Institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking UniversityBeijing 100871China ministry of education key laboratory for Transboundary Ecosecurity of Southwest China School of Ecology and Environmental ScienceYunnan UniversityKunming 650500China State key laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China

Soil is the largest carbon(C)reservoir in terrestrial ecosystems and plays a crucial role in regulating the global C cycle and climate *** nitrogen(N)deposition has been widely considered as a critical factor affecting soil organic carbon(SOC)storage,but its effect on SOC components with different stability remains ***,we analyzed extensive empirical data from 304 sites worldwide to investigate how SOC and its components respond to N *** analysis showed that N addition led to a significant increase in bulk SOC(6.7%),with greater increases in croplands(10.6%)and forests(6.0%)compared to grasslands(2.1%).Regarding SOC components,N addition promoted the accumulation of plant-derived C(9.7%–28.5%)over microbial-derived C(0.2%),as well as labile(5.7%)over recalcitrant components(–1.2%),resulting in a shift towards increased accumulation of plant-derived labile ***,N addition led to a greater increase in particulate organic C(11.9%)than mineral-associated organic C(3.6%),suggesting that N addition promotes C accumulation across all pools,with more increase in unstable than stable *** responses of SOC and its components were best predicted by the N addition rate and net primary ***,our findings suggest that N enrichment could promote the accumulation of plant-derived and non-mineral associated C and a subsequent decrease in the overall stability of soil C pool,which underscores the importance of considering the effects of N enrichment on SOC components for a better understanding of C dynamics in soils.

关键词： meta-analysis nitrogen enrichment soil organic carbon carbon accumulation carbon stability

On-chip light control of semiconductor optoelectronic devices using integrated metasurfaces

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Opto-Electronic Advances 2025年第1期8卷 5-30页

作者： Cheng-Long Zheng Pei-Nan Ni Yi-Yang Xie Patrice Genevet Henan key laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Materials PhysicsMinistry of EducationSchool of PhysicsZhengzhou UniversityZhengzhou 450052China key laboratory of Optoelectronics Technology Beijing University of TechnologyMinistry of EducationBeijing 100124China Colorado School of Mines 1523 Illinois St.GoldenCO 80401USA

Semiconductor optoelectronics devices,capable of converting electrical power into light or conversely light into electrical power in a compact and highly efficient manner represent one of the most advanced technologies ever developed,which has profoundly reshaped the modern life with a wide range of *** recent decades,semiconductor technology has rapidly evolved from first-generation narrow bandgap materials(Si,Ge)to the latest fourth-generation ultra-wide bandgap semiconductor(GaO,diamond,AlN)with enhanced performance to meet growing ***,merging semiconductor devices with other techniques,such as computer assisted design,state-of-the-art micro/nano fabrications,novel epitaxial growth,have significantly accelerated the development of semiconductor optoelectronics *** them,integrating metasurfaces with semiconductor optoelectronic devices have opened new frontiers for on-chip control of their electromagnetic response,providing access to previously inaccessible degrees of *** review the recent advances in on-chip control of a variety of semiconductor optoelectronic devices using integrated metasurfaces,including semiconductor lasers,semiconductor light emitting devices,semiconductor photodetectors,and low dimensional *** integration of metasurfaces with semiconductors offers wafer-level ultracompact solutions for manipulating the functionalities of semiconductor devices,while also providing a practical platform for implementing cuttingedge metasurface technology in real-world applications.

关键词： optoelectronics nanophotonics metasurfaces semiconductor

MoS2 synaptic transistor with one-step manufacture

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Science China(Information Sciences) 2025年第1期68卷 357-365页

作者： Yihao GUO Yang WANG Wenjie DENG Yi WU Jingtao LI Kexin LI Yuehui ZHAO Songlin YU Xiaoting WANG Yongzhe ZHANG Hui YAN key laboratory of Optoelectronics Technology of education ministry of China Faculty of Information TechnologyBeijing University of Technology key laboratory of Advanced Functional Materials Ministry of Education Faculty of Materials and ManufacturingBeijing University of Technology The 11th Research Institute of Electronics Technology Group Corporation

The synaptic transistor,which is a neuromorphic device with brain-like functions,has garnered significant attention due to characteristics such as low energy consumption,high integration,multiple functions,and high computational ***,the current synaptic transistor possesses a complicated structure and involves complex manufacturing steps,which is not conducive to low-cost,large-scale bionic ***,we introduce a simple MoS2synaptic transistor exhibiting robust synaptic *** transistor utilizes magnetron sputtering manufacture to combine the process of device metal electrode deposition and the introduction of defect states,which helps streamline the manufacturing process into a single *** long-term potentiation and long-term depression in photoelectric coordination are initially ***,biological functions,such as double pulse facilitation and the transformation behavior of short-term memory to long-term memory,are thoroughly evaluated,along with learning-forgetting-relearning ***,the device exhibits robust synaptic plasticity until incident light angles down to 30° to imitate the multi-to-one axon-cellular ***,a classical simulation of Pavlov's dog conditioned reflex is demonstrated along with the multiview extraction *** experimental results demonstrate a promising synaptic transistor with a simple structure,manufacturing technique,and excellent *** further indicates the potential for large-scale integration of bionic neuromorphic systems.

关键词： process optimization artificial synaptic device one-stepmanufacture synaptic plasticity bionic simulation

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MixerKT:A Knowledge Tracing Model Based on Pure MLP Architecture

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Computers, Materials & Continua 2025年第1期82卷 485-498页

作者： Jun Wang Mingjie Wang Zijie Li Ken Chen Jiatian Mei Shu Zhang key laboratory of education Informatization for Nationalities Ministry of EducationYunnan Normal UniversityKunming650000China Yunnan key laboratory of Smart education Yunnan Normal UniversityKunming650000China

In the field of intelligent education,the integration of artificial intelligence,especially deep learning technologies,has garnered significant *** tracing(KT)plays a pivotal role in this field by predicting students’future performance through the analysis of historical interaction data,thereby assisting educators in evaluating knowledgemastery and tailoring instructional *** knowledge tracingmethods,largely based on Recurrent Neural Networks(RNNs)and Transformer models,primarily focus on capturing long-term interaction patterns in sequential ***,these models may neglect crucial short-term dynamics and other relevant *** paper introduces a novel approach to knowledge tracing by leveraging a pure Multilayer Perceptron(MLP)*** proposeMixerKT,a knowledge tracing model based on theHyperMixer framework,which uniquely integrates global and localMixer feature *** architecture enables more effective extraction of both long-terminteraction trends and recent learning behaviors,addressing limitations in currentmodels thatmay overlook these key *** evaluations on twowidely-used datasets,ASSIS Tments2009 and Algebra2005,demonstrate that MixerKT consistently outperforms several state-of-the-art models,including DKT,SAKT,and Separated Self-Attentive Neural Knowledge Tracing(SAINT).Specifically,MixerKT achieves higher prediction accuracy,highlighting its effectiveness in capturing the nuances of learners’knowledge *** results indicate that our model provides a more comprehensive representation of student learning patterns,enhancing the ability to predict future performance with greater precision.

关键词： Knowledge tracing multilayer perceptron channel mixer sequence mixer

Value Iteration-Based Distributed Adaptive Dynamic Programming for Multi-Player Differential Game With Incomplete Information

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 436-447页

作者： Yun Zhang Yuqi Wang Yunze Cai the Department of Automation Shanghai Jiao Tong University the key laboratory of System Control and Information Processing Ministry of Education of China the National key laboratory of Air-based Information Perception and Fusion

In this paper, a distributed adaptive dynamic programming(ADP) framework based on value iteration is proposed for multi-player differential games. In the game setting,players have no access to the information of others' system parameters or control laws. Each player adopts an on-policy value iteration algorithm as the basic learning framework. To deal with the incomplete information structure, players collect a period of system trajectory data to compensate for the lack of information. The policy updating step is implemented by a nonlinear optimization problem aiming to search for the proximal admissible policy. Theoretical analysis shows that by adopting proximal policy searching rules, the approximated policies can converge to a neighborhood of equilibrium policies. The efficacy of our method is illustrated by three examples, which also demonstrate that the proposed method can accelerate the learning process compared with the centralized learning framework.

关键词： Distributed adaptive dynamic programming incomplete information multi-player differential game (MPDG) value iteration