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Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 716-731页

作者： Hsiang-Chun Lai Ju-Chien Cheng Hei-Tung Yip Long-Bin Jeng Sheng-Teng Huang graduate Institute of Chinese Medicine School of Chinese MedicineCollege of Chinese MedicineChina Medical UniversityTaichung 404328TaiwanChina department of medical Laboratory Science and Biotechnology China Medical UniversityTaichung 404TaiwanChina Management office for Health Data China Medical University HospitalTaichung 404327TaiwanChina Organ Transplantation Center China Medical University HospitalTaichung 40447TaiwanChina department of Chinese Medicine China Medical University HospitalSchool of Chinese MedicineChina Medical UniversityTaichung 40447TaiwanChina

BACKGROUND Type 2 diabetes mellitus(DM)is an independent risk factor for hepatocellular carcinoma(HCC),while insulin is a potent *** a new therapeutic modality for preventing insulin users from developing HCC is a critical goal for *** To investigate whether regular herbal medicine use can decrease HCC risk in DM patients with regular insulin *** We used data acquired from the Taiwan,Chinaese National Health Insurance research database between 2000 and *** identified patients with DM who were prescribed insulin for>3 *** herb user group was further defined as patients prescribed herbal medication for DM for>3 months per annum during RESULTS We initially enrolled 657144 DM patients with regular insulin use from 2000 to *** these,46849 patients had used a herbal treatment for DM,and 140547 patients were included as the matched control *** baseline variables were similar between the herb users and *** patients with regular herb use had a 12%decreased risk of HCC compared with the control group[adjusted hazard ratio(aHR)=0.88,95%CI=0.80–0.97].The cumulative incidence of HCC in the herb users was significantly lower than that of the *** with a herb use of>5 years cumulatively exhibited a protective effect against development of HCC(aHR=0.82,P<0.05).Of patients who developed HCC,herb users exhibited a longer survival time than nonusers(aHR=0.78,P=0.0001).Additionally,we report the top 10 herbs and formulas in prescriptions and summarize the potential pharmacological effects of the *** analysis indicated that Astragalus propinquus(Huang Qi)plus Salvia miltiorrhiza Bunge(Dan Shen),and Astragalus propinquus(Huang Qi)plus Trichosanthes kirilowii Maxim.(Tian Hua Fen)were the most frequent combination of single ***,Ji Sheng Shen Qi Wan plus Dan Shen was the most frequent combination of herbs and *** This large-scale retrospective cohort study reveals th

关键词： Hepatocellular carcinoma Diabetes mellitus Insulin Herb Taiwan,Chinaese National health insurance research database

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Body-Shaping Membrane to Regenerate Breast Fat by Elastic Structural Holding

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Research 2024年第1期2023卷 165-180页

作者： Hye-Seon Kim Jeongeun Park Hyun-Su Ha Sewoom Baek Chan Hee Lee Kyubae Lee Suji Park Jueun Kim Se Won Yi Hak-Joon Sung department of medical Engineering Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Republic of Korea TMD LAB Co.Ltd. 6th Floor31Gwangnaru-ro 8-gilSeongdong-guSeoul 04799Republic of Korea

Tissue regeneration requires structural holding and movement support using tissue-type-specific aids such as bone casts,skin bandages,and joint ***,an unmet need exists in aiding breast fat regeneration as the breast moves following continuous body motion by exposing the breast fat to dynamic ***,the concept of elastic structural holding is applied to develop a shape-fitting moldable membrane for breast fat regeneration(“adipoconductive”)after surgical defects are *** membrane has the following key characteristics:(a)It contains a panel of honeycomb structures,thereby efficiently handling motion stress through the entire membrane;(b)a strut is added into each honeycomb in a direction perpendicular to gravity,thereby suppressing the deformation and stress concentration upon lying and standing;and(c)thermo-responsive moldable elastomers are used to support structural holding by suppressing large deviations of movement that occur *** elastomer became moldable upon a temperature shift above T_(m).The structure can then be fixed as the temperature *** a result,the membrane promotes adipogenesis by activating mechanotransduction in a fat miniature model with pre-adipocyte spheroids under continuous shaking in vitro and in a subcutaneous implant placed on the motion-prone back areas of rodents in vivo.

关键词： thereby shaking Elastic

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Deep learning models semi-automatic training system for quality control of transthoracic echocardiography

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中国医学影像技术 2024年第8期40卷 1140-1145页

作者： QIAN Sunnan WENG Hexiang CHENG Hanlin SHI Zhongqing WANG Xiaoxian GUO Guanjun FANG Aijuan LUO Shouhua YAO Jing QI Zhanru department of Information office Jiangsu Province Official HospitalNanjing 210009China department of Intelligent Medicine School of Biological Sciences and Medical EngineeringSoutheast UniversityNanjing 210096China department of Ultrasound Medicine Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China department of medical Imaging Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China department of Ultrasound Medicine Yizheng Hospital of Nanjing Drum Tower Hospital GroupYangzhou 211400China

Objective To explore the value of deep learning(DL)models semi-automatic training system for automatic optimization of clinical image quality control of transthoracic echocardiography(TTE).Methods Totally 1250 TTE videos from 402 patients were retrospectively collected,including 490 apical four chamber(A4C),310 parasternal long axis view of left ventricle(PLAX)and 450 parasternal short axis view of great vessel(PSAX GV).The videos were divided into development set(245 A4C,155 PLAX,225 PSAX GV),semi-automated training set(98 A4C,62 PLAX,90 PSAX GV)and test set(147 A4C,93 PLAX,135 PSAX GV)at the ratio of 5∶2∶*** on development set and semi-automatic training set,DL model of quality control was semi-automatically iteratively optimized,and a semi-automatic training system was constructed,then the efficacy of DL models for recognizing TTE views and assessing imaging quality of TTE were verified in test *** After optimization,the overall accuracy,precision,recall,and F1 score of DL models for recognizing TTE views in test set improved from 97.33%,97.26%,97.26%and 97.26%to 99.73%,99.65%,99.77%and 99.71%,respectively,while the overall accuracy for assessing A4C,PLAX and PSAX GV TTE as standard views in test set improved from 89.12%,83.87%and 90.37%to 93.20%,90.32%and 93.33%,*** The developed DL models semi-automatic training system could improve the efficiency of clinical imaging quality control of TTE and increase iteration speed.

关键词： echocardiography quality control artificial intelligence

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Early adenocarcinoma mixed with a neuroendocrine carcinoma component arising in the gastroesophageal junction: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 563-570页

作者： Yu-Qing Cheng Geng-Fang Wang Xiao-Li Zhou Min Lin Xin-Wen Zhang Qin Huang department of Pathology The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Gastroenterology Center The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMA 02215United States

BACKGROUND Early adenocarcinoma mixed with a neuroendocrine carcinoma(NEC)component arising in the gastroesophageal junctional(GEJ)region is rare and even rarer in young ***,we report such a case in a 29-year-old Chinese *** SUMMARY This patient presented to our hospital with a 3-mo history of dysphagia and *** endoscopy revealed an elevated nodule in the distal esophagus 1.6 cm above the GEJ line,without Barrett’s esophagus or involvement of the gastric *** nodule was completely resected by endoscopic submu-cosal dissection(ESD).Pathological examination confirmed diagnosis of intra-mucosal adenocarcinoma mixed with an NEC component,measuring 1.5 ***,both adenocarcinoma and NEC components were positive for P53 with a Ki67 index of 90%;NEC was positive for synaptophysin and ***-generation sequencing of 196 genes demonstrated a novel germline mutation of the ERCC3 gene in the DNA repair pathway and a germline mutation of the RNF43 gene,a common gastric cancer driver gene,in addition to pathogenic somatic mutations in P53 and CHEK2 *** patient was alive without evidence of the disease 36 mo after *** Early adenocarcinoma with an NEC component arising in the distal esophageal side of the GEJ region showed evidence of gastric origin.

关键词： Adenocarcinoma Neuroendocrine carcinoma Gastroesophageal junction Next generation sequencing Case report

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Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents:A metaanalysis

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World Journal of Diabetes 2024年第6期15卷 1353-1366页

作者： Le-Yang Li Song-Mei Li Bo-Xian Pang Jun-Ping Wei Qiu-Hong Wang department of Endocrinology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China graduate School Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Obesity in children and adolescents is a serious problem,and the efficacy of exercise therapy for these patients is *** To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory *** The PubMed,Web of Science,and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October *** meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese *** In total,1010 patients from 28 studies were *** therapy reduced the levels of fasting blood glucose(FBG)[standardized mean difference(SMD):-0.78;95%confidence interval(CI):-1.24 to-0.32,P=0.0008],fasting insulin(FINS)(SMD:-1.55;95%CI:-2.12 to-0.98,Ptraining increased adiponectin levels(SMD:1.24;95%CI:0.30 to 2.18,P=0.01)but did not improve tumor necrosis factor-alpha(TNF-α)levels(SMD:-0.80;95%CI:-1.77 to 0.18,P=0.11).CONCLUSION In summary,exercise therapy improves glucose metabolism by reducing levels of FBG,FINS,HOMA-IR,as well as improves inflammatory status by reducing levels of IL-6,CRP,leptin,and increasing levels of adiponectin in overweight and obese *** was no statistically significant effect between exercise training and levels of TNF-α.Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.

关键词： Exercise training Obesity Children and adolescents Glucose metabolism Inflammatory markers Meta-analysis

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Diversity of Macro Invertebrates of the River Rwizi in Western Uganda: A Citizen Science-BioBlitz Approach

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Open Journal of Ecology 2024年第4期14卷 343-365页

作者： John Bosco Nkurunungi Godwin Muhairwe Upton Nuwagira Nickson Araka Nestor Mugabe Osbert Natwijuka Jeninah Atwebembeire Mbarara University of Science and Technology Mbarara Uganda department of Directorate of Research and graduate training Makerere University Kampala Uganda

This study elucidates the pivotal role of citizen science-BioBlitz methodologies for rapid assessment of the macro-invertebrate taxa within the threatened River Rwizi of South-western Uganda. Utilizing a comprehensive mixed-methods approach, the investigation focused on six distinct river segments to demonstrate the efficacy of participatory citizen science-BioBlitz approaches conducted by experts, students and community volunteers. BioBlitz events included rigorous macro-invertebrate sampling at each of the selected sites along River Rwizi on nine occasions, incorporating collaborative taxonomic identification procedures involving experts, students, and the local community. Analyzing pollution concerns, diversity metrics, and community narratives yielded insights into river health and socio-ecological dynamics. A total of 43 macro-invertebrate families across 17 orders were documented with class Insecta dominating. Participants in BioBlitz events expressed predominantly positive sentiments, emphasizing satisfaction, education, and heightened awareness, besides negative sentiments rooted in historical mistrust. Intriguingly, the study unveiled an unforeseen trend in macro-invertebrate taxa richness, rising from upstream to urban sprawl and diminishing at peri-urban downstream sites. The study underscores the potential of citizen science-BioBlitz methodologies in advancing community science education and unraveling the intricate dynamics of threatened river ecosystems. The insights offered are invaluable for policymakers and conservationists seeking effective strategies to address challenges in the River Rwizi and comparable ecosystems. .

关键词： Diversity Macroinvertebrates Rwizi Citizen-Science-BioBlitz 6

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Few-shot incremental radar target recognition framework based on scattering-topology properties

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Chinese Journal of Aeronautics 2024年第8期37卷 246-260页

作者： Chenxuan LI Weigang ZHU Bakun ZHU Yonggang LI graduate School Space Engineering UniversityBeijing 101400China department of Electronic and Optical Engineering Space Engineering UniversityBeijing 101400China

The continuous emergence of new targets in open scenarios leads to a substantial decrease in the performance of Inverse Synthetic Aperture Radar(ISAR)recognition ***,data scarcity further exacerbates the challenge of identifying new classes of ISAR *** this paper,a few-shot incremental target recognition framework based on Scattering-Topology Properties(STPIL)is ***,STPIL extracts scattering-topology properties of ISAR targets as recognition ***,the pseudo-incremental training strategy effectively alleviates the algorithm’s forgetting of old knowledge,and improves compatibility with new ***,a feature embedding network,with few parameters,is designed based on the graph neural *** embedding network is highly adaptable to changes in data ***,STPIL fully considers the joint distribution and marginal distribution in scattering features,and uses the Brownian distance metric module to make the scattering-topology features more *** results on both the simulation dataset and the public measured data indicate that STPIL can effectively balance new classes with old classes,and has superior performance to other advanced methods in the incremental recognition of targets.

关键词： Brownian distance metric Graph neural networks Incremental learning Inverse Synthetic Aperture Radar(ISAR) Scattering

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Integrated photonic fractional convolution accelerator

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Photonics Research 2024年第8期12卷 1828-1839页

作者： KEVIN ZELAYA MOHAMMED-ALI MIRI department of Physics Queens College of the City University of New York Physics Program The Graduate Center of the City University of New York

An integrated photonic circuit architecture to perform a modified-convolution operation based on the discrete fractional Fourier transform(DFrFT) is introduced. This is accomplished by utilizing two nonuniformly coupled waveguide lattices with equally spaced eigenmode spectra, the lengths of which are chosen so that the DFrFT and its inverse operations are achieved. A programmable modulator array is interlaced so that the required fractional convolution operation is performed. Numerical simulations demonstrate that the proposed architecture can effectively perform smoothing and edge detection tasks even for noisy input signals, which is further verified by electromagnetic wave simulations. Notably, mild lattice defects do not jeopardize the architecture performance, showing its resilience to manufacturing errors. ? 2024 Chinese Laser Press

关键词： Array waveguide devices Edge detection Fourier transforms Free space optics Numerical simulation Optical elements

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Improvement of the nutritional support management system for patients in intensive care units

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World Journal of Psychiatry 2024年第1期14卷 44-52页

作者： Yuan-Yuan Zhang Chun-Yi Wang Dong-Xian Guo Hai-Nu Gao Xian-Shan Jin Yan-Li Wu Lu-Han Chen Zhi-Xian Feng department of Critical Care Medicine Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina department of Information Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina department of Pharmacy Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina department of Nutrition Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Administrative office Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina

BACKGROUND Nutritional support for patients hospitalized in the intensive care unit(ICU)is an important part of clinical treatment and care,but there are significant implementation *** To introduce a modified nutritional support management system for ICU patients based on closed-loop information management and psychological *** The division of functions,personnel training,system construction,development of an intelligent decision-making software system,quality control,and improvement of the whole process were carried out to systematically manage nutritional support for ICU *** Following the implementation of the whole process management system,the scores of ICU medical staff’s knowledge,attitudes/beliefs,and practices regarding nutritional support were comprehensively *** proportion of hospital bed-days of total enteral nutrition(EN)in ICU patients increased from 5.58%to 11.46%,and the proportion of EN plus parenteral nutrition increased from 42.71%to 47.07%.The rate of EN initiation within 48 h of ICU admission increased from 37.50%to 48.28%,and the EN compliance rate within 72 h elevated from 20.59%to 31.72%.After the implementation of the project,the Self-rating Anxiety Scale score decreased from 61.07±9.91 points to 52.03±9.02 points,the Self-rating Depression Scale score reduced from 62.47±10.50 points to 56.34±9.83 points,and the ICU stay decreased from 5.76±2.77 d to 5.10±2.12 *** The nutritional support management system based on closed-loop information management and psychological counseling achieved remarkable results in clinical applications in ICU patients.

关键词： Closed-loop information Psychological counseling Intensive care unit patients Nutritional support Management system

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Socioeconomic Factors Influencing the Adoption of Cenchrus ciliaris among the Pastoralist Communities in South Baringo, Kenya

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Open Journal of Ecology 2024年第8期14卷 629-650页

作者： Nyambari Davis Mathew Ogendi George Morara Atalitsa Caren Navalia Dryland Research training & Ecotourism Centre Egerton University Kenya Directorate of Post-graduate Studies Egerton University Kenya department of Environmental Science Egerton University Kenya

Land degradation poses significant threats to food and environmental security globally. In arid and semi-arid lands (ASALs), livestock production is an important and significant livelihood. Unfortunately, overstocking and overgrazing have diminished pasture availability, and thus adversely impacting on the sector’s contribution to food security for many ASAL communities. The Global Environment Facility’s Small Grants Program in its quest to combat soil erosion, deforestation, and Prosopis juliflora invasion in the Lake Bogoria Landscape, Baringo County, Kenya has supported the establishment of Cenchrus ciliaris (buffel grass) since 2018. Despite its introduction and establishment, the socioeconomic factors influencing its adoption remain undocumented. This study evaluated these factors in three administrative wards, namely: Ilchamus, Mochongoi, and Marigat of Baringo South Sub-County. Data was collected from 103 households using a semi-structured questionnaire, key informant interviews (KIIs), and Focus Group Discussions (FGDs). Our results revealed that Cenchrus ciliaris adoption has partially reduced soil erosion and deforestation, improved livelihoods and environmental conservation. Nearly 50% of the respondents have established 2 to 5 acres of buffel grass pasturelands on their farms. The level of education of the respondents for had a significant association with the participants’ knowledge regarding the advantages of pasture production for environmental conservation (χ2 = 16.93;p χ2 = 77.71;p χ2 = 18.3;p χ2 = 3.8;p Cenchrus ciliaris value chain are recommended as practical strategies of enhancing livestock production and environmental conservation in Kenya’s ASALs.

关键词： Cenchrus ciliaris Pasture Ecology Conservation

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