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health behavior outcomes in stroke survivors prescribed wearables for atrial fibrillation detection stratified by age

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Journal of Geriatric Cardiology 2024年第3期21卷 323-330页

作者： Joanne Mathew Jordy Mehawej Ziyue Wang Taylor Orwig Eric Ding Andreas Filippaios Syed Naeem Edith Mensah Otabil Alex Hamel Kamran Noorishirazi IrinaRadu Jane Saczynski David D.McManus Khanh-Van Tran Division of Cardiovascular Medicine Department of MedicineUniversity of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA Department of Internal Medicine Central Michigan UniversityMount PleasantUSA Department of Pharmacy and health Systems Sciences School of PharmacyNortheastern UniversityBostonUSA Department of Population and Quantitative health Sciences University of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA

BACKGROUND Smartwatches have become readily accessible tools for detecting atrial fibrillation(AF).There remains limited data on how they affect psychosocial outcomes and engagement in older *** examine the health behavior outcomes of stroke survivors prescribed smartwatches for AF detection stratified by *** We analyzed data from the Pulsewatch study,a randomized controlled trial that enrolled patients(≥50 years)with a history of stroke or transient ischemic attack and CHA2DS2-VASc≥*** participants were equipped with a cardiac patch monitor and a smartwatch-app dyad,while control participants wore the cardiac patch monitor for up to 44 *** evaluated health behavior parameters using standardized tools,including the Consumer health Activation Index,the Generalized Anxiety Disorder questionnaire,the 12-Item Short Form health Survey,and wear time of participants categorized into three age groups:Group 1(ages 50-60),Group 2(ages 61-69),and Group 3(ages 70-87).We performed statistical analysis using a mixedeffects repeated measures linear regression model to examine differences amongst age *** Comparative analysis between Groups 1,2 and 3 revealed no significant differences in anxiety,patient activation,perception of physical health and wear *** use of smartwatch technology was associated with a decrease in perception of mental health for Group 2 compared to Group 1(β=-3.29,P=0.046).CONCLUSION Stroke survivors demonstrated a willingness to use smartwatches for AF ***,among these study participants,the majority did not experience negative health behavior outcomes or decreased engagement as age increased.

关键词： prescribed stratified wear

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Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory

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Neural Regeneration Research 2024年第5期19卷 1133-1141页

作者： Baicheng Zhao Hang Zhang Ying Liu Gaoyu Zu Yuxiao Zhang Jiayi Hu Shuai Liu Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghaiChina Shanghai Key Laboratory of Brain Functional Genomics(Ministry of Education) Affiliated Mental Health Center(ECNU)School of Psychology and Cognitive ScienceEast China Normal UniversityShanghaiChina Shanghai Changning mental health Center ShanghaiChina NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai ShanghaiChina Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai ShanghaiChina

Bromodomain and plant homeodomain(PHD)finger containing protein 1(Brpf1)is an activator and scaffold protein of a multiunit complex that includes other components involving lysine acetyltransferase(KAT)6A/6B/***1,KAT6A,and KAT6B mutations were identified as the causal genes of neurodevelopmental disorders leading to intellectual *** previous work revealed strong and specific expression of Brpf1 in both the postnatal and adult forebrain,especially the hippocampus,which has essential roles in learning and ***,we hypothesized that Brpf1 plays critical roles in the function of forebrain excitatory neurons,and that its deficiency leads to learning and memory *** test this,we knocked out Brpf1 in forebrain excitatory neurons using *** found that Brpf1 deficiency reduced the frequency of miniature excitatory postsynaptic currents and downregulated the expression of genes Pcdhgb1,Slc16a7,Robo3,and Rho,which are related to neural development,synapse function,and memory,thereby damaging spatial and fear memory in *** findings help explain the mechanisms of intellectual impairment in patients with BRPF1 mutation.

关键词： behavioral test Brpf1 CAMKIIa-Cre intellectual disability miniature excitatory postsynaptic current mRNA-Seq

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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Understanding and addressing the challenges of online gambling addiction in China's Mainland

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General Psychiatry 2024年第2期37卷 315-318页

作者： Gangliang Zhong Jiang Du Min Zhao Shanghai mental health Center Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghaiChina CAS Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of SciencesShanghaiChina

Introduction Gambling in China has a long and evolving history,from ancient court cockfighting to preliberation casinos with games like baccarat.1 Over time,gambling in China has evolved to include a wide range of activities,including gaming machines,online gambling and commercial *** being declared illegal and regulated after the establishment of the People’s Republic of China,gambling remains deeply ingrained in Chinese culture.

关键词： mainland fighting spite

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The Influence of Vulnerable Narcissism on Social Anxiety among Adolescents:The Mediating Role of Self-Concept Clarity and Self-Esteem

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International Journal of mental health Promotion 2024年第6期26卷 429-438页

作者： Yuetan Wang Xianle Yan Lili Liu Xiran Lu Lan Luo Xiaobin Ding Key Laboratory of Behavioral and mental health of Gansu Province Northwest Normal UniversityLanzhou730070China School of Psychology Northwest Normal UniversityLanzhou730070China

Social anxiety (SA) is a prevalent mental health issue among adolescents, and vulnerable narcissism (VN) can exacerbate thiscondition. This study aims to investigate the impact of vulnerable narcissism on social anxiety in adolescents, specificallyfocusing on the mediating effects of self-concept clarity (SCC) and self-esteem (SE) in the relationship between vulnerablenarcissism and social anxiety. Through cluster sampling, a questionnaire survey was conducted among 982 students from threesecondary schools in two provinces. The data was analyzed using structural equation modeling (SEM). The results revealedthat there was a significant negative correlation between vulnerable narcissism and both self-concept clarity and self-esteem,while there was a significant positive correlation between vulnerable narcissism and social anxiety. Additionally, self-conceptclarity showed a significant positive correlation with self-esteem but had a negative correlation with social anxiety. Both selfconceptclarity and self-esteem played an intermediary role in the chain linking vulnerable narcissism to social anxiety. Thisstudy confirms the mediating role of both self-concept clarity and self-esteem in explaining how vulnerable narcissisminfluences social anxiety, providing valuable insights into its underlying mechanism.

关键词： Social anxiety vulnerable narcissism self-concept clarity self-esteem adolescent

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Improving treatment plan and mental health in children with abdominal infection for broad-spectrum bacterial infections

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World Journal of Psychiatry 2024年第9期14卷 1319-1325页

作者： Gui-Bo Wang Xue-Feng Zhang Bing Liang Jie Lei Jun Xue Department of Pediatric Surgery the First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Department of General Surgery the First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Pediatric abdominal infection is a common but serious disease that requires timely and effective *** surgical treatment,accurate diagnosis and rational application of antibiotics are the keys to improving treatment *** To investigate the effect of broad-spectrum bacterial detection on postoperative antibiotic *** A total of 100 children with abdominal infection who received surgical treatment in our hospital from September 2020 to July 2021 were *** observation group collected blood samples upon admission and sent them for broad-spectrum bacterial infection nucleic acid testing,and collected pus or exudate during the operation for bacterial culture and drug sensitivity testing;the control group only sent bacterial culture and drug sensitivity testing during the *** White blood cell count,C-reactive protein,procalcitonin,3 days after surgery,showed better postoperative index than the control group(P<0.05).The hospital stay in the observation group was significantly shorter than that in the control *** hospitalization cost in the observation group was significantly lower than that in the control group,and the difference between the two groups was statistically significant(P<0.05).CONCLUSION Early detection of broad-spectrum bacterial infection nucleic acids in pediatric abdominal infections can help identify pathogens sooner and guide the appropriate use of antibiotics,improving treatment outcomes and reducing medical costs to some extent.

关键词： Pediatric abdominal infection Nucleic acid detection of broad-spectrum bacterial infection Bacterial culture Drug sensitivity testing Treatment effect Cost mental health

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mental health in the virtual world:Challenges and opportunities in the metaverse era

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World Journal of Clinical Cases 2024年第17期12卷 2939-2945页

作者： Yolanda López del Hoyo Matilde Elices Javier Garcia-Campayo Department of Psychology and Sociology University of ZaragozaZaragoza 50009Spain mental health Research Group Hospital del Mar Medical Research InstituteBarcelona 08003Spain Department of Psychiatry Miguel Servet HospitalAragon Institute for Health ResearchUniversity of ZaragozaZaragoza 50009Spain

Current rates of mental illness are *** illness mainly affects females and younger age *** use of the internet to deliver mental health care has been growing since 2020 and includes the implementation of novel mental health treatments using virtual reality,augmented reality,and artificial intelligence.A new three dimensional digital environment,known as the metaverse,has emerged as the next version of the *** intelligence,augmented reality,and virtual reality will create fully immersive,experiential,and interactive online environments in the *** will use a unique avatar to do anything they do in their“real”lives,including seeking and receiving mental health *** this opinion review,we reflect on how the metaverse could reshape how we deliver mental health treatment,its opportunities,and its challenges.

关键词： Metaverse Virtual world Artificial intelligence mental health Virtual reality Augmented reality Technology

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Keep in mind sex differences when prescribing psychotropic drugs

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World Journal of Psychiatry 2024年第2期14卷 194-198页

作者： Marianna Mazza Domenico De Berardis Giuseppe Marano Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy mental health NHSASL 4 TeramoTeramo 64100Italy

Women represent the majority of patients with psychiatric diagnoses and also the largest users of psychotropic *** are inevitable differences in efficacy,side effects and long-term treatment response between men and *** research needs to develop adequately powered animal and human trials aimed to consider pharmacokinetics and pharmacodynamics of central nervous system drugs in both male and female *** professionals have the responsibility to prescribe sex-specific psychopharmacotherapies with a priority to differentiate between men and women in order to minimize adverse drugs reactions,to maximize therapeutic effectiveness and to provide personalized management of care.

关键词： Women Psychopharmacology Psychotropic drugs Sex differences

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Human lineage mutations regulate RNA-protein binding of conserved genes NTRK2 and ITPR1 involved in human evolution

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General Psychiatry 2024年第3期37卷 375-387页

作者： Wenxiang Cai Weichen Song Shunying Yu Min Zhao Guan Ning Lin Shanghai mental health Center Shanghai Jiao Tong University School of MedicineSchool of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina

Background The role of human lineage mutations(HLMs)in human evolution through post-transcriptional modification is *** To investigate the contribution of HLMs to human evolution through post-transcriptional *** We applied a deep learning model Seqweaver to predict how HLMs impact RNA-binding protein *** We found that only 0.27%of HLMs had significant impacts on RNA-binding proteins at the threshold of the top 1%of human common *** HLMs enriched in a set of conserved genes highly expressed in adult excitatory neurons and prenatal Purkinje neurons,and were involved in synapse organisation and the GTPase *** genes also carried excess damaging coding mutations that caused neurodevelopmental disorders,ataxia and *** these genes,NTRK2 and ITPR1 had the most aggregated evidence of functional importance,suggesting their essential roles in cognition and *** Our findings suggest that a small subset of human-specific mutations have contributed to human speciation through impacts on post-transcriptional modification of critical brain-related genes.

关键词： evolution conserved Human

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Systemic low-grade inflammation associated with specific depressive symptoms:insights from network analyses of five independent NHANES samples

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General Psychiatry 2024年第2期37卷 284-288页

作者： Jingyu Lin Haiming Huang Tianmei Si Lin Chen Jingxu Chen Yun-Ai Su Beijing Huilongguan Hospital BeijingChina Department of Clinical Laboratory Peking University First HospitalBeijingChina Neuropsychopharmacology Peking University Institute of Mental HealthBeijingChina National Clinical Research Center for mental Disorders BeijingChina

To the editor:Major depressive disorder(MDD)is a heterogeneous disorder with varying symptom presentations and underlying biological mechanisms.1 The mainstream neurobiological hypotheses of depression involve monoami... 详细信息

关键词： inflammation depress pituitary

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