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Research on virtual entity decision model for LVC tactical confrontation of army units

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Journal of Systems Engineering and Electronics 2022年第5期33卷 1249-1267页

作者： GAO Ang GUO Qisheng DONG Zhiming TANG Zaijiang ZHANG Ziwei FENG Qiqi military exercise and training center Army Academy of Armored ForcesBeijing 100072China

According to the requirements of the live-virtual-constructive(LVC)tactical confrontation(TC)on the virtual entity(VE)decision model of graded combat capability,diversified actions,real-time decision-making,and generalization for the enemy,the confrontation process is modeled as a zero-sum stochastic game(ZSG).By introducing the theory of dynamic relative power potential field,the problem of reward sparsity in the model can be *** reward shaping,the problem of credit assignment between agents can be *** on the idea of meta-learning,an extensible multi-agent deep reinforcement learning(EMADRL)framework and solving method is proposed to improve the effectiveness and efficiency of model *** show that the model meets the requirements well and the algorithm learning efficiency is high.

关键词： live-virtual-constructive(LVC) army unit tactical confrontation(TC) intelligent decision model multi-agent deep reinforcement learning

Knowledge-oriented modeling for influencing factors of battle damage in military industrial logistics:An integrated method

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Defence Technology（防务技术） 2020年第3期16卷 571-587页

作者： Xiong Li Xiao-dong Zhao Wei Pu military exercise and training center Army Academy of Armored ForcesBeijing 100072China

Modeling influencing factors of battle damage is one of essential works in implementing military industrial logistics simulation to explore battle damage laws ***,one of key challenges in designing the simulation system could be how to reasonably determine simulation model input and build a bridge to link battle damage model and battle damage laws *** this paper,we propose a novel knowledge-oriented modeling method for influencing factors of battle damage in military industrial logistics,integrating conceptual analysis,conceptual modeling,quantitative modeling and simulation *** conceptualize influencing factors of battle damage by using the principle of hierarchical decomposition,thus classifying the related battle damage knowledge ***,we construct the conceptual model of influencing factors of battle damage by using Entity-Relations hip approach,thus describing their interactions ***,we extract the important influencing factors by using social network analysis,thus evaluating their importance quantitatively and further clarifying the elements of ***,we develop an agent-based military industry logistics simulation system by taking the modeling results on influencing factors of battle damage as simulation model input,and obtain simulation model output,i.e.,new battle damage laws knowledge,thus verifying feasibility and effectiveness of the proposed *** results show that this method can be used to support human decision-making and action.

关键词： Battle damage Industrial logistics Entity-relationship approach Social network analysis Agent-based simulation

Research on the Design Method of Equipment in Service Assessment Subjects

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Computers, Materials & Continua 2022年第11期73卷 2473-2484页

作者： Jianhua Luo Yuhang Zhou Hua Li Xi Chen Xigong Xia military exercise and training center Army Academy of Armored ForcesBeijing100072China

Combined with equipment activities such as combat readiness,training, exercises and management, it is proposed that the design of equipment in-service assessment subjects should follow the principles of combination, stage and operability. Focusing on the design of equipment in-serviceassessment subjects, a design method for in-service assessment subjects basedon the combination of trial and training mode is proposed. Based on theactual use of high-equipment use management and training and the established indicator system, the army’s bottom-level equipment activity subjectsand bottom-level assessments are combined. The indicators are mapped andanalyzed. Through multiple rounds of iterations, the mapping relationshipbetween in-service assessment indicators and military equipment activitysubjects is established. Finally, the equipment activity subjects whose data iscollected (reflecting the underlying assessment indicators) are generated inservice assessment subjects. The orthogonal test method is used to optimizethe samples in the assessment subjects to form an in-service assessmentimplementation plan. Taking a certain type of armored infantry fightingvehicle as an example, the sample optimization design of the initially generatedin-service assessment subjects is analyzed. It provides methods and ideas tocarry out in-service assessment work.

关键词： Equipment in-service assessment subject design mapping

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi Han Jun Xiao Jian-Feng Ma Wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

Operational effectiveness evaluation based on the reduced conjunctive belief rule base

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Journal of Systems Engineering and Electronics 2022年第5期33卷 1161-1172页

作者： ZHANG Ziwei GUO Qisheng DONG Zhiming LIU Hongxiang GAO Ang QI Pengcheng military exercise and training center Army Academy of Armored ForcesBeijing 100072China Unit 32128 of the PLA Ji’nan 250024China Department of Equipment Support and Remanufacture Army Academy of Armored ForcesBeijing 100072China

To address the issue of rule premise combination explosion in the construction of the traditional complete conjunctive belief rule base(BRB),this paper introduces an orthogonal design method to reduce the conjunctive *** reasoning method based on reduced conjunctive BRB is designed with the help of the conversion technology from conjunctive BRB to disjunctive ***,the operational mission effectiveness evaluation is taken as an example to verify the proposed *** results show that the method proposed in this paper is feasible and effective.

关键词： operational effectiveness evaluation reduced conjunctive belief rule base(BRB) orthogonal design evidence reasoning(ER)

Comparison of TGF-β_1 in tears and corneal haze following Epi-LASIK with and without mitomycin C

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 312-315页

作者： Jing Chen Yi Chen Su-Ning Han Department of Ophthalmology Guangzhou General Hospital of Guangzhou Military Command training center Guangzhou General Hospital of Guangzhou Military Command

AIM: To compare transforming growth factor-β1 (TGF- β1 ) levels in tears and the degree of corneal haze formation following epithelial laser in situ keratomileusis (Epi -LASIK) with and without the use of mitomycin C (MMC) and to investigate the effect of MMC on corneal wound healing. ·METHODS: Thirty-two patients (64 eyes) with high myopia underwent Epi -LASIK surgery, and MMC was randomly used in one eye in each patient. The epithelialization process was observed, and the TGF -β1 level in tears was measured at 1 day, 3, and 7 days postoperatively for comparison with baseline. Corneal haze was graded at 1 month, 3, and 6 months after surgery. · RESULTS: Mean preoperative spherical equivalent refraction was -8.24 ±2.18D (range-6.00 to -10.50D) in the MMC group and -7.82±1.55D (range -6.00 to -9.75D) in the non -MMC group. There was no significant difference between the two groups (P =0.38). Mean epithelialization time was (5.02 ±0.68) days in the MMC group and (4.86±0.57) days in the non-MMC group (P = 0.31). Tear fluid TGF-β1 levels were similar before surgery (P =0.34), but were significantly higher in the non-MMC group at 1 day, 3, and 7 days postoperatively (P =0.004, 0.008, and 0.012, respectively). Corneal haze scores 1 month after surgery were significantly higher in the non -MMC group (P =0.03), and similar at 3 and 6 months after surgery (P =0.28 and 0.62, respectively). ·CONCLUSION: MMC did not delay epithelialization. Inearly postoperative period, lower TGF -β1 levels in tears and a lower grade of corneal haze were observed in the MMC group. Our findings suggest that the ability of MMC to inhibit Epi -LASIK -induced haze might be mediated through TGF-β1 suppression.

关键词： Epi-LASIK MMC TGF-β1 haze

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

Thermodynamic Characteristics of Tropical Cyclones with Rapid Intensity Change over the Coastal Waters of China

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Acta meteorologica Sinica 2011年第4期25卷 467-477页

作者：于玉斌姚秀萍 China Meteorological Administration training center

In order to investigate the different thermodynamic mechanisms between rapid intensifying （RI） and rapid weakening （RW） tropical cyclones （TCs）, the thermodynamic structures of two sets of composite TCs are analyzed based on the complete-form vertical vorticity tendency equation and the NCEP/NCAR reanalysis data. Each composite is composed of five TCs, whose intensities change rapidly over the coastal waters of China. The results show that the maximum apparent heating source Q1 exists in both the upper and lower troposphere near the RI TC center, and Q1 gets stronger at the lower level during the TC intensification period. But for the RW TC, the maximum Q1 exists at the middle level near the TC center, and Q1 gets weaker while the TC weakens. The maximum apparent moisture sink Q2 lies in the mid troposphere. Q2 becomes stronger and its peak-value height rises while TC intensifies, and vice versa. The increase of diabatic heating with height near the TC center in the mid-upper troposphere and the increase of vertical inhomogeneous heating near the TC center in the lower troposphere are both favorable to the TCs＇ rapid intensification; otherwise, the intensity of the TC decreases rapidly.

关键词： coastal waters tropical cyclone rapid intensity change thermodynamic mechanism