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Acute.and chronic e.citotoxicity in ische.ic stroke.and late.onse. Alzhe.me.'s dise.se

Ne.ral Re.e.e.ation Re.e.rch 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu e.ily Choi michael QJiang Ling We. De.artme.t of Ane.the.iology Emory University School of MedicineAtlantaGAUSA center for Visual and Ne.rocognitive.Re.abilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke.and Alzhe.me.'s dise.se.are.common ne.rological disorde.s and ofte. occur in the.same.*** comorbidity of the.two ne.rological disorde.s re.re.e.ts a grave.he.lth thre.t to olde. *** re.ie. pre.e.ts a brie. background of the.de.e.opme.t of nove. conce.ts and the.r clinical *** activity of glutamate.gic N-me.hyl-D-aspartate.re.e.tors and N-me.hyl-D-aspartate.re.e.tor-me.iate. Ca^(2+)influx is critical for ne.ronal *** ische.ic insult induce. prompt and e.ce.sive.glutamate.re.e.se.and drastic incre.se. of intrace.lular Ca^(2+)mainly via N-me.hyl-D-aspartate.re.e.tors,particularly of those.at the.e.trasynaptic *** Ca^(2+)-e.oke. ne.ronal ce.l de.th in the.ische.ic core.is dominate. by ne.rosis within a fe. hours and days known as acute.***,mild but sustaine. Ca^(2+)incre.se. unde. ne.rode.e.e.ative.conditions such as in the.distant pe.umbra of the.ische.ic brain and e.rly stage. of Alzhe.me.'s dise.se.are.not imme.iate.y toxic,but gradually se. off de.e.iorating Ca^(2+)-de.e.de.t signals and ne.ronal ce.l loss mostly be.ause.of activation of programme. ce.l de.th *** on the.Ca^(2+)hypothe.is of Alzhe.me.'s dise.se.and re.e.t advance.,this Ca^(2+)-activate.“sile.t”de.e.e.ative.e.citotoxicity e.olve. from ye.rs to de.ade. and is re.ognize. as a unique.slow and chronic *** N-me.hyl-D-aspartate.re.e.tor subunit GluN3A,primarily at the.e.trasynaptic site.se.ve. as a gate.e.pe. for the.N-me.hyl-D-aspartate.re.e.tor activity and is ne.roprote.tive.against both acute.and chronic *** stroke.and Alzhe.me.'s dise.se.the.e.ore.share.an N-me.hyl-D-aspartate.re.e.tor-and Ca^(2+)-me.iate. me.hanism,although with much diffe.e.t time.*** is thus propose. that e.rly inte.ve.tions to control Ca^(2+)home.stasis at the.pre.linical stage.are.pivotal for individuals who are.susce.tible.to sporadic late.onse. Alzhe.me.'s dise.se.and Alzhe.me.'s dise.se.re.ate.

关键词： Ca^(2+)hypothe.is cognitive.de.icits hype.activity late.onse. Alzhe.me.'s dise.se ne.rode.e.e.ation N-me.hyl-D-aspartate.re.e.tors N-me.hyl-D-aspartate.re.e.tor subunits pathoge.e.is pre.e.tive.tre.tme.t

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Pancre.tic e.zyme.re.lace.e.t the.apy for pancre.tic e.ocrine.insufficie.cy in the.21^(st) ce.tury

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World Journal of Gastroe.te.ology 2014年第33期20卷 11467-11485页

作者： Tony Trang Johanna Chan David Y Graham De.artme.t of Me.icine Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine Houston TX 77030 United States

Re.titution of normal fat absorption in e.ocrine.pancre.tic insufficie.cy re.ains an e.usive.goal. Although many patie.ts achie.e.satisfactory clinical re.ults with e.zyme.the.apy, fe. e.pe.ie.ce.normalization of fat absorption, and many, if not most, will re.uire.individualize. the.apy. Incre.sing the.quantity of lipase.administe.e. rare.y e.iminate. ste.torrhe. but incre.se. the.cost of the.apy. e.te.ic coate. e.zyme.microbe.d formulations te.d to se.arate.from nutrie.ts in the.stomach pre.luding coordinate. e.ptying of e.zyme. and nutrie.ts. Unprote.te. e.zyme. mix we.l and e.pty with nutrie.ts but are.inactivate. at pH 4 or be.ow. We.de.cribe.approache. for improving the.re.ults of e.zyme.the.apy including changing to, or adding, a diffe.e.t product, adding non-e.te.ic coate. e.zyme.,(e.g., giving unprote.te. e.zyme. at the.start of the.me.land acid-prote.te. formulations late.), use.of antise.re.ory drugs and/or antacids, and changing the.timing of e.zyme.administration. Be.ause.conside.able.lipid is e.ptie. in the.first postprandial hour, it is prude.t to start the.apy with e.te.ic coate. microbe.d prior to the.me.l so that some.e.zyme. are.available.during that first hour. Patie.ts with hype.acidity may be.e.it from adjuvant antise.re.ory the.apy to re.uce.the.duode.al acid load and possibly also sodium bicarbonate.to pre.e.t duode.al acidity. Comparative.studie. of clinical e.fe.tive.e.s of diffe.e.t formulations as we.l as the.characte.istics of dispe.sion, e.ptying, and dissolution of e.te.ic-coate. microsphe.e. of diffe.e.t diame.e. and de.sity are.ne.de.; many such studie. have.be.n comple.e. but not ye. made.public. We.discuss the.history of pancre.tic e.zyme.the.apy and de.cribe.curre.t use.of mode.n pre.arations, approache. to ove.coming unsatisfactory clinical re.ponse., as we.l as studie. ne.de. to be.able.to provide.re.iably e.fe.tive.the.apy.

关键词： Pancre.tic insufficie.cy Pancre.tic e.zyme.re.lace.e.t the.apy Lipase Clinical trials Ste.tor-rhe. Fat malabsorption Chronic pancre.titis

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Approache. to improve.quality of care.in inflammatory bowe. dise.se.

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World Journal of Gastroe.te.ology 2014年第28期20卷 9281-9285页

作者： Raje.h Shah Jason K Hou De.artme.t of Me.icine Baylor College of Medicine Houston VA HSR&D center of e.ce.le.ce Michael E DeBakey Veterans Affairs Medical Center

Studie. across medical discipline. have.shown gaps in the.care.re.omme.de. in e.ide.ce.base. guide.ine. and the.care.actually de.ive.e.. Quality improve.e.t proje.ts using syste.atic audit and fe.dback inte.ve.tions such as quality me.sure., will be.ome.incre.singly important tools to addre.s the.e.gaps in care. The.e.gaps are.also appare.t in the.care.of patie.ts with inflammatory bowe. dise.se. Multiple.organizations, including the.Ame.ican Gastroe.te.ology Association and the.Crohn’s and Colitis Foundation of Ame.ica, have.de.e.ope. programs de.igne. to imple.e.t quality me.sure. to improve.the.care.of inflammatory bowe. dise.se.(IBD) patie.ts. e.rly re.ults show promise.of improving quality, but nume.ous barrie.s re.ain. Gastroe.te.ologists ne.d to be.aware.of the.e.proce.se. to provide.the.highe.t care.possible.to patie.ts with IBD. We.re.ie. the.e.isting lite.ature.on approache. to quality improve.e.t and the.r pote.tial application and barrie.s whe. applie. to IBD care.

关键词： Inflammatory bowe. dise.se Crohn's dise.se Ulce.ative.colitis Quality

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Role. of He.icobacte. pylori BabA in gastroduode.al pathoge.e.is

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World Journal of Gastroe.te.ology 2008年第27期14卷 4265-4272页

作者： Yoshio Yamaoka De.artme.t of Me.icine.Gastroe.te.ology Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine

Inte.actions be.we.n BabA and Le.is b (Le.) re.ate. antige.s are.the.be.t characte.ize. adhe.in-re.e.tor inte.actions in He.icobacte. pylori (H pylori). Se.e.al me.hanisms for the.re.ulation of BabA e.pre.sion are.pre.icte., including at both transcriptional and translational le.e.s. The.formation of chime.ic prote.ns (babA /B or babB /A chime.as) se.ms to play an e.pe.ially important role.in translational re.ulation. Chime.ic BabB/A prote.n had the.pote.tial to bind Le.; howe.e., prote.n production was subje.t to phase.variation through slippe. strand mispairing. The.babA ge.e.was clone. initially from strain CCUG17875, which contains a sile.t babA1 ge.e.and an e.pre.se. babA2 ge.e. The.se.ue.ce.of the.e.two ge.e. diffe.s only by the.pre.e.ce.of a 10 bp de.e.ion in the.signal pe.tide.se.ue.ce.of babA1 that e.iminate. its translational initiation codon. Howe.e., the.babA1 type.de.e.ion was found only in strain CCUG17875. A fe. studie. e.aluate. BabA status by immunoblot and confirme. that BabA-positive.status in We.te.n strains was close.y associate. with se.e.e.clinical outcome.. BabA-positive.status also was associate. with the.pre.e.ce.of othe. virule.ce.factors (e.g. cagA-positive.status and vacA s1 ge.otype.. A small class of strains produce. low le.e.s of the.BabA prote.n and lacke. Le. binding activity. The.e.we.e.more.like.y to be.associate. with incre.se. mucosal inflammation and se.e.e.clinical outcome. than BabA-positive.strains that e.hibite. Le. binding activity. The.unde.lying me.hanism is uncle.r, and furthe. studie. will be.ne.e.sary to inve.tigate.how the.comple. BabA-re.e.tor ne.work is functionally coordinate. during the.inte.action of H pylori with the.gastric mucosa.

关键词： He.icobacte. pylori BabA Pathoge.e.is Le.is antige.s

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Te.ofovir *** in re.ucing he.atoce.lular carcinoma risk in patie.ts with chronic HBV infe.tion?-Still an unsolve. que.tion

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He.atobiliary Surge.y and Nutrition 2021年第1期10卷 119-122页

作者： Hyun-Se.k Kim Hashe. B.e.-Se.ag Se.tion of Gastroe.te.ology and He.atology Baylor College of MedicineHoustonTXUSA U.S.michael e.debakey veterans affairs medical center HoustonTXUSA

Chronic he.atitis B virus(CHB)infe.tion affe.ts approximate.y 250 million pe.sons worldwide.1).CHB is a major risk factor for live. failure.cirrhosis,and he.atoce.lular carcinoma(HCC),accounting for 45-55%of HCC case.(1).The.incide.ce.rate. of HCC among CHB patie.ts are.0.02-0.2 pe. 100 pe.son-ye.rs in inactive.carrie.s,0.3-0.6 pe. 100 pe.son-ye.rs in those.without cirrhosis,and 2.2-3.7 pe. 100 pe.son-ye.rs for those.with compe.sate. cirrhosis(2).

关键词： patie.ts he.atoce.lular infe.tion

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Low-to-Mode.ate.Alcohol Consumption May Be.Safe.Whe. Taking Me.hotre.ate.for Rhe.matoid Arthritis or Psoriasis

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Ope. Journal of Rhe.matology and Autoimmune.Dise.se. 2012年第3期2卷 39-46页

作者： Be.nard S. Ng Houston veterans affairs HSR & D center of e.ce.le.ce Michael E DeBakey Veterans Affairs Medical Center Houston USA

It is uncle.r if consumption of small to mode.ate.amounts of alcohol is safe.while.taking me.hotre.ate. We.se. out to de.e.mine.whe.he. the.e.is an association be.we.n live. e.zyme.abnormalitie. and alcohol consumption in subje.ts taking me.hotre.ate. The.study sample.was ide.tifie. from the.database.of the.South Ce.tral Ve.e.an affairs He.lthcare.Ne.work, consisting of 10 hospitals in Te.as, Oklahoma, Mississippi and Louisiana. From a cohort of 2443 e.igible.veterans with rhe.matoid arthritis and/or psoriasis taking me.hotre.ate.from 10/1/2007 to 9/30/2009, 120 case. with abnormal live.-e.zyme.e.e.ation we.e.randomly se.e.te. to compare.with 120 controls. Data we.e.colle.te. from maile. surve. forms that inquire. about alcohol consumption habits, physicians’ advice.on alcohol, and me.hotre.ate.compliance. The.e.was no significant diffe.e.ce.in the.numbe. of non-drinke.s and low-to-mode.ate.alcohol drinke.s be.we.n case. and controls (p = 0.217). Fe. pe.sons ide.tifie. the.se.ve. as he.vy drinke.s. Our data sugge.t that it is like.y safe.for patie.ts with rhe.matoid arthritis and psoriasis to consume.low-to-mode.ate.amounts of alcohol while.taking me.hotre.ate. Howe.e., alte.native.me.hods to improve.capturing alcohol consumption in he.vy drinke.s are.ne.de. for more.compre.e.sive.re.ults.

关键词： Me.hotre.ate Alcohol Live. e.zyme. Rhe.matoid Arthritis Psoriasis

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History of He.icobacte. pylori,duode.al ulce.,gastric ulce. and gastric cance.

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World Journal of Gastroe.te.ology 2014年第18期20卷 5191-5204页

作者： David Y Graham michael e.debakey VA medical center Baylor College of MedicineHoustonTX 77030United States

He.icobacte. pylori (H. pylori) infe.tion unde.lie. gastric ulce. dise.se. gastric cance. and duode.al ulce. dise.se. The.dise.se.e.pre.sion re.le.ts the.patte.n and e.te.t of gastritis/gastric atrophy (i.e., duode.al ulce. with non-atrophic and gastric ulce. and gastric cance. with atrophic gastritis). Gastric and duode.al ulce.s and gastric cance. have.be.n known for thousands of ye.rs. Ulce.s are.ge.e.ally non-fatal and until the.20th ce.tury we.e.difficult to diagnose. Howe.e., the.pre.e.ce.and patte.n of gastritis in past civilizations can be.de.uce. base. on the.dise.se. pre.e.t. It has be.n sugge.te. that gastric ulce. and duode.al ulce. both arose.or be.ame.more.fre.ue.t in e.rope.in the.19th ce.tury. He.e. we.show that gastric cance. and gastric ulce. we.e.pre.e.t throughout the.17th to 19th ce.turie. consiste.t with atrophic gastritis be.ng the.pre.ominant patte.n, as it prove. to be.whe. it could be.e.amine. dire.tly in the.late.19th ce.tury. The.e.vironme.t be.ore.the.20th ce.tury favore. acquisition of H. pylori infe.tion and atrophic gastritis (e.g., poor sanitation and standards of living, se.sonal die.s poor in fre.h fruits and ve.e.able., e.pe.ially in winte., vitamin de.icie.cie., and fre.ue.t fe.rile.infe.tions in childhood). The.latte. part of the.19th ce.tury saw improve.e.ts in standards of living, sanitation, and die.s with a corre.ponding de.re.se.in rate.of de.e.opme.t of atrophic gastritis allowing duode.al ulce.s to be.ome.more.promine.t. In the.e.rly 20th ce.tury physician’s be.ie.e. the. could diagnose.ulce.s clinically and that the.diagnosis re.uire. hospitalization for “surgical dise.se.#x0201d; or for “Sippy” die.s. We.show that while.H. pylori re.aine. common and virule.t in e.rope.and the.Unite. State., e.vironme.tal change. re.ulte. in change. of the.patte.n of gastritis producing a change.in the.manife.tations of

关键词： He.icobacte. pylori Duode.al ulce. Gastric ulce. Gastric cance. medical history Ulce. surge.y e.ide.iology Gastritis Atrophic gastritis Antiquity

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Hybrid the.apy for He.icobacte. pylori infe.tion:A syste.ic re.ie. and me.a-analysis

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World Journal of Gastroe.te.ology 2015年第45期21卷 12954-12962页

作者： Ping-I Hsu Pe.-Chin Lin David Y Graham Division of Gastroe.te.ology Department of Internal Medicine Kaohsiung Veterans General Hospital and National Yang-Ming University De.artme.t of Pharmacy Kaohsiung Veterans General Hospital Colle.e.of Pharmacy Kaohsiung Medical University De.artme.t of Me.icine.Gastroe.te.ology Michael E. De Bakey Veterans Affairs Medical Center and Baylor College of Medicine Houston

AIM: To compare.the.e.fe.tive.e.s of hybrid the.apy with othe. re.omme.de. re.ime.s using ***: Bibliographical se.rche. for randomize. trials comparing hybrid and othe. the.apie. we.e.pe.forme. in Pubme., the.Cochrane.Library and re.e.ant congre.se. up to Fe.ruary 2015 using the.following ke.words(all fie.ds and/or me.SH):("He.icobacte. pylori " or "H. pylori") and("hybrid the.apy" or "se.ue.tial-concomitant the.apy"). me.aanalyse. we.e.pe.forme. with Cochrane.Re.ie. manage. 5.1. The.random e.fe.t mode. propose. by De. Simonian and Laird and the.mante.-Hae.sze. me.hod we.e.use. to e.timate.the.poole. re.ative.risk and 95%CI of the.e.ficacy outcome. be.we.n hybrid the.apy and othe. e.adication the.apie.. Re.ULTS: e.ght studie.(2516 subje.ts) me. e.try crite.ia. The.antimicrobial re.istance.in the.study groups range. from 6.9% to 23.5%. The.me.n cure.rate. of hybrid the.apy by inte.tion-to-tre.t(ITT) and pe.protocol analyse. we.e.88.5%(n = 1207; range. 80.0% to 97.4%) and 93.3%(n = 1109; range. 85.7% to99.1%), re.pe.tive.y. me.a-analysis showe. the.e.was no significant diffe.e.ce.in ITT e.adication rate.be.we.n hybrid and se.ue.tial the.apy(re.ative.risk: 1.01; 95%CI: 0.92-1.11). Subgroup analysis re.e.le. hybrid the.apy was more.e.fe.tive.than se.ue.tial the.apy in the.non-Italian populations(95%CI: 1.01-1.18) and was only le.s e.fe.tive.in one. Italian population(95%CI: 0.83-0.98). The.e.was no significant diffe.e.ce.in e.adication rate.be.we.n hybrid the.apy and concomitant the.apy(95%CI: 0.93-1.02). No he.d-tohe.d comparisons of hybrid the.apy and standard triple.the.apy or bismuth quadruple.the.apy we.e.found. Howe.e., a multicenter, randomize. trial showe. that re.e.se.hybrid the.apy was supe.ior to standard triple.the.apy(95.5% vs 88.6% ITT; P = 0.011).CONCLUSION: Hybrid the.apy appe.rs to be.an e.fe.tive. safe. and we.l-tole.ate. tre.tme.t for H. pylori infe.tion in the.e.a of incre.sing antibiotic re.istance.

关键词： He.icobacte. pylori Concomitant the.apy Hybrid the

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Unde.standing risk of thrombosis with thrombocytope.ia syndrome.afte. ***2.S vaccination

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Frontie.s of Me.icine 2021年第6期15卷 938-941页

作者： Prathit A.Kulkarni Vinay Prasad Infe.tious Dise.se. Se.tion Department of MedicineBaylor College of MedicineHoustonTX77030USA medical Care.Line Michael E.DeBakey Veterans Affairs Medical CenterHoustonTX77030USA De.artme.t of e.ide.iology and Biostatistics School of MedicineUniversity of California-San FranciscoSan FranciscoCA94143USA

On April 13,2021,the.US centers for Dise.se.Control and Pre.e.tion(CDC)and the.US Food and Drug Administration(FDA)re.omme.de. a pause.in administration of the.***2.S(Johnson&Johnson[Jansse.])coronavirus dise.se.2019(COVID-19)vaccine.for all pe.sons[1].At that time.approximate.y 6.8 million dose. of vaccine.had be.n administe.e. around the.Unite. *** pause.was prompte. by 6 case. of ce.e.ral ve.ous sinus thrombosis(CVST)in combination with thrombocytope.ia,a condition whose.nome.clature.is in flux but which we.will re.e. to as thrombosis with thrombocytope.ia syndrome.TTS),as use. by CDC in de.cribing the.condition[2].All patie.ts we.e.wome. younge. than 50 *** note.2 of 6 patie.ts also had splanchnic and portal ve.n thrombosis.

关键词： thrombosis vaccine dose.

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Ron re.e.tor-de.e.de.t ge.e.re.ulation of Kupffe. ce.ls during e.dotoxe.ia

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He.atobiliary & Pancre.tic Dise.se. Inte.national 2014年第3期13卷 281-292页

作者： Rishike.h M Kulkarni William D Stuart Susan e.Waltz De.artme.t of Cance. Biology University of Cincinnati De.artme.t of Re.e.rch Cincinnati Veterans Affairs Medical Center

BACKGROUND: Ron re.e.tor tyrosine.kinase.signaling in macrophage., including Kupffe. ce.ls and alve.lar macrophage.,suppre.se. e.dotoxin-induce. proinflammatory cytokine.che.okine.production. Furthe., we.have.also ide.tifie. ge.e. from Ron re.le.e.and Ron de.le.e.live.s that we.e.diffe.e.tially e.pre.se. during the.progre.sion of live. inflammation associate. with acute.live. failure.in mice.by microarray *** important ge.e. and signaling pathways have.be.n ide.tifie. downstre.m of Ron signaling during progre.sion of inflammation by this approach, the.pre.ise.role.that Ron re.e.tor plays in re.ulating the.transcriptional landscape.in macrophage., and particular in isolate. Kupffe. ce.ls, has still not be.n ***: Kupffe. ce.ls we.e.isolate. from wild-type.TK+/+)and Ron tyrosine.kinase.de.icie.t(TK-/-) mice. e. vivo, the.ce.ls we.e.tre.te. with lipopolysaccharide.LPS) in the.pre.e.ce.or abse.ce.of the.Ron ligand, he.atocyte.growth factor-like.prote.n(HGFL). Microarray and qRT-PCR analyse. we.e.utilize. to ide.tify alte.ations in ge.e.e.pre.sion be.we.n ***: Microarray analyse. ide.tifie. ge.e. e.pre.se. diffe.e.tially in TK+/+ and TK-/- Kupffe. ce.ls basally as we.l as afte. HGFL and LPS tre.tme.t. Inte.e.tingly, our studie. ide.tifie. Me.v, a ge.e.that code. for the.anti-inflammatory prote.n pyrin, as an HGFL-stimulate. Ron-de.e.de.t ***, lipocalin 2, a proinflammatory ge.e. which is induce. by LPS, was significantly suppre.se. by HGFL *** re.ults we.e.validate. by qRT-PCR studie. on Kupffe. ce.ls tre.te. with LPS and ***: The.studie. he.e.n sugge.t a nove. me.hanism whe.e.y HGFL-induce. Ron re.e.tor activation promote. the.e.pre.sion of anti-inflammatory ge.e. while.inhibiting ge.e. involve. in inflammation with a ne. e.fe.t of diminishe. inflammation in macrophage..

关键词： Mst1R Me.v Lcn2 Me. re.e.tor Kupffe. ce.ls macrophage.

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