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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

China: Between Social Stability and Market Integration

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China & World Economy 2006年第3期14卷 95-108页

作者： Giovanni B. Andornino Russell G. Wilcox PhD candidate Catholic University of Milan Italy. PhD candidate School of Oriental and African Studies UK

China＇s gradual integration with the global market is responsible for exceptional rates of economic growth and for the substantial sociopolitical stability enjoyed by the country over the past decades. Nevertheless, the choice to increasingly adhere to the competitive dynamic of the market has thrown up a battery of problems for China＇s leadership, as increasing affluence has favored the pluralization and diversification of social interests. In a country where the existence of divergent and competing social claims has traditionally been regarded as a grave threat to stability, marketization, whereas on the one hand acting as a source of political legitimacy, has, on the other, paved the way for a potentially more strained relationship between relevant corporative interests and the central government. By studying China＇s recent development from the complementary perspectives of the ＂horizontal＂ and ＂vertical＂ forms of decentralization and devolution, this paper aims to highlight the tensions with which China has had to contend since its adoption of reform and opening-up policies in the late 1970s. It aims also to suggest how the Chinese leadership＇s instinct for continued social control has cut against market reform just enough to effect a process of controlled macroeconomic integration that has been more successful than wholesale resistance or immediate unquestioning acceptance would have been.

关键词： China decentralization globalization market integration

Comparative untargeted proteomic analysis of ADME proteins and tumor antigens for tumor cell lines

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Acta Pharmaceutica Sinica B 2018年第2期8卷 252-260页

作者： Xiaomei Gu Qing Xiao Qian Ruan Yuezhong Shu Ashok Dongre Ramaswamy Iyer W.Griffith Humphreys Yurong Lai Pharmaceutical candidate Optimization Bristol-Myers Squibb Company Genomics Bristol-Myers Squibb Company

In the present study, total membrane proteins from tumor cell lines including HepG2, Hep3 B2,H226, Ovcar3 and N87 were extracted and digested with γLys C and trypsin. The resulting peptide lysate were pre-fractionated and subjected to untargeted quantitative proteomics analysis using a high resolution mass spectrometer. The mass spectra were processed by the Max Quant and the protein abundances were estimated using total peak area(TPA) method. A total of 6037 proteins were identified, and the analysis resulted in the identification of 2647 membrane proteins. Of those, tumor antigens and absorption,metabolism, disposition and elimination(ADME) proteins including UDP-glucuronosyltransferase,cytochrome P450, solute carriers and ATP-binding cassette transporters were detected and disclosed significant variations among the cell lines. The principal component analysis was performed for the cluster of cell lines. The results demonstrated that H226 is closely related with N87, while Hep3 B2 aligned with HepG2. The protein cluster of Ovcar3 was apart from that of other cell lines investigated. By providing for the first time quantitative untargeted proteomics analysis, the results delineated the expression profiles of membrane proteins. These findings provided a useful resource for selecting targets of choice for anticancer therapy through advancing data obtained from preclinical tumor cell line models to clinical outcomes.

关键词： Cancer cell lines Untargeted quantitative proteomics Tumor-associated membrane proteins Cytochrome P450 ABC transporters SLC transporters

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Construction of a new STS from X chromosome

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Chinese Science Bulletin 1995年第10期40卷 850-855页

作者：吴学军杨忠伟李宗东柴建华 Fudan University Shanghai 200433 China Master candidate of medical genetics from Shanghai Second medical University To whom correspondence should be addressed :Institute of Genetics Fudan Universtity Shanghai 20043China.

It is one of those important aims in the new 5-year plan of the human genome researchproject to construct the STS with the resolution at 100kb. Thus it requires about 30000new STS to cover the whole genome. In 1989, O... 详细信息

关键词： X chromosome single copy sequence sequence tagged sites (STS).

An Introduction to 2-CCD Digital Particle Image Velocimetry System and Its Application in Ocean Engineering

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China Ocean Engineering 1997年第3期12卷 347-356页

作者： Daichin Timothy P.Dewhirst Ph.D.candidate State Key Laboratory of Coastal and Offshore EngineeringDalian University of Technology(DUT)Dalian 116023Ph.D.CandidateDepartment of PhysicsUniversity of EdinburghEdinburghUK.

The basic principle of particle image velocinmetry (PIV) is described. When a PIV image is analyzed by the method of auto-correlation, there is a direction ambiguity of 180 degrees iii velocity measurement. The problem can be solved by using 'Image Shifting Technique', but this makes devices much complicated and difficult to control. A new arrangement of 2-CCD (Charge Coupled Device) fully digitized PIV system, which can also solve the problem successfully, is introduced in the paper. As an example of application of the system, an experimental result of flow field around a horizontal cylinder in wave is presented.

关键词： particle image velocimetry CCD camera cross-correlation

New characteristics of intensity assessment of Sichuan Lushan “4.20” M_s7.0 earthquake

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Earthquake Engineering and Engineering Vibration 2014年第S1期13卷 123-139页

作者： Sun Baitao Yan Peilei Chen Xiangzhao Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake Administration Professor PhD PhD candidate

The post-earthquake rapid accurate assessment of macro influence of seismic ground motion is of significance for earthquake emergency relief,post-earthquake reconstruction and scientific research. The seismic intensity distribution map released by the Lushan earthquake field team of the China Earthquake Administration(CEA) five days after the strong earthquake(M7.0) occurred in Lushan County of Sichuan Ya’an City at 8:02 on April 20,2013 provides a scientific basis for emergency relief,economic loss assessment and post-earthquake reconstruction. In this paper,the means for blind estimation of macroscopic intensity,field estimation of macro intensity,and review of intensity,as well as corresponding problems are discussed in detail,and the intensity distribution characteristics of the Lushan '4.20' M7.0 earthquake and its influential factors are analyzed,providing a reference for future seismic intensity assessments.

关键词： Lushan earthquake intensity assessment damage index remote sensing strong earthquake record

Stem cells:a promising candidate to treat neurological disorders

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Neural Regeneration Research 2018年第7期13卷 1294-1304页

作者： Chang-Geng Song Yi-Zhe Zhang Hai-Ning Wu Xiu-Li Cao Chen-Jun Guo Yong-Qiang Li Min-Hua Zheng Hua Han Department of medical Genetics and Developmental Biology Fourth Military Medical University Department of Biochemistry and Molecular Biology Fourth Military Medical University

Neurologic impairments are usually irreversible as a result of limited regeneration in the central nervous ***,based on the regenerative capacity of stem cells,transplantation therapies of various stem cells have been tested in basic research and preclinical trials,and some have shown great *** manuscript overviews the cellular and molecular characteristics of embryonic stem cells,induced pluripotent stem cells,neural stem cells,retinal stem/progenitor cells,mesenchymal stem/stromal cells,and their derivatives in vivo and in vitro as sources for regenerative *** cells have all been considered as candidates to treat several major neurological disorders and diseases,owing to their self-renewal capacity,multi-directional differentiation,neurotrophic properties,and immune modulation *** also review representative basic research and recent clinical trials using stem cells for neurodegenerative diseases,including Parkinson＇s disease,Alzheimer＇s disease,and age-related macular degeneration,as well as traumatic brain injury and *** spite of a few unsuccessful cases,risks of tumorigenicity,and ethical concerns,most results of animal experiments and clinical trials demonstrate efficacious therapeutic effects of stem cells in the treatment of nervous system *** summary,these emerging findings in regenerative medicine are likely to contribute to breakthroughs in the treatment of neurological ***,stem cells are a promising candidate for the treatment of nervous system diseases.

关键词： nerve regeneration stem cells transplantation stem cell therapy nervous system neurodegenerative disease neurological disorders animal experiment clinical trial regenerative medicine neural regeneration

Understanding and Treating Arthrogenic Muscle Inhibition

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中国运动医学杂志 2009年第3期28卷 322-326页

作者： Brian G. Pietrosimone M. Ed, ATC Doctoral candidate in Sports Medicine at the University of Virginia

Quadriceps muscle weakness and dysfunction are common consequences of knee joint injury or effusion.[1-7] Deficits in quadriceps muscle function have been reported following various knee joint pathologies including

关键词：肌肉拉伤运动损伤医学治疗