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Factors Affecting Catecholamines in Caregivers of Patients with Dementia

Journal of Geriatric Medicine 2021年第1期3卷 32-37页

作者： Akemi Hirano Yusuke Suzuki Toshio Hayashi Koichiro Ina Joji Onishi Department of Adult Nursing Shubun University6 Nikko-choIchinomiyaAichi 491-0938Japan Centre for Community Liaison and Patient Consultations Nagoya University Hospital65 TsurumaShowaNagoyaAichi 466-8550Japan Department of Community and In-Home Nursing Nagoya University Graduate School of MedicineSchool of Health SciencesDaiko-MinamiHigashi-kuNagoyaAichi 461-8673Japan Department of Internal Medicine Ina Clinic3-111 HirabariTenpakuNagoyaAichi 468-0011Japan Department of Community healthcare&Geriatrics Nagoya University Graduate School of Medicine65 TsurumaShowaNagoyaAichi 466-8550Japan

Background:Caregivers of dementia patients have significantly higher levels of serum IL-6 and CRP compared to non-caregivers,and the accumulation of everyday stressors reportedly promotes the induction of inflammatory ***,few studies have identified factors that affect catecholamine levels in caregivers who experience a combination of physical and mental stress from ***:This study aimed to identify physical factors that impact catecholamine levels in caregivers of dementia ***:Participants were elderly caregivers living together with elderly Alzheimer’s-type dementia *** performed logistic regression analysis,with levels of adrenaline,noradrenaline,and dopamine(indicators of catecholamine)as dependent ***:Caregiver BMI had a significant impact on adrenaline levels(OR:0.792;95%CI:0.654-0.960)and noradrenaline levels(OR:1.210;95%CI:1.009-1.451),whereas age had a significant impact on dopamine levels(OR:1.162;95%CI:1.019-1.324).Discussion:While caregiver BMI significantly impacted adrenaline and noradrenaline levels,the mechanism underlying these relationships is *** possibility is that obesity(BMI)and a rise in sympathetic nerve activity contributed to *** findings suggest that chronic stress in elderly caregivers may potentially impair the dopaminergic activation system in the ***:There is a need to identify factors which increase BMI in *** studies aimed at gaining a better understanding of the lifestyle habits of caregivers and intervention studies aimed at reducing their BMI are warranted.

关键词： Age BMI Caregiver burden Catecholamine Dementia

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