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Massive low-grade myxoid liposarcoma of the floor of the mouth:A case report and review of literature

World Journal of Clinical Cases 2022年第34期10卷 12742-12749页

作者： Takuma Kugimoto Yuko Yamagata Toshimitsu Ohsako Hideaki Hirai Naoto Nishii Kou Kayamori Tohru Ikeda Hiroyuki Harada Department of Oral and Maxillofacial Surgical Oncology Division of Oral Health ScienceGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8549TokyoJapan Department of Oral Pathology Division of Oral Health ScienceGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8549TokyoJapan

BACKGROUND Oral liposarcoma is an extremely rare lesion that is often clinically misdiagnosed as a benign tumor due to its asymptomatic and indolent clinical ***,we report a case of massive low-grade myxoid liposarcoma(MLS)of the floor of the *** SUMMARY A 71-year-old man presented with a huge mass in the left floor of the mouth.A biopsy was performed,and a diagnosis of a myxoid tumor suspicious for lowgrade MLS or myxoma was ***-enhanced T1-weighted magnetic resonance imaging showed an intensely enhanced tumor lesion that occupies the left sublingual space and extends to the submandibular *** dissection,tumor resection,and reconstruction with a radial forearm flap were *** surgical specimen exhibited histologically low-grade *** in sarcoma(FUS,also known as TLS)and DNA damage-inducible transcript 3(DDIT3,also known as CHOP)break-apart was not detected in the fluorescence in situ hybridization *** tumor was completely encapsulated and did not require additional ***,no recurrence was reported 40 mo after *** We experienced an extremely rare,massive,low-grade MLS emerging from the floor of the ***,an MLS of the floor of the mouth lacks significant clinical findings and is often *** no FUS-DDIT3 fusion gene was detected,a low-grade MLS was ultimately diagnosed based on the histological findings.

关键词： Myxoid liposarcoma Floor of mouth Surgery Fluorescence in situ hybridization Sublingual space Case report

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Oral granuloma in a pediatric patient with chronic graft-versus-host disease:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5663-5669页

作者： Atsushi Uesugi Fumihiko Tsushima Makoto Kodama Takeshi Kuroshima Jinkyo Sakurai Hiroyuki Harada Oral and Maxillofacial Surgery Tokyo Medical and Dental UniversityTokyo 113-8549Japan Human Pathology Tokyo Medical and Dental UniversityTokyo 113-8510Japan

BACKGROUND Oral mucositis is often observed with graft-versus-host disease(GVHD);however,the occurrence of oral granuloma is *** rapid increase in granulomatous lesions should be distinguished from malignant tumors in patients with GVHD because malignant diseases can develop in those *** case is the youngest pediatric patient with granuloma associated with *** SUMMARY The patient was a 1-year and 5-mo-old girl who presented to our department for the management of oral *** the age of 5 mo,she was diagnosed with primary immunodeficiency disease,cord blood transplant was performed at 11 mo and bone marrow transplant at 1 year of *** transplantation,GVHD and oral mucositis developed,and tacrolimus was ***,nodules appeared on the lower lip and buccal mucosa,which spontaneously ***,a new nodule appeared on the left lateral border of the *** was performed and the histopathological diagnosis was *** origin of these nodules were considered to be the fibroblasts activated under inflammation caused by GVHD because the calcineurin inhibitor tacrolimus acted on their *** It is very important to distinguish oral granulomatous lesions from malignancies if GVHD is present at the base and if immunosuppressive agents and steroids are being administered.

关键词： Oral granuloma Graft-versus-host disease Bone marrow transplantation Primary immunodeficiency disease Tacrolimus Case report

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Impact of continuous positive airway pressure therapy for nonalcoholic fatty liver disease in patients with obstructive sleep apnea

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World Journal of Clinical Cases 2021年第19期9卷 5112-5125页

作者： Haruka Hirono Kazuhiko Watanabe Katsuhiko Hasegawa Masaki Kohno Shuji Terai Shogo Ohkoshi Department of Internal Medicine The Nippon Dental University School of Life Dentistry at NiigataNiigata 951-8580Japan The center for dental Sleep Medicine The Nippon Dental University Niigata HospitalNiigata 951-8580Japan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan

BACKGROUND Obstructive sleep apnea(OSA)has been suggested as an independent risk factor for nonalcoholic fatty liver disease(NAFLD),and continuous positive airway pressure(CPAP)is the first-line therapy for *** To clarify the efficacy of effective CPAP therapy on NAFLD of OSA patients by serum markers and transient elastography(TE)using FibroScan®(Echosens,Paris,France).METHODS We prospectively enrolled 123 consecutive patients with OSA who met the indications for *** fibrosis and steatosis were assessed using *** and after 6 mo of CPAP therapy,serum markers and TE were assessed for all *** mean usage rate of CPAP therapy for 6 mo was arbitrarily calculated in each patient and expressed as“mean compliance index”(m-CI).RESULTS In 50 OSA patients with NAFLD,both aspartate aminotransferase(AST)and alanine aminotransferase(ALT)levels were significantly decreased after 6 mo of CPAP *** analysis showed that decreased body weight(BW),decreased body mass index(BMI),decreased AST level,decreased hemoglobin A1c,and high m-CI were significantly related with improved ALT *** multivariate regression model adjusted for quantities of BW change during 6 mo of CPAP therapy,high m-CI tended to improve ALT level(P=0.051).All 17 OSA patients with NAFLD,high m-CI and no BMI changes showed significant improvements in AST and ALT ***,no significant changes in TE data or serum fibrosis markers were *** Some NAFLD could be associated with chronic intermittent hypoxia due to OSA independent of BW *** those cases,adequate reoxygenation from effective CPAP therapy may improve NAFLD.

关键词： Nonalcoholic fatty liver disease Obstructive sleep apnea Continuous positive airway pressure Chronic intermittent hypoxia Transient elastography

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VPS4B mutation impairs the osteogenic differentiation of dental follicle cells derived from a patient with dentin dysplasia type I

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International Journal of Oral Science 2020年第3期12卷 220-226页

作者： Qiang Li Fangli Lu Tianxuan Chen Ke Zhang Yuping Lu Xiaocong Li Yingying Wang Ling Liu Qing Tian Fu Xiong Dong Chen Department of Stomatology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina The Academy of medical Sciences Zhengzhou UniversityZhengzhouChina Department of Stomatology Henan Provincial HospitalZhengzhouChina Implant dental Clinic ZhengzhouChina Department of Stomatology Puyang People’s HospitalPuyangChina Department of medical Genetics School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina

A splicing mutation in VPS4B can cause dentin dysplasia type I(DD-I),a hereditary autosomal-dominant disorder characterized by rootless teeth,the etiology of which is genetically *** our study,dental follicle cells(DFCs)were isolated and cultured from a patient with DD-I and compared with those from an age-matched,healthy *** a previous study,this DD-I patient was confirmed to have a loss-of-function splicing mutation in VPS4B(IVS7+46C>G).The results from this study showed that the isolated DFCs were vimentin-positive and CK14-negative,indicating that the isolated cells were derived from the *** harboring the VPS4B mutation had a significantly higher proliferation rate from day 3 to day 8 than control DFCs,indicating that VPS4B is involved in cell *** cells were then replenished with osteogenic medium to investigate how the VPS4B mutation affected osteogenic *** of osteogenesis,detected by alizarin red and alkaline phosphatase staining in vitro,was decreased in the DFCs from the DD-I patient compared to the control ***,we also found that the VPS4B mutation in the DD-I patient downregulated the expression of osteoblast-related genes,such as ALP,BSP,OCN,RUNX2,and their encoded *** outcomes confirmed that the DD-I-associated VPS4B mutation could decrease the capacity of DFCs to differentiate during the mineralization process and may also impair physiological root formation and bone *** might provide valuable insights and implications for exploring the pathological mechanisms underlying DD-I root development.

关键词： patient dysplasia matched

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Surface modification strategies to reinforce the soft tissue seal at transmucosal region of dental implants

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Bioactive Materials 2024年第12期42卷 404-432页

作者： Siqi Jin Yameng Yu Ting Zhang Daping Xie Yufeng Zheng Chunming Wang Yunsong Liu Dandan Xia Department of dental Materials Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&NHC Key Laboratory of Digital Stomatology&NMPA Key Laboratory for Dental MaterialsBeijing100081China School of Materials Science and Engineering Peking UniversityBeijing100871China State Key Laboratory in Quality Research of Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR999078China Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing100081China International Research Organization for Advanced Science and Technology(IROAST) Kumamoto University2-39-2 Kumamoto860-8555Japan

Soft tissue seal around the transmucosal region of dental implants is crucial for shielding oral bacterial invasion and guaranteeing the long-term functioning of *** with the robust periodontal tissue barrier around a natural tooth,the peri-implant mucosa presents a lower bonding efficiency to the transmucosal region of dental implants,due to physiological structural *** such,the weaker soft tissue seal around the transmucosal region can be easily broken by oral pathogens,which may stimulate serious inflammatory responses and lead to the development of peri-implant *** timely treatment,the curable peri-implant mucositis would evolve into irreversible peri-implantitis,finally causing the failure of ***,this review has summarized current surface modification strategies for the transmucosal region of dental implants with improved soft tissue bonding capacities(e.g.,improving surface wettability,fabricating micro/nano topographies,altering the surface chemical composition and constructing bioactive coatings).Furthermore,the surfaces with advanced soft tissue bonding abilities can be incorporated with antibacterial properties to prevent infections,and/or with immunomodulatory designs to facilitate the establishment of soft tissue ***,we proposed future research orientations for developing multifunctional surfaces,thus establishing a firm soft tissue seal at the transmucosal region and achieving the long-term predictability of dental implants.

关键词： Surface modifications dental implant transmucosal region Soft tissue seal Antibacterial Immunomodulation

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dental anomalies in first-degree relatives of transposed canine probands

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International Journal of Oral Science 2015年第3期7卷 169-173页

作者： Adriana Bartolo Neville Calleja Fraser McDonald Simon Camilleri Broadstreet dental Centre Department of Public Health Medical School University of Malta dental Institute Department of Orthodontics Kings College London

The aim of this study was to investigate and compare the inheritance pattern and prevalence of inheritable dental anomalies in a sample of patients with maxillary canine—first premolar transposition and their first-degree relatives with a sample of palatally displaced canine families. Thirty-five consecutive maxillary canine—first premolar transposition probands and 111 first-degree relatives were matched to 35 consecutive palatally displaced canine probands and 115 first-degree relatives. These were assessed for palatally displaced canines and incisor-premolar hypodontia. Parental age at birth of the proband was also noted. The results revealed that（i） there is no difference in the overall prevalence of palatally displaced canine or incisor-premolar hypodontia between the groups of relatives;（ii） first-degree relatives of bilateral palatally displaced canine probands have a higher prevalence of palatally displaced canine and incisor-premolar hypodontia than those with unilateral palatally displaced canine; and（iii） maternal age at birth of the maxillary canine—first premolar transposition probands was significantly higher than that of the palatally displaced canine *** results suggest that maxillary canine—first premolar transposition and palatally displaced canine are unlikely to be different genetic entities and also indicate environmental or epigenetic influences on dental development.

关键词： ectopic epigenomics genetics hypodontia orthodontics tooth eruption

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The recent advances in scaffolds for integrated periodontal regeneration

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Bioactive Materials 2021年第10期6卷 3328-3342页

作者： Hyun Nyun Woo Young Joon Cho Solaiman Tarafder Chang H.Lee center for dental and Craniofacial Research Columbia University Medical Center630 W.168 St.VC12-212New YorkNY10032USA

The periodontium is an integrated,functional unit of multiple tissues surrounding and supporting the tooth,including but not limited to cementum(CM),periodontal ligament(PDL)and alveolar bone(AB).Periodontal tissues can be destructed by chronic periodontal disease,which can lead to tooth *** support of the treatment for periodontally diseased tooth,various biomaterials have been applied starting as a contact inhibition membrane in the guided tissue regeneration(GTR)that is the current gold standard in dental ***,various biomaterials have been prepared in a form of tissue engineering scaffold to facilitate the regeneration of damaged periodontal *** a physical substrate to support healing of a single type of periodontal tissue to multi-phase/bioactive scaffold system to guide an integrated regeneration of periodontium,technologies for scaffold fabrication have emerged in last *** review covers the recent advancements in development of scaffolds designed for periodontal tissue regeneration and their efficacy tested in vitro and in *** and Cons of different biomaterials and design parameters implemented for periodontal tissue regeneration are also discussed,including future perspectives.

关键词： Periodontium Periodontitis Bioactive scaffold Multi-phase scaffold Periodontal regeneration

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A new approach to transfect NF-κB decoy oligodeoxynucleotides into the periodontal tissue using the ultrasound-microbubble method

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International Journal of Oral Science 2017年第2期9卷 80-86页

作者： Hiroyuki Yamaguchi Yuji Ishida Jun Hosomichi Jun-ichi Suzuki Risa Usumi-Fujita Yasuhiro Shimizu Sawa Kaneko Takashi Ono Department of Orthodontic Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Advanced Clinical Science and Therapeutics Graduate School of MedicineThe University of TokyoTokyoJapan

The objective of this study is to investigate the effect of the ultrasound-microbubble technique in nuclear factor kappa B(NF-κB) decoy oligodeoxynucleotide(ODN) transfection in the gingival tissue in mice. The 6-FAM-labeled scrambled decoy ODN with microbubbles was applied to the periodontal tissue in 8-week-old male C57BL/6J mice by ultrasound radiation at low(LUM-Sc) and high(HUM-Sc) intensities to optimize the transfection condition of the ultrasound-microbubble *** inspections were performed two hours after transfection to compare the expression with that in the sham-operated group without ultrasound radiation(A-Sc). Then, an NF-κB decoy was transfected into the periodontal tissue using the highintensity ultrasound-microbubble(HUM-NF) technique to examine the anti-inflammatory effects of the decoy ODN. Western blot analysis was performed to investigate the expression of interleukin(IL)-1β, IL-6 and intercellular adhesion molecule-1(ICAM-1)in the gingival tissues in the HUM-Sc, the HUM-NF and control groups. The fluorescence microscopy results showed that the fluorescent intensity in the periodontal tissues in the LUM-Sc and HUM-Sc groups was significantly higher than that in the A-Sc and the control groups. The fluorescent intensity in the HUM-Sc group, especially in the gingival connective tissue,was the highest of all groups. Western blot analysis indicated that the protein expression levels of IL-1β, IL-6 and ICAM-1 in the HUM-NF group were significantly lower than those in the HUM-Sc and the control groups. These findings suggest that the high-intensity ultrasound-microbubble technique is an effective tool for decoy transfection into the periodontal tissue.

关键词： decoy oligodeoxynucleotide gene therapy periodontal tissue ultrasound

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Influence of surface roughness on the color of dental-resin composites

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第7期12卷 552-562页

作者： Razvan GHINEA Laura UGARTE-ALVAN Ana YEBRA Oscar E.PECHO Rade D.PARAVINA Maria del Mar PEREZ Department of Optics Faculty of ScienceUniversity of Granada Department of Stomatology Faculty of OdontologyUniversity of Granada Houston center for Biomaterials and Biomimetics & Department of Restorative Dentistry and Biomaterials University of Texas Dental Branch at Houston

This study deals with the influence of surface roughness on the color of resin *** resin composites (microfilled,hybrid,and microhybrid) were each polished with 500-grit,1 200-grit,2 000-grit,and 4 000-grit SiC *** roughness parameter (Ra) was measured using a Plμ confocal microscope,and field-emission scanning electron microscope (Fe-SEM) images were used to investigate filler *** was measured using a spectroradiometer and a D65 standard illuminant (geometry diffuse/0° specular component excluded (SCE) mode).Surface roughness decreased with grit number and was not influenced by filler size or size distribution.A significant influence of Ra on lightness (L*) was *** increased with decreases in roughness,except for specimens that underwent polishing procedure 4 (PP4;500-grit,1 200-grit,2 000-grit,and 4 000-grit SiC papers consecutively).Generally,it was found that surface roughness influenced the color of resin *** composites that underwent PP1 (500-grit SiC paper) exhibited significant differences in chroma (C*),hue (h°),and lightness (L*) compared to composites that underwent PP3 (500-grit,1 200-grit,and 2 000-grit SiC papers consecutively) and *** difference (E*) between the polishing procedures was within acceptability thresholds in dentistry.

关键词： Color measurement dental resin composites Roughness

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Stem cell-based bone and dental regeneration: a view of microenvironmental modulation

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International Journal of Oral Science 2019年第3期11卷 161-175页

作者： Chenxi Zheng Ji Chen Shiyu Liu Yan Jin State Key Laboratory of Military Stomatology & National Clinical Research center for Oral Diseases & Shaanxi International Joint Research center for Oral Diseases Center for Tissue Engineering School of Stomatology The Fourth Military Medical University

In modern medicine,bone and dental loss and defects are common and widespread morbidities,for which regenerative therapy has shown great *** stem cells,obtained from various sources and playing an essential role in organ development and postnatal repair,have exhibited enormous potential for regenerating bone and dental ***,mesenchymal stem cells (MSCs)-based bone and dental regeneration mainly includes two strategies: the rescue or mobilization of endogenous MSCs and the application of exogenous MSCs in cytotherapy or tissue ***,the efficacy of MSCbased regeneration is not always fulfilled,especially in diseased ***,the diseased microenvironment not only impairs the regenerative potential of resident MSCs but also controls the therapeutic efficacy of exogenous MSCs,both as donors and ***,approaches targeting a diseased microenvironment have been established,including improving the diseased niche to restore endogenous MSCs,enhancing MSC resistance to a diseased microenvironment and renormalizing the microenvironment to guarantee MSC-mediated ***,the application of extracellular vesicles (EVs) as cell-free therapy has emerged as a promising therapeutic *** this review,we summarize current knowledge regarding the tactics of MSC-based bone and dental regeneration and the decisive role of the microenvironment,emphasizing the therapeutic potential of microenvironment-targeting strategies in bone and dental regenerative medicine.

关键词： stem cells cytotherapy microenvironment

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