检索结果-南通市图书馆

Ramucirumab as a second-line treatment for hepatocellular carcinoma: reaching out further to patients with elevated alpha-fetoprotein

引用

Hepatobiliary Surgery and Nutrition 2019年第5期8卷 515-518页

作者： Edoardo G.Giannini Franco Trevisani Gastroenterology unit Department of Internal MedicineOspedale Policlinico San Martino IRCCS per l’OncologiaUniversity of GenoaGenoaItaly medical semeiotics unit Sant’Orsola HospitalAlma Mater Studiorum University of BolognaBolognaItaly

Hepatocellular carcinoma(HCC)occurs at a rate of 3-5%per year in patients with compensated cirrhosis,and itoften represents the first disease complication and themain cause of death in these patients(1).Surveillance forHCC is recommended by all liver disease associations,as it increases patient survival mainly as a result of earlydiagnosis of the tumour,allowing most patients to conveyto curative treatments(2,3).

关键词： diagnosis treatment curative death

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease

引用

World Journal of Gastroenterology 2019年第4期25卷 509-520页

作者： Marco Biolato Fiorella Manca Giuseppe Marrone Consuelo Cefalo Simona Racco Giacinto A Miggiano Venanzio Valenza Antonio Gasbarrini Luca Miele Antonio Grieco Department of Gastroenterological Endocrine-Metabolic and Nefro-Urological Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS Institute of Special medical Pathology and medical semeiotics Università Cattolica del Sacro Cuore Institute of Internal Medicine and Geriatrics Università Cattolica del Sacro Cuore Department of Image Diagnostics Oncological Radiotherapy and Hematology Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS Nuclear Medicine Institute Università Cattolica del Sacro Cuore

BACKGROUND In non-alcoholic fatty liver disease(NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver *** hypothesize that, diet could be able to modulate intestinal permeability in patients with *** To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat *** The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing(51 CrEDTA).RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index(BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight(-5.3 ± 4.1 kg,P = 0.003), mean waist circumference(-7.9 ± 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase(ALT)-28.3 ± 11.9 IU/L, P =0.0001; aspartate aminotransferase(AST)-6.4 ± 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline(mean percentage retention of51 Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat *** Mediterranean diet is an effective strategy for treating overweight, visceral obesit

关键词： Liver steatosis Gut-liver axis Nutrition Personalized medicine Visceral obesity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：