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Celastrol activates caspase-3/GSDME-dependent pyroptosis in tumor cells by inducing endoplasmic reticulum stress Author links open overlay panel

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 330-339页

作者： Jiajian Guo Dongxiao Cui Yuping Tang Sanjiao Wang Cuiyan Ma Wenfu Ma School of Life Sciences Beijing University of Chinese MedicineBeijing 102488China Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi'an 712046China School of Literature and History Mianyang Teachers'CollegeMianyang 621000China

Objective To investigate the pyroptosis-inducing effects of celastrol on tumor cells and to explore the potential mechanisms involved,specifically focusing on the role of the caspase-3/gasdermin E(GSDME)signaling pathway and the impact of endoplasmic reticulum(ER)stress and *** Necrostatin-1(Nec-1),lactate dehydrogenase release(LDH)assay,and Hoechst/propidium iodide(PI)double staining were employed to validate the mode of cell *** blot was used to detect the cleavage of GSDME and the expression of light chain 3(LC3)and *** Celastrol induced cell swelling with large bubbles,which is consistent with the pyroptotic ***,treatment with celastrol induced GSDME cleavage,indicating the activation of GSDME-mediated *** knockout via CRISPR/Cas9 blocked the pyroptotic morphology of celastrol in HeLa *** addition,cleavage of GSDME was attenuated by a specific caspase-3 inhibitor in celastrol-treated cells,suggesting that GSDME activation was induced by ***,celastrol induced endoplasmic reticulum(ER)stress and autophagy in HeLa cells,and other ER stress inducers produced effects consistent with those of *** These findings suggest that celastrol triggers caspase-3/GSDME-dependent pyroptosis via activation of ER stress,which may shed light on the potential antitumor clinical applications of celastrol.

关键词： Celastrol Tumor cells Pyroptosis GSDME Caspase-3 Endoplasmic reticulum stress stress Cell death Traditional Chinese medicine

Anti-explosion performance and dynamic response of an innovative multi-layer composite explosion containment vessel

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Defence Technology（防务技术） 2024年第6期36卷 105-121页

作者： Zhen Wang Heng Chen Qi Yuan Wenbin Gu Xingbo Xie Hongwei Li college of Field Engineering Army Engineering University of PLANanjing 210007China college of Civil Engineering and Architecture Southwest University of Science and TechnologySichuanMianyang 621010China

An innovative multi-layer composite explosion containment vessel(CECV)utilizing a sliding steel platealuminum honeycomb-fiber cloth sandwich is put forward to improve the anti-explosion capacity of a conventional single-layer explosion containment vessel(SECV).Firstly,a series of experiments and finite element(FE)simulations of internal explosions are implemented to understand the basic anti-explosion characteristics of a SECV and the rationality of the computational models and methods is verified by the comparison between the experimental results and simulation *** on this,the CECV is designed in detail and a variety of FE simulations are carried out to investigate effects of the sandwich structure,the explosive quantity and the laying mode of the fiber cloth on anti-explosion performance and dynamic response of the CECV under internal *** results indicate that the end cover is the critical position for both the SECV and *** maximum pressure of the explosion shock wave and the maximum strain of the CECV can be extremely declined compared to those of the *** a result,the explosive quantity the CECV can sustain is up to 20 times of that the SECV can ***,as the explosive quantity increases,the internal pressure of the CECV keeps growing and the plastic deformation and failure of the sandwich structure become more and more severe,yielding plastic strain of the CECV in addition to elastic *** results also reveal that the laying angles of the fiber cloth's five layers have an impact on the anti-explosion performance of the *** example,the CECV with fiber cloth layered in 0°/45°/90°/45°/0°mode has the optimal anti-capacity,compared to 0°/0°/0°/0°/0°and 0°/30°/60°/30°/0°***,owing to remarkable anti-explosion capacity,this CECV can be regarded as a promising candidate for explosion resistance.

关键词： Explosive container Honeycomb-fiber cloth Anti-explosion Aluminum honeycomb core Composite

Design of integral sliding mode guidance law based on disturbance observer

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Journal of Systems Engineering and Electronics 2024年第1期35卷 186-194页

作者： ZHOU Jianping ZHANG Wenjie ZHOU Hang LI Qiang XIA Qunli School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China School of Informatic Engineering Mianyang Techers’CollegeMianyang 62100China Beijing Institute of Electronic System Engineering Beijing 100854China Beijing Institute of Space Long March Vehicle Beijing 100076China

With the increasing precision of guidance,the impact of autopilot dynamic characteristics and target maneuvering abilities on precision guidance is becoming more and more *** order to reduce or even eliminate the autopilot dynamic operation and the target maneuvering influence,this paper suggests a guidance system model involving a novel integral sliding mode guidance law(ISMGL).The method utilizes the dynamic characteristics and the impact angle,combined with a sliding mode surface scheme that includes the desired line-ofsight angle,line-of-sight angular rate,and second-order differential of the angular *** the same time,the evaluation scenario considere the target maneuvering in the system as the external disturbance,and the non-homogeneous disturbance observer estimate the target maneuvering as a compensation of the guidance *** proposed system’s stability is proven based on the Lyapunov stability *** simulations reveale that ISMGL effectively intercepted large maneuvering targets and present a smaller miss-distance compared with traditional linear sliding mode guidance laws and trajectory shaping guidance ***,ISMGL has a more accurate impact angle and fast convergence speed.

关键词： disturbance observer pilot dynamics integral sliding mode impact angle constraint maneuvering target

An effective bimetallic oxide catalyst of RuO_(2)-Co_(3)O_(4) for alkaline overall water splitting

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Nano Research 2024年第5期17卷 3785-3793页

作者： Fangfang Ren Jiayu Xu Ligang Feng college of Chemical and Environmental Engineering Yancheng Teachers UniversityYancheng 224007China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

The rational design of effective bifunctional electrocatalysts is of paramount importance for overall water-splitting technology in sustainable energy ***,bimetallic oxide catalysts(RuO_(2)-Co_(3)O_(4))derived from Ru combined MOF-derivatives(MOF=metal-organic framework)were demonstrated effective for overall water splitting in an alkaline solution,owing to the combined merits such as the two-dimensional interconnected network structure,the synergetic coupling effects and increased chemical *** as-prepared RuO_(2)-Co_(3)O_(4) only requires an overpotential of 260 mV for oxygen evolution and 75 mV for hydrogen evolution at 10 mA/cm^(2) in 1 M KOH solution;a low cell voltage of 1.54 V was required to reach the kinetic current density of 10 mA/cm^(2) for the water electrolysis when supporting on glass carbon electrode,and very good stability for 40 h was *** and theoretical results demonstrated the electronic structure optimization of bimetallic RuO_(2)-Co_(3)O_(4) compared to the individual metal oxide,which promoted interface charges redistribution and the d-band center downshift,resulting in increased activity and stability for water-splitting *** work provides a feasible approach for developing bimetallic oxides for application in energy-relevant electrocatalysis reactions.

关键词： ruthenium dioxide cobalt oxide metal-organic frameworks heterostructures overall water splitting

Virtual source approach for maximizing resolution in high-penetration gamma-ray imaging

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Matter and Radiation at Extremes 2024年第3期9卷 19-30页

作者： Yuchi Wu Shaoyi Wang Bin Zhu Yonghong Yan Minghai Yu Gang Li Xiaohui Zhang Yue Yang Fang Tan Feng Lu Bi Bi Xiaoqin Mao Zhonghai Wang Zongqing Zhao Jingqin Su Weimin Zhou Yuqiu Gu National Key Laboratory of Plasma Physics Laser Fusion Research CenterCAEPMianyangSichuan 621900China college of Physics Sichuan UniversityChengdu 610065China

High-energy gamma-ray radiography has exceptional penetration ability and has become an indispensable nondestructive testing(NDT)tool in various *** high-energy photons,point projection radiography is almost the only feasible imaging method,and its spatial resolution is primarily constrained by the size of the gamma-ray *** conventional industrial applications,gamma-ray sources are commonly based on electron beams driven by accelerators,utilizing the process of bremsstrahlung *** size of the gamma-ray source is dependent on the dimensional characteristics of the electron *** research has been conducted on various advanced accelerator technologies that have the potential to greatly improve spatial resolution in *** our investigation of laser-driven gamma-ray sources,a spatial resolution of about 90μm is achieved when the areal density of the penetrated object is 120 g/cm^(2).A virtual source approach is proposed to optimize the size of the gamma-ray source used for imaging,with the aim of maximizing spatial *** this virtual source approach,the gamma ray can be considered as being emitted from a virtual source within the convertor,where the equivalent gamma-ray source size in imaging is much smaller than the actual emission *** the basis of Monte Carlo simulations,we derive a set of evaluation formulas for virtual source scale and gamma-ray emission *** optimal conditions,the virtual source size can be as small as 15μm,which can significantly improve the spatial resolution of high-penetration imaging to less than 50μm.

关键词： resolution approach utilizing

Iterative Model Predictive Control for Automatic Carrier Landing of Carrier-Based Aircrafts Under Complex Surroundings and Constraints

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Journal of Shanghai Jiaotong university(Science) 2024年第4期29卷 712-724页

作者： ZHANG Xiaotian HE Defeng LIAO Fei college of Information Engineering Zhejiang University of TechnologyHangzhou310023China Aerospace Technology Institute China Aerodynamics Research and Development CenterMianyang621000SichuanChina

This paper considers the automatic carrier landing problem of carrier-based aircrafts subjected to constraints,deck motion,measurement noises,and unknown *** iterative model predictive control(MPC)strategy with constraints is proposed for automatic landing control of the ***,the long short-term memory(LSTM)neural network is used to calculate the adaptive reference trajectories of the *** the Sage-Husa adaptive Kalman filter and the disturbance observer are introduced to design the composite ***,an iterative optimization algorithm is presented to fast solve the receding horizon optimal control problem of MPC based on the Lagrange’s ***,some sufficient conditions are derived to guarantee the stability of the landing system in a closed loop with the ***,the simulation results of F/A-18A aircraft show that compared with the conventional MPC,the presented MPC strategy improves the computational efficiency by nearly 56%and satisfies the control performance requirements of carrier landing.

关键词： automatic carrier landing model predictive control(MPC) long short-term memory(LSTM)neural network stability computational efficiency

High-static-low-dynamic stiffness isolator based on an electromagnetic negative stiffness spring with long linear stroke

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Science China(Technological Sciences) 2024年第3期67卷 740-752页

作者： YUAN ShuJin WU YaJun SONG DaiPing PU HuaYan MOU LiSheng HOU Lei ZHAO JingLei LI XuePing LUO Jun WU Jie HUANG XiaoXu State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China China Aerodynamics Research and Development Center Mianyang 621000China college of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Negative stiffness mechanisms can improve low-frequency vibration isolation performance and have been widely used in the vibration isolation of precision equipment. However, the negative stiffness mechanism usually introduces a nonlinear stiffness,resulting in a nonlinear response and worsening the vibration isolation performance, especially under large amplitude *** this paper, an electromagnetic spring with linear negative stiffness(ESLNS) is proposed, in which the antagonistic ampere forces of the energized coils are used to generate negative stiffness within a long linear stroke. The magnetic field distribution is improved through the design of the magnetic circuit, thereby increasing the stiffness generation efficiency. The stiffness can be adjusted bidirectionally by current within the range of positive and negative stiffness. An electromagnetic stiffness model was established based on the equivalent magnetic circuit method. Experimental measurements verified the accuracy of the model and proved the linearity of the electromagnetic spring. A vibration isolator with high static and low dynamic stiffness(HSLDS) based on the ESLNS is designed and tested. The experimental results prove that the introduction of the ESLNS can effectively expand the isolation frequency band without changing the equilibrium position. Moreover, the vibration isolator with ESLNS does not produce nonlinear response. The proposed electromagnetic spring with linear negative stiffness extends the application range of HSLDS isolators to a large amplitude vibration environment.

关键词： linear negative stiffness mechanism low-frequency vibration isolation electromagnetic spring vibration control

Bionic Design and Experimental Validation of a Robotic Airship Inspired by the Physalia physalis

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Journal of Bionic Engineering 2024年第2期21卷 740-753页

作者： Yueneng Yang Lili Chen Zhiyang Liu Shifeng Zhang college of Aerospace Science and Engineering National University of Defense TechnologyNo.109Deya RoadKaiFu DistrictChangsha410073China Aerospace Technology Institute China Aerodynamics Research and Development CenterMianyang621000China

The robotic airship is one of the most unique and promising green aircraft,however,as a“lighter-than-air aircraft”and“thermal aircraft”,its long-endurance flight has great difficulties in decreasing drag and controlling buoyancy and pressure under thermal *** this work,we reported a robotic airship inspired by the Physalia physalis,imitating its morphology,physiological structure,and biological *** hull is designed by imitating the morphology of the Physalia physalis,and the gasbags including a helium balloon,two ballonets,and a thermoregulation gasbag are designed by imitating the physiological structure and biological behaviors of the pneumatophore,bladder,and gland of the Physalia physalis,*** results show that the bionic airship has an increase of about 40%in lift-to-drag and decreases the pressure in helium balloon by 47.5%under thermal effects,and has better aerodynamic performances and thermoregulation performances than conventional airships.

关键词： Robotic airship Bionic design Aerodynamic performances Thermoregulation Physalia physalis

First-principles study of structural and electronic properties of multiferroic oxide Mn_(3)TeO_(6) under high pressure

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Chinese Physics B 2024年第7期33卷 448-454页

作者：潘小龙王豪柳雷陈向荣耿华运 college of Physics Sichuan UniversityChengdu 610065China National Key Laboratory of Shock Wave and Detonation Physics Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China HEDPS Center for Applied Physics and Technologyand College of EngineeringPeking UniversityBeijing 100871China

Mn_(3)TeO_(6)(MTO) has been experimentally found to adopt a P2_(1)/In structure under high pressure,which exhibits a significantly smaller band gap compared to the atmospheric R3 *** this study,we systematically investigate the magnetism,structural phase transition,and electronic properties of MTO under high pressure through first-principles *** R3 and P2_(1)/n phases of MTO are antiferromagnetic at zero *** R3 phase transforms to the P2_(1)/n phase at 7.5 8 GPa,accompanied by a considerable volume collapse of about 6.47%.Employing the accurate method that combines DFT+U/and GW,the calculated band gap of R3 phase at zero pressure is very close to the experimental values,while that of the P2_(1)/n phase is significantly *** main reason for this difference is that the experimental study incorrectly used the Kubelka-Munk plot for the indirect band gap to obtain the band gap of the P2_(1)/n phase instead of the Kubelka-Munk plot for the direct band ***,our study reveals that the transition from the R3 phase to the P2_(1)/n phase is accompanied by a slight reduction in the band gap.

关键词： magnetism phase transition band gap high pressure