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抗病毒治疗和监控以及针刺伤或性接触后早期处理的可能性

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德国医学 1998年第3期15卷 171-173页

作者： F.-D.Goebel 夏军 medizinische poliklinik der ludwig-Maxiwiliaus-universitt Pettenkoferstr.8aD-80336 MünchenGermany 同济医科大学附属同济医院

近几年来,HIV感染的治疗有了显著的改善,发病率和死亡率明显下降。在临床研究中,欧洲-澳洲的“Delta”研究和美国的“ACTG 175”研究均证实联合治疗优于单一疗法,因此现在联合治疗成为了标准疗法。某一种药物的单一疗法已被淘汰。

关键词：艾滋病突变型终生疗法病毒负荷病原体

Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis

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World Journal of Gastroenterology 2005年第44期11卷 7001-7006页

作者： Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert l(o|¨)fberg Evangelisches Krankenhaus Kalk medizinische Klinik für Hepatologie und Gastroenterologie medizinische Klinik und poliklinik Ⅱ medizinische Klinik Dep of Int Medicine IRCCS Ospedale Policlinico Istituto Clinico Humanitas Innere Medizin Karolinska Institute at the IBD unit

AIM： To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy. METHODS： An open label multicenter study was carried out in 39 patients with active ulcerative colitis （CAI 6-8） despite continuous use of steroids （a minimum total dose of 400 mg prednisone within the last 4 wk）. Patients received a total of five aphereses using a granulocyte adsorptive technique （Adacolumn, Otsuka Pharmaceutical Europe, UK）. Assessments at wk 6 and during follow-up until 4 mo comprised clinical （CAI） and endoscopic （EI） activity index, histology, quality of life （IBDQ）, and laboratory tests. RESUlTS： Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 （37.1%） patients achieved clinical remission and 10/35 （28.6%） patients had endoscopic remission （CAI〈4, EI〈4）. Quality of life （IBDQ） increased significantly （24 points, P〈0.01） at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia. CONClUSION： In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/ monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent.

关键词： Steroid Refractory colitis Ulcerative colitis Granulocyte Apheresis

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急性药物性肾小管间质性肾炎

德国医学 1999年第3期16卷 127-128页

作者： D.Schlndorff S.Segerer 冯玉锡 medizinische poliklinik Pettenkoferstr.8aD-80336 MünchenGermany 同济医科大学附属协和医院

随着应用种类繁多的药物,药物诱发的肾脏副反应也日愈增多,除较常见的肾中毒性(例如环孢酶素A和氨基甙类药物)和功能性副作用(例如非水杨酸抗风湿药、NSAR和血管紧张素转换抑制酶)外,药物对产生免疫原性间质性肾炎(AIN)起着重要作用。... 详细信息

随着应用种类繁多的药物,药物诱发的肾脏副反应也日愈增多,除较常见的肾中毒性(例如环孢酶素A和氨基甙类药物)和功能性副作用(例如非水杨酸抗风湿药、NSAR和血管紧张素转换抑制酶)外,药物对产生免疫原性间质性肾炎(AIN)起着重要作用。急性肾小管间质性肾炎组织学可见肾间质浸润、间质水肿和肾小管损伤。服用药物距离发病的问期有很大的差异,再次暴露药物可以复发,故应避免再次用药。仅根据临床诊断并不可靠,而且,因摄入多种药物可增加诊断的困难。

关键词：肾小管间质性肾炎药源性疾病

速激肽对大鼠小肠上行及下行反射通路的作用(英文)

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Acta Pharmacologica Sinica 2002年第4期23卷 3-9页

作者： Andreas HAHN, Martin STORR, Hans-Dieter AllESCHER(// medizinische Klinik und poliklinik der Technischen Universitat Munchen, 81675 Munchen, Germany) ll medizinische Klinik und poliklinik der Technischen Universitat München 81675 Mtnchen 德国 ll medizinische Klinik und poliklinik der Technischen Universitat München 81675 Mtnchen1 德国

AIM: To examine the effect of tachykinins on the ascending reflex pathway in rat small intestine, we used different selective neurokinin (NK) receptor antagonists (RA); a) NK1-RA; GR-82334 and CP-96.345, b) NK2-RA: MEN-10.376 and l-659.877. The aim was further to investigate the effect of substance P (SP) on the ascending excitatory and descending inhibitory reflex pathway. METHODS: The whole segments of rat ileum (10 cm in length) were studied in an organ bath. Ascending contraction of circle muscle was elicited by anal electrical stimulation (3 Hz, 1ms, 20 V) and measured as change of intraluminal pressure by a perfused manometric system 2 cm and 4 cm orad of the stimulation site. RESUlTS: GR-82334 and CP-96.345 (NK1-RA) caused a significant dose-related inhibition of the oral contraction at a distance of 4 cm: GR-82334 [area: -10 % ± 8 % (10 nmol/l); - 29 %±10 % (1000 nmol/l). P l/l);-14 %±10 %(10nmol/ l). P 8], whereas the contractil

关键词：速激肽类神经激肽-1受体神经激肽-2受体 P物质

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抗氧化维生素的作用确定了吗?

德国医学 1996年第2期13卷 77-78页

作者： G.Wolfram 王红 medizinische poliklinik Klinikum Innenstadt der Ludwig-Maxim ilians-UniversittPettenkoferstr.8aD-80336 MünehenGermany 同济医科大学附属同济医院

1990年德国耗费了1130多亿马克来研究癌症及动脉粥样硬化症。近年来,关于抗氧化物质在预防及治疗这些疾病方面的作用十分引人注目。疾病的原因:氧化应激反应目前,习惯上把氧化与抗氧化系统之间的失衡状态称为'氧化应激反应'。其结果为... 详细信息

1990年德国耗费了1130多亿马克来研究癌症及动脉粥样硬化症。近年来,关于抗氧化物质在预防及治疗这些疾病方面的作用十分引人注目。疾病的原因:氧化应激反应目前,习惯上把氧化与抗氧化系统之间的失衡状态称为'氧化应激反应'。其结果为触发炎症。

关键词：抗氧化维生素维生素抗氧化作用

Anti-angiogenesis in hepatocellular carcinoma treatment: Current evidence and future perspectives

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World Journal of Gastroenterology 2011年第26期17卷 3075-3081页

作者： Martin-Walter Welker Joerg Trojan medizinische Klinik 1 Klinikum der Johann Wolfgang Goethe-Universitt

Hepatocellular carcinoma(HCC) is among the most common cancer diseases *** hypervascularisation is an essential step for HCC tumorigenesis and can be targeted by transarterial chemoembolization(TACE).This interventional method is the standard treatment for patients with intermediate stage HCC,but is also applied as "bridging" therapy for patients awaiting liver transplantation in many centers *** the devascularization effect induced by TACE is transient,consequently resulting in repeated cycles of TACE every 4-8 *** documented survival benefits,TACE can also induce the up-regulation of proangiogenic and growth factors,which might contribute to accelerated progression in patients with incomplete *** 2007,sorafenib,a multi-tyrosine kinase and angiogenesis inhibitor,was approved as the first systemic treatment for advanced stage *** active targeted compounds,either inhibitors of angiogenesis and/or growth factors,are currently being investigated in numerous clinical *** overcome revascularisation or tumor progression under TACE treatment it seems therefore attractive to combine TACE with systemic targeted agents,which might theoretically block the effects of proangiogenic and growth *** the last 12 mo,several retrospec-tive or prospective cohort studies combining TACE and sorafenib have been ***,robust results of the efficacy and tolerability of such combination strategies as proven by randomized,controlled trials are awaited in the next two years.

关键词： Hepatocellular carcinoma Sorafenib Anti-angiogenesis Transarterial chemoembolization

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胆石的体外震波碎石法结果及展望

放射学实践 1988年第4期 161-163页

作者： Von M.Staritz 陈远岫 l.medizinische Klinik und poliklinik 同济医科大学附属同济医院

胆石病在十年前仅限于外科治疗,近年来已成一系列讨论的重点。目前,胆石病首先考虑用内窥镜处理,特别是对已经动过手术的或年龄超过50岁的病人。潜在的缺点是要经内窥镜作乳头切开术而发生胆管括约肌关闭不全。与手术风险相比,这一小缺... 详细信息

胆石病在十年前仅限于外科治疗,近年来已成一系列讨论的重点。目前,胆石病首先考虑用内窥镜处理,特别是对已经动过手术的或年龄超过50岁的病人。潜在的缺点是要经内窥镜作乳头切开术而发生胆管括约肌关闭不全。与手术风险相比,这一小缺点还是值得忍受的。我们可以用药物性乳头扩张(硝酸甘油)而免除这一缺点。这就可使直径约8mm以内小胆管结石在短暂的括约肌松驰下,用内窥镜取出。内

关键词：结石内窥镜工作组胆石体外震波震波碎石碎石机破碎机

运动时扩张型心肌病患者运动耐量及左心室功能变化研究

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中华超声影像学杂志 2003年第3期12卷 137-139页

作者：饶莉 Bruder Stephanie 四川大学华西医院心内科成都610041 medizinische Klinik und poliklinik Johannes-Gutenberg-Universitaet Mainz

目的　探讨运动时扩张型心肌病 (DCM)患者的左心室射血功能变化以及左心室功能改变与运动量的关系。方法　 2 8例DCM患者接受了症状限制性踏车负荷超声心动图检查 ,评价运动耐量、运动前和峰值运动量时的左心室收缩及舒张功能变化。结... 详细信息

目的　探讨运动时扩张型心肌病 (DCM)患者的左心室射血功能变化以及左心室功能改变与运动量的关系。方法　 2 8例DCM患者接受了症状限制性踏车负荷超声心动图检查 ,评价运动耐量、运动前和峰值运动量时的左心室收缩及舒张功能变化。结果　峰值运动量时所有超声心动图指标与运动前比较差异均无显著性意义。运动时心率和血压明显增高。运动前左室射血分数EF(2 7%± 7% )与最大运动量 [(92± 3 7)W ]之间无相关性 ,r =0 .2 9,P >0 .0 5 ;但峰值运动量时的EF(2 7%± 11% )与最大运动量之间具有相关性 ,r =0 .42 ,P 87± 0 .3 1)m/s]均与最大运动量呈负相关关系 ,r =-0 .42～ -0 .70 ,P <0 .0 5。结论　DCM患者可以达到一个较高水平的运动量 ,运动前的左室EF与最大运动量无明显关系。左室收缩及舒张功能在峰值运动量时与运动前比较无明显变化。

关键词：超声心动描记术运动耐受性心肌病充血性左心室功能

A Schematic Simulation for Health Economic Feasibility Studies: Results from a Model for Cardiac Remote Monitoring

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Open Journal of Modelling and Simulation 2016年第3期4卷 118-128页

作者： Christian Elsner Guiseppe Boriani Dennis Häckl Steffen Desch Holger Thiele medizinische Klinik II Universit&auml tsklinikum Schleswig-Holstein Campus Lübeck Lübeck Germany Cardiology Department University of Modena Modena Italy WIG2 Institut für Gesundheits&ouml konomie und Gesundheitssystemforschung Leipzig Germany

The market for active implants and biosensors is of high economic and medical interest. As health economic considerations get into focus in terms of business planning and reimbursement, valid and flexible economic feasibility studies get more important. Unfortunately, literature mostly provides only single economic views on specific aspects like cost savings from reduced rehabilitation in a special patient cohort. To make planning and technology value negotiation more effective and more valid, a methodology to collect relevant data from different studies and normalize it to a common set of parameters was developed for the field of cardiac monitoring in a mixed example population with an approach of simple external weight, ECG and blood-pressure measurement or implanted devices for cardiac monitoring. The target entities taken into account by the simulation model were the impacts on heart attack, stroke, heart failure and the process of implant monitoring. Simulation took place at an example population of 500 patients with specific morbidity criteria. The health economic value was calculated over a period of three years and was split into a technology effectiveness measurement in Quality-adjusted-lifetime-Years (QAlYs) and a “cost- saving-part”. QAlYs were chosen as technology effectiveness parameter for a combined and weighted mortality- and morbidity-reduction. Allocating 24.000 Euro to a saved QAlY, 42% of the cost would be allocated to QAlYs meaning money being spent for gained lifetime-years. The remaining 58% would be the different real cost savings: a per patient gross saving of 3.308 € per year would result for that part (21% on heart attack, 3% on stroke, 68% on heart failure and 8% on implant monitoring). Up-to-date studies do not provide a simple mechanism to allow custom-tailored health economic feasibility study results in terms of other specific population mixes or outcome parameters. Target audiences for the methodology of the described simulation are

关键词： Economic Feasibility Health Economics Active Implants Simulation Biosensors Technology Effectiveness