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Eosinophilic Meningitis in a Patient With Early HIV Infection,Latent Syphilis and Herpes Simplex Virus 2 Meningitis

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Infectious Microbes & Diseases 2024年第4期6卷 210-212页

作者： Chaowen Deng Qingyan Yang Lina Li Fanfan Xing Department of InfectiousDiseases and Microbiology The University of Hong Kong–Shenzhen HospitalShenzhenChina Neuromedicine Center The University of Hong Kong-Shenzhen HospitalShenzhenChina

Eosinophilic meningitis is an unusual condition,particularly in patients with HIV infection or *** detection of herpes simplex virus(HSV)-2 and HIV-1 in cerebrospinal fluid from a patient with acute eosinophilic meningitis has not been previously ***,we report a case of a 26-year-old cisgender man newly diagnosed with HIV-1 infection and latent syphilis,who presented with headache and low-grade *** was diagnosed with both acute eosinophilic meningitis and HSV-2 meningitis,and his condition improved after treatment with acyclovir and *** compelling case indicates that HSV-2 meningitis may manifest concurrently with acute eosinophilia meningitis in patients coinfected with HIV and Treponema *** next-generation sequencing plays an important role in identifying and further confirming pathogens responsible for central nervous system infections.

关键词： eosinophilic meningitis HIV herpes simplex virus 2 syphilis next-generation sequencing

Implication of Receptor Activator of NF-κB Ligand in Wnt/β-Catenin Pathway Promoting Osteoblast-like Cell Differentiation

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Journal of Huazhong university of Science and Technology(medical Sciences) 2012年第6期32卷 818-822页

作者：聂斌周韶琼方欣李伟王斌管思明 Department of Geriatrics Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Geriatrics Union HospitalTongji Medical College Huazhong University of Science and Technology

Recent studies showed that activation of Wnt/β-catenin pathway promoted the differentiation of osteoblast-like cells in the arterial calcification, but its mechanism remains unknown. In this study, the hypothesis that Wnt/β-catenin pathway promotes the differentiation of osteoblast-like cells by upregulating the expression of receptor activator of NF-κB ligand (RANKL) was examined. LiCl was used to activate the Wnt/β-catenin pathway. The differentiation of osteoblast-like cells was observed by Von Kossa staining, calcium content assay, alkaline phosphatase (ALP) activity assay, and detection of osteocalcin expression. Real-time PCR was performed to detect the expression of RANKL and osteoprotegerin (OPG, the decoy receptor of RANKL) during the osteoblast-like cell differentiation. Different concentrations of OPG were added to the culture media respectively to inhibit the function of RANKL, and the change in the differentiation of osteoblast-like cells was evaluated. The results showed that when the Wnt/β-catenin pathway was activated by LiCl, the expression of RANKL was significantly in-creased, which coincided with the differentiation of osteoblast-like cells (P<0.05), and the OPG treatment could partly attenuate the promoting effect of Wnt/β-catenin pathway on the differentiation of osteoblast-like cells (P<0.05), but it failed to completely abolish such effect. It was concluded that activation of Wnt/β-catenin pathway promotes the differentiation of osteoblast-like cells by both RANKL-dependent and RANKL-independent mechanisms.

关键词： arterial calcification Wnt/β-catenin pathway osteoblast-like cell osteoprotegerin

Polarization-controlled dual resonant lattice Kerker effects

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Nano Research 2023年第2期16卷 3195-3200页

作者： Lei Xiong Xueqian Zhao Xiang Du Shuai Chen Yuanfu Lu Hongwei Ding Guangyuan Li School of Information Science and Engineering Yunnan UniversityKunming 650500China CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Computer Electronic and InformationGuangxi UniversityNanning 530004China college of Physics and Electronic Technology Anhui Normal UniversityWuhu 241000China Tianjin H-Chip Technology Group Corporation Tianjin 300467China SIAT Branch Shenzhen Institute of Artificial Intelligence and Robotics for SocietyShenzhen 518055China

The generalized Kerker effects have attracted increasing interests in recent years due to their abilities to manipulate the far-field properties of ***,the dual-polarized generalized Kerker effect enabling different tailoring of orthogonally-polarized electromagnetic waves has not yet been ***,we demonstrate polarization-controlled dual resonant lattice Kerker effects in periodic silicon *** varying the incident angle,the electric dipole and magnetic dipole surface lattice resonances can spectrally overlap,causing zero reflectance and unitary transmittance,i.e.,the resonant lattice Kerker *** incident angle for achieving this effect can be tuned differently for s-and p-polarizations over large regions by varying the nanodisk size or the lattice *** proposed dual-polarized resonant lattice Kerker effects open up avenues for polarization-controlled manipulation of the phase and wavefront of light with metasurfaces.

关键词： Kerker effect surface lattice resonances dual-polarized silicon metasurface

A Machine Learning Approach for Behavioral Recognition of Stress Levels in Mice

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Neuroscience Bulletin 2024年第12期40卷 1950-1954页

作者： Hao Song Shirley Shimin Qiu Binghao Zhao Xiuling Liu Yu-Ting Tseng Liping Wang college of Electronic and Information Engineering Hebei UniversityBaoding071002China Key Laboratory of Digital medical Engineering of Hebei Hebei UniversityBaoding071002China CAS Key Laboratory of Brain Connectome and Manipulation Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China

Dear Editor,alLuitol,Stress contributes significantly to many diseases in modern *** studies have revealed that exposure to stress leads to increased vulnerability to anxiety,depression,and other mood disorders,which ... 详细信息

关键词： diseases cardiovascular impairment

A microRNA encoded by HSV-1 inhibits a cellular transcriptional repressor of viral immediate early and early genes

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Science China(Life Sciences) 2013年第4期56卷 373-383页

作者： WU WenJuan GUO ZhongPing ZHANG XueMei GUO Lei LIU LongDing LIAO Yun WANG JingJing WANG LiChun LI QiHan Institute of medical Biology Chinese Academy of Medical Sciences Peking Union Medical College First Affilliated Hospital of Kunming medical university Chinese Pharmacopoeia Commission

Viral microRNAs are one component of the RNA interference phenomenon generated during viral infection. They were first identified in the Herpesviridae family, where they were found to regulate viral mRNA translation. In addition, prior work has suggested that Kaposi＇s sarcoma-associated herpesvirus （KSHV） is capable of regulating cellular gene transcription by miRNA. We demonstrate that a miRNA, hsvl-mir-H27, encoded within the genome of herpes simplex virus 1 （HSV-1）, targets the mRNA of the cellular transcriptional repressor Kelch-like 24 （KLHL24） that inhibits transcriptional efficiency of viral imme- diate-early and early genes. The viral miRNA is able to block the expression of KLHL24 in cells infected by HSV-1. Our dis- covery reveals an effective viral strategy for evading host cell defenses and supporting the efficient replication and prolifera- tion of HSV- 1.

关键词： herpes simplex virus I (HSV-1) microRNAs (miRNAs) cellular transcriptional repressor Kelch-like 24

Unraveling the interfacial effect of PdBi bimetallic catalysts on promoting CO_(2)electroreduction to formate

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Nano Research 2023年第8期16卷 10822-10831页

作者： Wenhui Liu Lingtong Ding Minmin Liu Xiao Wang Zhengrong Zhang Tian-Wen Jiang Shengjuan Huo Wen-Bin Cai International Joint Laboratory of Catalytic Chemistry Department of ChemistryInstitute for Sustainable EnergyCollege of SciencesShanghai UniversityShanghai 200444China shenzhen Key Laboratory of Nanobiomechanics Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Paul C.Lauterbur Research Center for Biomedical Imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryFudan UniversityShanghai 200438China

Through interface engineering and content control strategy,a PdBi bimetallic interface structure was constructed for the first time to selectively convert CO_(2)to formate with a remarkably high Faraday efficiency(FEformate)of 94%and a partial current density(jformate)of 34 mA·cm^(−2)at−0.8 V *** hydrogen electrode(RHE)in an ***,the PdBi interface electrocatalyst even exhibited a high current density of 180 mA·cm^(−2)with formate selectivity up to 92%in a flow cell and could steadily operate for at least 20 *** in-situ attenuated total reflection surface enhanced infrared absorption spectroscopy(ATR-SEIRAS)confirmed that the PdBi interface could greatly weaken the adsorption of*CO intermediates due to electronic and geometric *** functional theory(DFT)calculations also established that the PdBi interface regulated the CO_(2)-to-formate pathway by reducing the energy barrier toward HCOOH and largely weakening the adsorption of*CO intermediates on the catalyst *** study reveals that the unique PdBi bimetallic interface can provide a novel platform to study the reaction mechanism through combining in-situ ATR-SEIRAS and DFT calculations.

关键词： carbon dioxide reduction reaction bimetallic PdBi interface engineering formate in-situ attenuated total reflection surface enhanced infrared absorption spectroscopy(ATR-SEIRAS)

The blood-brain barrier models to study apolipoprotein E genotypes in Alzheimer’s disease

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Neural Regeneration Research 2022年第9期17卷 1973-1974页

作者： Irundika HK Dias Rachelle Taiwo Dan Ma Aston medical School College of Health and Life SciencesAston UniversityBirminghamUK

Alzheimer’s disease(AD)is a neurodegenerative disease that is characterized by an age-dependent progressive decline of memory,impairment of cognitive functions and changes in personality and *** the improvement in understanding of the mechanisms underlying the disease,AD remains an incurable complex disorder with multifaceted pathophysiology to *** E(ApoE)is the main cholesterol carrier in the brain that supports lipid transport between brain *** individuals carrying the APOE4 allele are known to be at increased risk of developing AD compared with those carrying the more common APOE3 allele.

关键词： Alzheimer cholesterol impairment

Children emotional and behavioural problems and its association with maternal depression in Jimma town, southwest Ethiopia

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General Psychiatry 2020年第4期33卷 201-208页

作者： Arefayne Alenko Shimelis Girma Mubarek Abera Abdulhalik Workicho Psychiatry Jimma University College of Public Health and Medical SciencesJimmaEthiopia Epidemiology Jimma University College of Public Health and Medical SciencesJimmaEthiopia

Background In sub-Saharan countries,one in five children and one in three women experiences emotional and behavioural problems(EBPs)and depression,*** various factors were reported to affect the mental health of children,little is known about the impact of maternal depression on the ***,the magnitude of children’s EBPs is barely known in *** To determine the magnitude of child EBPs and its association with maternal depression in Jimma town,southwest *** A quantitative cross-sectional study was conducted among 734 mother-child pairs in Jimma town from January to June,*** was assessed by using the parent version of Strengths and Difficulties Questionnaire(SDQ)with cut-off score of>*** depression was assessed using Patient Health Questionnaire-9 with a cut-off score of>*** were entered into Epidata V.3.1 and exported to SPSS V.24 for *** logistic regression was fitted to identify the strength of association between exposure and outcome *** Of the 734 participants,146(19.9%,95%Cl:16.9%to 22.9%)met EBP criteria based on parent version of *** depression had significant association with child EBP(adjusted 0R=2.38,95%Cl:1.55 to 3.66).In addition,children aged 7-10 years,family size categories of<3 and 4-6,maternal intimate partner violence and maternal khat use had significant association with child *** and recommendations A significant number of children suffer from EBP in Jimma *** depression is found to be a predictor of children's ***,there is a need to design and implement an integrated maternal and child mental health *** maternal and child health section at the national level should integrate and cascade routine maternal and child mental health screening and intervention modalities down to the family healthcare system.

关键词： routine southwest behaviour

Reflections and Improvements on China’s Asset-Backed Securities Information Disclosure System

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Contemporary Social Sciences 2024年第1期9卷 122-136页

作者： Zhao Mingxin shenzhen university

Asset-backed securities are developed through complex processes such as asset restructuring and credit ***,the information asymmetry between issuers and investors is greater compared to traditional securities,which imposes higher requirements on information disclosure for asset-backed ***-backed securities have characteristics such as diversified disclosers,differentiated disclosure content,and specialized risk *** has already formulated a series of rules and regulations regarding information disclosure of asset-backed *** is imperative to develop specialized laws and regulations for asset-backed securities,encompass original equity holders and credit enhancement agencies as information disclosers,incorporate information such as underlying asset details,cash flow projections,and credit ratings and enhancements into the disclosure content,and improve the legal liability rules to effectively address false disclosures.

关键词： asset-backed securities asset securitization information disclosure