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A modified method for locating parapharyngeal space neoplasms on magnetic resonance images: implications for differential diagnosis

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Chinese Journal of Cancer 2014年第10期33卷 511-520页

作者： Xue-Wen Liu Ling Wang Hui Li Rong Zhang Zhi-Jun Geng De-Ling Wang Chuan-Miao Xie State Key Laboratory of Oncology in South China Medical Imaging and minimally invasive interventional Center Sun Yat-sen University Cancer Center Collaborative Innovation Center for Cancer medicine the Six Affiliated Hospital of Sun Yat-sen University

The parapharyngeal space(PPS) is an inverted pyramid-shaped deep space in the head and neck region, and a variety of tumors, such as salivary gland tumors, neurogenic tumors, nasopharyngeal carcinomas with parapharyngeal invasion, and lymphomas, can be found in this space. The differential diagnosis of PPS tumors remains challenging for radiologists. This study aimed to develop and test a modified method for locating PPS tumors on magnetic resonance(MR) images to improve preoperative differential diagnosis. The new protocol divided the PPS into three compartments: a prestyloid compartment, the carotid sheath, and the areas outside the carotid sheath. PPS tumors were located in these compartments according to the displacements of the tensor veli palatini muscle and the styloid process, with or without blood vessel separations and medial pterygoid invasion. This protocol, as well as a more conventional protocol that is based on displacements of the internal carotid artery(ICA), was used to assess MR images captured from a series of 58 PPS tumors. The consequent distributions of PPS tumor locations determined by both methods were compared. Of all 58 tumors, our new method determined that 57 could be assigned to precise PPS compartments. Nearly all(13/14; 93%) tumors that were located in the pre-styloid compartment were salivary gland tumors. All 15 tumors within the carotid sheath were neurogenic tumors. The vast majority(18/20; 90%) of trans-spatial lesions were malignancies. However, according to the ICA-based method, 28 tumors were located in the pre-styloid compartment, and 24 were located in the post-styloid compartment, leaving 6 tumors that were difficult to locate. Lesions located in both the pre-styloid and the post-styloid compartments comprised various types of tumors. Compared with the conventional ICA-based method, our new method can help radiologists to narrow the differential diagnosis of PPS tumors to specific compartments.

关键词：恶性肿瘤图像定位鉴别诊断磁共振诊断意义间隙 PPS 颈动脉

Animal models used to study direct peripheral nerve repair: a systematic review

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Neural Regeneration Research 2020年第3期15卷 491-502页

作者： Francisco Javier Vela Guadalupe Martínez-Chacón Alberto Ballestín JoséLuis Campos Francisco Miguel Sánchez-Margallo Elena Abellán Department of Microsurgery Jesús Usón Minimally Invasive Surgery CentreCáceresSpain Scientific Director Jesús Usón Minimally Invasive Surgery CentreCáceresSpain

Objective:Peripheral nerve repair is required after traumatic *** common condition represents a major public health problem *** after nerve repair depends on several factors,including the severity of the injury,the nerve involved,and the surgeon’s technical *** the precise microsurgical repair of nerve lesions,adequate functional recovery is not always achieved and,therefore,the regeneration process and surgical techniques are still being ***-clinical animal models are essential for this research and,for this reason,the focus of the present systematic review(according to the PRISMA statement)was to analyze the different animal models used in pre-clinical peripheral nerve repair *** sources:Original articles,published in English from 2000 to 2018,were collected using the Web of Science,Scopus,and PubMed *** selection:Only preclinical trials on direct nerve repair were included in this *** articles were evaluated by the first two authors,in accordance with predefined data *** measures:The primary outcomes included functional motor abilities,daily activity and regeneration *** outcomes included coaptation technique and animal ***:This review yielded 267 articles,of which,after completion of the screening,49 studies were *** were 1425 animals in those 49 studies,being rats,mice,guinea pigs,rabbits,cats and dogs the different pre-clinical *** nerves used were classified into three groups:head and neck(11),forelimb(8)and hindlimb(30).The techniques used to perform the coaptation were:microsuture(46),glue(12),laser(8)and mechanical(2).The follow-up examinations were histology(43),electrophysiological analysis(24)and behavioral observation(22).Conclusion:The most widely used animal model in the study of peripheral nerve repair is the *** animal models are also used but the cost-benefit of the rat model provides several strengths over the ***

关键词： nerve microsurgery peripheral nerve regeneration repair reconstruction direct nerve repair animal model coaptation PRISMA systematic review

Dose optimization of intrathecal administration of human umbilical cord mesenchymal stem cells for the treatment of subacute incomplete spinal cord injury

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Neural Regeneration Research 2022年第8期17卷 1785-1794页

作者： Ting-Ting Cao Huan Chen Mao Pang Si-Si Xu Hui-Quan Wen Bin Liu Li-Min Rong Mang-Mang Li Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Spine Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of minimally invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of minimally invasive Spine Surgery GuangzhouGuangdong ProvinceChina Department of Radiology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Human umbilical cord mesenchymal stem cells(hUC-MSCs)are a promising candidate for spinal cord injury(SCI)repair owing to their advantages of low immunogenicity and easy accessibility over other MSC ***,modest clinical efficacy hampered the progression of these cells to clinical *** discrepancy may be due to many variables,such as cell source,timing of implantation,route of administration,and relevant efficacious cell dose,which are critical factors that affect the efficacy of treatment of patients with ***,we have evaluated the safety and efficacy of 4×10^(6) hUC-MSCs/kg in the treatment of subacute SCI by intrathecal implantation in rat *** search for a more accurate dose range for clinical translation,we compared the effects of three different doses of hUC-MSCs-low(0.25×10^(6) cells/kg),medium(1×10^(6) cells/kg)and high(4×10^(6) cells/kg)-on subacute SCI repair through an elaborate combination of behavioral analyses,anatomical analyses,magnetic resonance imaging-diffusion tensor imaging(MRI-DTI),biotinylated dextran amine(BDA)tracing,electrophysiology,and quantification of mRNA levels of ion channels and neurotransmitter *** study demonstrated that the medium dose,but not the low dose,is as efficient as the high dose in producing the desired therapeutic ***,partial restoration of theγ-aminobutyric acid type A(GABAA)receptor expression by the effective doses indicates that GABAA receptors are possible candidates for therapeutic targeting of dormant relay pathways in injured spinal ***,this study revealed that intrathecal implantation of 1×10^(6) hUC-MSCs/kg is an alternative approach for treating subacute SCI.

关键词： effective dose human umbilical cord mesenchymal stem cells intrathecal implantation ion channels neurotransmitter receptors spinal cord injury subacute spinal cord injury γ-aminobutyric acid type A(GABA_(A))receptors

Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1

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Oncology Research 2022年第6期30卷 277-288页

作者： FANBIAO KONG KUN WU LIMING PANG YULIANG HUANG LEI LI JING XU FEITONG LI YAN QING ZHONGYU WANG XIURONG HUANG SHENG XU XIAOGANG ZHONG ZHOU ZHU XIAOTONG WANG JIANRONG YANG Department of General Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou510630China Department of Colorectal and Anal Surgery The People’s Hospital of Guangxi Zhuang Autonomous Region&Institute of Minimally Invasive Technology and ApplicationsGuangxi Academy of Medical SciencesNanning530021China Departments of Gastrointestinal Hernia and Enterofistula SurgeryPeople’s Hospital of Guangxi Zhuang Autonomous Region&Institute of Minimally Invasive Technology and ApplicationsGuangxi Academy of Medical SciencesNanning530021China Departments of Hepatobiliary and Gastrointestinal Surgery Minzu Hospital of Guangxi Autonomous RegionNanning530001China Department of Hepatobiliary Pancreas and Spleen SurgeryThe People’s Hospital of Guangxi Zhuang Autonomous Region&Institute of Minimally Invasive Technology and ApplicationsGuangxi Academy of Medical SciencesNanning530021China

Introduction:Siva-1,as a pro-apoptotic protein,has been shown to induce extensive apoptosis in a number of different cell *** our previous study,we showed that overexpressed Siva-1 decreased the apoptosis of gastric cancer ***,we believe that it can also work as an anti-apoptotic *** present study aimed to determine the speciﬁc role of Siva-1 in anticancer drug resistance in gastric cancer in vivo and in vitro and preliminarily reveal the *** and Methods:A vincristine-resistant MKN-28/VCR gastric cancer cell line with stably downregulated Siva-1 was *** effect of Siva-1 downregulation on chemotherapeutic drug resistance was assessed by measuring the IC50 and pump rate of ***,apoptosis of cells,and cell cycle were detected via colony formation assay andﬂow cytometry,***,migration and invasion of cells was detected via wound healing and transwell ***,we determined in vivo effects of LV-Siva-1-RNAi on tumor size,and apoptotic cells in tumor tissues were detected using TUNEL and hematoxylin and eosin ***:Siva-1 downregulation reduced the pump rate of doxorubicin and enhanced the response to drug ***-1 negatively regulated proliferation and promoted apoptosis of cells by potentiality G2-M phase *** of Siva-1 expression in MKN-28/VCR cells signiﬁcantly weakened wound healing ability and decreased invasion ***(C)-binding protein 1(PCBP1)was identiﬁed as a Siva-1-interacting protein in yeast two-hybrid *** RT-PCR and western blotting revealed that Siva-1 downregulation could inhibit expression of PCBP1,Akt,and NF-κB and eventually decrease the expression of MDR1 and ***:The current study demonstrated that the downregulation of Siva-1,which functions as a regulator of MDR1 and MRP1 gene expression in gastric cancer cells by inhibiting PCBP1/Akt/NF-κB signaling pathway expression,enhanced the

关键词： Multidrug resistance Gastric cancer Siva-1 PCBP1

Transrectal ultrasound examination of prostate cancer guided by fusion imaging of multiparametric MRI and TRUS:avoiding unnecessary mpMRI-guided targeted biopsy

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Asian Journal of Andrology 2023年第3期25卷 410-415页

作者： Guang Xu Jun-Heng Li Li-Hua Xiang Bin Yang Yun-Chao Chen Yi-Kang Sun Bing-Hui Zhao Jian Wu Li-Ping Sun Hui-Xiong Xu Department of Medical Ultrasound Center of Minimally Invasive Treatment for TumorShanghai Tenth People’s HospitalUltrasound Research and Education InstituteClinical Research Center for Interventional MedicineSchool of MedicineTongji UniversityShanghai 200072China Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment Shanghai 200072China Department of Radiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Urology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Medical Ultrasound Xiang’an Hospital of Xiamen UniversityXiamen 361101China Department of Ultrasound Zhongshan HospitalInstitute of Ultrasound in Medicine and EngineeringFudan UniversityShanghai 200032China

The purpose of this study was to explore transrectal ultrasound(TRUS)findings of prostate cancer(PCa)guided by multiparametric magnetic resonance imaging(mpMRI)and to improve the Prostate Imaging Reporting and Data System(PI-RADS)system for avoiding unnecessary mpMRI-guided targeted biopsy(TB).From January 2018 to October 2019,fusion mpMRI and TRUS-guided biopsies were performed in 162 consecutive *** study included 188 suspicious lesions on mpMRI in 156 patients,all of whom underwent mpMRI-TRUS fusion imaging-guided TB and 12-core transperineal systematic biopsy(SB).Univariate analyses were performed to investigate the relationship between TRUS features and ***,logistic regression analysis with generalized estimating equations was performed to determine the independent predictors of PCa and obtain the fitted probability of *** detection rates of PCa based on TB alone,SB alone,and combined SB and TB were 55.9%(105 of 188),52.6%(82 of 156),and 62.8%(98 of 156),*** significant predictors of PCa on TRUS were hypoechogenicity(odds ratio[OR]:9.595,P=0.002),taller-than-wide shape(OR:3.539,P=0.022),asymmetric vascular structures(OR:3.728,P=0.031),close proximity to capsule(OR:3.473,P=0.040),and irregular margins(OR:3.843,P=0.041).We propose subgrouping PI-RADS score 3 into categories 3a,3b,3c,and 3d based on different numbers of TRUS predictors,as the creation of PI-RADS 3a(no suspicious ultrasound features)could avoid 16.7%of mpMRI-guided *** stratification of PCa with mpMRI-TRUS fusion imaging-directed ultrasound features could avoid unnecessary mpMRI-TBs.

关键词： fusion biopsy multiparametric MRI prostate cancer transrectal ultrasound

A ResNet-based approach for accurate radiographic diagnosis of knee osteoarthritis

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CAAI Transactions on Intelligence Technology 2022年第3期7卷 512-521页

作者： Yu Wang Shibo Li Baoliang Zhao Jianwei Zhang Yuanyuan Yang Bing Li School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhenChina Shenzhen Key Laboratory of minimally invasive Surgical Robotics and System Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina TAMS Department of InformaticsUniversity of HamburgHamburgGermany

Currently X-ray images are clinically graded by experienced clinicians using the Kellgren and Lawrence(KL)scoring ***,individual scoring is subjective and error *** study proposes an approach for automated knee osteoarthritis classification based on deep neural *** knee X-ray images are first preprocessed with frequency-domain filtering and histogram normalisation,making the trabecular bone texture more obvious and benefiting the subsequent classification ***,a two-step classification strategy is proposed by extracting the joint centre based on the VGG network and classifying osteoarthritis grades based on the ResNet-50 *** addition,a rebalance operation is proposed to deal with the dataset unbalance problem,and a quick search technique is proposed to improve the iterative search efficiency for the joint *** all of these techniques,a classification accuracy of 81.41%is obtained,which is higher compared to the state-of-the-art approaches.

关键词： AMSGrad knee osteoarthritis recognition ResNet VGG

Neisseria mucosa-A rare cause of peritoneal dialysis-related peritonitis:A case report

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World Journal of Clinical Cases 2023年第14期11卷 3311-3316页

作者： Jian-Min Ren Xiao-Yao Zhang Si-Yu Liu Department of Clinical Laboratory The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Rehabilitation The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina The Key Laboratory of Imaging Diagnosis and minimally invasive interventional Research of Zhejiang Province Zhejiang University Lishui HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Neisseria mucosa is a gram negative diplococcus belonging to the genus Neisseria found commonly in the upper respiratory *** is typically a commensal organism when it is parasitic on oral and nasal *** our knowledge,it does not cause disease in healthy individuals with normal immunity,but can be pathogenic in those with impaired immune function or change in bacterial colonization *** mucosa has been reported to cause bacterial meningitis,conjunctivitis,pneumonia,endocarditis,peritonitis and ***,peritoneal dialysis-related peritonitis caused by Neisseria mucosa is extremely rare in clinical practice,which has not previously been reported in *** SUMMARY A 55-year-old female presented to the nephrology clinic with upper abdominal pain without apparent cause,accompanied by nausea,vomiting and diarrhea for two *** patient had a history of Stage 5 chronic kidney disease for five years,combined with renal hypertension and renal anemia,and was treated with peritoneal dialysis for renal replacement *** patient was subsequently diagnosed with peritoneal dialysis-related *** examination of peritoneal dialysis fluid showed abdominal infection,and the results of microbial culture of the peritoneal dialysis fluid confirmed Neisseria ***-penem/cilastatin 1.0 g q12h was added to peritoneal dialysis fluid for anti-infection *** 24 d,the patient underwent upper extremity arteriovenous *** month later,the patient was discharged home in a clinically stable *** Peritonitis caused by Neisseria mucosa is *** with home-based self-dialysis cannot guarantee good medical and health conditions,and require education on self-protection.

关键词： Peritoneal dialysis Peritonitis Neisseria mucosa Case report

Giant bile duct dilatation in newborn:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1150-1156页

作者： Dong-Wen Quan Peng-Gang Li Xiang-Hua Xu Shi-Qi Liu The Second Clinical Medical School Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina The First School of Clinical medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Neonatal Surgery Xi’an Children’s Hospital Affiliated Xi’an Jiaotong UniversityXi’an 710003Shaanxi ProvinceChina

BACKGROUND Giant congenital biliary dilation(CBD)is a rare condition observed in clinical *** born with this condition often experience a poor overall health status,and the disease progresses rapidly,leading to severe biliary obstruction,infections,pressure exerted by the enlarged CBD on abdominal organs,disturbances in the internal environment,and multiple organ *** treatment of giant CBD using laparoscopy is challenging due to the high degree of variation in the shape of the bile duct and other organs,making it difficult to separate the bile duct wall from adjacent tissues or to control *** SUMMARY Herein,we present the details of an 11-d-old male newborn who was diagnosed with giant *** patient was admitted to the neonatal surgery department of our hospital due to a history of common bile duct cyst that was detected more than 3 mo ago,and also because the patient had been experiencing yellowish skin for the past 9 *** abnormal echo in the fetal abdomen was first noticed by the patient’s mother during a routine ultrasound examination at a local hospital,when the patient was at 24 wk+6 d of *** finding raised concerns about the possibility of congenital biliary dilatation(22 mm×21 mm).Subsequent ultrasound examinations at different hospitals consistently confirmed the presence of a congenital biliary *** specific treatment was administered for biliary dilatation during this period.A computed tomography scan conducted during the hospitalization revealed a large cystic mass in the right upper quadrant and pelvis,measuring approximately 9.2 cm×7.4 cm×11.3 *** on the CONCLUSION The analysis reveals that prenatal imaging techniques,such as ultrasound and magnetic resonance imaging,play a crucial role in the early diagnosis,fetal prognosis,and treatment plan for giant *** surgery for giant CBD presents certain challenges,including difficulties in separating the cyst wall,anastomosis,and hemos

关键词： Acute cholangitis Congenital biliary dilation Laparoscopic surgery vs Open hepatic duct-jejunostomy Case report

MOF负载Weel抑制剂实现p53突变胆囊癌的合成致死靶向治疗

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Science Bulletin 2024年第9期69卷 1286-1301页

作者：郦仕杰 Sarun Juengpanich Win Topatana 谢天傲侯丽丹朱怡远陈佳东单煜凯韩依纳陆子毅陈天恩 Charlie Topatana 张斌曹佳胜胡家豪严加费陈迎鑫顾臻俞计成蔡秀军陈鸣宇 Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of medicine Zhejiang UniversityHangzhou 310058China National Engineering Research Center of Innovation and Application of minimally invasive Instruments Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Materials Science and Engineering Zhejiang UniversityHangzhou 310058China Department of Chemistry Zhejiang UniversityHangzhou 310016China Department of Pathology Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China International College Zhejiang UniversityHangzhou 310058China Institute of Advanced Magnetic Materials and International Research Center for EM Metamaterials College of Materials&Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018China Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Liangzhu Laboratory Zhejiang UniversityHangzhou 311121China Jinhua Institute of Zhejiang University Jinhua 321299China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Adavosertib(ADA)is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer(GBC).However,drug resistance due to DNA damage response compensation pathways and high toxicity limits further ***,estrone-targeted ADA-encapsulated metal–organic frameworks(ADA@MOF-EPL)for GBC synthetic lethal treatment by inducing conditional factors are *** high expression of estrogen receptors in GBC enables ADA@MOF-EPL to quickly enter and accumulate near the cell nucleus through estrone-mediated endocytosis and release ADA to inhibit WEE1 upon entering the acidic tumor *** irradiation induces ADA@MOF-EPL to generate reactive oxygen species(ROS),which leads to a further increase in DNA damage,resulting in a higher sensitivity of p53-mutated cancer cells to WEE1 inhibitor and promoting cell death via conditional synthetic *** conditional factor induced by ADA@MOF-EPL further enhances the antitumor efficacy while significantly reducing systemic ***,ADA@MOF-EPL demonstrates similar antitumor abilities in other p53-mutated solid tumors,revealing its potential as a broad-spectrum antitumor drug.

关键词： Synthetic lethality Nanomedicine Sonodynamic therapy Gallbladder cancer Metal-organic frameworks DNA damage response