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膜科学与技术 2010年第2期30卷 74-78页

作者： Stefan Krause 学贤董正军 Hans Joerg Heckmann microdyn-nadir gmbh wiesbaden 65203 迈纳德膜技术(厦门)有限公司厦门361022

用于废水处理的膜生物反应器工艺(MBR),是指通过膜过滤实现活性污泥与产水的分离的新型生化法处理废水技术.由于MBR具有占地面积小和出水水质好的优点,膜生物反应器成功应用到废水处理中的案例正在迅速增加.膜污染是MBR废水处理工艺面... 详细信息

用于废水处理的膜生物反应器工艺(MBR),是指通过膜过滤实现活性污泥与产水的分离的新型生化法处理废水技术.由于MBR具有占地面积小和出水水质好的优点,膜生物反应器成功应用到废水处理中的案例正在迅速增加.膜污染是MBR废水处理工艺面临的主要问题之一.膜污染会导致膜的渗透性能降低,为此必须通过化学清洗才能恢复膜的性能.为了实现无化学清洗的MBR工艺,研究使用持续物理冲刷去除膜污染层的方法.在活性污泥中加入颗粒物质(粉料),通过这些颗粒物质的持续冲刷作用实现去除膜污染层的目的.经过8个多月的实验,膜组件的渗透性能保持不变,通量可以达到40 L/(m2.h)以上.系统安装了在线的浊度仪作为产水质量的检测,在试验过程中,浊度始终没有变化.作为对比,同时也进行了一个参照实验(MBR标准工艺,没有加入颗粒物质),实验结果表明,传统的MBR工艺的膜组件渗透性能会不断下降导致通量下降,需要进行化学清洗.新型MBR工艺高通量和无需化学清洗的优势,将极大地提高MBR工艺的成本效益.

关键词： MBR 颗粒污染控制聚合平板膜

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State of the Art in High Compression Comminution

State of the Art in High Compression Comminution

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第三届北京国际水泥与混凝土学术会议

作者： Dr.-Ing. Fritz Feige Chief Editor of "ZKG INTERNATIONAL" Bauverlag gmbh Wiesbaden Germany

Summary The idea of stressing a bulk material between two counterrotating rollers goes back to the 30s. Further investigations in the 70s confirmed that this new principle of operation was also suitable for fine comminution, and led in 1985 to the first high-pressure grinding rolls for industrial use. Since then more than 300 sets of high-pressure grinding rolls have come into use throughout the world;at present these are mainly built by Krupp-Polysius AG, KHD Humboldt Wedag AG, and also by Maschinenfabrik Koppern gmbh & Co KG. The operation of high-pressure grinding rolls is modelled on that of compacting presses. Because of the application of high to very high pressures the ground material generally leaves the roller gap in compacted form;it then requires subsequent disagglomeration for which hammer mills and tube mills are particularly suitable. The proportion of fines released by disagglomeration, defined for example as the material passing 90 urn, may be as high as 40 % depending on the setting and the properties of the material. High compression comminution was first used in *** industry, mainly to increase the output of existing cement grinding plants;since then it has also proved its value in the comminution of cement raw materials, quick lime, ores, and other mineral raw materials. Depending on the technological arrangement, plant configuration and product quality required, the use of high-pressure grinding rolls can lead to increases in throughput of between 30 and 200 % and to power savings of between 15 and 50 %. In a process engineering comparison with roller grinding mills the high-pressure grinding rolls have the advantage from the energy point of view that the layers of material processed in them are subjected to substantially fixed stressing and motional control. On the other hand it is a disadvantage as far as throughput is concerned that high-pressure grinding rolls are still fixed in a speed range of 1.2 to 1.8 m/s, and that such process e

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MCC1019,a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel,potent anticancer candidate

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Acta Pharmaceutica Sinica B 2019年第5期9卷 1021-1034页

作者： Sara Abdelfatah Angela Berg Qi Huang Li Jun Yang Sami Hamdoun Anette Klinger Henry J.Greten Edmond Fleischer Thorsten Berg Vincent K.W.Wong Thomas Efferth Department of Pharmaceutical Biology Institute of Pharmacy and BiochemistryJohannes Gutenberg UniversityMainz55128Germany Leipzig University Institute of Organic ChemistryLeipzig04103Germany State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacaoChina MicroCombiChem gmbh Wiesbaden65203Germany Abel Salazar Institute of Biomedical Sciences University of PortoPorto4099-003Portugal

Polo-like kinase(PLK1) has been identified as a potential target for cancer *** a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain(PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethylbenzofuran-2-carboxylic acid ethyl ester(designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1 PBD was confirmed using fluorescence polarization and microscale *** compound exerted specificity towards PLK1 over PLK2 and PLK3. MCC1019 showed cytotoxic activity in a panel of different cancer cell lines. Mechanistic investigations in A549 lung adenocarcinoma cells revealed that MCC1019 induced cell growth inhibition through inactivation of AKT signaling pathway, it also induced prolonged mitotic arrest—a phenomenon known as mitotic catastrophe, which is followed by immediate cell death via apoptosis and necroptosis. MCC1019 significantly inhibited tumor growth in vivo in a murine lung cancer model without affecting body weight or vital organ size, and reduced the growth of metastatic lesions in the lung. We propose MCC1019 as promising anti-cancer drug candidate.

关键词： Polo-like kinase PLK1 Polo box domain Mono-targeted therapy Cell cycle Necroptosis Spindle damage

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Amino Acid Composition Reduces Frequency of Common Colds. Results of a Controlled Randomised Completely Masked Trial

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Food and Nutrition Sciences 2013年第3期4卷 262-269页

作者： Alfons Meyer Doris Meister Wilhelm Gaus Institute of Epidemiology and Medical Biometry University of Ulm Ulm Germany. Kaiser-Friedrich-Ring 77 Wiesbaden Germany Medical Science Department Kyberg Vital GmbH Oberhaching Germany

Purpose: Special nutrients have an impact on common cold infections. In this trial we have investigated the effectiveness of the specific amino acid composition “aminoplus? immun” on the occurrence, duration and severity of common cold. Material and Methods: Our study is a controlled, randomised completely masked trial comparing genuine trial remedy versus placebo in parallel groups. Eligible subjects were people with recurrent and chronic infections of the ear, nose and pharyngeal area. The treatment period was 90 days. The primary outcome was the mean number of days that the patients had symptoms of infections. Results: From Oct. 2009 to Feb. 2010 a total of 145 patients were recruited, of whom 119 had no major protocol violation and were valid for assessment. Two thirds of the patients were female. The mean age of the patients was 45 years. 65% of participants had come into contact with many people and thereby an increased risk of infection. On average the patients had 11.1 infections during the 12 months before the study. Compliance for the intake of the study preparation was 98.9%. Due to randomisation, the groups were very similar and balanced. The primary and all 6 secondary outcome variables showed a clear superiority of the investigated amino acid composition over placebo (p Conclusion: The specific composition “aminoplus? immun is effective in preventing recurrent and chronic infections of the ear, nose and upper respiratory tract.

关键词： Amino Acids Immune System Vitamins Common Cold Chronic Infection of Ear Nose Pharyngeal Area

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水泥厂生产过程监控:熟料和水泥制备工艺的优化和Rietveld分析法的结合

水泥厂生产过程监控:熟料和水泥制备工艺的优化和Rietveld分析法...

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2005年水泥技术大会暨第七届全国水泥技术交流大会

作者： M.Paul D.Hornung M.Enders R.Schmidt Wilhelm Dyckerhoff Institut Wiesbaden Dr. DeunaZementgmbh Deuna Dr. PolysiusAG Beckum Dr. BrukerAXSgmbh Karlsruhe Germany

一段时间以来,水泥质量实验室一直在期待Rietveld法的应用。众所周知,Bogue算法只是熟料真实矿物相组成的粗略估算,新燃料在水泥厂的应用使熟料的矿物组成发生变化,并影响到最终产品的质量。Rietveld法对熟料矿物进行定量,而不是根据化...

一段时间以来,水泥质量实验室一直在期待Rietveld法的应用。众所周知,Bogue算法只是熟料真实矿物相组成的粗略估算,新燃料在水泥厂的应用使熟料的矿物组成发生变化,并影响到最终产品的质量。Rietveld法对熟料矿物进行定量,而不是根据化学分析对它们进行计算。在研究室里Rietveld法随着软件包、快速的x射线探测器和现代化计算机,以及独特的水泥厂样品制备工艺的不断完善而变得通用。在Deuna水泥厂安装了最先进的X射线硬件和软件(D4 Endeavor,Bruker AXS gmbh)和自动化制样系统(Polab-APM,Polysius AG)来监测熟料烧成和水泥粉磨过程。事实证明根据矿物组成而不是化学成分来优化水泥生产的Rietveld分析法是极有价值的工具。

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