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Cognitive dysfunction in schizophrenia patients caused by downregulation of γ-aminobutyric acid receptor subunits

World Journal of Psychiatry 2024年第6期14卷 784-793页

作者： Xi Chen Ya-Nan Zhou Xiao-Zi Lu Ren-Jiao Li Yi-Fan Xiong Xia Sheng Wei-Wei Zhu Department of Child and Adolescent Psychiatric Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Psychiatry Qingdao Mental Health CenterQingdao 266034Shandong ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Sleep Disorders and Neurosis Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina

BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotion,and *** To explore GABA receptor expression and its relationship with schizophrenia and to provide insights into more effective *** This case-control study enrolled 126 patients with schizophrenia treated at our hospital and 126 healthy volunteers who underwent physical examinations at our hospital during the same *** expression levels of the GABA receptor subunits were detected using 1H-magnetic resonance *** recognized cognitive battery tool,the MATRICS Consensus Cognitive Battery,was used to evaluate the scores for various dimensions of cognitive *** correlation between GABA receptor subunit downregulation and schizophrenia was also *** Significant differences in GABA receptor subunit levels were found between the case and control groups(P0.05).CONCLUSION Downregulation of the GABA receptor subunits is positively correlated with *** other words,when GABA receptor subunits are downregulated in patients,cognitive impairment becomes more severe.

关键词： Cognitive function Schizophrenia Downregulation Gamma-aminobutyric acid receptor subunits Correlation

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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied healthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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Impact of adverse childhood experiences on the symptom severity of different mental disorders: a cross-diagnostic study

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General Psychiatry 2022年第2期35卷 127-136页

作者： Wenjie Gu Qing Zhao Chengmei Yuan Zhenghui Yi Min Zhao Zhen Wang Shanghai mental health Center Shanghai Jiao Tong University School of MedicineShanghai China

Background Adverse childhood experiences have a significant impact on different mental *** To compare differences in adverse childhood experiences among those with different mental disorders and their relationships in a cross-disorder *** The study included 1513 individuals aged≥18 years:339 patients with substance use disorders,125 patients with schizophrenia,342 patients with depression,136 patients with bipolar disorder,431 patients with obsessive-compulsive disorder(OCD),and 140 healthy *** Early Trauma Inventory Self Report-Short Form was used to investigate childhood traumatic experiences,and the Addiction Severity Index,Positive and Negative Syndrome Scale,Hamilton Depression Scale,Young Mania Rating Scale,and Yale-Brown Obsessive-Compulsive Scale were used to assess mental disorder *** and multivariate logistic regression were analysed between adverse childhood experiences and clinical *** Levels of adverse childhood experiences were significantly different among different mental ***,25.8%of patients with substance use disorders reported childhood trauma,which was significantly higher than found in the other four psychiatric disorder *** abuse scores were positively correlated with disease severity:the higher the total trauma score,the more severe the mental *** Adverse childhood experiences are a common phenomenon in those with mental disorders,and the level of trauma affects mental disorder *** abuse is closely related to many mental *** incidence or severity of mental disorders can be reduced in the future by reducing the incidence of adverse childhood experiences or by timely intervention in childhood trauma.

关键词： severity disorders childhood

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Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair Ahmed WMatthijs Blankesteijn Sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-School for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for mental health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

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Estimated prevalence and sociodemographic correlates of mental disorders in medical students of Hebei Province,China:A crosssectional study

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World Journal of Psychiatry 2023年第5期13卷 215-225页

作者： Wen-Ting Lu Pei-Hua Hu Na Li Lan Wang Ran Wang Zeng Wang Mei Song Tian-Yu Zhao Shi-Jie Guo Fan-Fan Huang Bu-Fan Liu Ruo-Jia Ren Li Yang Quan Lin Yue-Hang Xu Na Jin Huan Chen Yuan-Yuan Gao Zhi-Feng Wu Guang-Yu Shi Da-Peng Liu Zhong-Qi Pan Chun-Chao Du Cui-Xia An Xue-Yi Wang mental health Center Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Hebei Technical Innovation Center Mental Health Assessment and InterventionShijiazhuang 050031Hebei ProvinceChina Hebei Clinical Research Center of mental Disorders Institute of Mental HealthShijiazhuang 050031Hebei ProvinceChina Counseling and mental health Research Center Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Hebei Saitron Information Technology Co. LtdCangzhou 060000Hebei ProvinceChina

BACKGROUND In China,the identification rate and treatment rate of mental disorders are low,and there are few surveys on the prevalence of mental disorders among college students using diagnostic tools such as Mini-International Neuropsychiatric Interview(MINI),so the prevalence and treatment of mental disorders among college students are *** To estimate prevalence of mental disorders among medical students in Hebei Province,and provide guidance for improving their mental *** This was a cross-sectional study based on an Internet-based *** levels of medical students in Hebei Province were randomly selected(by cluster sampling)for *** the information network assessment system,the subjects scanned the 2D code with their mobile phones,clicked to sign the informed consent,and answered a scale.A self-designed general status questionnaire was used to collect information about age,gender,ethnicity,grade,and origin of *** MINI *** used to investigate mental *** analysis was performed with SPSS *** significant findings were determined using a two-tailed P value of *** A total of 7117 subjects completed the survey between October 11 and November 7,*** estimated prevalence of any mental disorders within 12 mo was 7.4%.Mood disorders were the most common category(4.3%),followed by anxiety disorders(3.9%);15.0%had been to psychological counseling,while only 5.7%had been to a psychiatric consultation,and only 10%had received drug therapy in the past 12 *** Although the estimated prevalence of mental disorders in medical students is lower than in the general population,the rate of adequate treatment is *** determined that improving the mental health of medical students is an urgent matter.

关键词： Hebei sectional college

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Psychological Consequences of a Mass Attack Following Multiple Gunshots and Explosions among Victims in a State in Southwest Nigeria

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Open Journal of Epidemiology 2024年第1期14卷 90-109页

作者： Adewale Moses Adejugbagbe Dele David Omoniyi Akinola Ayoola Fatiregun Modupeola Oluwakemi Dosumu Ngozi Onyejiaka Banji Awolowo Ajaka Stephen Fagbemi World health Organization Nigeria Ondo State Ministry of health Akure Nigeria

Introduction: On the 5th of June 2022, an incident of a mass attack following multiple gunshots and explosions occurred in a community in Ondo State Nigeria. This study aims to assess the mental health status of victims of the mass attack to guide further interventions among them. Methods: A cross-sectional study was conducted among victims of a mass attack in Owo community, Ondo State. A total of 209 affected victims were interviewed on socio-demographic characteristics, symptoms of anxiety (AD) and post-traumatic stress disorder (PTSD), threat experienced, and mental health support received. A 7-item Generalized Anxiety Disorder (GAD-7) and 9-item Post Traumatic Stress Disorder (PTSD) scale were used to assess the mental health status of the victims. A point was assigned to respondents who reported the symptoms of GAD, with a maximum score of 7 attained. For GAD, scores were categorized as follows: 1 - 2 as mild, 2 - 3 as minimal, 4 - 5 as moderate and 6 - 7 as severe. The PTSD symptoms were rated using a 5-point Likert scale response, and assigned the following points;4 = extremely, 3 = quite a bit, 2 = moderate, 1 = a little bit and 0 = not at all. From a maximum score of 36, participants with scores 18 and above were categorized as those with provisional PTSD. The independent samples t-test and correlational analysis were used to determine the association between PTSD score and other independent variables, with an alpha level of significance set at 0.05. Results: Generally, 38 (18.2%) of the respondents had severe AD. About half (89;42.6%) were categorized as those with provisional PTSD. The mean level of both AD (3.40 ± 2.26) and PTSD (16.51 ± 7.63) score is higher among those who were married compared to those not married (anxiety disorder;2.52 ± 2.20, P = 0.005 and PTSD;13.20 ± 8.86, P = 0.004). Respondents who have been counseled by a healthcare worker had a higher mean level (15.89 ± 7.58) of provisional PTSD compared to those not counseled by a

关键词： Mass Attack Mass Casualty Anxiety Disorder Posttraumatic Stress Disorder

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The Risk Role of Defeat on the mental health of College Students:A Moderated Mediation Effect of Academic Stress and Interpersonal Relationships

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International Journal of mental health Promotion 2024年第9期26卷 731-744页

作者： Ruiyang Han Tingting Xu Yin Shi Wuyi Liu School of Public health Shandong Second Medical UniversityWeifang261053China Faculty of Education Beijing Normal UniversityBeijing100875China School of Clinical Medicine Shandong Second Medical UniversityWeifang261053China

Background:College students face significant academic and physiological changes,making them more susceptible to psychological issues such as depression,self-injury,and suicidal *** of defeat can exacerbate these risks by increasing academic ***,interpersonal relationships can moderate the impact of academic stress on students’mental *** the presage–process–product model,this study aims to empirically investigate how feelings of defeat influence depression,self-injury,and suicidal ideation among college ***,it explores the mediating role of academic stress and the moderating role of various types of interpersonal ***:A total of 1612 college students(750 females,862 males,mean age=19.64±0.62 years)were recruited through cluster *** were collected via offline questionnaires administered by a trained psychology teacher and a postgraduate student,ensuring high reliability with two examiners per *** profile analysis(LPA)was used to examine the impact of defeat on mental health outcomes,while mediation analysis was conducted to assess the roles of academic stress and interpersonal ***:*** is identified as a significant risk factor for mental health issues among college students;*** distinct patterns of interpersonal relationships were identified:the interpersonal-relationship risk group,the father–child-relationship high-risk group,the general interpersonal-relationship group,and the superior interpersonal-relationship group;*** stress partially mediates the relationship between defeat and mental health issues such as depression,self-injury,and suicidal ideation;*** interpersonal relationship models moderate the impact of academic stress on depression and suicidal ***:Defeat is a significant risk factor for mental health problems in college *** stress partially mediates the negative impact of defeat on mental he

关键词： Student mental health defeat academic stress interpersonal relationships mediation test

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Cath-KP,a novel peptide derived from frog skin,prevents oxidative stress damage in a Parkinson’s disease model

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Zoological Research 2024年第1期45卷 108-124页

作者： Huanpeng Lu Jinwei Chai Zijian Xu Jiena Wu Songzhe He Hang Liao Peng Huang Xiaowen Huang Xi Chen Haishan Jiang Shaogang Qu Xueqing Xu Department of Neurology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence GuangzhouGuangdong 510515China Key Laboratory of mental health of the Ministry of Education Southern Medical UniversityGuangzhouGuangdong 510515China Department of Dermatology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Neurology Ganzhou Hospital-Nanfang HospitalSouthern Medical UniversityGanzhouJiangxi 341001China

Parkinson’s disease(PD)is a neurodegenerative condition that results in dyskinesia,with oxidative stress playing a pivotal role in its *** peptides may thus present therapeutic potential for *** this study,a novel cathelicidin peptide(Cath-KP;GCSGRFCNLF NNRRPGRLTLIHRPGGDKRTSTGLIYV)was identified from the skin of the Asiatic painted frog(Kaloula pulchra).Structural analysis using circular dichroism and homology modeling revealed a uniqueαββconformation for *** vitro experiments,including free radical scavenging and ferric-reducing antioxidant analyses,confirmed its antioxidant *** the 1-methyl-4-phenylpyridinium ion(MPP^(+))-induced dopamine cell line and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced PD mice,Cath-KP was found to penetrate cells and reach deep brain tissues,resulting in improved MPP^(+)-induced cell viability and reduced oxidative stress-induced damage by promoting antioxidant enzyme expression and alleviating mitochondrial and intracellular reactive oxygen species accumulation through Sirtuin-1(Sirt1)/Nuclear factor erythroid 2-related factor 2(Nrf2)pathway *** focal adhesion kinase(FAK)and p38 were also identified as regulatory *** the MPTP-induced PD mice,Cath-KP administration increased the number of tyrosine hydroxylase(TH)-positive neurons,restored TH content,and ameliorated *** the best of our knowledge,this study is the first to report on a cathelicidin peptide demonstrating potent antioxidant and neuroprotective properties in a PD model by targeting oxidative *** findings expand the known functions of cathelicidins,and hold promise for the development of therapeutic agents for PD.

关键词： Cath-KP Peptide Parkinson’s disease Oxidative stress Neuroprotection

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Special Topic on mental health and Addiction

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Neuroscience Bulletin 2016年第6期32卷 509-511页

作者： Lin Lu Wenhua Zhou Institute of mental health National Clinical Research Center for Mental DisordersKey Laboratory of Mental Health and Sixth Affiliated Hospital of Peking University Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research Peking University Laboratory of Behavioral Neuroscience Ningbo Addiction Research and Treatment CenterMedical School of Ningbo University

We are delighted to have been invited to edit this Special Topic on mental health and Addiction. mental disorders like drug addiction, mood disorders, and schizophrenia affect a sizeable proportion of the human population, severely compromise the quality of life, and constitute a large global burden of disease. The evolution of molecular, cellular, and neurophysiological studies of rodents and the technical advances in human imaging and assessment have gradually extended our understanding of the molecular and neural mechanisms underlying these disorders.

关键词： Special Topic on mental health and Addiction gene VNTR

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Global lessons on delivery of primary healthcare services for people with non-communicable diseases:convergent mixed methods

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Family Medicine and Community health 2024年第3期12卷 13-24页

作者： Robert Mash Lisa R Hirschhorn Inayat Singh Kakar Renu John Manushi Sharma Devarsetty Praveen Stellenbosch University StellenboschSouth Africa northwestern University ChicagoIllinoisUSA The George Institute for Global health New DelhiIndia The George Institute for Global health HyderabadIndia Manipal Academy of Higher Education ManipalIndia

Objective To extract key lessons on primary healthcare(PHC)service delivery strategies for non-communicable diseases(NCD)from the work of researchers funded by the Global Alliance for Chronic Diseases(GACD).Design A convergent mixed methods study that extracted data using a standardised template from research projects funded by the GACD that focused on *** strategies implemented in these studies were mapped onto the PHC Performance Initiative *** qualitative interviews were conducted with researchers from purposefully selected projects to understand the strategies and contextual factors in more *** PHC contexts from low or middle-income countries(LMIC)as well as vulnerable groups within high-income *** came from all regions of the world,particularly East Asia and Pacific,sub-Saharan Africa,South Asia,Latin America and *** The study extracted data on 84 research projects and interviewed researchers from 16 research *** Research projects came from all regions of the world,and mainly focused on diabetes(35.3%),hypertension(28.3%)and mental health(27.6%).Mapped onto the PHC Performance Initiative framework:49.4%focused on high-quality PHC(particularly the comprehensiveness of NCD care,41.2%);41.2%on the availability of PHC services(particularly the competence of healthcare workers,36.5%);35.3%on population health management(particularly community-based services,35.3%);34.1%on facility organisation and management(particularly team-based care,20.0%)and 31.8%on access(particularly digital technology,23.5%).Most common strategies were task shifting and training to improve the comprehensiveness of NCD care through community-based *** factors related to inputs:infrastructure,equipment and medication,workforce(particularly community health workers),finances,health information systems and digital *** Key strategies and contextual factors to improve PHC service del

关键词： services convergent income

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