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Social-epigeneticmediators for racial disparities in pulmonary impairment among childhood cancer survivors

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Cancer Communications 2023年第2期43卷 290-293页

作者： Nan Song Qian Dong Cheng Chen Qian Li Heather Mulder Emily Plyler John Easton Emily Walker Scott Olson Geoffrey Neale Kevin RKrull Deo Kumar Srivastava Kirsten K.Ness Jinghui Zhang Melissa M.Hudson Leslie L.Robison I-Chan Huang Zhaoming Wang Department of Epidemiology and Cancer Control St.Jude Children’s Research HospitalMemphisTN 38105USA College of Pharmacy Chungbuk National UniversityCheongjuChungbuk 28160South Korea School of Public Health Shanghai Jiaotong UniversityShanghai 200025P.R.China Department of Biostatistics St.Jude Children’s Research HospitalMemphisTN 38105USA Department of Computational Biology St.Jude Children’s Research HospitalMemphisTN 38105USA Hartwell Center St.Jude Children’s Research HospitalMemphisTN 38105USA Department of Oncology St.Jude Children’s Research HospitalMemphisTN 38105USA

Dear Editor Previous research found that childhood cancer survivors of African ancestry have significantly higher morbidity and mortality than those of European ancestry[1].However,after adjusting for socio-economic factors,the magnitudes of racial health disparities are either substantially decreased or become statistically non-significant[1],suggesting that social and economic determinants may contribute to racial health ***,we conducted epigenome-wide association studies(EWAS)for three key social determinants of health(SDOHs),namely,personal educational attainment,personal income,and neighborhood deprivation among survivors of childhood cancer,where 130 epigenome-wide significant SDOH-CpG associationswere identified among European ancestry survivors,and 25 of which were also validated in African ancestry survivors[2].Notably,many SDOH-associated CpG sites are also associated with tobacco use.

关键词： vivo cancer mortality

Public Participation GIS (PPGIS) for Regional Mapping and Environmental Awareness

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Journal of Geographic Information System 2014年第2期6卷 135-149页

作者： Simon Foteck Fonji Michael Larrivee Gregory N. Taff Department of Earth Sciences University of Memphis Memphis USA Norwegian Forest and Landscape Institute Norway

Giant Hogweed is a poisonous invasive weed in Latvia that poses significant threat to biodiversity and human health. Local residents are afraid and have very special concerns about the safety of their children because the plant causes phytophotodermatitis (severe burns), painful blistering, permanent scarring and blindness when the sap of the plant comes in contact with the human body and is exposed to sunlight. This study utilizes public participation GIS (PPGIS) involving Latvian high school students as data collectors to monitor the geographic distribution of Giant Hogweed in Northeast Latvia. This paper also explores challenges with implementing such a public program, how to maximize participation, and how participation impacts environmental awareness of participants. In this study we also assessed the accuracy of PPGIS-collected data and how the utilization of such data impacts mapping and monitoring of Giant Hogweed in the study area. Results indicate that this PPGIS program is effective in facilitating data collection for monitoring Giant Hogweed in Latvia. Tested methods of increasing participation have proven largely unsuccessful to date. Statistical analyses of survey responses indicate participation had a marked effect on sensitivity towards environmental issues. Accuracy assessments indicate that quality of point data collected by participants is sufficient for mapping and for use as ground verification.

关键词： GIS PPGIS Mapping Google Maps Invasive Species Environmental Awareness Latvia

Binding energies and interaction origins between nonclassical single-electron hydrogen,sodium and lithium bonds and neutral boron-containing radicals:a theoretical investigation

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Chinese Science Bulletin 2014年第21期59卷 2597-2607页

作者： Zhifeng Li Xiaoping Yang Nathan J.DeYonker Xianyan Xu Zhen Guo Cunyuan Zhao Key Laboratory for New Molecule Design and Function of Gansu Universities College of Life Science and ChemistryTianshui Normal University Department of Chemistry The University of MemphisMemphisTN 38152-3550USA School of Chemistry and Chemical Engineering Sun Yat-Sen University Department of Chemistry State Key Laboratory of Synthetic ChemistryThe University of Hong Kong

Nonclassical single electron hydrogen,sodium and lithium bonds(SEHBs,SENaBs and SELiBs)between single electron acceptors X–A(A=H,Na,Li;X=CN,HCC,HO,NC,CF3)and neutral radicals BY2(Y=H,OH,CH3)and have been systematically investigated by high level theoretical methods,such as second-order Mφller-Plesset perturbation theory(MP2),spin-component-scaled MφllerPlesset theory(SCS-MP2),the coupled cluster method with perturbative triples(CCSD(T)),and the correlation consistent composite approach(ccCA).Binding energies have been corrected for zero-point vibrational effects and(when applicable)basis set superposition *** quantum theory of atoms in molecules(AIM)and natural bond orbital(NBO)analyses were also employed to qualitatively characterize the single electron bond *** stabilization energy was partitioned via the localized molecular orbital energy decomposition analysis(LMOEDA)method,and both electrostatic and exchange interactions were seen to be major driving forces for the complex ***,the sum of the energy contributors of exchange(EEX),repulsion(EREP),polarization(EPOL),dispersion(EDIS)is close to zero and the changes in the interaction energy follow the trend of the electrostatic energy(EES).We observe several linear relationships among the optimized intermolecular parameters and the interaction energies of the various complexes.

关键词：相互作用能单电子非经典结合能中性债券能量分解分析 CCSD(T)

MULTI-DIMENSIONAL QUANTITATIVE RESULTS FOR PROBABILITY MEASURES APPROXIMATING THE UNIT MEASURE

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Analysis in Theory and Applications 1986年第4期 93-103页

作者： GEORGEA.ANASTASSIOV Department of Mathematical Sciences memphis State University memphis Tennessee U.S.A. 38159

Introduction The convergence of a sequence of positive linear operators{L;};to the identity operator I acting on C（[a,b]）, [a,b]IR,has been studied extensively by P. P. Korovkin （1953）（see [8]）.Later on O. Shisha and B. Mond （1968） put this convergence in aquantitative form. And E. Censor （1971） produced similar quantita-tive results on IR;,

关键词： MULTI-DIMENSIONAL QUANTITATIVE RESULTS FOR PROBABILITY MEASURES APPROXIMATING THE UNIT MEASURE 子仪一丈

Transcriptome and Proteome Expressions Involved in Insulin Resistance in Muscle and Activated T-Lymphocytes of Patients with Type 2 Diabetes

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Genomics, Proteomics & Bioinformatics 2007年第3期5卷 216-235页

作者： Frankie B.Stentz Abbas E.Kitabchi Division of Endocrinology Diabetes and MetabolismDepartment of MedicineThe University of Tennessee Health Science CenterMemphisTN 38163USA.

We analyzed the genes expressed （transcriptomes） and the proteins translated （pro- teomes） in muscle tissues and activated CD4^＋ and CD8^＋ T-lymphocytes （T-cells） of five Type 2 diabetes （T2DM） subjects using Affymetrix microarrays and mass spectrometry, and compared them with matched non-diabetic controls. Gene expressions of insulin receptor （INSR）, vitamin D receptor, insulin degrading enzyme, Akt, insulin receptor substrate-1 （IRS-1）, IRS-2, glucose transporter 4 （GLUT4）, and enzymes of the glycolytic pathway were decreased at least 50% in T2DM than in controls. However, there was greater than two-fold gene upregulation of plasma cell glycoprotein-1, tumor necrosis factor a （TNFα）, and gluconeogenic enzymes in T2DM than in controls. The gene silencing for INSR or TNFα resulted in the inhibition or stimulation of GLUT4, respectively. Proteome profiles corresponding to molecular weights of the above translated transcriptomes showed different patterns of changes between T2DM and controls. Meanwhile, changes in transcriptomes and proteomes between muscle and activated T-cells of T2DM were comparable. Activated T-cells, analogous to muscle cells, expressed insulin signaling and glucose metabolism genes and gene products. In conclusion, T-cells and muscle in T2DM exhibited differences in expression of certain genes and gene products relative to non-diabetic controls. These alterations in transcriptomes and proteomes in T2DM may be involved in insulin resistance.

关键词： genomics proteomics T-lymphocytes activation muscle Type 2 diabetes

UNDERSTANDING THE ANCIENT EGYPTIANS:AN EXAMINATION OF LIVING CREATURE HIEROGLYPHS

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Journal of Ancient Civilizations 2001年第1期16卷 59-85页

作者： Gorey C.Ray Rhodes College memphis TN

Weight Loss and Improved Metabolic Health Measures Using a One-Week Active Nutrition Jumpstart Program in Overweight and Obese Men and Women

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Health 2023年第6期15卷 640-653页

作者： Richard J. Bloomer Jacquelyn Pence Allyson Davis Michelle Stockton Center for Nutraceutical and Dietary Supplement Research College of Health Sciences University of Memphis Memphis TN USA

Background: The prevalence of individuals who are obese or overweight is an increasing global epidemic that is associated with a multitude of adverse health conditions. Multiple strategies are available to promote weight loss in these populations, including the use of caloric restriction and/or liquid diets. We determined the impact of a low-calorie, nutrient-dense, primarily liquid diet on body weight and associated measures of metabolic health in overweight and obese men and women. Methods: Twenty-six men and women (age: 42.6 ± 10.8) completed a seven-day intervention using the USANA Active Nutrition Jumpstart program, which consisted of consuming three meal replacement shakes and three to four servings of fruits and vegetables, along with a probiotic, three metabolism supplements, and two vitamin packs each day. Pre-post measurements included body composition—determined (via DXA), fasting levels of lipids and glucose in heparinized whole blood, weight, waist circumference, hip circumference, heart rate, and blood pressure. Subjective mood and hunger were also assessed. Results: The dietary program was well-tolerated, and the intervention resulted in a mean weight loss of approximately 4.5 pounds. Clinically relevant reductions were noted in systolic and diastolic blood pressure, cholesterol (total and LDL), and glucose. In addition, there were favorable changes in self-esteem, energy, motivation, and physical appearance. Conclusion: A one-week period of adherence to the Active Nutrition Jumpstart program positively impacted subjective feelings, while resulting in significant weight loss and other health benefits that may have clinical relevance. Longer-term interventions are needed to sustain these initial results.

关键词： Weight Loss Supplement Fiber Caloric Restriction

Tibiofemoral Joint Forces during the Stance Phase of Gait after ACL Reconstruction

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Open Journal of Biophysics 2013年第4期3卷 277-284页

作者： Brooke A. Sanford John L. Williams Audrey R. Zucker-Levin William M. Mihalko Campbell Clinic Department of Orthopaedics and Biomedical Engineering University of Tennessee Health Science Center Memphis USA Department of Biomedical Engineering University of Memphis Memphis USA Department of Physical Therapy University of Tennessee Health Science Center Memphis USA

The main goals of anterior cruciate ligament reconstruction (ACLR) are to restore knee function and prevent development of osteoarthritis (OA). However, the incidence of early-onset OA remains higher in patients following ACLR. The purpose of this study was to compare the computed tibiofemoral joint (TFJ) forces and muscle forces of ACLR knees to those of BMI-matched control subjects during the stance phase of gait. We hypothesized that the use of principal component analysis would allow us to characterize alterations in three-dimensional TFJ loads and muscle forces after ACLR as compared to a healthy control population. Of the eight ACLR knees, four displayed an abnormal TFJ compressive force. In three of these four ACLR knees that displayed abnormal compressive forces, one of the major muscles/muscle groups crossing the knee also deviated from the control group. We believe that each subject has a unique response to their injury, reconstructive surgery, and rehabilitation.

关键词： ACL Reconstruction Tibiofemoral Joint Forces Gait

Mapping genetic variations in the first assembled human genome

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Quantitative Biology 2021年第4期9卷 361-365页

作者： Jinghui Zhang Department of Computational Biology St.Jude Children's Research HospitalMemphisTN 38105-3678USA

On June 26,2000,President Bill Clinton held aceremony at the White House announcing the completion of the human genome ***,the leaders of the two competing groups,*** Collins from the National Institute of Health,and *** Venter from Celera Genomics,shook their *** a scientist who had been actively involved in both the public and private sides of human genome sequencing,I can still feel the excitement of being a contributor of this landmark scientific project even after 20 ***,I can also attest the significance of this achievement as the reference human genome sequence is being used every day by my research team to find cures for pediatric *** this feature I would like to present a foot soldier’s account on assembling and analyzing the sequence of the human genome.

关键词： Mapping Clinton pediatric