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Cardiac resynchronization in the elderly is beneficial, but could we implant our devices in old patients safer？

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Journal of Geriatric Cardiology 2016年第3期13卷 277-278页

作者： Evgeny N Mikhaylov Dmitry S Lebedev Arrhythmia Department Almazov Federal North-West Medical Research Centre Saint-Petersburg Russia neuromodulation Unit Almazov Federal North-West Medical Research Centre Saint-Petersburg Russia

We read with interest the article by Olechowski, et aL recently published in the Journal of Geriatric Cardiology. The results of this retrospective analysis of patients under- going cardiac resynchronization therapy （CRT） device implantation are in line with previous reports, suggesting that resynchronization therapy in the elderly is feasible and may lead to significant improvement of cardiac function and clinical status.

关键词： Cardiac resynchronization therapy Implantable cardioverter-defibrillator Pneumothorax

A time-synchronized multimodal monitoring system for general anesthesia

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Medicine in Novel Technology and devices 2024年第3期23卷 116-127页

作者： Zhenhu Liang Guanwei Geng Qifeng Song Mengmeng Tang Institute of Electrical Engineering Yanshan UniversityQinhuangdao066004China Key Laboratory of Intelligent Rehabilitation and neuromodulation of Hebei Province Qinhuangdao066004China

In clinical settings,different kinds of patient monitoring systems and depth of anesthesia monitoring(DoA)systems have been widely used to assess the depth of sedation and patient's ***,all these monitoring systems are independent of each *** date,no monitoring system has focused on the synchronized neural activities,cerebral metabolism,autonomic nervous system,and drug effects on the brain,as well as their interactions between neural activities and cerebral metabolism(i.e.,neurovascular coupling),and between brain and heart(i.e.,brain-heart coupling).In this study,we developed a time-synchronized multimodal monitoring system(TSMMS)that integrates electroencephalogram(EEG),near-infrared spectroscopy(NIRS),and standard physiological monitors(electrocardiograph,blood pressure,oxygen saturation)to provide a comprehensive view of the patient's physiological state during *** coherence and Granger causality(GC)methods were used to quantify the neurovascular coupling and brain-heart *** response surface model was used to estimate the combined propofol-remifentanil drug effect on the *** integrates data from various devices for a comprehensive analysis of vital *** enhances anesthesia monitoring through detailed EEG features,neurovascular,and brain-heart coupling ***,a response surface model estimates the combined effects of propofol and remifentanil,aiding anesthesiologists in drug *** conclusion,TSMMS provides a new tool for studying the coupling mechanism among neural activities,cerebral metabolism,and autonomic nervous system during general anesthesia.

关键词： General anesthesia Multimodal monitoring system Time-synchronized Neurovascular coupling Brain-heart coupling

Composite multiscale coherence and application to functionalcorticomuscular coupling

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Medicine in Novel Technology and devices 2023年第3期19卷 70-81页

作者： Xiaoling Chen Ying Liu Shengcui Cheng Tingting Shen Huipeng Gao Peiguo Hou Ping Xie Key Laboratory of Intelligent Rehabilitation and neuromodulation of Hebei Province Institute of Electric EngineeringYanshan UniversityQinhuangdaoHebeiChina Key Laboratory of Measurement Technology and Instrumentation of Hebei Province Institute of Electric EngineeringYanshan UniversityQinhuangdaoHebeiChina

Though coherence, a classical method to describe the linear correlation between two time series, has wideranging applications, from economics to neuroscience, it fails to illustrate the inherently multi-time scalesbased correlations. In this paper, we proposed a multiscale-like coherence model, defined as composite multiscalecoherence (CMSC) by combining the kth coarse-grain processing with the coherence. We made a comparison withthe multiscale coherence (MSC) with coarse-grain process in numerical data to compare the sensitivity profiles tothe coupling strength, data length and white Gaussian noise. After that, we applied the proposed model to explorethe functional corticomuscular coupling (FCMC) by analyzing the correlation between the EEG and EMG *** results reflected that the CMSC method were sensitive to the coupling strength, data length and thewhite Gaussian noise, and presented more stability along the time scale compared to the MSC method. Ourapplication of CMSC methods on the EEG and EMG signals indicated that the FCMC was of multi-time scalecharacteristics and higher coherence mainly consisted in the alpha and beta bands at about scale 10, thoughsignificant area showed a gradual decline with the scale increasing. Further comparison indicated that bothmodels are equally effective to describe the multiscale characteristics of the FCMC at lower time scales, whilesome differences emerge at the high time scales. Both simulation and experimental data demonstrate the effectiveness of the proposed multiscale-like model to describe the multiscale correlation between two time series. Thisstudy extends the relative researches on the FCMC to the multi-time scale.

关键词： Coherence Composite multiscale Coarse graining Functional corticomuscular coupling

Emerging Noninvasive Neurostimulation Technologies: CN-NINM and SYMPATOCORECTION

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Journal of Behavioral and Brain Science 2014年第3期4卷 105-113页

作者： Yuri P. Danilov Vladimir S. Kublanov Research medical and Biological Engineering Center of High Technologies Institute of Radio Engineering and Information Technology Ural Federal University Mira Str. 32 Ekaterinburg Russia Tactile Communication and neuromodulation Laboratory Biomedical Engineering Department University of Wisconsin-Madison 1550 Engineering Drive Madison USA

Two emerging noninvasive neurostimulation technologies, based on electrocutaneius stimulation of the tongue (CN-NINM) and the neck (SYMPATOCORRECTION) are presented. Currently, two portable devices were developed and introduced in clinical practice: PoNSTM (portable neurostimulator) and SYMPATOCOR. Both technologies are complement each other and demonstrate perspectives in various applications for purpose of neurorehabilitation and neurological symptoms management in such difficult rehabilitation areas, as traumatic brain injury, stroke, Parkinson’s disease, multiple sclerosis and many other neurological disorders.

关键词： Neurostimulation Neurorehabilitation Noninvasive medical Device

Adverse events of sacral neuromodulation for fecal incontinence reported to the federal drug administration

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 294-305页

作者： Klaus Bielefeldt Division of Gastroenterology University of Pittsburgh Medical Center

AIM:To investigate the nature and severity of AE related to sacral neurostimulation(SNS).METHODS:Based on Pubmed and Embase searches,we identified published trials and case series of SNS for fecal incontinence(FI)and extracted data on adverse events,requiring an active *** problems were operationally defined as infection,device removal explant or need for lead and/or generator *** addition,we analyzed the Manufacturer and User Device Experience registry of the Federal Drug Administration for the months of August-October *** were included if the report specifically mentioned gastrointestinal(GI),bowel and FI as indication and if the narrative did not focus on bladder *** classification,reporter,the date of the recorded complaint,time between initial implant and report,the type of AE,steps taken and outcome were extracted from the *** cases of device removal or replacement,we looked for confirmatory comments by healthcare providers or the ***:Published studies reported adverse events and reoperation rates for 1954 patients,followed for 27(1-117)*** rates were 18.6%(14.2-23.9)with device explants accounting for 10.0%(7.8-12.7)of secondary surgeries;rates of device replacement or explant or pocket site and electrode revisions increased with longer follow *** the period examined,the FDA received 1684 reports of AE related to SNS with FI or GI listed as indication.A total of 652 reports met the inclusion criteria,with 52.7%specifically listing *** or loss of benefit(48.9%),pain or dysesthesia(27.8%)and complication at the generator implantation site(8.7%)were most commonly *** led to secondary surgeries in 29.7%of the *** were performed to explant(38.2%)or replace(46.5%)the device or a lead,or revise the generator pocket(14.6%).Conservative management changes mostly involved changes in stimulation parameters(44.5%),which successfully addressed concerns in 35.

关键词： Sacral nerve stimulation Implanted medical devices Treatment complications Defecation disorders Device registry

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高性能医用钴基合金强化机理的研究进展

中国有色金属学报 2016年第5期26卷 1045-1053页

作者：李伟雄许赪李琼韦习成杨丽景宋振纶上海大学材料科学与工程学院上海200072 中国科学院宁波工业技术研究院慈溪生物医学工程研究所宁波315300 中国科学院宁波材料技术与工程研究所宁波315201 Medtronic neuromodulation Minnesota 55432 USA

MP35N合金是一种高性能医用钴基合金,具有优良力学性能、耐腐蚀和良好的生物相容性等优点,在医疗器械和航天航空具有广阔的应用前景。综述MP35N合金的力学性能和两种强化工艺冷变形和时效处理对其性能的影响,将MP35N合金强化机理分为4... 详细信息

MP35N合金是一种高性能医用钴基合金,具有优良力学性能、耐腐蚀和良好的生物相容性等优点,在医疗器械和航天航空具有广阔的应用前景。综述MP35N合金的力学性能和两种强化工艺冷变形和时效处理对其性能的影响,将MP35N合金强化机理分为4类并加以详细阐述,描述不同强化机理的发展历程和现状。分析MP35N合金不同强化机理的优缺点和未来关于MP35N合金的研究思路。

关键词：医用钴基合金 MP35N 强化机理时效冷变形

Neuron devices:emerging prospects in neural interfaces and recognition

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Microsystems & Nanoengineering 2022年第6期8卷 1-13页

作者： Yang Wang Shuangjie Liu Hao Wang Yue Zhao Xiao-Dong Zhang Tianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational MedicineTianjin University300072 TianjinChina Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology Institute of Advanced Materials PhysicsSchool of SciencesTianjin University300350 TianjinChina

Neuron interface devices can be used to explore the relationships between neuron firing and synaptic transmission,as well as to diagnose and treat neurological disorders,such as epilepsy and Alzheimer’s *** is crucial to exploit neuron devices with high sensitivity,high biocompatibility,multifunctional integration and high-speed data *** the past decades,researchers have made significant progress in neural electrodes,artificial sensory neuron devices,and neuromorphic optic neuron *** main part of the review is divided into two sections,providing an overview of recently developed neuron interface devices for recording electrophysiological signals,as well as applications in neuromodulation,simulating the human sensory system,and achieving memory and *** mainly discussed the development,characteristics,functional mechanisms,and applications of neuron devices and elucidated several key points for clinical *** present review highlights the advances in neuron devices on brain-computer interfaces and neuroscience research.

关键词： Neuron epilepsy neural

Non-invasive transcutaneous electrical stimulation in the treatment of overactive bladder

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Asian Journal of Urology 2015年第2期2卷 92-101页

作者： Martin Slovak Christopher R.Chapple Anthony T.Barker Department of medical Physics&Clinical Engineering Sheffield Teaching Hospitals NHS Foundation TrustSheffieldUK Department of Urology Sheffield Teaching Hospitals NHS Foundation TrustSheffieldUK

We reviewed the literature on transcutaneous electrical nerve stimulation(TENS)used as a therapy for overactive bladder(OAB)symptoms,with a particular focus on:stimulation site,stimuli parameters,neural structures thought to be targeted,and the clinical and urodynamic outcomes *** majority of studies used sacral or tibial nerve *** literature suggests that,whilst TENS therapy may have neuromodulation effects,patient are unlikely to benefit to a significant extent from a single application of TENS and indeed clear benefits from acute studies have not been *** long-term studies there were differences in the descriptions of stimulation intensity,strategy of the therapy,and positioning of the electrodes,as well as in the various symptoms and pathology of the ***,most studies were uncontrolled and hence did not evaluate the placebo *** is known about the underlying mechanism by which these therapies work and therefore exactly which structures need to be stimulated,and with what *** is promising evidence for the efficacy of a transcutaneous stimulation approach,but adequate standardisation of stimulation criteria and outcome measures will be necessary to define the best way to administer this therapy and document its efficacy.

关键词： Overactive bladder Posterior tibial nerve stimulation Sites of stimulation Sacral stimulation Sham stimulation methodology Surface electrodes Transcutaneous electrical nerve stimulation

The outcomes of hypoglossal nerve stimulation in the management of OSA: A systematic review and meta-analysis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第1期5卷 41-48页

作者： Anvesh R.Kompelli Jonathan S.Ni Shaun A.Nguyen Eric J.Lentsch David M.Neskey Ted A.Meyer Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSCUSA

Objectives:Obstructive sleep apnea (OSA) is a prevalent disease with significant health *** first line therapy is CPAP,long-term compliance is low and device misuse is common,highlighting the need for alternative *** airway surgery is one alternative,but substantial side effects hamper efficacy.A new alternative is an implantable hypoglossal nerve stimulator (HNS).These devices utilize neuromodulation to dilate/reinforce the airway and reduce side effects associated with traditional *** recent trials investigated the efficacy of these *** purpose of this study was to perform meta-analysis of available HNS studies investigating treatment of OSA to analyze objective and subjective outcomes and side ***:A comprehensive literature search of PubMed and Scopus was *** independent reviewers examined clinical trials investigating HNS in treatment of sleep apnea in *** with objective and subjective endpoints in sleep were included for *** events from trials were also ***:Across 16 studies,381 patients were *** 6 months (p =0.008),mean SAQLI improved by 3.1 (95%CI,2.6-3.7).At 12 months (p < 0.0001),mean AHI was reduced by 21.1 (95%Cl,16.9-25.3),mean ODI was reduced by 15.0 (95%CI,12.7-17.4),mean ESS was reduced by 5.0 (95%CI,4.2-5.8),mean FOSQ improved by 3.1 (95%CI,2.6-3.4).Pain (6.2%:0.7-16.6),tongue abrasion (11.0%:1.2-28.7),and internal (3.0%:0.3-8.4)/external device (5.8%:0.3-17.4) malfunction were common adverse ***:HNS is a safe and effective treatment for CPAP refractory *** study comparing HNS to other therapies is required.

关键词： Surgical treatment of obstructive sleep apnea Sleep medicine Obstructive sleep apnea