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Science Bulletin 2025年第2期70卷 162-166页

作者： Yibin Jiang Sin Man Lam Shuixian Zhang Huan Miao Yong Zhou Qian Zhang Tengyuan Zhou Hui Feng Ning Ding Haomiao Wang Ran Luo Yi Yin Hua Feng Guanghou Shui Rong Hu Department of Neurosurgery and Key Laboratory of Neurotrauma Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Chongqing Key Laboratory on Big Data for Bio Intelligence Chongqing University of Posts and TelecommunicationsChongqing 400065China Clinical medical Research Center Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China

Constituting 6.5%to 19.6%of all stroke cases worldwide,non-traumatic intracerebral hemorrhage(ICH)represents the most devastating form of stroke,with aging,male gender,and hypertension being important risk factors that predispose individuals to ICH[1,2].Injuries following episodes of ICH can be classified into two forms,namely(1)primary injury arising from mechanical pressure exerted by the hematoma on adjacent tissues,(2)secondary injury resulting from oxidative stress and inflammation mediated by blood cell degradation products and coagulation factors[3].

关键词： metabolism hemorrhage intracerebral

Comparison of biomechanical indices measured by ocular response analyzer between children and elderly:a systematic review

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 154-159页

作者： Hassan Hashemi Fereshteh Shokrollahzadeh Hadi Ostadimoghaddam Abbasali Yekta Mehdi Khabazkhoob Noor Ophthalmology Research Center Noor Eye HospitalTehran ***Iran Rehabilitation Research Center Department of OptometrySchool of Rehabilitation SciencesIran University of Medical SciencesTehran ***Iran Refractive Errors Research Center Mashhad University of Medical SciencesMashhad ***Iran Department of Optometry School of Paramedical SciencesMashhad University of Medical SciencesMashhad ***Iran Department of medical Surgical Nursing School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

Biomechanical study of the visual system by ocular response analyzer investigates the inter-structural biological relationships,mechanics,and function of the visual *** review aimed to investigate the changes in corneal biomechanical parameters with age and *** articles published in PubMed between 2000 and 2021 were investigated and critiqued,and valid scientific evidence was collected,reviewed and concluded according to the inclusion and exclusion *** studies showed that corneal biomechanical changes occur infrequently in children up to the age of 20y,and with increasing age and wider age range,there was a significant decrease in corneal biomechanical indices,especially corneal *** children and adults,most studies have shown that these biomechanical indicators,especially corneal resistance factor,were higher in *** hormonal changes may contribute to this finding,the role of axial length and other biometric indicators should not be *** axial length,the intraocular pressure,and the corneal thickness are other factors associated with biomechanical parameters that should be taken into account in clinical diagnosis and management especially for patients undergoing refractive surgery as well as keratoconus patients.

关键词： ocular response analyzer corneal biomechanics visual function children elderly

Palindrome-mediated DNA nanotubes with cell-specific aptamers to improve targeted antitumor effects and reduce toxicity on non-small cell lung cancer

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Science China(Life Sciences) 2025年第2期68卷 454-466页

作者： Cheng Zheng Lanlan Song Chang Yu Lingye Zhu Jing Zhang Ning Wang Mengchu Liu Shini Li Liangxing Wang Zhifa Shen Xiaoying Huang Division of Pulmonary Medicine the First Affiliated Hospital of Wenzhou Medical UniversityKey Laboratory of Interdiscipline and Translational MedicineWenzhou 325000China Intervention Department the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Key Laboratory of Laboratory Medicine Ministry of Education of Chinaand Zhejiang Provincial Key Laboratory of Medical GeneticsSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhou 325035China

Chemotherapy is regarded as a widely used and effective treatment strategy for lung cancer,although most conventional chemotherapeutics cause severe toxic side-effects due to their indiscriminate attacks on both cancerous and normal *** nucleic acid nanomaterials are emerging as a promising drug delivery strategy,their clinical applications are limited by rapid degradation by nucleases and difficulties in targeting cancer *** this study,we have developed a Rhein-loaded aptamer-based DNA nanotube(DNT-S6@Rhein)for the targeted and efficient therapy of non-small cell lung *** the palindrome segments,two specified oligonucleotides were hybridized and folded into the well-defined nanotubes(DNT-S6),with the S6 aptamer distributed *** obtained nanotubes exhibited excellent serum stability and targeting ability towards A549 cells due to the firm structure and decoration of the S6 ***,as an antitumor drug and DNA intercalator,can be effectively inserted into the *** drug-loaded nanotubes rapidly disassembled in intracellular environment and then the released Rhein was found to activate cellular apoptotic process and significantly suppress proliferation,migration and invasion of A549 ***,DNT-S6@Rhein could efficiently accumulate in tumor regions,offering compelling therapeutic efficacy and biocompatibility under both in vitro and in vivo *** findings of this study provide a promising strategy for mitigating the inevitable systemic side-effects of chemotherapy and expand the potential application of DNA nanostructure on targeted drug delivery.

关键词： DNA nanotube self-assembly Rhein targeted drug delivery cancer therapy

The regulatory effects of gut microbiota on breast health and human milk composition via gut-mammary gland axis

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Food Science and Human Wellness 2025年

作者： Manlin Zhou Xi He Qidi Xue Muhammad Naveed Binqi Rui Ye Wang Yinhui Liu Ming Li Department of Microecology， College of Basic medical Science， Dalian medical University

The gut-mammary gland axis connects the communication between the gut microbiota and the mammary gland. Studies have reported that dysbiosis in gut microbiota is involved in the pathogenesis of breast diseases such as mastitis and breast cancer. In addition， different diets， including the supplementation of probiotics or prebiotics， which are closely related to the alteration of gut microbiota， were found to affect the nutritional contents of human milk and contribute to the development or alleviation of breast diseases. These studies suggested that the gut microbiota might be a new target for the regulation of human milk components or breast diseases. In this article， we summarized recent research advances in the gut-mammary gland axis and discussed some of the effective mechanisms and pathways involved， including distal translocation of gut microbiota， circulation of metabolites across the blood-milk barrier， the delivery of immune cells and their secreted antibodies to the mammary gland. This article also provides new strategies for preventing women's breast diseases and improving the composition of human milk through the gut-mammary axis.

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis

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Science China(Life Sciences) 2025年第2期68卷 467-483页

作者： Xiao Liu Chaojuan Yang Zhuoran Lin Jianing Li Bin Yin Xuepei Lei Wei Han Boqin Qiang Pengcheng Shu Chen Zhang Xiaozhong Peng State KeyLaboratoryofCommon Mechanism Research for Major Diseases Departmentof Biochemistry&Molecular BiologyMedicalPrimate Research CenterNeuroscienceCenterInstituteof Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China State Key Laboratory of Respiratory Health and Multimorbidity Beijing 100005China Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China School of Basic medical Sciences Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijing 100069China Key Laboratoryof Biomechanics and Mechanobiology(Beihang University) Ministryof EducationBeijing AdvancedInnovation Center for Biomedical EngineeringSchoolof Engineering MedicineBeihang UniversityBeijing 100191China Chinese Institute for Brain Research Beijing 102206China

D-serine and D-aspartate are involved in N-methyl-D-aspartate receptor(NMDAR)-related physiological and pathological ***-t RNA deacylase 1(DTD1)may biochemically contribute to D-serine or D-aspartate ***,it is unclear thus far whether DTD1 regulates D-serine or D-aspartate content in neurobiological *** the present research,we found that DTD1 was essential to maintain the D-serine or D-aspartate homeostasis,which was consistent with the phenomenon that DTD1-deficiency resulted in changes in the quantity changes of functional NMDAR subunits in postsynaptic ***,DTD1 played a considerable role in regulating dendritic morphology and synaptic *** a consequence,DTD1 affected neurobiological events,including the synaptic strength of the CA3-to-CA1 circuit,dendritic spine density of hippocampal pyramidal neurons,and behavioral performance of mice in the Morris water *** findings highlight the important role of DTD1 in synaptic transmission,neuronal morphology,and spatial learning and memory and suggest an undisclosed mechanism of DTD1 that participates the regulation of D-serine or D-aspartate homeostasis in hippocampal neurons.

关键词： D-aminoacyl-tRNA deacylase 1 D-serine D-aspartate synaptic transmission neuronal morphology spatial learning and memory

Role of glutathione transferase in phase separation of FUS and TAF15 in neurons

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Neural Regeneration Research 2025年第7期20卷 1999-2000页

作者： Kiyoung Kim Department of medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(Cleveland and Rothstein,2001).Frontotemporal lobar degeneration(FTLD)is a neurodegenerative disease affecting the frontal and temporal lobes of the brain,leading to changes in behavior,personality,and language(Van Langenhove et al.,2012).Both ALS and FTLD are classified as proteinopathies in which abnormal protein aggregation and accumulation in neurons contribute to the disease *** in sarcoma(FUS)is a DNA/RNA-binding protein involved in various cellular processes,including transcriptional regulation,RNA splicing,and DNA *** in the FUS gene have been linked to familial ALS,highlighting the importance of FUS in the disease pathogenesis(Vance et al.,2009).In ALS and FTLD,aberrant post-translational modifications(PTMs)of FUS,such as phosphorylation,acetylation,and methylation,have been implicated in the promotion of FUS aggregation and neurotoxicity(Choi et al.,2023).Therefore,understanding the regulatory mechanisms of FUS PTMs is crucial for developing targeted therapies against these diseases.

关键词： degeneration FUS aggregation

Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第8期20卷 2319-2320页

作者： Kiyoung Kim Department of medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei Xia Yue Ma Mingtong Gao Shuai Hou Shanshan Xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

Integration of Melanin-Resveratrol Nanosystem for the Diagnostic-therapeutic of Renal Fibrosis

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Chemical Research in Chinese Universities 2025年第1期41卷 86-94页

作者： LI Tingting JIAMengni JI Huifang ZHANG Ruiping The Third Hospital of Shanxi medical University Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan030032P.R.China Medicinal Basic Research Innovation Center of Chronic Kidney Disease Ministry of EducationShanxi Medical UniversityTaiyuan030001P.R.China School of Pharmacy Shanxi Medical UniversityTaiyuan030001P.R.China The Radiology Department of Shanxi Provincial People’s Hospital Affiliated to Shanxi medical University Taiyuan030012P.R.China

In this work,melanin nanoparticle-resveratrol(MNP-RES)nanosystem was excogitated and constructed for the treatment and imaging of folate-induced renal fibrosis(RF)mice model to fulfill the combination of diagnosis and *** characterization indicated that MNP-RES was a monodisperse spherical framework with a uniform diameter of(18.6±2.7)nm and the drug loading content of RES was 44.8%.The inhibition ratios of reactive oxygen species,such as·OH,·O_(2)−,ABTS’and DPPH were all greater than 80%.After systemic therapy with MNP-RES,the levels of serum creatinine(SCr)and blood urea nitrogen(BUN)were decreased,and the extent of renal fibrosis was considerably relieved,which was verified by H&E,Masson and terminal-deoxynucleoitidyl transferase mediated nick end labeling(TUNEL)*** MNP-RES nanosystem can diagnose and monitor the therapeutic efficacy of RF in real time and noninvasively via photoacoustic/magnetic resonance imaging(PA/MRI)dual-modality imaging,and the MNP-RES diagnostic-therapeutic nanosystem had satisfactory biocompatibility in vivo,which facilitated its future bio-transformation for RF treatment in clinical application.

关键词： Melanin Resveratrol Diagnostic-therapeutic nanosystem Dual-modal imaging Renal fibrosis