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Burden of gallstone disease in the United States population:Prepandemic rates and trends

World Journal of Gastrointestinal Surgery 2024年第4期16卷 1130-1148页

作者： Aynur Unalp-Arida Constance E Ruhl National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of HealthBethesdaMD 20892-5458United States Social&Scientific Systems Inc.DLH Holdings Corp CompanySilver SpringMD 20910United States

BACKGROUND Gallstone disease is one of the most common digestive disorders in the United States and leads to significant morbidity,mortality,and health care *** To expand on earlier findings and investigate prepandemic rates and trends in the gallstone disease burden in the United States using national survey and claims *** The National Ambulatory Medical Care Survey,National Inpatient Sample,Nationwide Emergency Department Sample,Nationwide Ambulatory Surgery Sample,Vital Statistics of the United States,Optum Clinformatics®Data Mart,and Centers for Medicare and Medicaid Services Medicare 5%Sample and Medicaid files were used to estimate claims-based prevalence,medical care including cholecystectomy,and mortality with a primary or other gallstone *** were age-adjusted(for national databases)and shown per 100000 *** Gallstone disease prevalence(claims-based,2019)was 0.70%among commercial insurance enrollees,1.03%among Medicaid beneficiaries,and 2.09%among Medicare beneficiaries and rose over the previous ***,in the United States population,gallstone disease contributed to approximately 2.2 million ambulatory care visits,1.2 million emergency department visits,625000 hospital discharges,and 2000 deaths *** had higher medical care rates with a gallstone disease diagnosis,but mortality rates were higher among *** had higher ambulatory care visit and hospital discharge rates compared with Whites,but not mortality *** had lower ambulatory care visit and mortality rates,but similar hospital discharge rates compared with *** the study period,ambulatory care and emergency department visit rates with a gallstone disease diagnosis rose,while hospital discharge and mortality rates *** commercial insurance enrollees,rates were higher compared with national data for ambulatory care visits and hospitalizations,but lower for emergency department ***

关键词： Gallstone disease Burden Cholecystectomy Mortality health care use Cholelithiasis Gallstones Epidemiology

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SinGRAV: Learning a Generative Radiance Volume from a Single Natural Scene

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Journal of Computer Science & Technology 2024年第2期39卷 305-319页

作者：王玉洁陈学霖陈宝权 School of Computer Science and Technology Shandong UniversityQingdao 266237China State Key Laboratory of General Artificial Intelligence Beijing 100871China School of Intelligence Science and Technology Peking UniversityBeijing 100871China Tencent AI Lab Tencent Holdings LimitedShenzhen 518057China

We present SinGRAV, an attempt to learn a generative radiance volume from multi-view observations of a single natural scene, in stark contrast to existing category-level 3D generative models that learn from images of many object-centric scenes. Inspired by SinGAN, we also learn the internal distribution of the input scene, which necessitates our key designs w.r.t. the scene representation and network architecture. Unlike popular multi-layer perceptrons (MLP)-based architectures, we particularly employ convolutional generators and discriminators, which inherently possess spatial locality bias, to operate over voxelized volumes for learning the internal distribution over a plethora of overlapping regions. On the other hand, localizing the adversarial generators and discriminators over confined areas with limited receptive fields easily leads to highly implausible geometric structures in the spatial. Our remedy is to use spatial inductive bias and joint discrimination on geometric clues in the form of 2D depth maps. This strategy is effective in improving spatial arrangement while incurring negligible additional computational cost. Experimental results demonstrate the ability of SinGRAV in generating plausible and diverse variations from a single scene, the merits of SinGRAV over state-of-the-art generative neural scene models, and the versatility of SinGRAV by its use in a variety of applications. Code and data will be released to facilitate further research.

关键词： generative model neural radiance field 3D scene generation

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Interstitial carbon induces enriched Cu^(δ+) sites in Cu_(2)O nanoparticles to facilitate CO_(2) electroreduction to C_(2+) products

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Nano Research 2024年第8期17卷 7013-7019页

作者： Haoran Wang Rongbo Sun Peigen Liu Haohui Hu Chen Ling Xiao Han Yi Shi Xusheng Zheng Geng Wu Xun Hong Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryHefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Sinochem holdings Co Ltd Xiongan New AreaHebei 071700China National Synchrotron Radiation Laboratory(NSRL) University of Science and Technology of ChinaHefei 230029China

The electrochemical CO_(2) reduction reaction(CO_(2)RR)holds significant promise in advancing carbon *** catalysts for the electrochemical CO_(2)RR to multi-carbon(C_(2+))products(e.g.,C_(2)H_(4))under industrial-level current density is urgently needed and ***,we report the Cu_(2)O nanoparticles doped with interstitial carbon atoms(denoted as C-Cu_(2)O NPs)for the conversion of CO_(2) to C_(2+)*** interstitial carbon promotes the C-Cu_(2)O NPs to possess abundant unsaturated Cu–O bonds,leading to a high-density Cu^(δ+)(0<δ<1)*** obtained C-Cu_(2)O NPs exhibited significant Faradic efficiency(FE)of C_(2+) products approaching 76.9%and a partial current density reaching 615.2 mA·cm^(–2)under an industrial-level current density of 800 mA·cm^(–2).Furthermore,the efficient electrosynthesis of C_(2)H_(4) achieved an FE of 57.4%with a partial current density of 459.2 mA·cm^(–2).In situ electrochemical attenuated total reflection Fourier transform infrared spectroscopy and in situ Raman spectroscopy analyses revealed that C-Cu_(2)O NPs stabilized the intermediate*CO and facilitated C–C coupling,leading to increased selectivity towards C_(2+) products.

关键词： CO_(2) electroreduction C-C coupling interstitial carbon *CO coverage industrial-level current density

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Thermodynamic model for deoxidation of liquid steel considering strong metal-oxygen interaction in the quasichemical model framework

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 988-1002页

作者： Yong-Min Cho Youn-Bae Kang Graduate Institute of Ferrous and Eco Materials Technology Pohang University of Science and TechnologyPohangKyungbuk37673Rep.of Korea N.EX.T Hub POSCO HoldingsPohangKyungbuk37673Rep.of Korea Department of Materials Science and Engineering Pohang University of Science and TechnologyPohangKyungbuk37673Rep.of Korea

Herein,a thermodynamic model aimed at describing deoxidation equilibria in liquid steel was *** model provides explicit forms of the activity coefficient of solutes in liquid steel,eliminating the need for the minimization of internal Gibbs energy preliminarily when solving deoxidation *** elimination of internal Gibbs energy minimization is particularly advantageous during the coupling of deoxidation equilibrium calculations with computationally intensive approaches,such as computational fluid *** model enables efficient calculations through direct embedment of the explicit forms of activity coefficient in the computing *** proposed thermodynamic model was developed using a quasichemical approach with two key approximations:random mixing of metallic elements(Fe and oxidizing metal) and strong nonrandom pairing of metal and oxygen as nearest *** these approximations,the quasichemical approach yielded the activity coefficients of solutes as explicit functions of composition and temperature without requiring the minimization of internal Gibbs energy or the coupling of separate *** model was successfully applied in the calculation of deoxidation equilibria of various elements(Al,B,C,Ca,Ce,Cr,La,Mg,Mn,Nb,Si,Ti,V,and Zr).The limitations of the model arising from these assumptions were also discussed.

关键词： deoxidation equilibria thermodynamics quasichemical approach computational fluid dynamics

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Patients with culture negative pyogenic liver abscess have the same outcomes compared to those withKlebsiella pneumoniae pyogenic liver abscess

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Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 504-511页

作者： Vishal G Shelat Qiao Wang Clement LK Chia Zhongkai Wang Jee Keem Low Winston WL Woon Department of General Surgery Tan Tock Seng Hospital Singapore 308433 Singapore ministry of health holdings Pte Ltd. Singapore 099253 Singapore

BACKGROUND: Etiologic organism is not frequently isolated despite multiple blood and lfuid cultures during management of pyogenic liver abscess (PLA). Such culture negative pyogen-ic liver abscess (CNPLA) is routinely managed by antibiotics targeted toKlebsiella pneumoniae. In this study, we evaluated the outcomes of such clinical practice. METHODS: All the patients with CNPLA andKlebsiella pneu-moniaePLA (KPPLA) admitted from January 2003 to Decem-ber 2011 were included in the study. A retrospective review of medical records was performed and demographic, clinical and outcome data were collected. RESULTS: A total of 528 patients were treated as CNPLA or KPPLA over the study period. CNPLA presented more com-monly with abdominal pain (P=0.024). KPPLA was more com-mon in older age (P=0.029) and was associated with thrombo-cytopenia (P=0.001), elevated creatinine (P=0.002), bilirubin (P=0.001), alanine aminotransferase (P=0.006) and C-reactive protein level (P=0.036). CNPLA patients tend to have anemia (P=0.015) and smaller abscess (P=0.008). There was no differ-ence in hospital stay (15.7 vs 16.8 days) or mortality (14.0% vs 11.0%). No patients required surgical drainage after initiation of medical therapy. CONCLUSION: Despite demographic and clinical differences between CNPLA and KPPLA, overall outcomes are not different.

关键词： culture negative Klebsiella pneumoniae pyogenic liver abscess

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Enhancing volatile fatty acids production from waste activated sludge: The role of pretreatment by N,N-bis(carboxymethyl)-L-glutamate (GLDA)

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Environmental Science and Ecotechnology 2024年第5期21卷 149-157页

作者： Chang Liu Lin Li Linji Xu Tanglong Zhang Qiang He Xiaodong Xin Key Laboratory of the Three Gorges Reservoir Region's Eco-environment Ministry of EducationCollege of Environment and EcologyChongqing UniversityChongqing400045PR China Research Center for Eco-Environmental Engineering Dongguan University of TechnologyDongguan523808PR China

N,N-bis(carboxymethyl)-L-glutamate(GLDA)is an eco-friendly chelating agent that effectively extracts multivalent metal ions from waste activated sludge(WAS)flocs,which could potentially alter their ***,the effect of GLDA on the production of volatile fatty acids(VFAs)from WAS is not well ***,we demonstrate that pretreatment with GLDA at a concentration of 200 mmol per kg VSS results in a significant increase of 142%in extractable extracellular polymeric substances and enhances the total VFAs yield by 64%compared to untreated *** reveal GLDA's capability to mobilize organic-binding multivalent metal ions within sludge ***,post-pretreatment analyses showed the release of 69.1 mg L^(-1) of Ca and 109.8 mg L^(-1) of Fe ions from the flocs,leading to a more relaxed floc structure and a reduced apparent activation energy(10.6 versus 20 kJ mol1)for WAS *** dynamic simulations further demonstrate GLDA's preferential binding to Fe3þand Ca2þover Mg2þ.Our study suggests that GLDA pretreatment causes minimal disruption to reactor stability,thereby indicating the stability of microbial community *** has emerged as a viable pretreatment agent for enhancing volatile fatty acids production from waste activated sludge.

关键词： Anaerobic fermentation Pretreatment Resource recovery Multivalent metals Solubilization

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Mobile technology:Usage and perspective of patients and caregivers presenting to a tertiary care emergency department

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World Journal of Emergency Medicine 2020年第1期11卷 5-11页

作者： Zhenghong Liu Mingwei Ng Dinesh V.Gunasekeran Huihua Li Kishanti Ponampalam R Ponampalam Singhealth Emergency Medicine Residency Programme Singapore Health ServicesSingapore ministry of health holdings Singapore health Services Research Unit Singapore General HospitalSingapore University of Newcastle Australia Department of Emergency Medicine Singapore General HospitalSingapore

BACKGROUND:Developments in information technology(IT)have driven a push in healthcare innovation in the emergency department(ED).Many of these applications rely on mobile technology(MT)such as smartphones but not everyone is comfortable with MT *** study aims to characterize the technology usage behavior of users in the ED so as to guide the implementation of IT interventions in the ***:A cross-sectional survey was conducted in the emergency department of a tertiary *** and their caregivers aged 21 and above were *** survey collected demographic information,technology usage patterns,and participant reported comfort level in the usage of *** performed descriptive statistics and multivariate logistic regression to identify factors differentially associated with comfort in usage of ***:A total of 498 participants were recruited,and 299(60%)were *** was the most commonly written and read language(66.9%)and 64.2%reported a comfort level of 3/5 or more in using *** that were associated with being comfortable in using MT include having a tertiary education,being able to read and write English,as well as being a frequent user of *** were more likely to display these ***:A large proportion of ED patients are not comfortable in the usage of *** that predicted comfort level in the usage of MT were common amongst *** interventions should take this into consideration in the design of MT interventions.

关键词： Mobile health technology Information technology Emergency department

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Metrology for sub-Rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High Power Laser Science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyakov A.Sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo C.D.Armstrong T.A.Pikuz S.A.Pikuz W.Yan T.M.Jeong S.Singh P.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla C.M.Lazzarini A.Velyhan T.Hayakawa Y.Fukuda J.K.Koga M.Ishino K.Kondo Y.Miyasaka A.Kon M.Nishikino Y.V.Nosach D.Khikhlukha I.P.Tsygvintsev D.Kumar J.Nejdl D.Margarone P.V.Sasorov S.Weber M.Kando H.Kiriyama Y.Kato G.Korn K.Kondo S.V.Bulanov T.Kawachi A.S.Pirozhkov ELI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Science(KPSI) QSTKyotoJapan Central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 Energy holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics ASCR PragueCzech Republic FZU-Institute of Physics ASCR PragueCzech Republic Czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine ISTEQ AR YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

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Radiofrequency ablation of pancreatic ductal adenocarcinoma:The past,the present and the future

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World Journal of Gastrointestinal Oncology 2015年第2期7卷 6-11页

作者： Garvi J Pandya Vishal G Shelat Medicine Ministry of Health Holdings Pte LtdSingapore 308433 Singapore Division of Hepato-pancreatico-biliary Surgery Tan Tock Seng HospitalSingapore 308433Singapore

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive cancers with a grim overall 5-year survival rate of 5%.Advances in surgical techniques,critical care,molecular diagnosis,diagnostic imaging,endosonology and adjuvant therapy have improved outcomes;but still more needs to be *** is an urgent need to discover new avenues that may impact *** ablation(RFA)has attracted attention as an adjunctive treatment in PDAC.A review of English literature in Pub Med was done using the MESH terms for PDAC and *** the articles were reviewed and core information was tabulated for *** a comprehensive review of all articles the data was evaluated to discover the role of RFA in PDAC ***,contraindications,feasibility,success rate,safety,complications and impact on survival were reviewed and are discussed *** appears to be an attractive option for nonmetastatic locally advanced *** is feasible but has a significant *** the present time the integration of RFA into the management of pancreatic ductal adenocarcinoma is *** should be considered as having a complimentary role to current standard therapy in the multimodal management care *** is likely that indications and patient selection for pancreatic RFA will expand.

关键词： Pancreatic cancer Radiofrequency ablation

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Robust Machine Learning Mapping of sEMG Signals to Future Actuator Commands in Biomechatronic Devices

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Journal of Bionic Engineering 2024年第1期21卷 270-287页

作者： Ali Nasr Sydney Bell Rachel L.Whittaker Clark R.Dickerson John McPhee Systems Design Engineering University of WaterlooWaterloo N2L 3G1Canada Kinesiology and health Sciences University of WaterlooWaterloo N2L3G3Canada

A machine learning model for regression of interrupted Surface Electromyography(sEMG)signals to future control-oriented signals(e.g.,robot’s joint angle and assistive torque)of an active biomechatronic device for high-level myoelectric-based hierarchical control is proposed.A Recurrent Neural Network(RNN)was trained using output data,initially obtained from offline optimization of the biomechatronic(human–robot)device and shifted by the prediction *** input of the RNN consisted of interrupted sEMG signals(to mimic signal disconnections)and previous kinematic signals of the assistive *** RNN with a 0.1-s prediction horizon could predict the control-oriented joint angle and assistive torque with 92%and 86.5%regression accuracy,respectively,for the test *** proposed approach permits a fast,predictive,and direct estimation of control-oriented signals instead of an iterative process that optimizes assistive torque in the inverse dynamic simulation of a multibody human–robot *** with these interrupted input signals significantly improves the regression accuracy in the case of sEMG signal *** Robust Predictive Control-oriented Machine Learning(Robust-MuscleNET)model can support volitional high-level myoelectric-based control of biomechatronic devices,such as exoskeletons,prostheses,and assistive/resistive *** work should study the application to prosthesis control as well as the repeatability of the high-level controller with electrode *** low-level hierarchical controller that manages the human–robot interaction,the assistance/resistance strategy,and the actuator coordination should also be studied.

关键词： Myoelectric-based control-Surface electromyography Machine learning Multibody system dynamics Exoskeleton Bionic

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