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基于人工智能的前列腺癌影像的现状与展望

中华放射学杂志 2019年第10期53卷 804-807页

作者：王良陈敏 Li Qiubai Hebert Alberto Vargas 华中科技大学同济医学院附属同济医院放射科武汉430030 北京医院放射科国家老年医学中心 100730 Department of Radiology University of Texas Southwestern Medical Center at DallasDallasTXUSA Department of Radiology Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA

在前列腺癌影像中,人工智能(AI)在执行3个主要临床任务中具有较大实用价值,包括前列腺癌的检测、表征(肿瘤和器官的分割、诊断和分期、预后和结果预测等)和监视。尽管AI在前列腺癌影像中取得了巨大成功,但在AI广泛临床应用之前还必须克... 详细信息

在前列腺癌影像中,人工智能(AI)在执行3个主要临床任务中具有较大实用价值,包括前列腺癌的检测、表征(肿瘤和器官的分割、诊断和分期、预后和结果预测等)和监视。尽管AI在前列腺癌影像中取得了巨大成功,但在AI广泛临床应用之前还必须克服一些限制和障碍。期望未来临床医师可以基于AI技术分析的结果进行决策。

关键词：前列腺肿瘤人工智能

^(18)F-FDG PET/CT肿瘤显像报告书写指南

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中华核医学与分子影像杂志 2021年第2期41卷 124-128页

作者：黎翔(译) 杨卫东汪静(审校) Ryan D.Niederkohr Bennett S.Greenspan John O.Prior Heiko Schöder Marc A.Seltzer Katherine A.Zukotynski Eric M.Rohren 空军军医大学第一附属医院西安710032 Department of Nuclear Medicine Kaiser Permanente Medical CenterSanta ClaraCalifornia Department of Radiology Medical College of Georgia/Georgia Regents UniversityAugustaGeorgia Department of Nuclear Medicine Lausanne University HospitalLausanneSwitzerland Department of Radiology Memorial Sloan-Kettering Cancer CenterNew YorkNew York Department of Radiology Dartmouth-Hitchcock Medical CenterLebanonNew Hampshire Department of medical Imaging University of TorontoTorontoOntarioCanada Department of Radiology Harvard Medical SchoolBostony Massachusetts Department of Diagnostic Radiology and Nuclear Medicine University of Texas M.D.Anderson Cancer CenterHoustonTexas

纸质报告或其电子版报告是影像医师与转诊医师的主要沟通方式。报告的内容不仅影响患者的管理和临床结果,而且可以作为法律性文件用于医疗纠纷的评判,用于证明医疗的必要性、计费的准确性和监管的合规性。融合显像的复杂性使得完成一份... 详细信息

纸质报告或其电子版报告是影像医师与转诊医师的主要沟通方式。报告的内容不仅影响患者的管理和临床结果,而且可以作为法律性文件用于医疗纠纷的评判,用于证明医疗的必要性、计费的准确性和监管的合规性。融合显像的复杂性使得完成一份高质量的PET/CT报告可能较其他影像学检查报告困难。该文讨论了一份简洁、完整的18F-脱氧葡萄糖(FDG)PET/CT肿瘤显像报告应具有的基本要素,并通过日常临床实践中的例子对这些要素进行阐述。

关键词：肿瘤学 PET/CT 报告

An international survey of classification and treatment choices for group D retinoblastoma

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 961-967页

作者： Christina Scelfo Jasmine H Francis Vikas Khetan Thomas Jenkins Brian Marr David H Abramson Carol L Shields Jacob Pe’er Francis Munier Jesse Berry J.William Harbour Andrey Yarovoy Evandro Lucena Timothy G Murray Pooja Bhagia Evelyn Paysse Samuray Tuncer Guillermo L Chantada Annette C Moll Tatiana Ushakova David A Plager Islamov Ziyovuddin Carlos A Leal Miguel A Materin Xun-Da Ji Jose W Cursino Rodrigo Polania Hayyam Kiratli Charlotta All-Ericsson Rejin Kebudi Santosh G Honavar Vicktoria Vishnevskia-Dai Sidnel Epelman Anthony B Daniels Jeanie D Ling Fousseyni Traore Marco A Ramirez-Ortiz Ophthalmic Oncology Service Department of Surgery Memorial Sloan Kettering Cancer Center New York 10065 USA Department of Ophthalmology Weill-Cornell Medical Center New York 10065 USA Department of Vitreoretinal and Ocular Oncology Sankara Nathralaya Chennai 600066 India Ocular Ontology Service Wills Eye Hospital Thomas Jefferson University Pennsylvania 19107 USA Hadassah - Hebrew University medical center Jerusalem 91120 Israel jules-Gonin Eye Hospital Lausanne 1004 Switzerland USC Roski Eye Institute Children＇s Hospital of Los Angeles California 90033 USA Ocular Oncology Service Bascom Palmer Eye Institute University of Miami Miller School of Medicine Florida 33136 USA Ocular Oncology Department S.N. Fyodorov Eye Microsurgery Federal State Institution Moscow 127486 Russia Department of Ocular Oncology Instituto Nacional de Cancer Rio de Janeiro 1122 Brazil Murray Ocular Oncology and Retina Miami Children＇s Hospital Florida 33143 USA St. Joseph＇s Children＇s Hospital New Jersey 07504 USA Department of Ophthalmology Baylor College of Medicine Texas 77030 USA Department of Ophthalmology Ocular Oncology Istanbul Medical Faculty Istanbul University Istanbul 34452 Turkey Oncology Department Hospital JP Garrahan Buenos Aires 1245 Argentina Department of Ophthalmology VU University Medical Center Amsterdam 1081 the Netherlands Department of Head and Neck Tumors Science Research Institute of Pediatric Oncology and Hematology N.N. Blokhin Russian Cancer Research Center Moscow 115478 Russia Pediatric Ophthalmology and Adult Strabismus Riley Hospital for Children Indiana University Medical Center Indiana 46202 USA National Oncology center of Uzbekistan Tashkent 110508 Uzbekistan nstituto Nacional de Pediatria Coyoacan 04530 Mexico Department of Ophthalmology and Visual Science Smilow Cancer Hospital at Yale New Haven CT 06520 USA Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Ophthalmology Santa Casa Mi

AIM： To determine which IIRC scheme was used by retinoblastoma centers worldwide and the percentage of D eyes treated primarily with enucleation versus globe salvaging therapies as well as to correlate trends in treatment choice to IIRC version used and geographic region. METHODS： An anonymized electronic survey was offered to 115 physicians at 39 retinoblastoma centers worldwide asking about IIRC classification schemes and treatment patterns used between 2008 and 2012. Participants were asked to record which version of the IIRC was used for classification, how many group D eyes were diagnosed, and how many eyes were treated with enucleation versus globe salvaging therapies. Averages of eyes per treatment modality were calculated and stratified by both IIRC version and geographic region. Statistical significance was determined by Chi-square, ANOVA and Kruskal-Wallis tests using Prism. RESULTS： The survey was completed by 29% of physicians invited to participate. Totally 1807 D eyes were diagnosed. Regarding IIRC system, 27% of centers used the Children＇s Hospital of Los Angeles （CHLA） version, 33% used the Children＇s Oncology Group （COG） version, 23% used the Philadelphia version, and 17% were unsure. The rate for primary enucleation varied between 0 and 100% and the mean was 29%. By IIRC version, primary enucleation rates were： Philadelphia, 8%; COG, 34%; and CHLA, 37%. By geographic region, primary enucleation rates were： Latin America, 57%; Asia, 40%; Europe, 36%; Africa, 10%, US, 8%; and Middle East, 8%. However, systemic chemoreduction was used more often than enucleation in all regions except Latin America with a mean of 57% per center （P〈0.0001）. CONCLUSION： Worldwide there is no consensus on which IIRC version is used, systemic chemoreduction was the most frequently used initial treatment during the study period followed by enucleation and primary treatment modality, especially enucleation, varied greatly with regards to IIRC version used and geographic r

关键词： retinoblastoma oncology retina enucleation chemotherapy intra-arterial chemotherapy ophthalmic arterychemosurgery cancer

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深刻认识低价值医疗的弊端可以减少伤害

英国医学杂志中文版 2022年第2期25卷 72-76页

作者： Shannon M Brownlee Deborah Korenstein 陆昌兴(译) 周红霞(校) Lown Institute 21 Longwood AveBrooklineMA 02446USA memorial sloan kettering cancer center New YorkNYUSA weill cornell medical college New YorkNYUSA 广西医科大学外国语学院广西医科大学公共卫生学院

如果我们懂得过度使用低价值医疗会对患者造成很多伤害,我们会停止使用吗?Shannon Brownlee和Deborah Korenstein呼吁应对过度医疗造成的可预防性伤害进行量化研究。

关键词：可预防性过度医疗过度使用深刻认识量化研究

肿瘤诊断的隐患在确诊前后数周内患者的损伤风险升高

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英国医学杂志中文版 2017年第1期20卷 1-2页

作者： Holly G Prigerson Susan C Vaughan Wendy G Lichtenthal 徐佳晨李俏 center for Research on End-of-Life Care Department of Medicine Weill Cornell Medicine New York NY 10065 USA Department of Psychiatry Columbia College of Physicians and Surgeons New York NY 10032 USA Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center New York NY 10065 USA 中国医学科学院肿瘤医院

毋庸置疑，医学的发展可以延长人类的寿命并改善人类的身体状态。然而，医学带来的后果并不全是有利的。在公元前19世纪，诗人维吉尔写过，“疾病随着治疗恶化”的情况很常见。在一篇相关链接文章（doi：10．1136／bmj．i4218）中，She... 详细信息

毋庸置疑，医学的发展可以延长人类的寿命并改善人类的身体状态。然而，医学带来的后果并不全是有利的。在公元前19世纪，诗人维吉尔写过，“疾病随着治疗恶化”的情况很常见。在一篇相关链接文章（doi：10．1136／bmj．i4218）中，Shen教授团队。将这句话延展为“疾病随着诊断恶化”。他们致力于确定除了肿瘤本身及其治疗之外。

关键词：肿瘤诊断方法隐患损伤风险

Performance of risk stratification systems for gastrointestinal stromal tumors: A multicenter study

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World Journal of Gastroenterology 2019年第10期25卷 1238-1247页

作者： Tao Chen Liang-Ying Ye Xing-Yu Feng Hai-Bo Qiu Peng Zhang Yi-Xin Luo Li-Yi Yuan Xin-Hua Chen Yan-Feng Hu Hao Liu Yong Li Kai-Xiong Tao Jiang Yu Guo-Xin Li Department of General Surgery Nanfang HospitalSouthern Medical University Department of Gastroenterology Nanfang HospitalSouthern Medical University Department of General Surgery Guangdong General HospitalGuangdong Academy of Medical Sciences Department of Gastric Surgery Sun Yat-sen University Cancer CenterSun Yatsen University Department of General Surgery Wuhan Union HospitalHuazhong University of Science and Technology

BACKGROUND Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumor type in the gastrointestinal system. Presently, various classification systems to prognosticate GISTs have been *** To evaluate the application value of four different risk stratification systems for *** Patients who were diagnosed with GISTs and underwent surgical resection at four hospitals from 1998 to 2015 were identified from a database. Risk of recurrence was stratified by the modified National Institute of Health(NIH)criteria, the Armed Forces Institute of Pathology(AFIP) criteria, the memorial sloan kettering cancer center(MSKCC) prognostic nomogram, and the contour maps. Receiver operating characteristic(ROC) curves were established to compare the four abovementioned risk stratification systems based on the area under the curve(AUC).RESULTS A total of 1303 patients were included in the study. The mean age of the patients was 55.77 ± 13.70 yr; 52.3% of the patients were male. The mean follow-up period was 64.91 ± 35.79 mo. Approximately 67.0% the tumors were located in the stomach, and 59.5% were smaller than 5 cm; 67.3% of the patients had a mitotic count ≤ 5/50 high-power fields(HPFs). Thirty-four tumors ruptured before and during surgery. Univariate analysis demonstrated that tumor size > 5 cm(P 5/50 HPFs(P < 0.05), non-gastric location(P < 0.05), and tumor rupture(P < 0.05) were significantly associated with increased recurrence rates. According to the ROC curve, the AFIP criteria showed the largest AUC(0.754).CONCLUSION According to our data, the AFIP criteria were associated with a larger AUC than the NIH modified criteria, the MSKCC nomogram, and the contour maps, which might indicate that the AFIP criteria have better accuracy to support therapeutic decision-making for patients with GISTs.

关键词： Gastrointestinal stromal tumors Risk stratification Prognosis Modified National Institute of Health criteria Armed Forces Institute of Pathology criteria memorial sloan kettering cancer center prognostic nomogram Contour maps Gastrointestinal tumors

北美神经内分泌肿瘤学会和核医学与分子影像学会有关177Lu-DOTATATE肽受体放射性核素治疗患者选择和合理应用共识

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中华核医学与分子影像杂志 2020年第11期40卷 679-685页

作者：邓艳(译) 张伟(审校) Thomas A.Hope Lisa Bodei Jennifer A.Chan Ghassan El-Haddad Nicholas Fidelman Pamela L.Kunz Josh Mailman Yusuf Menda David C.Metz Erik S.Mittra Daniel A.Pryma Diane L.Reidy-Lagunes Simron Singh Jonathan R.Strosberg 西南医科大学附属医院儿科泸州646000 西南医科大学附属医院核医学科、核医学与分子影像四川省重点实验室泸州646000 Department of Radiology and Biomedical Imaging University of CaliforniaSan FranciscoSan FranciscoCalifornia Department of Radiology San Francisco VA Medical CenterSan FranciscoCalifornia Molecular Imaging and Therapy Service Department of RadiologyMemorial Sloan Kettering Cancer CenterNew YorkNew York Department of Medicine Dana-Farber Cancer InstituteBostonMassachusetts Department of Radiology Moffitt Cancer CenterTampaFlorida Department of Medicine Stanford University School of MedicineStanfordCalifornia NorCal CarciNET Community RiponCalifornia Department of Radiology Carver College of MedicineUniversity of IowaIowa CityIowa Division of Gastroenterology Department of MedicinePerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPennsylvania Department of Diagnostic Radiology Division of Nuclear Medicine&Molecular ImagingOregon Health&Science UniversityPortlandOregon Division of Nuclear Medicine&Clinical Molecular Imaging Department of RadiologyPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaPennsylvania Department of Medicine Memorial Sloan Kettering Cancer CenterNew YorkNew York Department of medical Oncology Odette Cancer CentreSunnybrook Health Sciences CentreTorontoOntario Department of Gastrointestinal Oncology Moffitt Cancer CenterTampaFlorida

随着177Lu-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DOTATATE)肽受体放射性核素治疗(PRRT)的日益普及,有关患者合理选择的问题日益增多。该文回顾了有关177Lu-DOTATATE在不同原发性神经内分泌肿瘤... 详细信息

随着177Lu-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DOTATATE)肽受体放射性核素治疗(PRRT)的日益普及,有关患者合理选择的问题日益增多。该文回顾了有关177Lu-DOTATATE在不同原发性神经内分泌肿瘤(NETs)中的应用文献,讨论了一些有争议的问题,并回顾了治疗的潜在禁忌证。此共识是由北美神经内分泌肿瘤学会(NANETS)和核医学与分子影像学会(SNMMI)共同制定的。NANETS是成立于2005年的北美多学科神经内分泌专家专业学会,目的在于通过增加研究和教育机会改善对NETs的管理。NANETS致力于多学科研究,由NETs涉及的不同专业的医师和科学家组成。SNMMI成立于1954年,旨在促进核医学科学、技术和实践应用的国际性科学专业组织,除了出版期刊、时事通讯和书籍外,还主办提高核医学从业人员能力和促进核医学科学新发展的国际会议及讲习班。

关键词： 177Lu-DOTATATE 肽受体放射性核素治疗神经内分泌肿瘤共识

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纵隔肿物活检小标本的获取与病理报告指南

中国肺癌杂志 2014年第2期17卷 104-109页

作者：付浩中国胸腺瘤协作组全体成员 Alberto Marchevsky Alex Marx Philipp Strobel Saul Suster Federico Venuta Mirella Marino Samuel Yousem Maureen Zakowski 北京大学肿瘤医院 Department of Pathology and Laboratory Medicine Cedars Sinai Medical Center Department of Pathology University Medical Center Mannheim Department of Pathology and Laboratory Medicine Medical College of Wisconsin Department of Thoracic Surgery University of Rome La Sapienza Department of Pathology Regina Elena National Cancer Institute Department of Pathology UPMC Presbyterian University Hospital Department of Pathology Memorial Sloan Kettering Cancer Center

目前，胸腺恶性肿瘤治疗方案大多是根据术后病理确定，然而，多数临床治疗决策需要在术前通过活检小标本的病理报告来制定。所以，术前活检小标本的正确获取和病理解读对治疗决策的制定显得非常重要[1]。这些标本包括细针活检标本，带... 详细信息

目前，胸腺恶性肿瘤治疗方案大多是根据术后病理确定，然而，多数临床治疗决策需要在术前通过活检小标本的病理报告来制定。所以，术前活检小标本的正确获取和病理解读对治疗决策的制定显得非常重要[1]。这些标本包括细针活检标本，带芯穿刺活检标本和手术切取活检标本[2-7]。由于胸腺肿瘤的病理诊断对组织的获取方法和获取量都有较高的要求，加之对病理的描述也没有统一的标准，使得小标本在诊断胸腺瘤方面存在诸多问题。为此，ITMIG在病理科医生和外科医生回顾相关文献和提出初步建议的基础上，经集体讨论制定了活检规范操作流程，提出了对纵隔肿物小活检标本处理和病理报告的建议。旨在为术前患者的治疗提供一个统一和具有循证医学证据的方法；同时，将有利于全球数据之间的比较和开展合作研究，充分利用医疗资源。

关键词：肿物活检术后病理纵隔肿物小标本报告指南肿瘤治疗方案活检标本循证医学证据

Surgical outcomes of pulmonary resection for lung cancer after neo-adjuvant treatment

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World Journal of Surgical Procedures 2016年第2期6卷 19-29页

作者： Benedetto Mungo Cheryl K Zogg Francisco Schlottmann Arianna Barbetta Craig M Hooker Daniela Molena Divisionof Thoracic Surgery Department of SurgeryJohns Hopkins University School of Medicine Thoracic Service Department of SurgeryMemorial Sloan-Kettering Cancer Center

AIM: To evaluate the outcomes of surgery for lung cancer after induction ***: Using the American college of Surgeons National Surgical Quality Improvement Program(ACSNSQIP) database(2005-2012), we identified 4063 patients who underwent a pulmonary resection for lung cancer. Two hundred and thirty-six(5.8%) received neo-adjuvant therapy prior to surgery(64 chemo-radiation, 103 radiation alone, 69 chemotherapy alone). The outcomes were compared to 3827 patients(94.2%) treated with surgery alone. Primary outcome was 30-d mortality, and secondary outcomes included length of stay, operative time and NSQIP measured postoperative ***: Lung cancer patients who received preoperative treatment were younger(66 vs 69, P cancer have worse early surgical outcomes. Although NSQIP does not provide stage information, this analysis shows important findings that should be considered when selecting patients for induction treatment.

关键词： Lung cancer Pulmonary resection Neoadjuvant therapy Surgical outcomes