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Chinese Herbal Medicines 2025年第1期17卷 156-165页

作者： Lina Sun Cuiling Zuo Baonan Ma Xinxin Liu Yifei Guo Xiangtao Wang Meihua Han Institute of Medicinal Plant development Chinese Academy of Medical Sciences & Peking Union Medical College Research center of Pharmaceutical Engineering Technology Harbin University of Commerce

Objective:In order to enhance the efficacy of anti-breast cancer,paclitaxel nanoparticles（PTX NPs） and polypyrrole nanoparticles（PPy NPs） were combined with photothermal therapy and *** the same time,the two dosage forms of PTX NPs and PTX NPs gel were ***:PTX NPs were prepared by self-assembly method,and then the cytotoxicity in vitro was investigated by Methyl thiazolyl tetrazolium（MTT） and other methods,and the efficacy and side effects in vivo were further ***:The average hydrated diameter,PDI and electric potential of PTX NPs were（210.20±1.57） nm,（0.081±0.003） mV and（15.80±0.35） mV,*** results showed that the IC50value of PTX NPs on 4 T1 cells was 0.490 μg/mL,while that of PTX injection was 1.737 μg/*** cell inhibitory effect of PTX NPs was about 3.5 times higher than that of PTX *** tumor inhibition rates of PTX NPs and gel were 48.64% and 56.79%,*** with local photothermal stimulation,the tumor inhibition rate of the PTX NPs reached 91.05%,surpassing that of the gel under the same conditions（48.98%）,moreover,the organ index and H&E staining results of PTX NPs showed a decrease in ***:This combination therapy can significantly enhance the effect of anti-breast cancer,and the synergistic effect of chemotherapy and light and heat provides a feasible and effective strategy for the treatment of tumor.

关键词： breast cancer combination therapy paclitaxel photothermal therapy polypyrrole

A highly sensitive electrochemical sensor based on poly(3-aminobenzoic acid)/graphene oxide-gold nanoparticles modified screen printed carbon electrode for paraquat detection

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Journal of Environmental Sciences 2025年第2期148卷 139-150页

作者： Dechnarong Pimalai Thitirat Putnin Suwussa Bamrungsap National Nanotechnology center(NANOTEC) National Science and Technology Development Agency(NSTDA)Pathum Thani 12120Thailand

Herein,a modified screen printed carbon electrode(SPCE)based on a composite material,graphene oxide-gold nanoparticles(GO-AuNPs),and poly(3-aminobenzoic acid)(P3ABA)for the detection of paraquat(PQ)is *** modified electrode was fabricated by drop casting of the GO-AuNPs,followed by electropolymerization of 3-aminobenzoic acid to achieve SPCE/GO-AuNPs/*** morphology and microstructural characteristics of the modified electrodes were revealed by scanning electron microscopy(SEM)for each step of *** composite GO-AuNPs can provide high surface area and enhance electroconductivity of the *** addition,the presence of negatively charged P3ABA notably improved PQ adsorption and electron transfer rate,which stimulate redox reaction on the modified electrode,thus improving the sensitivity of PQ *** SPCE/GOAuNPs/P3ABA offered a wide linear range of PQ determination(10^(−9)-10^(−4) mol/L)and low limit of detection(LOD)of 0.45×10^(−9) mol/L or 0.116μg/L,which is far below international safety *** modified electrode showed minimum interference effect with percent recovery ranging from 96.5%to 116.1%after addition of other herbicides,pesticides,metal ions,and *** stability of the SPCE/GO-AuNPs/P3ABA was evaluated,and the results indicated negligible changes in the detection signal over 9 ***,this modified electrode was successfully implemented for PQ analysis in both natural and tapped water with high accuracy.

关键词： Paraquat Electrochemical sensor Graphene oxide(GO) Gold nanoparticle(AuNP) Poly(3-aminobenzoic acid)(P3ABA)

Rare tumor list provide vast opportunities for novel drug development in China

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Science Bulletin 2025年第2期70卷 132-134页

作者： Rongshou Zheng Shuhang Wang Guo Zhao Wenqiang Wei Ning Li National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Clinical Trial center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

During the last decade,common cancer understanding and treatment have significantly improved[1,2,3].However,rare tumors are still poorly *** the low incidence of rare tumors,including soft tissue sarcoma,malignant peripheral nerve sheath tumor,malignant pleural mesothelioma,and others,they impose formidable clinical challenges due to inadequate information regarding their diagnosis and treatment,especially in ***,the rare tumor definition was the first issue encountered by researchers in this ***,no unanimous rare tumor definition has been established ***,there are disparities between rare tumor lists in different *** previously defined rare as those with a<50/100,000people prevalence in *** European Union initiated a project known as the Surveillance of Rare Cancer in Europe(RARECARE).

关键词： diagnosis rare Rare

High-resolution, high-speed, chromotropic color printing based on fs-laser-induced gold/graphene HSFLs

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Photonics Research 2025年第1期13卷 125-139页

作者： SHIRU JIANG WOO-BIN LEE STUART ABERDEEN SANG-SHIN LEE Department of Electronic Engineering Kwangwoon University Nano device Application center Kwangwoon University

Through achieving high-spatial-frequency laser-induced periodic surface structures （HSFLs） on a gold/graphene hybrid film,we introduce a high-speed,high-resolution,and wide-gamut chromotropic color printing *** method effectively addresses the trade-off between throughput and resolution in laser *** realize Au HSFL,disordered lattice structures and high transmittance of amorphous Au （a-Au） thin film are used to overcome the rapid hot-electron diffusion and loss of plasmonic coherence typically observed on low-loss metal surfaces,*** with crystallization in Au and modulated surface plasmon polaritons by artificial"seed"pre-structure growing in a SiO2/Si substrate,HSFL emerged with a period of 100 nm on crystalline Au after single and rapid femtosecond laser *** equips the proposed color printing with highresolution and high-speed features *** addition,the crystallization process is demonstrated to initiate change in the complex refractive index of Au,which causes wide-gamut *** chromotropic capability,which facilitates the background color to be tailored in color as well as into desirable shapes independently,enables three-level anti-counterfeiting based on the proposed color ***,the proposed color printing is amenable for practical implementation in diverse applications,including security marking and data storage,ranging from nanoscale to large-scale fabrication.?2024 Chinese Laser Press

关键词： Chemical vapor deposition Electron beam lithography Localized surface plasmon resonance Scanning electron microscopy Thin films Ultrafast lasers

Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi Robert Chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic medical Sciences Chinese Academy of medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

Numerical Study of Flow and Heat Transfer Characteristics of Shell-and-Tube Molten Salt Electric Heater with Circularly Perforated Baffles

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Journal of Thermal Science 2025年第1期34卷 24-33页

作者： LIN Yongjie ZHANG Cancan WU Yuting ZHANG Yi LU Yuanwei Key Laboratory of Heat Transfer and Energy Conversion National User-Side Energy Storage Innovation Research and Development CenterBeijing University of TechnologyBeijing 100124China

Numerical simulations of the flow and heat transfer characteristics of four shell-and-tube molten salt electric heaters with different perforation rates was ***-and-tube electric heaters have the same geometry and tube arrangement,and all of them use single segmental baffles,but there exist four different baffle openings(φ),i.e.,0%,2.52%,4.06%,and 6.31%.The results indicated that the reasonable baffle opening could significantly reduce the shell-side pressure drop,effectively decreasing the shell-side flow dead zone *** can eliminate the local high-temperature phenomenon on the surface of electric heating tubes,but the heat transfer coefficient is slightly *** perforated schemes significantly reduce shell-side pressure drop compared to the baseline solution without open *** particular,the φ=6.31% scheme exhibits the optimal performance among all the schemes,with a maximum reduction of up to 50.50% in shell-side pressure drop relative to the unopened holes *** heat transfer coefficient is the highest for φ=0%,exhibiting a range of5.26% to 5.73%,5.14% to 5.99%,and 7.31% to 8.54% higher than φ=2.52%,4.06%,and 6.31%,respectively,within the calculated *** composite index h/(Δp)^(1/3)was higher for all open-hole solutions than that for the unopened-hole *** best overall performance was for φ=6.31%,which improved the composite index by15.29%to 17.18%over the unopened-hole solution.

关键词： molten salt electric heater perforated baffles heat transfer

Purinergic signaling by TCRaβ~+double-negative T regulatory cells ameliorates liver ischemia–reperfusion injury

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Science Bulletin 2025年第2期70卷 241-254页

作者： Hua Jin Mingyang Li Xiyu Wang Lu Yang Xinjie Zhong Zihan Zhang Xiaotong Han Jingjing Zhu Mengyi Li Songlin Wang Simon C.Robson Guangyong Sun Dong Zhang Immunology Research center for Oral and Systemic Health Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China medical Research center Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Gastroenterology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China General Surgery Department Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Beijing Laboratory of Oral Health Capital Medical University School of Basic MedicineBeijing 100069China center for Inflammation Research Department of AnesthesiaCritical Care&Pain Medicineand Department of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02115USA

Hepatic ischemia–reperfusion injury(HIRI)is an important cause of liver injury following liver transplantation and major resections,and neutrophils are the key effector cells in ***-negative T regulatory cells(DNT)are increasingly recognized as having critical regulatory functions in the immune *** DNT expresses distinct immunoregulatory mechanisms to modulate neutrophils,as in HIRI,remains largely *** this study,we found that murine and human DNT highly expressed CD39that protected DNT from extracellular ATP-induced apoptosis and generated adenosine in tandem with CD73,to induce high levels of neutrophil ***,extracellular adenosine enhanced DNT survival and suppressive function by upregulating survivin and NKG2D expression via the A2AR/pAKT/FOXO1 signaling *** transfer of DNT ameliorated HIRI in mice through the inhibition of neutrophils in a CD39-dependent ***,the adoptive transfer of A2ar^(-/-)DNT validated the importance of adenosine/A2AR signaling,in promoting DNT survival and immunomodulatory function to protect against HIRI in *** conclusion,purinergic signaling is crucial for DNT homeostasis in *** of CD39 or activation of A2AR signaling in DNT may provide novel therapeutic strategies to target innate immune disorders.?2024 The *** by Elsevier *** behalf of Science China *** is an open accessarticle under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Double-negative T regulatory cells Hepatic ischemia and reperfusion injury CD39 Adenosine A2AR

Real-time synchronous detection of wind and aerosol using a coherent lidar

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Chinese Optics Letters 2025年第01期 60-66页

作者：史悦罗雄孙培育董吉辉汤磊周杰王柯陈春利王云石周鼎富 Southwest Institute of Technical Physics Science College Civil Aviation Flight University of China Lidar and device Laboratory Southwest Institute of Technical Physics Key Laboratory of Laser device Technology of China North Industries Group Corporation Limited China Research and development Academy of Machinery Equipment

Coherent lidar (CL) addresses existing constraints in CL data products by enabling simultaneous observation of multiple meteorological parameters such as cloud height, extinction coefficient, aerosol concentration, and wind field evaluation. A detailed analysis of CL echo signals was performed at a wavelength of 1550 nm, enabling accurate measurements of cloud height and aerosol concentration. Extensive data analyses and validation tests were conducted, aligning them with a 532 nm direct aerosol lidar (AL). The assessments of the aerosol extinction coefficient demonstrated notable consistency. This underscores the potential of advanced CL for providing prolonged and consistent observations across diverse meteorological conditions.

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Preparation and applications of calcium ferrite as a functional material:A review

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli Han Bowen Duan Lei Liu Shilong Fang Weiwei Wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation center of Green development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives

Movement analysis in the diagnosis and management of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 485-486页

作者： Johannes Burtscher Nicolas Bourdillon Jules MJanssen Daalen Aurélien Patoz Julien FBally Martin Kopp Davide Malatesta Bastiaan RBloem Institute of Sport Sciences University of LausanneLausanneSwitzerland Radboud University medical center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands Radboud University medical center Department of Medical BioSciencesNijmegenThe Netherlands Research and development Department Volodalen Swiss Sport LabAigleSwitzerland Service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually