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Higher ambient temperatures may worsen obstructive sleep apnea:A nationwide smartwatch-based analysis of 6.2 million person-days

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Science Bulletin 2024年第13期69卷 2114-2121页

作者： Anni Li Qingli Zhang Yuan Yao Xinlei Zhu Cong Liu Yutao Guo Haidong Kan Renjie Chen school of Public health Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology AssessmentFudan UniversityShanghai 200032China Ministry of Education-Shanghai Key Laboratory of Children’s Environmental health Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Pulmonary Vessel and Thrombotic Disease Sixth Medical CenterChinese PLA General HospitalBeijing 100048China Institute for Hospital Management Research Chinese PLA General HospitalBeijing 100048China Children’s Hospital of Fudan University National Children’s Medical CenterShanghai 201102China school of Public health Hengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Obstructive sleep apnea(OSA)is a serious type of sleep disorder that can lead to cardiometabolic and neurocognitive *** utilized smart device-based photoplethysmography technology to collect sleep data from the Chinese population from 2019 to *** lag nonlinear models combined with a generalized nonlinear model or a linear mixed effects model were used to investigate the shortterm associations between daily temperature and indicators of OSA *** included a total of 6,232,056 d of sleep monitoring data from 51,842 participants with moderate to severe risk of OSA from 313 Chinese *** relationships between ambient temperature and OSA exacerbation,apneahypopnea index(AHI),and minimum oxygen saturation(MinSpO_(2))were almost linear and present only on the same *** temperatures were associated with a greater risk of OSA exacerbation,with an 8.4%(95%confidence interval(CI):7.6%–9.3%)increase per 10℃increase in temperature.A 10℃increase in daily temperature corresponded to an AHI increase of 0.70 events/h(95%CI:0.65–0.76)and a MinSpO_(2)decrease of 0.18%(95%CI:0.16%–0.19%).Exposure to elevated temperatures during the night can also lead to adverse *** effects of higher temperatures on OSA severity were stronger among men,participants with a body mass index24 kg/m2,those aged 45 years and older,individuals with a history of hypertension and diabetes,and during the cold *** large-scale,nationwide,longitudinal study provides robust evidence suggesting that higher ambient temperatures may immediately worsen OSA.

关键词： Obstructive sleep apnea Temperature Apnea-hypopnea index Oxygen saturation Smart device

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Targeted therapeutic effects of oral magnetically driven pectin nanoparticles containing chlorogenic acid on colon cancer

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Particuology 2024年第1期84卷 53-59页

作者： Huatai Zhu Limei Zhang Fujia Kou Jingyang Zhao Jiandu Lei Jing He Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China Institute of Biopharmaceutical and health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China

Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent ***,the unique and complex structure of the gastrointestinal tract is still an obstacle to the safe delivery of drugs targeting sites in colon ***,we designed magnetically driven dual-targeted oral colonic nanoparticles loaded with chlorogenic acid using pectin and oleic acid-modified iron oxide(Fe3O4@OA).Specific degradation of pectin by pectinase produced by colonic flora and magnetic fields applied to the colon confers specific targeting of nanoparticles to the *** order to overcome the challenge of preparing magnetically driven nanoparticles with small and homogeneous particle sizes by a single conventional method,we developed the combined ultrasound-emulsification *** average particle size of the prepared nanoparticles was 81.04±1.02 nm,which showed good drug release in the simulated colonic *** vitro anticancer studies,the drug-loaded nanoparticles possess an obvious toxicity and apoptosis-inducing ability against cancer ***,the hemolysis results demonstrated the safety of the nanoplatform(PET/CGA/Fe_(3)O_(4)@OA).This work holds broad prospects as a new treatment modality for colon cancer.

关键词： Pectin Chlorogenic acid Ultrasound-emulsion Magnetically driven Colon cancer Colon targeted

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Rational design of hydroxytricyanopyrrole-based probes with high affinity and rapid visualization for amyloid-β aggregates in vitro and in vivo

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Chinese Chemical Letters 2024年第5期35卷 290-295页

作者： Jiajia Lv Jie Gao Hongyu Li Zeli Yuan Nan Dong school of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China school of Pharmacy Zunyi Medical UniversityZunyi 563003China Guizhou international Scientific and Technological Cooperation Base for medical Photo-Theranostics Technology and Innovative Drug Development Zunyi 563003China

As key biomarkers,amyloid-β(Aβ)plaques are frequently used to diagnose Alzheimer’s disease(AD).Although fluorescence imaging has proven to be effective in detecting these plaques,the gold standard probe thioflavin T(ThT),used for Aβaggregates,cannot be applied in vivo owing to its invasive ***,the development of novel fluorescent probes capable of identifying Aβplaques in situ is *** on the ThT structure,twoπ-conjugated heterocyclic D-π-A probes were designed bearing the hydroxytricyanopyrrole acceptor and N,N-dimethylaminophenyl *** probes exhibited red to near-infrared fluorescence emission(λ_(max)=732 nm),large Stokes shifts(>100 nm),exceptional signal-to-noise ratio,rapid response(<30 s),and high binding affinity(NT-HTCP=33.32 nmol/L;NF-HTCP=53.35 nmol/L)for Aβ*** the best candidate,NT-HTCP was used for in situ imaging of Aβplaques in AD mouse ***,in vivo research demonstrated that NT-HTCP could cross the blood-brain barrier and continue imaging the Aβplaques with a good signal-to-noise ***,the outcomes of the docking computations helped guide the development of the Aβ*** study expands the family of N,N-dimethylaminophenyl-based Aβ-sensitive fluorophores,with NTHTCP emerging as a highly promising imaging agent.

关键词： Amyloid-β Fluorescent probe Hydroxytricyanopyrrole Fluorescence imaging Alzheimer’s disease

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Advanced nano drug delivery systems for neuroprotection against ischemic stroke

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Chinese Chemical Letters 2024年第2期35卷 151-162页

作者： Chenchen Xie Jun Liao Ning Zhang Yuhan Sun Yi Li Liyan Xiong Yingnan Zhang Xiaoyan Liu Wei Su Heming Chen Ping Zeng Xiaoqing Zhang Ying Lu Tingfang Wang Chuan Zhang Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai 200444China Department of Pharmaceutical Science School of PharmacyNaval Medical UniversityShanghai 200433China Department of pharmacy the International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China school of Pharmacy Shanghai Jiao Tong UniversityShanghai 200040China

Ischemic stroke(IS)represents a significant threat to brain health due to its elevated mortality and disability *** efficacy of small-molecule neuroprotective agents has been impeded by challenges associated with traversing the blood-brain barrier(BBB)and limited ***,advanced nano drug delivery systems hold promise for overcoming these obstacles by facilitating efficient transportation across the BBB and maintaining optimal drug *** review aims to explore advanced neuroprotective nano drug delivery systems as a means of effectively administering neuroprotective agents to the brain using pharmaceutical approaches in the treatment of *** examining these systems,researchers and clinicians can gain valuable insights and innovative concepts,illuminating the potential of advanced neuroprotective nano drug delivery *** these advancements can drive the progress of pioneering and efficacious therapeutic interventions for IS.

关键词： Target Blood-brain barrier Ischemic stroke Nano drug delivery Neuroprotection

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Symmetry transformation of nonlinear optical current of tilted Weyl nodes and application to ferromagnetic MnBi_(2)Te_(4)

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Chinese Physics B 2024年第4期33卷 160-171页

作者：卢倬成冯济 international Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China

A Weyl node is characterized by its chirality and *** develop a theory of how nth-order nonlinear optical conductivity behaves under transformations of anisotropic tensor and tilt, which clarifies how chirality-dependent and-independent parts of optical conductivity transform under the reversal of tilt and *** on this theory, we propose ferromagnetic Mn Bi2Te4as a magnetoelectrically regulated, terahertz optical device, by magnetoelectrically switching the chiralitydependent and-independent DC *** results are useful for creating nonlinear optical devices based on the topological Weyl semimetals.

关键词： nonlinear optical response topological Weyl semimetals chiral anomaly

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GMAT:A Graph Modeling Method for Group Preference Prediction

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 475-493页

作者： Xiangyu Li Xunhua Guo Guoqing Chen international Business school Jinan UniversityZhuhai519070China school of Economics and Management Tsinghua UniversityBeijing100084China

Preference prediction is the building block of personalized services,and its implementation at the group level helps enterprises identify their target customers *** methods for preference prediction mainly focus on behavioral interactions to extract the associations between groups and products,ignoring the importance of other auxiliary records(e.g.,online reviews and social tags)in association *** paper proposes a novel method named GMAT for group preference prediction,aiming to collectively detect the sophisticated association patterns from user generated content(UGC)and behavioral *** doing so,we construct a tripartite graph to collaborate these two types of data,and design a deep-learning algorithm with mutual attention module for generating the contextualized representations of groups and *** experiments on two real-world datasets show that GMAT is superior to other baselines in terms of group preference ***,GMAT is able to improve prediction accuracy compared with its different variants,further verifying the proposed method’s effectiveness on association pattern detection.

关键词： Group preference UGC tripartite graph deep learning

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Crowding-in or Crowding-out:How Infrastructure Investment Affects Household Consumption

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China Finance and Economic Review 2024年第1期13卷 43-66页

作者： Zhiyu Yan Yufei Yuan Yi Xue school of international Business and Economics University of International Business and Economics

This paper constructs a dynamic model of household consumption decisions and accordingly designs empirical analyses to identify how infrastructure investment affects private *** estimation results of provincial panel data reveal that infrastructure investment can not only indirectly promote household consumption through the income channel but also directly promote household consumption expansion through the expectations channel,with a significant"crowding-in"***,the effect is significantly weaker in provinces with a lower housing supply elasticity,showing the"crowding-out"pattern through the wealth *** survey data provide an explanation for individual *** investment has a greater pushing effect on house prices in provinces with a lower housing supply *** house price growth has significant"crowding-out"effects on the consumption of wealthy *** not only significantly weakens the driving effect of infrastructure investment on aggregate household consumption,but also increases wealth inequality in the long *** paper explains how infrastructure investment affects household consumption and the corresponding role played by house prices,providing empirical evidences for theoretical studies related to macro-regulatory policies in China.

关键词： infrastructure investment household consumption housing supply elasticity macro regulatory policies

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Maternal serum branched-chain amino acids in early pregnancy and offspring growth patterns from 1 year to 8 years of age

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中华医学杂志(英文版) 2024年第15期137卷 1876-1878页

作者： Li Ninghua Leng Junhong Zhang Rui Wang Hui Li Weiqin Zhang Shuang Qiao Yijuan Li Jing Yu Zhijie Hu Gang Fang Zhongze Yang Xilin Department of Epidemiology and Biostatistics School of Public Health Tianjin Medical University Tianjin China Project Office Tianjin Women and Children’s Health Center Tianjin China Tianjin Key Laboratory of Environment Nutrition and Public Health Tianjin China Tianjin Center for international Collaborative Research on Environment Nutrition and Public Health Tianjin China Population Cancer Research Program and Department of Pediatrics Dalhousie University Halifax Canada Chronic Disease Epidemiology Laboratory Pennington Biomedical Research Center Baton Rouge LA USA Department of Toxicology and Sanitary Chemistry School of Public Health Tianjin Medical University Tianjin China

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Advances and perspectives in environmental health research in China

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 105-113页

作者： Tong Zhu Yingjun Liu Shunqing Xu Guanghui Dong Cunrui Huang Nan Sang Yunhui Zhang Guanyong Su Jingwen Chen Jicheng Gong Guohua Qin Xinghua Qiu Jing Shang Haobo Wang Pengpeng Wang Mei Zheng SKL-ESPC&SEPKL-AERM Department of Environmental HealthCollege of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Center for Environment and health Peking UniversityBeijing 100871China school of Life and health Sciences Huainan UniversityHaikou 570228China Joint international Research Laboratory of Environment and health(Ministry of Education) Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China Vanke school of Public health Tsinghua UniversityBeijing 100084China Research Center of Environment and health College of Environment and ResourceShanxi UniversityTaiyuan 030006China Department of Environmental health School of Public HealthFudan UniversityShanghai 200032China school of Environmental and Biological Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) Dalian Key Laboratory on Chemicals Risk Control and Pollution Prevention TechnologySchool of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China Department of Occupational and Environmental health College of Public HealthZhengzhou UniversityZhengzhou 450001China

Environmental health research aims to identify environmental conditions suitable for the healthy living and reproduction of human *** the interdisciplinary research bridging environmental sciences and health/medical sciences,the impacts of physical,chemical,and biological environmental factors on human health are *** includes identifying environmental factors detrimental to human health,evaluating human exposure characteristics to environmental factors,clarifying causal relationships between environmental exposure and health effects,analyzing the underlying biochemical mechanisms,linking environmental factors to the onset and progression of diseases,establishing exposure-response relationships,and determining effect ***,the results of environmental health research can serve as a scientific basis for formulating environmental management strategies and guiding prevention and intervention measures at both the public and individual *** paper summarizes the recent advances and future perspectives of environmental health research in China,as reported by a group of Chinese scientists who recently attended a workshop in Hainan,*** it is not intended to provide a comprehensive review of this expansive field,it offers a glimpse into the significant progress made in understanding the health impacts of environmental factors over the past *** ahead,it is imperative not only to sustain efforts in studying the health effects of traditional environmental pollution,but also to prioritize research on the health impacts of emerging pollutants and climate change.

关键词： Environmental pollution Emerging pollutants Climate change Exposure Mechanism

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Manipulation of band gap in 1T-TiSe_(2) via rubidium deposition

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Chinese Physics B 2024年第8期33卷 102-106页

作者：欧仪陈磊信子鸣任宇靖袁鹏浩王政国朱玉陈景芝张焱 international Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China

The 1T-TiSe_(2) is a two-dimensional charge-density-wave(CDW)material that attracts great interest.A small band gap locates at the Fermi level separating the Ti d-bands and Se p-bands,which makes 1T-TiSe_(2) a promising candidate for realizing excitonic ***,we studied the band gap in 1T-TiSe_(2) using angle-resolved photoemission spectroscopy(ARPES).Instead of only focusing on the in-plane band dispersions,we obtained the detailed band dispersions of both conduction and valance bands along the out-of-plane *** found that the conduction and valance bands split into multiple sub-bands in the CDW state due to band *** a result,the band gap between the Ti d-bands and Se p-bands reduces to~25 meV and becomes a direct gap in the CDW *** intriguingly,such band gap can be further reduced by the rubidium *** band structure becomes semimetallic in the rubidium-doped ***,exotic gapless behaviors were observed at the p-d band *** result characterized the band gap of 1T-TiSe_(2) in three-dimensional Brillouin zone with unpreceded *** also suggests a closing of band gap or a potential band inversion in 1T-TiSe_(2) driven by rubidium deposition.

关键词： angle-resolved photoemission spectroscopy metal–insulator transition transition metal dichalcogenides

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