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Promising effects of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome:a double-blinded randomized controlled trial

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Journal of Traditional Chinese Medicine 2025年第1期45卷 100-106页

作者： Neda Naimipoor Zahra Bagheri-Hosseinabadi Mohammad Reza Hajizadeh Mitra Abbasifard Mohammad Reza Mirzaei Akram Ghadiri Anari Maryam Mohammad-Sadeghipour Mehdi Mahmoodi Department of Clinical Biochemistry School of MedicineRafsanjan University of Medical Sciences Department of Internal Medicine School of MedicineAli-Ibn Abi-Talib HospitalRafsanjan University of Medical Sciences Molecular Medicine research center Research Institute of Basic Medical SciencesRafsanjan University of Medical Sciences Diabetes research center Shahid Sadoughi University of Medical Sciences Department of Clinical Biochemistry Afzalipour School of MedicineKerman University of Medical Sciences Physiology research center Institute of NeuropharmacologyKerman University of Medical Sciences

OBJECTIVE: To evaluate the effect of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome(MetS). METHODS: Fifty patients with Met S diagnosis were randomly assigned to the intervention(Persian shallot extract) and the control(placebo) group. Both groups received treatment for three months. Before the study and at the end of the study, 5 mL peripheral blood was taken from each patient. The measured factors included total antioxidant capacity(TAC), superoxide dismutase enzyme(SOD), malondialdehyde, oxidized low-density lipoprotein(Ox-LDL), apolipoprotein H(Apo-H), fasting blood glucose(FBS), total cholesterol, triglycerides, high-density lipoprotein(HDL), LDL, and systolic and diastolic blood pressure. RESULTS: At baseline, the evaluated parameters were not significantly different between the intervention and control groups. At the end of the study, the mean serum levels of malondialdehyde and ox-LDL were significantly lower in the intervention group. The mean FBS, cholesterol, triglycerides, and LDL were significantly lower in the intervention group. The mean TAC and HDL were significantly higher in the intervention group(P < 0.05). Moreover, the intervention group significantly reduced systolic and diastolic blood pressure. No other significant association was observed. CONCLUSION: Persian shallot extract has several beneficial effects in Met S patients, including optimizing oxidative balance, reducing blood pressure, fasting blood sugar, and blood lipid profile.

关键词： antioxidants medicine, Persian metabolic syndrome shallots

Comparison of biomechanical indices measured by ocular response analyzer between children and elderly:a systematic review

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 154-159页

作者： Hassan Hashemi Fereshteh Shokrollahzadeh Hadi Ostadimoghaddam Abbasali Yekta Mehdi Khabazkhoob Noor Ophthalmology research center Noor Eye HospitalTehran ***Iran Rehabilitation research center Department of OptometrySchool of Rehabilitation SciencesIran University of Medical SciencesTehran ***Iran Refractive Errors research center Mashhad University of Medical SciencesMashhad ***Iran Department of Optometry School of Paramedical SciencesMashhad University of Medical SciencesMashhad ***Iran Department of medical Surgical Nursing School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

Biomechanical study of the visual system by ocular response analyzer investigates the inter-structural biological relationships,mechanics,and function of the visual *** review aimed to investigate the changes in corneal biomechanical parameters with age and *** articles published in PubMed between 2000 and 2021 were investigated and critiqued,and valid scientific evidence was collected,reviewed and concluded according to the inclusion and exclusion *** studies showed that corneal biomechanical changes occur infrequently in children up to the age of 20y,and with increasing age and wider age range,there was a significant decrease in corneal biomechanical indices,especially corneal *** children and adults,most studies have shown that these biomechanical indicators,especially corneal resistance factor,were higher in *** hormonal changes may contribute to this finding,the role of axial length and other biometric indicators should not be *** axial length,the intraocular pressure,and the corneal thickness are other factors associated with biomechanical parameters that should be taken into account in clinical diagnosis and management especially for patients undergoing refractive surgery as well as keratoconus patients.

关键词： ocular response analyzer corneal biomechanics visual function children elderly

New Insights on Gamma-Ray Burst Radiation Mechanisms from Multiwavelength Observations

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research in Astronomy and Astrophysics 2025年第2期25卷 3-12页

作者： Yu-Hua Yao Fang-Sheng Min Shi Chen Yi-Qing Guo College of physics Chongqing University Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Wisconsin Ice Cube Particle Astrophysics center University of Wisconsin–Madison University of Chinese Academy of Sciences School of physics and Astronomy Yunnan University Tianfu Cosmic Ray research center

The study of high-energy gamma-ray emission from gamma-ray bursts(GRBs) involves complex synchrotron radiation and synchrotron self-Compton(SSC) scattering mechanisms with multiple parameters exhibiting a wide distribution. Recent advancements in GRB research, particularly the observation of very high energy(VHE,>100 Ge V) radiation, have ushered in a new era of multiwavelength exploration, offering fresh perspectives and limitations for understanding GRB radiation mechanisms. This study aimed to leverage VHE observations to refine constraints on synchrotron + SSC radiation from electrons accelerated by forward shocks. By analyzing two external environments—the uniform interstellar medium and stratified stellar wind medium, we conducted spectral and variability fitting for five specific bursts(GRB 180720B, GRB 190114C, GRB 190829A, GRB 201216C, and GRB 221009A) to identify the optimal parameters characterizing these events. A comparative analysis of model parameter distributions with and without VHE radiation observations reveals that the magnetic energy equipartition factor εBis more concentrated with VHE emissions. This suggests that VHE emissions may offer greater constraints on this microphysical parameter. Additionally, we found that the energy budget between VHE and ke V–Me V γ-ray emissions under the SSC radiation exhibits an almost linear relationship, which may serve as a tool to differentiate radiation mechanisms. We anticipate future statistical analyses of additional VHE bursts to validate our findings.

关键词： (transients:) gamma-ray bursts gamma-rays: ISM radiation mechanisms: non-thermal

Berberine Hydrochloride Improves Cognitive Function and Hippocampal Antioxidant Status in Subchronic and Chronic Lead Poisoning

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Chinese Journal of Integrative Medicine 2025年第1期31卷 49-54页

作者： Fatemeh Zare Mehrjerdi Azadeh Shahrokhi Raeini Fatemeh Sadate Zebhi Zeynab Hafizi Reyhaneh Mirjalili Faezeh Afkhami Aghda Yazd Neuroendocrine research center School of MedicineShahid Sadoughi University of Medical Sciences and Health ServicesYazd***Iran

Objective: To determine the neuroprotective effects of berberine hydrochloride(BBR) against lead-induced injuries on the hippocampus of rats. Methods: Wistar rats were exposed orally to doses of 100 and 500 ppm lead acetate for 1 and 2 months to develop subchronic and chronic lead poisening models, *** treatment, BBR(50 mg/kg daily) was injected intraperitoneally to rats poisoned with lead. At the end of the experiment, the spatial learning and memory of rats were assessed using the Morris water maze test. Hippocampal tissue changes were examined by hematoxylin and eosin staining. The activity of antioxidant enzymes catalase,superoxide dismutase, glutathione peroxidase, and malondialdehyde levels as parameters of oxidative stress and antioxidant status of the hippocampus were evaluated. Results: BBR reduced cognitive impairment in rats exposed to lead(P<0.05 or P<0.01). The resulting biochemical changes included a decrease in the activity of antioxidants and an increase in lipid peroxidation of the hippocampus of lead-exposed rats(P<0.05 or P<0.01), which were significantly modified by BBR(P<0.05). BBR also increased the density of healthy cells in the hippocampus of leadexposed rats(P<0.05). Significant changes in tissue morphology and biochemical factors of the hippocampus were observed in rats that received lead for 2 months(P<0.05). Most of these changes were insignificant in rats that received lead for 1 month. Conclusion: BBR can improve oxidative tissue changes and hippocampal dysfunction in lead-exposed rats, which may be due to the strong antioxidant potential of BBR.

关键词： lead acetate berberine hippocampus oxidative stress Morris water maze

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Purinergic signaling by TCRaβ~+double-negative T regulatory cells ameliorates liver ischemia–reperfusion injury

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Science Bulletin 2025年第2期70卷 241-254页

作者： Hua Jin Mingyang Li Xiyu Wang Lu Yang Xinjie Zhong Zihan Zhang Xiaotong Han Jingjing Zhu Mengyi Li Songlin Wang Simon C.Robson Guangyong Sun Dong Zhang Immunology research center for Oral and Systemic Health Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China medical research center Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Gastroenterology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China General Surgery Department Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Beijing Laboratory of Oral Health Capital Medical University School of Basic MedicineBeijing 100069China center for Inflammation research Department of AnesthesiaCritical Care&Pain Medicineand Department of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02115USA

Hepatic ischemia–reperfusion injury(HIRI)is an important cause of liver injury following liver transplantation and major resections,and neutrophils are the key effector cells in ***-negative T regulatory cells(DNT)are increasingly recognized as having critical regulatory functions in the immune *** DNT expresses distinct immunoregulatory mechanisms to modulate neutrophils,as in HIRI,remains largely *** this study,we found that murine and human DNT highly expressed CD39that protected DNT from extracellular ATP-induced apoptosis and generated adenosine in tandem with CD73,to induce high levels of neutrophil ***,extracellular adenosine enhanced DNT survival and suppressive function by upregulating survivin and NKG2D expression via the A2AR/pAKT/FOXO1 signaling *** transfer of DNT ameliorated HIRI in mice through the inhibition of neutrophils in a CD39-dependent ***,the adoptive transfer of A2ar^(-/-)DNT validated the importance of adenosine/A2AR signaling,in promoting DNT survival and immunomodulatory function to protect against HIRI in *** conclusion,purinergic signaling is crucial for DNT homeostasis in *** of CD39 or activation of A2AR signaling in DNT may provide novel therapeutic strategies to target innate immune disorders.?2024 The *** by Elsevier *** behalf of Science China *** is an open accessarticle under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Double-negative T regulatory cells Hepatic ischemia and reperfusion injury CD39 Adenosine A2AR

Fabrication and fracture behaviors of the continuous brittle fiber reinforced tungsten composites fabricated via field-assisted sintering technology

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Tungsten 2025年第1期7卷 172-182页

作者： Rui Shu Yi-Ran Mao Jan W. Coenen Alexis Terra Stephan Sch?nen Johann Riesch Christian Linsmeier Christoph Broeckmann Juelich research center Institute of Energy and Climate Research Plasma Physics (IEK-4) Partner in the Trilateral Euregio Cluster Institute of Materials Applications in Mechanical Engineering (IWM) RWTH Aachen University Department of Nuclear Engineering & Engineering physics University of Wisconsin Madison Central Institute of Engineering Electronics and Analytics Engineering and Technology (ZEA-1) Juelich Research Center Max Planck Institute for Plasma physics Institute of Materials Applications in Mechanical Engineering IWM RWTH Aachen University

Tungsten（W） is a promising candidate material for the plasma-facing components in future fusion ***,it has issues regarding the intrinsic brittleness as well as operational *** fiber reinforced tungsten（W_f/W） composites overcome these issues by using extrinsic toughening *** to neutron irradiation and high-temperature recrystallization during fusion operation,the ductility of the fibers may degrade over a long period of ***,it is necessary to investigate the fracture behavior of W_f/W composites with brittle *** the present work,the tungsten fibers were embrittled by ***,the continuous brittle W_f/W composite with yttrium oxide（Y2O3） interface was fabricated by the field-assisted sintering technology *** microstructure of the prepared W_f/W composites was *** fracture behavior and toughening mechanisms were discussed in detail based on the experimental results of 3-point bending tests and the corresponding finite element *** composites show a pseudo-ductile fracture *** are hindered and deflected by the de-bonded fiber-matrix *** extrinsic toughening mechanisms of interface de-bonding,crack bridging,and fiber pull-out are *** indicates the reinforcement concept still works even though all components in the W_f/W are brittle.

关键词： Field-assisted sintering technology (FAST) Fracture behavior Interface Numerical simulation Wf/W composites

Topographic factors associated with anterior chamber angle narrowing in patients with keratoconus

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 67-73页

作者： Hamed Soltan-Dehghan Abdollah Farzaneh Hassan Hashemi Payam Nabovati Mehdi Khabazkhoob Rehabilitation research center Department of OptometrySchool of Rehabilitation SciencesIran University of Medical SciencesTehran ***Iran Noor Ophthalmology research center Noor Eye HospitalTehran ***Iran Department of medical Surgical Nursing School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To identify topographic determinants of the anterior chamber angle(ACA)in patients with keratoconus(KCN).METHODS:Four hundred and ten eyes of 294 patients with KCN were recruited for this ***,complete ocular examinations were performed for all patients,including visual acuity measurement,refraction,and slit-lamp ***,all participants underwent corneal imaging by the Oculus Pentacam ***:The mean age of the participants was 32.40±8.52y(15-60y)and 69.5%of them were *** mean ACA was 38.47°±5.75°(range:14.40°to 56.50°)in the whole sample,38.24°±6.00°in males,and 38.98°±5.11°in females(P=0.447).The mean ACA was significantly different among different groups of cone morphology,as patients with nipple cones showed the lowest mean ***,there were statistically significant differences in the mean ACA among different groups of cone locations,with patients having central cones exhibiting the lowest mean ACA(P<0.001).Anterior and posterior Q values were significantly,directly correlated with ACA(anterior Q:r=0.122,P=0.014,posterior Q:r=0.192,P<0.001).CONCLUSION:This study provides critical insights into the risk factors for ACA narrowing in KCN patients,which is essential for planning intraocular *** with nipple and central cones exhibited the most significant ACA ***,more negative Q-values are associated with increased ACA narrowing,highlighting the need for targeted diagnostic and therapeutic strategies.

关键词： keratoconus anterior chamber angle cone morphology cone location

On the Riemann–Hilbert problem for the reverse space-time nonlocal Hirota equation with step-like initial data

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Communications in Theoretical physics 2025年第2期77卷 32-40页

作者： Bei-Bei Hu Ling Zhang Zu-Yi Shen Ji Lin School of Mathematics and Finance Chuzhou University Applied Mathematics research center Chuzhou University Department of physics Zhejiang Normal University

In this paper, we use the Riemann–Hilbert(RH) method to investigate the Cauchy problem of the reverse space-time nonlocal Hirota equation with step-like initial data: q(z, 0) = o(1) as z →-∞ and q(z, 0) = δ + o(1) as z → ∞, where δ is an arbitrary positive constant. We show that the solution of the Cauchy problem can be determined by the solution of the corresponding matrix RH problem established on the plane of complex spectral parameter λ. As an example, we construct an exact solution of the reverse space-time nonlocal Hirota equation in a special case via this RH problem.

关键词： nonlocal Hirota equation Cauchy problem Riemann-Hilbert problem step-like initial data

Perspectives of high-risk pregnant women on home care program in high-risk pregnancies: A multicenter, qualitative study

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Asian pacific Journal of Reproduction 2025年第1期14卷 13-20页

作者： Masoumeh Sayahi Shahrbanoo Salehin Mehrnoosh Zakerkish Afsaneh Keramat Shahrbanoo Goli Student research Committee School of Nursing and MidwiferyShahroud University of Medical SciencesShahroudIran Sexual Health and Fertility research center Shahroud University of Medical SciencesShahroudIran Diabetes research center Health Research InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran center for Health Related Social and Behavioral Sciences research Shahroud University of Medical SciencesShahroudIran

Objective:To explore the perspectives of high-risk pregnant women regarding the home care program for high-risk ***:This qualitative study was conducted in a university hospital and 5 comprehensive health centers in Ahvaz,Iran,from February 2023 to July *** sampling method used was purposive sampling considering the maximum possible diversity,which continued until data saturation.11 in-depth and semistructured interviews were conducted with high-risk pregnant *** were simultaneously analysed using Graneheim and Lundman content analysis by MAXQDA version 20 ***:Data analysis extracted 3 themes,12 categories,and 26 *** themes and categories were“high-risk pregnancy and related issues(pursuing treatment and paying attention to the high-risk situation by pregnant women,psychological aspect of high-risk pregnancy on pregnant women and caregivers,emotional and physical aspects of high-risk pregnancy,the consequences of high-risk pregnancy on the people around them and empowerment of high-risk pregnant women)”,“support dimension(family and community support for high-risk pregnant women)”,and“framework of program(acculturalization,means and equipment,security,manpower and the necessary arrangements for the home care)”.Conclusions:High-risk pregnancy affects various aspects of the lives of high-risk pregnant women and their *** the necessary conditions for providing care at home plays a vital role in supporting high-risk pregnant women and removing related obstacles to receiving prenatal care in *** will be especially beneficial for high-risk pregnant women in low-income areas.

关键词： High-risk pregnancy Home care Program Qualitative study