检索结果-南通市图书馆

Nicorandil potentiates sodium butyrate induced preconditioning of neurons and enhances their survival upon subsequent treatment with H_(2)O_(2)

引用

Translational Neurodegeneration 2017年第1期6卷 291-299页

作者： Parisa Tabeshmehr Haider Kh Husnain Mahin Salmannejad Mahsa Sani Seyed Mojtaba Hosseini Mohammad Hossein Khorraminejad Shirazi student Research Committee Shiraz University of Medical SciencesShirazIran Cell&Molecular Medicine student Research Group Medical FacultyShiraz University of Medical SciencesShirazIran Department of Basic Sciences SRURiyadhSaudi Arabia Stem Cell Laboratory Department of AnatomyShiraz University of Medical SciencesShirazIran

Background:Extensive loss of donor neural stem cell(NSCs)due to ischemic stress and low rate of differentiation at the site of cell graft are two of the major issues that hamper optimal outcome in NSCs transplantation *** that histone deacetylases(HDACs)modulate various cellular processes by deacetylating histones and non-histone proteins,we hypothesized that combined treatment with small molecules,sodium butyrate(NaB;a known HDAC inhibitor)and nicorandil,will enhance the rate neuronal differentiation of NSCs besides their preconditioning to resist oxidative ***:NSCs derived from 14-day old Sprague Dawley rat ganglion eminence were characterized for tri-lineage *** with 1 mM NaB significantly changed their culture characteristics while continuous treatment for 10 days enhanced their neural *** treatment also preconditioned the cells for their resistance to oxidative ***:The highest rate of neural differentiation and preconditioning effect was achieved when the NSCs were treated concomitantly with NaB and *** proliferation assay showed that concomitant treatment with NaB and nicorandil retarded their rate of ***:These data conclude that preconditioning of NSCs with NaB and nicorandil effectively enhances their differentiation capacity besides preconditioning the cells to support their survival under ischemic conditions.

关键词： Apoptosis Neural stem cells Oxidative stress Preconditioning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of the effects of Alkyl Phenolic compounds on kinetic coefficients and biomass activity in MBBR by means of respirometric techniques

引用

Chinese Journal of Chemical Engineering 2018年第4期26卷 822-829页

作者： Bijan Bina Farzaneh Mohammadi Mohammad Mehdi Amin Hamid Reza Pourzamani Zeynab Yavari Environment Research Center Research Institute for Primordial Prevention of Non-communicable Disease Isfahan University of Medical Sciences Department of Environmental Health Engineering School of Health Isfahan University of Medical Sciences student Research Committee Isfahan University of Medical Sciences

The presence of Alkyl Phenols(APs) in aquatic systems is considered as one of the environmental concerns in recent decades which are generally used as surfactants. APs are endocrine disruptors and estrogen-mimicking,causing harmful effects such as feminization and carcinogenesis on aquatic environment and human *** most commercially important APs are 4-Nonyl Phenol(4-NP) and 4-tert-OctylP henol(4-t-OP). Moving bed biofilm reactor(MBBR), which combined attached and suspended growth advantages, is an advanced biological treatment process for municipal and industrial wastewaters that has drawn considerable attention from many researchers to remove toxic pollutants from wastewater. The aim of this research was to evaluate Bacterial activities and kinetic coefficients in the presence of APs. This study was carried out using laboratory-scale MBBR fed with synthetic wastewater containing 4-NP and 4-t-OP. The reactor was operated at different loads of chemical oxygen demand(COD) and APs and different hydraulic retention time(HRT). The respirometric technique was applied to investigate the effect of APs on heterotrophic and autotrophic activity and kinetic coefficients in biomass obtained from MBBR. Respirometric technique demonstrates a reliable tool in order to assess the biofilm kinetic coefficients and biomass viability to insert in the mathematical models. The calculated kinetic parameters were in the range of conventional and extended aeration activated sludge processes. The results demonstrate that APs have significant inhibitory effects on activity and growth rate of heterotrophic and autotrophic bacteria, heterotrophs have been less affected by the presence of 4-NP and 4-t-OP, and these compounds had greater inhibitory effects on autotrophic bacteria.

关键词：呼吸运动 MBBR 生物资源烷基酚系数和技术评估混合物

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of chest CT scan findings between COVID-19 and pulmonary contusion in trauma patients based on RSNA criteria:Established novel criteria for trauma victims

引用

Chinese Journal of Traumatology 2022年第3期25卷 170-176页

作者： Hossein Abdolrahimzadeh Fard Salahaddin Mahmudi-Azer Qusay Abdulzahraa Yaqoob Golnar Sabetian Pooya Iranpour Zahra Shayan Shahram Bolandparvaz Hamid Reza Abbasi Shiva Aminnia Maryam Salimi Mohammad Mehdi Mahmoudi Shahram Paydara Roham Borazjani Ali Taheri Akerdi Masome Zare Leila Shayan Mohammadreza Sasani Trauma Research Center Shahid Rajaee(Emtiaz)Trauma HospitalShiraz University of Medical SciencesShirazIran Department of General Surgery Kufa University of Medical SciencesNajafIraq Department of Intensive Care Medicine Trauma Research CenterShahid Rajaee(Emtiaz)HospitalShiraz University of Medical SciencesShirazIran Department of Radiology Medical Imaging Research Center.School of MedicineShiraz University of Medical SciencesShirazIran Department of Biostatistics Trauma Research CenterSchool of MedicineShiraz University of Medical SciencesShirazIran student Research Committee Shiraz University of Medical SciencesShirazIran Trauma Intensive Care Unit Trauma Research CenterShahid Rajaee(Emtiaz)Trauma HospitalShiraz University of Medical SciencesShirazIran

Propose:In this study,we re-assessed the criteria defined by the radiological society of North America(RSNA)to determine novel radiological findings helping the physicians differentiating COVID-19 from pulmonary ***:All trauma patients with blunt chest wall trauma and subsequent pulmonary contusion,COVID-19-related signs and symptoms before the trauma were enrolled in this retrospective study from February to May *** patients(Group P)were then classified into two groups based on polymerase chain reaction tests(Group Pa for positive patients and Pb for negative ones).Moreover,44 patients from the prepandemic period(Group PP)were *** were matched to Group P regarding age,sex,and trauma-related *** radiologists blindly reviewed the CT images of all enrolled patients according to criteria defined by the RSNA *** radiological findings were compared between Group P and Group PP;statistically significant ones were re-evaluated between Group Pa and Group Pb ***,the sensitivity and specificity of each significant findings were *** Chi-square test was used to compare the radiologica丨findings between Group P and Group ***:In the Group PP,73.7%of all ground-glass opacities(GGOs)and 80%of all multiple bilateral GGOs were detected(p<0.001 and p=0.25,respectively).Single bilateral GGOs were only seen among the Group *** Chi-square tests showed that the prevalence of diffused GGOs,multiple unilateral GGOs,multiple consolidations,and multiple bilateral consolidations were significantly higher in the Group P(p=0.001,0.01,0.003,and 0.003,respectively).However,GGOs with irregular borders and single consolidations were more significant among the Group PP(p=0.01 and 0.003,respectively).Of note,reticular distortions and subpleural spares were exclusively detected in the Group ***:We concluded that the criteria set by RSNA for the diagnosis of COVID-19 are not appropriate in trauma ***

关键词： Chest wall CT Contusion COVID-19 RSNA criteria Trauma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Impact of the COVID-19 Pandemic on Urban Litter

引用

Biomedical and Environmental Sciences 2022年第10期35卷 954-956页

作者： Farogh Kazembeigi Parvin Ahmadinejad Mohammad Reza Aryaeefar Mehrdad Ghasemi Ghasem Hassani Giti Kashi Department of Environmental Health Engineering School of HealthIlam University of Medical SciencesIlamIran student Research Committe Ilam University of Medical SciencesIlamIran Department of Occupational Health and Safety Engineering School of HealthShiraz University of Medical SciencesShirazIran Department of Critical Care Nursing Neyshabur University of Medical SciencesNeyshaburIran Department of Environmental Engineering Faculty of EngineeringUniversity of TehranTehranIran Social Determinants of Health Research Center Yasuj University of Medical SciencesYasujIran Department of Environmental Health Engineering Faculty of HealthTehran Medical SciencesIslamic Azad UniversityTehranIran Water Purification Research Center Tehran Medical SciencesIslamic Azad UniversityTehranIran

The effect of the COVID-19 pandemic on the composition and quantity of municipal solid waste has become a serious environmental concern[1].For example,the change in the quantity of medical waste has been one of the de... 详细信息

关键词： consequences Impact demic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The occurrence,fate,and distribution of natural and synthetic hormones in different types of wastewater treatment plants in Iran

引用

Chinese Journal of Chemical Engineering 2018年第5期26卷 1132-1139页

作者： Mohammad Mehdi Amin Bijan Bina Afshin Ebrahimi Zeynab Yavari Farzaneh Mohammadi Somayeh Rahimi Environment Research Center Research Institute for Primordial Prevention of Non-communicable Disease Isfahan University of Medical Sciences Department of Environmental Health Engineering School of Health Isfahan University of Medical Sciences student Research Committee Isfahan University of Medical Sciences

Over the past few years, the presence of steroid estrogens in the environment has become a major concern. In this study, the concentrations of estrone(E1), 17β-estradiol(E2), and 17α-ethinyl estradiol(EE2) were measured in some wastewater treatment plants(WWTPs) in Iran. These samples were collected from the municipal, rural,livestock, commercial, and hospital WWTPs, extracted by dispersive liquid–liquid micro extraction(DLLME)technique, derivatized, and detected by GC/MS. In these treatment plants, various processes including conventional activated sludge(CAS), aerated lagoon(AL), moving bed biofilm reactor(MBBR), and activated sludge with wetland(AS + WL) are used. The highest concentration of hormones was observed in the influents and effluents of livestock, municipal, commercial, and hospital WWTPs, respectively. The maximum elimination rate was obtained in MBBR followed by AS + WL, CAS and AL. The biodegradation and adsorption rates along with adsorption coefficients of lg kdand lg kocwere measured for all target compounds.

关键词：废水处理荷尔蒙植物自然类型伊朗合成分发

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differentiation of Wharton's jelly mesenchymal stem cells into neurons in alginate scaffold

引用

Neural Regeneration Research 2015年第8期10卷 1312-1316页

作者： Seyed Mojtaba Hosseini Attiyeh Vasaghi Newsha Nakhlparvar Reza Roshanravan Tahereh Talaei-khozani Zahra Razi student Research Committee Shiraz University of Medical Sciences Cell and Molecular Medicine student Research Group Medical School Shiraz University of Medical Sciences Stem Cell Laboratory Department of Anatomy Shiraz University of Medical Sciences Colorectal Research Center Department of Surgery Shiraz University of Medical Science Tissue Engineering Laboratory Department of Tissue Engineering School of Advanced Medical Science and Technology Shiraz University of Medical Sciences Laboratory for Stem Cell Research Department of Anatomy Medical School Shiraz University of Medical Sciences Department of medical Physics Shiraz University of Medical Sciences

Alginate scaffold has been considered as an appropriate biomaterial for promoting the differentiation of embryonic stem cells toward neuronal cell lineage. We hypothesized that alginate scaffold is suitable for culturing Wharton’s jelly mesenchymal stem cells（WJMSCs） and can promote the differentiation of WJMSCs into neuron-like cells. In this study, we cultured WJMSCs in a three-dimensional scaffold fabricated by 0.25% alginate and 50 m M Ca Cl2 in the presence of neurogenic medium containing 10 μM retinoic acid and 20 ng/m L basic fibroblast growth factor. These cells were also cultured in conventional two-dimensional culture condition in the presence of neurogenic medium as controls. After 10 days, immunofluorescence staining was performed for detecting β-tubulin（marker for WJMSCs-differentiated neuron） and CD271（motor neuron marker）. β-Tubulin and CD271 expression levels were significantly greater in the WJMSCs cultured in the three-dimensional alginate scaffold than in the conventional two-dimensional culture condition. These findings suggest that three-dimensional alginate scaffold cell culture system can induce neuronal differentiation of WJMSCs effectively.

关键词： nerve regeneration Wharton’s jelly mesenchymal stem cells mesenchymal stem cells neurons motor neurons alginate 3D scaffold neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Could school programs based on social-emotional learning prevent substance abuse among adolescents?

引用

World Journal of Psychiatry 2024年第8期14卷 1143-1147页

作者： João Mauricio Castaldelli-Maia Nicolas Kohatsu Matakas Department of Neuroscience Medical SchoolFMABC University CenterSão Paulo 09060870SPBrazil Department of Substance Use Disorders Perdizes Institute-HCFMUSPSao Paulo 05021001SPBrazil

In this editorial,we comment on the article Adolescent suicide risk factors and the integration of social-emotional skills in school-based prevention programs by Liu et *** the article focused on the issue of suicide and social-emotional learning programs as a possible intervention,we here discuss evidence of other reported outcomes and if it could be an effective way to prevent substance abuse among adolescents.

关键词： Social-emotional learning Substance use Adolescent student Prevention Mental health

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The feasible application ofmicrofluidic tissue/organ-on-a-chip as an impersonator of oral tissues and organs:a direction for future research

引用

Bio-Design and Manufacturing 2023年第4期6卷 478-506页

作者： Nima Farshidfar Sahar Assar Mohammad Amin Amiri Sarina Sahmeddini Shahram Hamedani Moein Zarei Lobat Tayebi Orthodontic Research Center School of DentistryShiraz University of Medical SciencesShirazIran Section for Oral Ecology and Caries Control Department of Dentistry and Oral HealthAarhus UniversityAarhusDenmark student Research Committee Shiraz University of Medical SciencesShirazIran Oral and Dental Disease Research Center School of DentistryShiraz University of Medical SciencesShirazIran Department of Polymer and Biomaterials Science Faculty of Chemical Technology and EngineeringWest Pomeranian University of TechnologySzczecinAl.Piastow 4571-311 SzczecinPoland Marquette University School of Dentistry MilwaukeeWI 53233USA

Currently,cell culture models play a key role in determining cell behavior under various ***,the accurate simulation of cellular behavior that imitates the body’s conditions remains a ***,to overcome this obstacle,three-dimensional cell culture models have been *** tissues/organs-on-chips(TOOCs)are new devices that have provided the opportunity to culture cells in a medium that is almost similar to the physiological conditions of the *** can be designed in simple or complex models,which are mostly fabricated by soft *** novel structures have been developed to mimic the conditions of various tissues and organs;however,microfluidic models for oral and dental tissues have not yet been widely *** application of TOOCs for oral tissues/organs can provide the opportunity to study cell interactions with biomaterials used in ***,TOOCs can provide the opportunity to study the cellular interactions and developmental stages of oral tissues/organs more *** review of the current advances in the field of TOOC development for oral tissues provides a comprehensive understanding of this burgeoning concept,shows the progress and applications of these novel models in the imitation of oral tissues/organs thus far,and reveals the limitations that TOOCs ***,it suggests further perspectives for future applications.

关键词： Microfluidics Tissue-on-a-chip Organ-on-a-chip Tooth-on-a-chip Oral mucosa-on-a-chip Salivary gland-on-a-chip

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biodegradation of natural and synthetic estrogens in moving bed bioreactor

引用

Chinese Journal of Chemical Engineering 2018年第2期26卷 393-399页

作者： Mohammad Mehdi Amin Bijan Bina Karim Ebrahim Zeynab Yavari Farzaneh Mohammadi Environment Research Center Research Institute for Primordial Prevention of Non-communicable Disease Isfahan University of Medical Sciences Department of Environmental Health Engineering School of Health Isfahan University of Medical Sciences student Research Committee Isfahan University of Medical Sciences

Estrogen hormones as a group of endocrine disruptive compounds(EDC) can interfere with endocrine system in humans and animals. The goal of this study was to investigate the elimination rate of Estrone(El), 17β-estradiol(E2) and 17α-ethinyl estradiol(EE2) in Moving Bed Bioreactor(MBBR). These analytes extracted by Dispersive Liquid-Liquid Microextraction(DLLME) technique, followed by derivatization, and detected by GC/MS. Estrogen removal efficiency in MBBR improved at high solid retention times(SRTs), which notion is owing to development of nitrification. Estrogen specific removal rate was between 0.22-1.45 μg·(g VSS)^(-1)·d^(-1) for natural and synthetic hormones. The adsorption rate was 0.9%-3.2%, 0-1.3%, and 0.7%-5.7% for El, E2, and EE2, respectively. In addition, the biodegradation rates were more than 95% for these compounds. These results illustrated that in MBBR,the biodegradation and the adsorption to biomass are considered as two significant routes for elimination of estrogenic compounds. As a whole, the deterioration rate of estrogens enhanced by MBBR compared to other biological wastewater treatment processes such as conventional activated sludge.

关键词：生物反应器雌激素自然合成 MBBR GC/MS 水处理过程混合物

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mortality and Morbidity among COVID-19-Associated Mucormycosis Patients in Iran: A Prospective Cohort Study

引用

Advances in Infectious Diseases 2023年第3期13卷 407-423页

作者： Somayeh Dolatabadi Mehdi Bakhshaee Masoumeh Hosseinpoor Ali Alizadeh Noghani Mohammadreza Afzalzadeh Imaneh Roshanzamir Bashir Rasoulian Zahra Eslami Mohammadie Alireza Ghodsi Nazanin Forghani Parisa Arjmand Zahra Valipour Nima Ameli Department of Biology Hakim Sabzevari University Sabzevar Iran Sinus and Surgical Endoscopic Research Center Mashhad University of Medical Sciences Mashhad Iran student Research Committee Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran student Research Committee Faculty of Paramedical Sciences Mashhad University of Medical Sciences Mashhad Iran Department of Otolaryngology Mashhad University of Medical Sciences Mashhad Iran

Background: The key contribution of this paper is from investigating the mortality and morbidity rates and related factors associated with COVID-19-associated-mucormycosis among Iranian patients. The existing literature is scarce on this topic, particularly in the context of Iran. The present study investigates mortality and morbidity among 62 confirmed COVID-19-associated-mucormycosis Iranian patients in relation to their demographic characteristics, laboratory test results, predisposing factors, and COVID-related factors. Material and Methods: In this prospective cohort study, the patients were identified in the fifth wave of the disease, between 1st August and 15th October 2021, with data collected at baseline with a three-week follow-up. This was a multicenter investigation with patients admitted to two clinics in Iran. 62 participants were admitted, with the key criteria of them being COVID-19-associated-mucormycosis patients. 53 out of 60 patients underwent corticosteroid therapy and debridement surgery. Intravenous remdesivir (200 mg/ kg/day at day 1, 100 mg/kg/day in following days for up to 5 days) and corticosteroids were administered for 53 out 54 patients. Oxygen therapy was only needed for 30% (n = 19) of the patients. Results: A 40% mortality rate was observed within the three-week follow-up, with deaths concentrated among those with controlled diabetes mellitus (61%) and long-term diabetes mellitus patients (an average of eight versus four years). Higher mortality was also observed in patients with higher leucocytes and those with rhino-orbital-cerebral (59%), followed by nasal (55.6%) mucormycosis. Among survivors, 32% were reinfected, and 56% suffered from loss of vision. Conclusion: The study concludes that mucormycosis is associated with a higher mortality rate among COVID-19 patients with diabetes mellitus, particularly corticosteroid recipients. Thus, urgent attention to this coinfection is warranted in Iran.

关键词： Mucorales COVID-19 Mucormycosis Coinfection Dexamethasone Diabetes Mellitus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：