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Optimizing bone marrow harvesting sites for enhanced mesenchymal stem cell yield and efficacy in knee osteoarthritis treatment

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World Journal of Methodology 2025年第2期15卷 92-107页

作者： Arulkumar Nallakumarasamy Sandeep Shrivastava Ravi Velamoor Rangarajan Naveen Jeyaraman Avinash Gandi Devadas Swaminathan Ramasubramanian Madhan Jeyaraman Department of Orthopaedics Datta Meghe Institute of Higher Education and ResearchWardha 442004MaharashtraIndia Department of regenerative medicine Mother Cell Regenerative CentreTiruchirappalli 620017Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia

Knee osteoarthritis(OA)is a debilitating condition with limited long-term treatment *** therapeutic potential of mesenchymal stem cells(MSCs),particularly those derived from bone marrow aspirate concentrate,has garnered attention for cartilage repair in *** the iliac crest is the traditional site for bone marrow harvesting(BMH),associated morbidity has prompted the exploration of alternative sites such as the proximal tibia,distal femur,and proximal *** paper reviews the impact of different harvesting sites on mesenchymal stem cell(MSC)yield,viability,and regenerative potential,emphasizing their relevance in knee OA *** iliac crest consistently offers the highest MSC yield,but alternative sites within the surgical field of knee procedures offer comparable MSC characteristics with reduced *** integration of harvesting techniques into existing knee surgeries,such as total knee arthroplasty,provides a less invasive approach while maintaining thera-peutic ***,variability in MSC yield from these alternative sites underscores the need for further research to standardize techniques and optimize clinical *** directions include large-scale comparative studies,advanced characterization of MSCs,and the development of personalized harvesting ***,the findings suggest that optimizing the site of BMH can significantly influence the quality of MSC-based therapies for knee OA,enhancing their clinical utility and patient outcomes.

关键词： Knee Osteoarthritis Mesenchymal stem cells Bone marrow harvest regenerative medicine

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Stem cell differentiation and human liver disease

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World Journal of Gastroenterology 2012年第17期18卷 2018-2025页

作者： Wen-Li Zhou Claire N Medine Liang Zhu David C Hay Department of Gastroenterology Changzheng Hospital Second Military Medical University ofChina Shanghai 200003 China medical re-search council centre for regenerative medicine University ofEdinburgh Edinburgh EH 16 4UU Scotland United Kingdom

Human stem cells are scalable cell populations capable of cellular *** makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary *** an approach has the potential to improve our understanding of human biology and treating *** the future it may be possible to deploy novel stem cell-based approaches to treat human liver *** recent years,eff icient hepatic differentiation from human stem cells has been achieved by several research groups including our *** this review we provide an overview of the f ield and discuss the future potential and limitations of stem cell technology.

关键词： Differentiation Pluripotent stem cells Hepatocyte-like cells Liver development Polymer chemistry regenerative medicine Transplantation Bio-artif icial liver

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Stem cells for spinal cord injuries bearing translational potential

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Neural regeneration research 2018年第1期13卷 35-42页

作者： Kyriakos Dalamagkas Magdalini Tsintou Alexander M.Seifalian Department of Tissue Engineering Harvard Medical School Nanotechnology & regenerative medicine centre Division of Surgery and Interventional Science University College London Nanotechnology & regenerative medicine Commercialisation centre (Ltd). The London Bio Science Innovation Centre

Spinal cord injury （SCI） is a highly debilitating neurological disease, which still lacks effective treatment strategies, causing significant financial burden and distress to the affected families. Nevertheless, nanotechnology and regenerative medicine strategies holding promise for the development of novel therapies that would reach from bench to bedside to serve the SCI patients. There has already been significant progress in the field of cell-based therapies, with the clinical application for SCI, currently in phase II of the clinical trial. Stem cells （e.g., induced pluripotent stem cells, fetal stem cells, human embryonic stem cells, and olfactory ensheathing cells） are certainly not to be considered the panacea for neural repair but, especially when combined with rehabilitation or other combinatorial approaches using the help of nanotechnology, they seem to be the source of some of the most promising and clinical translatable cell-based therapies that could help solving impactful problems on neural repair.

关键词： spinal cord injury stem cells neuroregeneration plasticity repair

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Lessons from zebrafish on reprogramming the epigenetic ：ode after fertilisation

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Asian Journal of Andrology 2013年第5期15卷 582-583页

作者： Chris O'Neill centre for Developmental and regenerative medicine Kolling Institute for Medical Research Sydney MedicalSchool University of Sydney NSW 2065 Australia

Methylation of cytosine bases encodes epigenetic information that governs lineage-specific patterns of gene expression. remodelling the methylated genome accompanies major transitions during embryo development, including fertilisation, blastulation and gastrulation. The first whole genome epigenetic maps of this modification across these embryonic transitions in a metazoan has been reported in the zebrafish,

关键词： Lessons zebrafish fertilisation

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Brain age estimation:premise,promise,and problems

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Neural regeneration research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron Ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro research centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

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An aptamer-driven DNA nanodevice for improved delivery of synthetic immunostimulants

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Nano research 2024年第10期17卷 9078-9083页

作者： Dejie Lu Zhenghan Di Lele Li Jian Zhao Li Zheng Guangxi Engineering Center in Biomedical Materials for Tissue and Organ regeneration Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and ApplicationGuangxi Key Laboratory of Regenerative MedicineThe First Affiliated Hospital of Guangxi Medical UniversityGuangxi Medical UniversityNanning 530021China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

Efficient delivery of therapeutics to immune cells remains a formidable challenge for cancer *** this work,we demonstrate that an aptamer-driven DNA nanodevice,constructed through linkage of a synthetic immunostimulant(Toll-like receptor 9 agonist:CpG motif)to an aptamer,could significantly enhance the immunostimulatory activity by facilitating the uptake and retention of therapeutics in *** administration of the DNA nanodevice results in efficient tumor growth inhibition in both breast cancer and melanoma mouse *** studies suggest that the DNA nanodevice leads to reeducation of tumor-associated macrophages and ultimately to reversing the tumor immune *** strategy for aptamer-mediated and vehicle-free delivery of immunostimulatory oligonucleotides provides a potential platform for cancer immunotherapy.

关键词： aptamer immunostimulatory oligonucleotides DNA nanodevice tumor-associated macrophages cancer therapy

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Development of stem cell-based therapy for Parkinson’s disease

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Translational Neurodegeneration 2015年第1期4卷 120-132页

作者： Fabin Han Deborah Baremberg Junyu Gao Jing Duan Xianjie Lu Nan Zhang Qingfa Chen centre for Stem Cells and regenerative medicine The Liaocheng People’s Hospital/Affiliated Liaocheng HospitalTaishan Medical UniversityShandong 252000China

Parkinson’s disease(PD)is one of the most common neurodegenerative disorders of aging,characterized by the degeneration of dopamine neurons(DA neurons)in the substantial nigra,leading to the advent of both motor symptoms and non-motor *** treatments include electrical stimulation of the affected brain areas and dopamine replacement *** though both categories are effective in treating PD patients,the disease progression cannot be *** research advance into cell therapies provides exciting potential for the treatment of *** cell sources include neural stem cells(NSCs)from fetal brain tissues,human embryonic stem cells(hESCs),induced pluripotent stem cells(iPSCs)and directly induced dopamine neurons(iDA neurons).Here,we evaluate the research progress in different cell sources with a focus on using iPSCs as a valuable source and propose key challenges for developing cells suitable for large-scale clinical applications in the treatment of PD.

关键词： Parkinson’s disease Dopamine neuron Neural stem cell Human embryonic stem cells Induced pluripotent stem cell Induced dopamine neuron

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Current opinion on a role of the astrocytes in neuroprotection

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Neural regeneration research 2018年第5期13卷 797-798页

作者： Leon Teo James A.Bourne Australian regenerative medicine Institute Monash University

Central nervous system（CNS）injuries remain a leading cause of functional disabilities worldwide,often resulting in permanent neurological impairments,due to the inability to repair and regenerate damaged connections.A major contributing factor to this loss of regenerative capacity is the formation of glial scar tissue（Cregg et al.,2014）,traditionally regarded as a potent mechanical and molecular barrier to repair.

关键词： Current opinion on a role of the astrocytes in neuroprotection

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Asymptomatic dengue infection in adults of major cities of Pakistan

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Asian Pacific Journal of Tropical medicine 2017年第10期10卷 1002-1006页

作者： Ibrar Rafique Muhammad Arif Nadeem Saqib Muhammad Arif Munir Huma Qureshi Ijaz-ul-Haq Taseer Rizwan Iqbal Waqaruddin Ahmed Tasleem Akhtar Rizwanullah Pakistan Health research council Head OfficeIslamabadPakistan Pakistan Health research council Research CentreNishtar Medical CollegeMultanPakistan Pakistan Health research council Research CentreKing Edward Medical UniversityLahorePakistan Pakistan Health research council Research CentreJinnah Postgraduate Medical CentreKarachiPakistan Pakistan Health research council Research CentreKhyber Medical CollegePeshawarPakistan

Objective: To determine the asymptomatic dengue infection in adults of Pakistani ***: This study was conducted in five major cities(Islamabad, Karachi, Lahore,Multan, and Peshawar) of Pakistan.A total of 5 230 adults aged 18 years and above without a history of dengue fever at any point in their life were enrolled from participating *** who were confirmed for dengue previously were *** the total, 62.6%(n = 3 276) were male with an average age of 34.6 *** were briefed about the objectives of the study, and written consent was obtained to perform dengue Ig G test using enzyme linked immunosorbent *** brief information related to age, gender and area was also taken on ***: Overall 32.3%(n = 1 691) was having asymptomatic dengue infection which was 67.5%(n = 756) in Karachi followed by 39.1%(n = 391) in Islamabad, 29.9%(n =316) in Lahore and 21%(n = 228) in Peshawar and none from *** males were affected with asymptomatic dengue infection than *** asymptomatic dengue infection was significantly higher in different cities; however, there was no significant difference with respect to age ***: The asymptomatic dengue infection is higher in cities ***,Islamabad and Lahore which are at risk of developing secondary dengue *** is a need of awareness among the public about secondary dengue infection.

关键词： Dengue Exposure Secondary dengue infection Asymptomatic

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Microorganism-derived biological macromolecules for tissue engineering

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Frontiers of medicine 2022年第3期16卷 358-377页

作者： Naser Amini Peiman Brouki Milan Vahid Hosseinpour Sarmadi Bahareh Derakhshanmehr Ahmad Hivechi Fateme Khodaei Masoud Hamidi Sara Ashraf Ghazaleh Larijani Alireza rezapour Cellular and Molecular research Center Iran University of Medical SciencesTehran ***Iran Institutes of regenerative medicine Faculty of Advanced Technologies in MedicineIran University of Medical SciencesTehran ***Iran Department of Tissue Engineering and regenerative medicine Faculty of Advanced Technologies in MedicineIran University of Medical SciencesTehran ***Iran Department of Pharmaceutics University of MinnesotaMN 55455USA Burn research Center Department of Plastic and Reconstructive SurgeryIran University of Medical SciencesTehran ***Iran Department of medical Biotechnology Faculty of ParamedicineGuilan University of Medical SciencesRasht ***Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran ***Iran Cellular and Molecular research centre Qom University of Medical SciencesQom ***Iran Department of Tissue Engineering and regenerative medicine School of MedicineQom University of Medical SciencesQom ***Iran

According to literature,certain microorganism productions mediate biological ***,their beneficial characteristics remain ***,scientists concentrate on obtaining natural materials from live creatures as new sources to produce innovative smart biomaterials for increasing tissue reconstruction in tissue engineering and regenerative *** present review aims to introduce microorganism-derived biological macromolecules,such as pullulan,alginate,dextran,curdlan,and hyaluronic acid,and their available sources for tissue *** evidence indicates that these materials can be used as biological material in scaffolds to enhance regeneration in damaged tissues and contribute to cosmetic and dermatological *** natural-based materials are attractive in pharmaceutical,regenerative medicine,and biomedical *** study provides a detailed overview of natural-based biomaterials,their chemical and physical properties,and new directions for future research and therapeutic applications.

关键词： biological macromolecules regenerative medicine tissue engineering exopolysaccharide carbohydrate

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