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Psychology Research 2016年第10期6卷 559-566页

作者： Bernadette A. Fausto Bonnie Mclntosh Celisa Bonner Angela M. McBride University of South Florida Florida USA Madonna Ptak Center forAlzheimer's and memory Loss atMorton Plant Mease Florida USA Private Practice Florida USA

Test-Retest Reliability, Convergent Validity and Practice Effects of the RBANS in a memory clinic Setting: A Pilot Study

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Open Journal of Medical Psychology 2013年第4期2卷 11-16页

作者： Yanhong Dong Claire L. Thompson Shi Huey Joanne Tan Leon Ben Swie Lim Wanshin Pang Christopher Li-Hsian Chen 1memory Aging and Cognition Centre Department of Pharmacology National University Health System Singapore 2Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 1memory Aging and Cognition Centre Department of Pharmacology National University Health System Singapore 2Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 3Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre School of Psychiatrythe University of New South Wales Australia Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore James Cook University (Australia) Singapore Campus

This pilot study examined the psychometric properties and clinical utility of a brief neuropsychological instrument (Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The test-retest reliability, practice effects and convergent validity of RBANS were examined in participants without objective cognitive impairment. The tests were administered at two time points at approximately a two weeks’ interval, with 30 cognitively intact participants with a mean age of 63.3 ± 5.8 years. Adequate test-retest reliabilities were found for RBANS subtests, index and total scale scores with significant gain scores in immediate memory and visuospatial function. The RBANS showed good convergent validity and the RBANS supplemented with executive and language measures (Colour Trails Test and 30-item modified Boston Naming Test, respectively) demonstrated excellent convergent validity with a formal neuropsychological battery. This pilot study has provided the preliminary evidence of reliability and convergent validity of the RBANS. Additionally, it also provides insight on the practice effects so that clinicians may assess significant changes in RBANS subtests and domain indexes for clinical practice.

关键词： RBANS Neuropsychological Tests Test-retest Reliability Validity Practice Effect

Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration

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Neural Regeneration Research 2025年第8期20卷 2317-2318页

作者： Francesco Angelucci Jakub Hort memory clinic Department of NeurologySecond Faculty of MedicineCharles University and Motol University HospitalPragueCzech Republic International clinical Research Centre St.Anne’s University HospitalBrnoCzech Republic

Frontotemporal lobar degeneration(FTLD)is a form of progressive dementia characterized by degeneration of the frontal and temporal lobes of the *** pathology involves a series of cognitive,behavioral,and neurological ... 详细信息

关键词： degeneration elevated pathology

Square wave manoeuvre for apogeotropic variant of horizontal canal benign paroxysmal positional vertigo in neck restricted patients

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Journal of Otology 2021年第2期16卷 65-70页

作者： Dario A.Yacovino Estefania Zanotti Karen Roman Timothy C.Hain Department of Neurology Dr.Cesar Milstein HospitalBuenos AiresArgentina memory and Balance clinic Buenos AiresArgentina Northwestern University ChicagoILUSA

Objective:We aimed to describe the clinical features of the apogeotropic variant of horizontal canal benign paroxysmal positional vertigo(HC BPPV-AG)in a cluster of patients with restrictive neck movement disorders and a new therapeutic manoeuvre for its ***:In a retrospective review of cases from an ambulatory tertiary referral center,patients with HC BPPV-AG in combination with neck movement restriction that prevented any classical manual repositioning procedure or who were refractory to canalith repositioning manoeuvres,were treated with a new manoeuvre comprised of sequential square-wave pattern of head and body supine rotations while nystagmus was being monitored,until either an apogeotropic to geotropic conversion or resolution of the nystagmus was ***:Fifteen patients were *** but one[14/15 cases]showed a positive therapeutic response to the repositioning procedure in a single *** two cases,a direct relief of vertigo and elimination of nystagmus was observed without an intermediate geotropic *** in three patients the affected ear was not initially identified,it was ultimately identified and successfully treated by the square wave manoeuvre in all of ***:The square-wave manoeuvre is an alternative for HC BPPV-AG treatment in either cases with neck restriction,where the affected side is not well identified at the bedside or when other manoeuvres fail to resolve the HC BPPV-AG.

关键词： Benign paroxysmal positional vertigo Horizontal canal Cupulolithiasis treatment

Administration of pre/probiotics with conventional drug treatment in Alzheimer’s disease

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Neural Regeneration Research 2020年第3期15卷 448-449页

作者： Jakub Hort Martin Valis Francesco Angelucci memory clinic Department of Neurology2nd Faculty of MedicineCharles University and Motol University HospitalPragueCzech Republic International clinical Research Centre St.Anne’s University HospitalBrnoCzech Republic Department of Neurology University Hospital Hradec KraloveCharles University in PragueFaculty of Medicine in Hradec KraloveCzech Republic

Alzheimer’s disease(AD)is a neurodegenerative disease with long preclinical phase,typically followed by a slow decline in memory,thinking and reasoning *** underlying pathological processes are not yet fully elucidated,although two main disease hallmarks have been associated with AD pathology:amyloid beta species and neurofibrillary *** plaques are deposits of a protein fragment called beta-amyloid(Aβ),which accumulates in the spaces between *** are twisted fibers of the tau protein,which accumulates inside the cells.

关键词： Alzheimer amyloid clinical

Androgen deprivation therapy-associated vasomotor symptoms

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Asian Journal of Andrology 2012年第2期14卷 193-197页

作者： Jason M Jones Manish Kohli Charles L Loprinzi Department of Medical Oncology Mayo Clinic Rochester MN 55905 USA

Androgen deprivation therapy （ADT） is widely used as standard therapy in the treatment of locally advanced and metastatic prostate cancer. While efficacious, ADT is associated with multiple side effects, including decreased libido, erectile dysfunction, diabetes, loss of muscle tone and altered body composition, osteoporosis, lipid changes, memory loss, gynecomastia and hot flashes. The breadth of literature for the treatment of hot flashes is much smaller in men than that in women. While hormonal therapy of hot flashes has been shown to be effective, multiple non-hormonal medications and treatment methods have also been developed. This article reviews current options for the treatment of hot flashes in patients taking ADT.

关键词： androgen deprivation therapy hot flashes vasomotor symptoms

Amyotrophic lateral sclerosis as a synaptopathy

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Neural Regeneration Research 2019年第2期14卷 189-192页

作者： Matthew J.Fogarty Department of Physiology and Biomedical Engineering Mayo Clinic School of Biomedical Sciences The University of Queensland

The synapse is an incredibly specialized structure that allows for the coordinated communication of information from one neuron to another. When assembled into circuits, steady streams of excitatory and inhibitory synaptic activity shape neural outputs. At the organismal level, ensembles of neural networks underlie behavior, emotion and memory. Disorder or dysfunctions of synapses, a synaptopathy, may underlie a host of developmental and degenerative neurological conditions. There is a possibility that amyotrophic lateral sclerosis may be a result of a synaptopathy within the neuromotor system. To this end, particular attention has been trained on the excitatory glutamatergic synapses and their morphological proxy, the dendritic spine. The extensive detailing of these dysfunctions in vulnerable neuronal populations, including corticospinal neurons and motor neurons, has recently been the subject of original research in rodents and humans. If amyotrophic lateral sclerosis is indeed a synaptopathy, it is entirely consistent with other proposed pathogenic mechanisms – including glutamate excitotoxicity, accumulation of misfolded proteins and mitochondrial dysfunction at distal axon terminals(cortico-motor neuron and neuromuscular). Further, although the exact mechanism of disease spread from region to region is unknown, the synaptopathy hypothesis is consistent with emerging die-forward evidence and the prion-like propagation of misfolded protein aggregates to distant neuronal populations. Here in this mini-review, we focus on the timeline of synaptic observations in both cortical and spinal neurons from different rodent models, and provide a conceptual framework for assessing the synaptopathy hypothesis in amyotrophic lateral sclerosis.

关键词： motor neuron motor cortex corticospinal excitotoxicity synaptic transmission dendrites dendriticspines neuromuscular junction

Language training for oral and written naming impairment in primary progressive aphasia:a review

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Translational Neurodegeneration 2021年第3期10卷 297-330页

作者： Ilaria Pagnoni Elena Gobbi Enrico Premi Barbara Borroni Giuliano Binetti Maria Cotelli Rosa Manenti Neuropsychology Unit IRCCS Istituto Centro San Giovanni di Dio FatebenefratelliBresciaItaly Vascular Neurology Unit Department of Neurological and Vision SciencesASST Spedali CiviliBresciaItaly Neurology Unit Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly MAC memory clinic and Molecular Markers Laboratory IRCCS Istituto Centro San Giovanni di Dio FatebenefratelliBresciaItaly

Background Primary progressive aphasia(PPA)is a neurodegenerative disorder characterized by a gradual,insidious and progressive loss of language abilities,with naming difficulties being an early and persistent impairment common to all three *** the absence of effective pharmacological treatments and given the progressive nature of the disorder,in the past few decades,many studies have investigated the effectiveness of language training to minimize the functional impact of word-finding difficulties in daily *** body We review language treatments most commonly used in clinical practice among patients with different variants of PPA,with a focus on the enhancement of spoken and written naming *** of gains to the ability to name untrained stimuli or to other language abilities and the maintenance of these results over time are also ***-eight studies were included in this literature review,identifying four main types of language treatment:a)lexical retrieval treatment,b)phonological and/or orthographic treatment,c)semantic treatment,and d)a multimodality approach ***,language training is able to induce immediate improvements of naming abilities in all variants of ***,despite the large variability among results,generalization and long-term effects can be recorded after the *** reviewed studies also suggest that one factor that determines the choice of a particular approach is the compromised components of the lexical/semantic processing *** The majority of studies have demonstrated improvements of naming abilities following language *** the progressive nature of PPA,it is essential to apply language treatment in the early stages of the disease.

关键词： Agrammatic variant of primary progressive aphasia Semantic variant of primary progressive aphasia Logopenic/phonological variant of PPA Naming

Incorporating mucosal-associated invariant T cells into the pathogenesis of chronic liver disease

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World Journal of Gastroenterology 2021年第25期27卷 3705-3733页

作者： Albert J Czaja Department of Medicine Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States

Mucosal-associated invariant T(MAIT)cells have been described in liver and nonliver diseases,and they have been ascribed antimicrobial,immune regulatory,protective,and pathogenic *** goals of this review are to describe their biological properties,indicate their involvement in chronic liver disease,and encourage investigations that clarify their actions and therapeutic *** abstracts were identified in PubMed by multiple search terms,and bibliographies were *** cells are activated by restricted non-peptides of limited diversity and by multiple inflammatory *** pro-inflammatory,anti-inflammatory,and immune regulatory cytokines are released;infected cells are eliminated;and memory cells *** MAIT cells are hyper-activated,immune exhausted,dysfunctional,and depleted in chronic liver *** phenotype lacks disease-specificity,and it does not predict the biological *** cells have presumed protective actions in chronic viral hepatitis,alcoholic hepatitis,non-alcoholic fatty liver disease,primary sclerosing cholangitis,and decompensated *** have pathogenic and pro-fibrotic actions in autoimmune hepatitis and mixed actions in primary biliary *** factors in the hepatic microenvironment(cytokines,bile acids,gut-derived bacterial antigens,and metabolic by-products)may modulate their response in individual *** manipulations of function are warranted to establish an association with disease severity and *** conclusion,MAIT cells constitute a disease-nonspecific,immune response to chronic liver inflammation and *** pathological role has been deduced from their deficiencies during active liver disease,and future investigations must clarify this role,link it to outcome,and explore therapeutic interventions.

关键词： Innate-like lymphocytes Antimicrobial Immune regulatory Pathogenic Mucosal-associated invariant T cell

A comparative study of two methods for treatment of benign paroxysmal positional vertigo in the emergency department

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Journal of Otology 2021年第4期16卷 231-236页

作者： D.Giardino M.Musazzi M.Perez Akly M.Cherchi D.A.Yacovino Department of Neurology d Dr Cesar Milstein Hospital Buenos AiresArgentina Department of Neurology d Centro de Educacion Medica e Investigaciones Clínicas“Norberto Quirno”(CEMIC) Buenos AiresArgentina Department of Neurology d Feinberg School of Medicine Northwestern UniversityChicagoILUSA Chicago Dizziness and Hearing ChicagoILUSA memory and Balance clinic Buenos AiresArgentina

Introduction: Posterior canal benign paroxysmal positional vertigo (PC-BPPV) is considered the mostcommon cause of peripheral vertigo in the emergency department (ED). Although the canalith repositioning maneuver (CRM) is the standard of care, the most effective method to deliver it in the ED hasbeen poorly ***: To compare two protocols of the Epley maneuver for the treatment of *** and methods: We prospectively recruited 101 patients with unilateral PC-BPPV on physical examination, randomizing them to either a single Epley maneuver (EM) (n ¼ 46) or multiple maneuvers(n ¼ 55) on the same visit. Measured outcomes included presence/absence of positional nystagmus,resolution of vertigo, and score on the dizziness handicap inventory (DHI) at follow-up evaluations. TheDHI was stratified into mild ( 30) and moderate-severe (>30).Results: Normalization of the Dix-Hallpike maneuver at day 5 was observed in 38% of the single EMgroup and 44.4% in the multiple EM group (p ¼ 0.62). The DHI showed reduction from 42.2 (SD 18.4) to31.9 (SD 23.7) in the single EM group and from 43.7 (SD 22.9) to 33.5 (SD 21.5) in the multiple EM group(p ¼ 0.06). A higher number of patients improved from moderate-severe to mild DHI (p ¼ 0.03) in thesingle EM group compared to the multi-EM group (p ¼ 0.23).Conclusion: There was no statistically significant difference between performing a single EM versusmultiple EMs for treatment of PC-BPPV in the emergency department. The single EM approach isassociated with shorter physical contact between patients and examiner, which is logically safer in apandemic context.

关键词： Benign paroxysmal positional vertigo Epley maneuver Emergency department Pandemic