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颅内出血患者抗栓药逆转指南美国神经重症监护学会和美国重症医学会对医疗卫生专业人员的声明

国际脑血管病杂志 2016年第11期24卷 961-985页

作者： Jennifer A. Frontera John J. Lewin Ⅲ Alejandro A. Rabinstein Imo P. Aisiku Anne W. Alexandrov Aaron M. Cook Gregory J. del Zoppo Monisha A. Kumar Ellinor I. B. Peerschke Michael F. Stiefel Jeanne S Teitelbaum Katja E. Wartenberg Cindy L. Zerfoss 杨一萍谢丽丽宁小金季宇腾柯开富 From the Cerebrovascular Center Neurological Institute Cleveland Clinic and Case Western Reserve University 9500 Euclid Ave. S80 Cleveland OH44195 USA The departments of Pharmacy and Anesthesiology & Critical Care Medicine The Johns Hopkins Hospital and Johns Hopkins University School of Medicine Baltimore MD USA The Department of Neurology Mayo Clinic Rochester MN USA Harvard medical School Brigham and Women's Hospital Boston MA USA The University of Tennessee Health Science Center Memphis TN USA Department of Pharmacy Practice & Science (UK College of Pharmacy) University of Kentucky Lexington KY USA The departments of Medicine (Hematology) and Neurology University of Washington School of Medicine Seattle WA USA The departments of Neurology Neurosurgery Anesthesiology & Critical Care Perelman School of Medicine Hospital of the University of Pennsylvania Philadelphia PA USA The Department of Laboratory Medicine and pathology Memorial Sloan Kettering Cancer Center and Weill Comell Medical School New York NY USA The Department of Neurosurgery Westchester Medical Center New York Medical College Valhalla NY USA Hepital du Sacre-Coeur and University of Montreal and Montreal Neurological Institute and McGill University Montreal Quebec Canada Klinik fur Neurologie Martin-Luther-Universitat Halle-Wittenberg Halle Germany The Neuroscience and Neurosurgery departments Centra Lynchburg General Hospital Lvnchburg VA. USA 南通大学附属医院神经内科 226001

背景抗栓药的使用，包括抗凝药、抗血小板药和溶栓药，在过去10年中日益增多并且预计将继续上升。虽然抗栓药相关性颅内出血可能是灾难性的，但快速逆转凝血功能障碍可能有助于限制血肿增大和改善转归。方法美国神经重症监护学会联合美... 详细信息

背景抗栓药的使用，包括抗凝药、抗血小板药和溶栓药，在过去10年中日益增多并且预计将继续上升。虽然抗栓药相关性颅内出血可能是灾难性的，但快速逆转凝血功能障碍可能有助于限制血肿增大和改善转归。方法美国神经重症监护学会联合美国重症医学会组建了一个国际性多机构委员会，涉及的专业领域包括神经重症监护、神经内科、神经外科、卒中、血液学、血液病理学、急诊医学、药学、护理和指南制定，目的是进行文献评价并制定一份循证实践指南。该委员会进行了正式的文献检索，并对符合标准的研究进行了评价。结果利用GRADE方法学，委员会提出了在颅内出血情况下逆转维生素K拮抗药、直接Xa因子拮抗药、直接凝血酶抑制药、普通肝素、低分子肝素、类肝素、戊多糖、溶栓药和抗血小板药的推荐意见。结论该指南提供了及时和循证的抗栓药逆转策略以协助临床医生治疗抗栓药相关性颅内出血。

关键词：抗凝药抗血小板药抗栓药颅内出血脑出血脑实质出血蛛网膜下腔出血硬膜下出血逆转解药维生素K拮抗药华法林香豆素直接凝血酶抑制药达比加群 Xa因子抑制药阿哌沙班利伐沙班依杜沙班低分子肝素肝素类肝素戊多糖磺达肝素 TPA rtPA 阿替普酶溶栓药纤溶酶原激活物阿司匹林氯吡格雷凝血酶原复合物新鲜冰冻血浆重组因子Ⅶa 鱼精蛋白血小板去氨加压素冷沉淀指南 GRADE标准

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Convergence of normal stem cell and cancer stem cell developmental stage:Implication for differential therapies

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World Journal of Stem Cells 2011年第9期3卷 83-88页

作者： Shengwen Calvin Li Katherine L Lee Jane Luo Jiang F Zhong William G Loudon Neuro-oncology Research Laboratory Center for Neuroscience and Stem Cell ResearchChildren's Hospital of Orange CountyUniversity of California Irvine455 South Main StreetOrangeCA 92868United States Beckman Coulter Inc.250 South Kraemer BoulevardBreaCA 92821United States Department of pathology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033United States Department of Neurological Surgery University of California IrvineOrangeCA 92862United States

Increased evidence shows that normal stem cells may contribute to cancer development and progression by acting as cancer-initiating cells through their interactions with abnormal environmental *** postulate that normal stem cells and cancer stem cells (CSC) possess similar mechanisms of self-renewal and *** can be the key to the elaboration of anti-cancer-based *** this article,we focus on a controversial new theme relating to *** may have a critical stage characterized as a "therapeutic window",which can be identified by asso-ciation of molecular,biochemical and biological *** such a stage can allow the production of more effective therapies (*** stem cells) to treat several *** importantly,confirming the existence of a similar therapeutic window during the conversion of normal stem cells to malignant CSC may lead to targeted therapy specifically against *** conversion information may be derived from investigating the biological behaviour of both normal stem cells and cancerous stem ***,there is little knowledge about the cellular and molecular mechanisms that govern the initiation and maintenance of *** on co-evolution and interdependence of cancer with normal tissues may lead to a useful treatment paradigm of *** crosstalk between normal stem cells and cancer formation may converge developmental stages of different types of stem cells (*** stem cells,CSC and embryonic stem cells).The differential studies of the convergence may result in novel therapies for treating cancers.

关键词： Neural stem cell Cancer stem cell Convergence Therapeutic

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Regulation and functions of integrin a2 in cell adhesion and disease

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Genes & Diseases 2019年第1期6卷 16-24页

作者： Valery Adorno-Cruz Huiping Liu Department of Pharmacology Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Department of Pharmacology Graduate Program Case Western Reserve University School of MedicineClevelandOH 44106USA Department of Medicine Hematology/Oncology DivisionNorthwestern UniversityChicagoIL 60611USA Robert H.Lurie Comprehensive Cancer Center Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Department of pathology Case Western Reserve University School of MedicineClevelandOH 44106USA

Integrins are cell adhesion molecules that are composed of an alpha(a)subunit and a beta(b)subunit with affinity for different extracellular membrane *** integrin family includes 24 known members that actively regulate cellular growth,differentiation,and *** integrin heterodimer has a particular function in defined contexts as well as some partially overlapping features with other members in the *** many reviews have covered the general integrin family in molecular and cellular studies in life science,this review will focus on the specific regulation,function,and signaling of integrin a2 subunit(CD49b,VLA-2;encoded by the gene ITGA2)in partnership with b1(CD29)subunit in normal and cancer *** roles in cell adhesion,cell motility,angiogenesis,stemness,and immune/blood cell regulations are *** pivotal role of integrin a2 in many diseases such as cancer suggests its potential to be used as a novel therapeutic target.

关键词： Integrin a2 CD49b Molecular mechanisms Regulation Signaling

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The antibiotic utilization at the university dentistry clinical center of Kosovo

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Open Journal of Stomatology 2013年第9期3卷 492-496页

作者： Fehim Haliti Naim Haliti Ferit Kocani Agim Begzati Fatmir Dragidella Luljeta Ferizi Lumnije Krasniqi Dafina Doberdoli Shqiprim Bajrami Shaip Krasniqi Pediatric Dentistry Department of StomatologyFaculty of MedicineUniversity of Prishtina“Hasan Prishtina”PrishtinaKosovo Institute of Forensic pathology Faculty of MedicineUniversity of Prishtina“Hasan Prishtina”PrishtinaKosovo Restorative Dentistry and Endodontology Department of StomatologyFaculty of MedicineUniversity of Prishtina“Hasan Prishtina”PrishtinaKosovo Peridontology and Oral Medicine Department of StomatologyFaculty of MedicineUniversity of Prishtina“Hasan Prishtina”PrishtinaKosovo Institute of Pharmacology and Toxicology and Clinical Pharmacology Faculty of MedicineUniversity of Prishtina“Hasan Prishtina”PrishtinaKosovo

Antibiotic drugs are a very important drug group considering their frequent use, safety profile and their impact on bacterial resistance induction. Aim: To investigate the utilization of antibiotic drugs at the University Dentistry Clinical Center of Kosovo (UDCCK). Methodology: Retrospective and descriptive study. Patient records were used as a data source collected for a period of 3 months. The total number of registered outpatients in the UDCCK was 1117 patients. The data analysis was performed using the WHO methodology and results were expressed in DDD per 1000 inhabitants per day. Results: The total prescription of antibiotics at UDCCK was 7.18 DDD/ 1000 inhabitants/day. Antibiotics were prescribed for 86 or 7.70% of patients. The most commonly prescribed antibiotic was Amoxicillin with clavulonic acid 3.12 (43.45%) DDD, followed by Metronidazole 2.31 DDD and Amoxicillin 1.25 DDD. Erythromycin and Cefalexin were prescribed evidently less compared to other antibiotics (0.38 and 0.12 DDD/1000 inhabitant/day, respectively). Conclusions: The quantitative analysis showed no rationality of prescription of antibiotics in UDCCK. Generally, the use of antibiotics in both departments of UDCCK is higher compared to other countries. We recommend the implementation of restrictive prescription standards for antibiotics.

关键词： Antibiotic Utilization ATC/DDD

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Uterine intravenous leiomyomatosis with cardiac extension: Imaging characteristics and literature review

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World Journal of Clinical oncology 2013年第1期4卷 25-28页

作者： Zhi-Feng Xu Fang Yong Ying-Yu Chen Ai-Zhen Pan Department of medical Imaging The First People’s Hospital of Foshan

Intravenous leiomyomatosis(IVL),showing unusual growth patterns of uterine leiomyoma,is a rare neoplasm characterized by intravascular proliferation of a histologically benign-looking smooth muscle cell tumor mass,but not invading the *** date,less than 300 cases have been reported and fewer than 100 cases with cardiac *** characteristics of IVL are still not clear so it is usually misdiagnosed before surgery.A 36-year-old woman,who had undergone hysterectomy due to hysteromyoma,presented with shortness of breath after *** showed IVL with mass involvement of the left ovarian vein,left renal vein,left external and common iliac vein,as well as within the inferior vena cava(IVC),extending into the right *** operation demonstrated that the mass had no stalk and had welldemarcated borders with the wall of the right atrium and *** patient underwent a one-stage combined multidisciplinary thoraco-abdominal operation under general ***,the pathology report confirmed *** should be considered in a female patient presenting with an extensive mass in the right side of the *** technology,such as echocardiogram,contrast-enhanced computed tomography and magnetic resonance imaging,can provide important information to reveal the mass,the range and path of the lesion,and relates to the surgical plan ***,perfect and exact image examination is very necessary pre-operation.

关键词： Intravenous leiomyomatosis lower Hysterectomy Computed tomography Echocardiogram Imaging

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Changes in the clinicopathological characteristics of gastric cancer in Hehuang Valley of China–2379 cases of gastric cancer in recent 10 years

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The Chinese-German Journal of Clinical oncology 2014年第2期13卷 63-68页

作者： Su Yan Bin Li Junqi Wu Dawei Xie Yingcai Ma Yuanzhi Xiong Xuxiang Ma Xinjian Guo Man Dai Daquan Zhang Xinyang Liu Department of Gastrointestinal Surgery Affiliated Hospital of Qinghai University Department of Public Health and Statistics School of Medicine of Qinghai University Department of Digestive Medicine People's Hospital of Qinghai Province Department of Digestive Medicine Affiliated Hospital of Qinghai University Department of pathology Affiliated Hospital of Qinghai University

Objective： The aim of our studywas to discuss changes in the clinicopathological characteristics of gastric cancer in Hehuang Valley of China in recent 10 years. Methods： A retrospective case-control study was performed on 2379 newly-diagnosed gastric cancer patients. All of them came from Hehuang Valley. The patients were divided into two groups [recent 5 years （R5Y） and late 5 years （L5Y）] from February 2003 to February 2013, and the clinicopathological data were surveyed retrospectively. Results： The constituent ratio of upper 1/3 gastric cancer in R5Y and L5Y was 33.5% and 20.7%, respectively, and it showed a significant difference between the two groups （X2 = 21.28, P = 0.00）, The constituent ratio of squamous carcinoma/adenosquamous carcinoma was 2.7% and 1.6%, respectively, and it also showed a significant differ- ence between two groups （X2 = 50.91, P = 0.00）. The constituent ratio of moderately-poorly differentiated/poorly differentiated gastric carcinoma was 84.2% and 50.2%, respectively, and it showed statistically significant difference （X2 = 30.28, P = 0.00）. The detection rate of early gastric cancer （EGC） was 1.47% （35/2379）. The constituent ratio of the types of Borrmann II and Borrmann IV of advanced gastric cancer （AGC） among 2379 cases was 47.6% and 40.8%, respectively, and that still showed statistically significant difference （X2 = 18,80, P = 0.00）. The constituent ratio of diffuse-type of gastric cancer in R5Y and L5Y was 36.2% and 30.8%, respectively, even there was a significant difference （X2 = 7.49, P = 0.01）. Furthermore, there were also significant differences in regional lymph nodes metastasis, perineural infiltration and vascular invasion （P 〈 0.05）. The positive detection rate of HER2, ER and PR was 14.88%, 17.23% and 15.93%, respectively. The constituent ratio of HP in two groups was 43.8% and 36.2% respectively, and it also showed a significant difference （~2 = 13.51, P = 0.00）. Conclusion： The pathogenic sites in gastric cancer chan

关键词： Hehuang Valley gastric cancer clinicopathological characteristics

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Preclinical therapy of benign prostatic hyperplasia with neuropeptide hormone antagonists

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World Journal of Clinical Urology 2014年第3期3卷 184-194页

作者： Petra Popovics Andrew V Schally Norman L Block Ferenc G Rick Division of Cardiovascular Diseases Department of Medicine Miller School of Medicine University of MiamiMiami FL 33136 United States Department of Medicine Ⅲ Medical Faculty Carl Gustav CarusD-01307 TU Dresden Germany Veterans Affairs medical Center and South Florida Veterans Affairs Foundation for Research and Education Miami FL 33125 United States Divisions of Hematology/oncology and Endocrinology Department of Medicine Miller School of Medicine University of MiamiMiami FL 33136 United States Department of Urology Florida International University Herbert Wertheim College of MedicineMiami FL 33199 United States

Benign prostatic hyperplasia(BPH)is a pathologic condition of the prostate described as a substantial increase in its number of epithelial and stromal *** may significantly reduce the quality of life due to the initiation of bladder outlet obstruction and lower urinary tract *** medical therapies mostly consist of inhibitors of 5α-reductase orα1-adrenergic blockers;their efficacy is often *** analogs of neuropeptide hormones are novel candidates for the management of *** first,antagonists of luteinizing hormone-releasing hormone(LHRH)have been introduced to the therapy aimed to reduce serum testosterone ***,they have also been found to produce an inhibitory activity on local LHRH receptors in the prostate as well as impotence and other related side *** then,several preclinical and clinical studies reported the favorable effects of LHRH antagonists in *** contrast,antagonists of growth hormone-releasing hormone(GHRH)and gastrin-releasing peptide(GRP)have been tested only in preclinical settings and produce significant reduction in prostate size in experimental models of *** act at least in part,by blocking the action of respective ligands produced locally on prostates through their respective receptors in the prostate,and by inhibition of autocrine insulin-like growth factors-Ⅰ/Ⅱand epidermal growth factor *** and LHRH antagonists were also tested in combination resulting in a cumulative effect that was greater than that of each *** article will review the numerous studies that demonstrate the beneficial effects of antagonistic analogs of LHRH,GHRH and GRP in BPH,as well as suggesting a potential role for somatostatin analogs in experimental therapies.

关键词： Benign prostatic hyperplasia Luteinizing hormone-releasing hormone Growth hormone-releasing hormone Gastrin-releasing peptide Somatostatin Targeted therapy

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Anesthetic Treatment in Operations of Small Pelvic Organs pathology

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Open Journal of Anesthesiology 2021年第12期11卷 355-360页

作者： Taalaibek Atabaev Zamirbek Arynov Maksatbek Tashbaev Akperi Gaipova Gulshat Matkasymova Iskenderbek Abdraiimov Absalam Zhunusov Begmamat Nyshanov Syrgak Bakirov Zhypargul Abdullaeva Department of Urology and Operative Surgery Osh State University Osh Kyrgyzstan Department of Surgical Disciplines with Traumatology Course International Medical Faculty Osh State University Osh Kyrgyzstan Department of Surgical Diseases Osh State University Osh Kyrgyzstan Science and Research Department Osh State University Osh Kyrgyzstan

The article presents data on the surgical treatment of 405 patients with pelvic organ surgical and gynecological diseases. When using regional anesthesia during operations in the lower abdominal cavity of patients with pelvic pathology, a smoother operation course and early postoperative period were observed compared with general anesthesia use. In this work, 405 patients with surgical and gynecological diseases of pelvic organs, operated in the surgical and gynecological departments were analyzed. When using regional anesthesia, it was observed that intraoperative blood loss in patients and consumption of narcotic analgesics in the postoperative period decreases.

关键词： Surgery Pelvic Organ Diseases Anesthesia Treatment pathology

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Highly accurate colorectal cancer prediction model based on Raman spectroscopy using patient serum

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World Journal of Gastrointestinal oncology 2020年第11期12卷 1311-1324页

作者： Hiroaki Ito Naoyuki Uragami Tomokazu Miyazaki William Yang Kenji Issha Kai Matsuo Satoshi Kimura Yuji Arai Hiromasa Tokunaga Saiko Okada Machiko Kawamura Noboru Yokoyama Miki Kushima Haruhiro Inoue Takashi Fukagai Yumi Kamijo Digestive Disease Center Showa University Koto Toyosu HospitalTokyo 135-8577Japan Research Division JSR CorporationTokyo 105-0021Japan BaySpec Inc. San JoseCA 95131United States Fuji Technical Research Inc. Yokohama 220-6215Japan Department of Laboratory Medicine and Central Clinical Laboratory Showa University Northern Yokohama HospitalYokohama 224-8503Japan Department of Clinical Laboratory Showa University Koto Toyosu HospitalTokyo 135-8577Japan Department of Clinical Laboratory Showa University HospitalTokyo 142-8555JapanBML Inc.Tokyo 151-0051Japan Department of Hematology Saitama Cancer CenterInamachiSaitama 362-0806Japan Department of pathology Showa University Koto Toyosu HospitalTokyo 135-8577Japan Department of Urology Showa University Koto Toyosu HospitalTokyo 135-8577Japan Showa University Koto Toyosu Hospital Tokyo 135-8577Japan

BACKGROUND Colorectal cancer(CRC) is an important disease worldwide, accounting for the second highest number of cancer-related deaths and the third highest number of new cancer cases. The blood test is a simple and minimally invasive diagnostic test. However, there is currently no blood test that can accurately diagnose *** To develop a comprehensive, spontaneous, minimally invasive, label-free, bloodbased CRC screening technique based on Raman *** We used Raman spectra recorded using 184 serum samples obtained from patients undergoing colonoscopies. Patients with malignant tumor histories as well as those with cancers in organs other than the large intestine were excluded. Consequently, the specific diseases of 184 patients were CRC(12), rectal neuroendocrine tumor(2), colorectal adenoma(68), colorectal hyperplastic polyp(18), and others(84). We used the 1064-nm wavelength laser for excitation. The power of the laser was set to 200 *** Use of the recorded Raman spectra as training data allowed the construction of a boosted tree CRC prediction model based on machine learning. Therefore, the generalized R^2 values for CRC, adenomas, hyperplastic polyps, and neuroendocrine tumors were 0.9982, 0.9630, 0.9962, and 0.9986, *** For machine learning using Raman spectral data, a highly accurate CRC prediction model with a high R^2 value was constructed. We are currently planning studies to demonstrate the accuracy of this model with a large amount of additional data.

关键词： Colorectal cancer Raman spectroscopy Machine learning Blood Serum Diagnosis

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光动力疗法治疗非小细胞肺癌

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国际病理科学与临床杂志 2013年第3期33卷 185-197页

作者： Charles B Simone II Joseph S Friedberg Eli Glatstein James P Stevenson Daniel H Sterman Stephen M Hahn Keith A Cengel 袁光金李金銮朱宇熹凌扬 Department of Radiation oncology Department of Surgery Division of Thoracic Surgery Department of Medicine Division ofMedical Oncology Department of Medicine Division of PulmonaryAllergy and Critical CareHospital of the University of PennsylvaniaPhiladelphiaPAUSA 解放军第82医院肿瘤内科江苏淮安215008 福建省肿瘤医院放疗科福州350014 重庆医科大学附一院肿瘤科重庆400042 日本京都大学附属病院放射性肿瘤科苏州大学附属常州肿瘤医院肿瘤内科常州江苏213001

光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软... 详细信息

光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。

关键词：光动力疗法肺癌支气管内姑息疗法非小细胞肺癌

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