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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi Lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo Takashi Suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

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Prevalence of parasitemia and associated immunodeficiency among HIV—malaria co—infected adult patients with highly active antiretroviral therapy

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Asian Pacific Journal of Tropical Medicine 2013年第2期6卷 148-152页

作者： Caroline Edijana Omoti Chiedozie K.Ojide Patrick V.Lofor Emeka Eze Joy C Eze Department of Haematology and Blood Transfusion University of Benin Teaching HospitalBenin CityNigeria Department of Medical Microbiology University of Benin Teaching HospitalBenin CityNigeria Department of Internal Medicine University of Benin Teaching HospitalBenin CityNigeria

Objective:To investigate the malaria parasitemia,CD4~+ cell counts and some haematological indices among HIV-malaria co-infected adult patients with highly active antiretroviral therapy (HAART).Methods:A total of 342 adult HIV positive subjects were recruited at the consultant outpatient HIV/AIDS *** of Benin teaching hospital,Benin city,Nigeria between June 2011 to November *** samples were taken for malaria parasite count,CD4~+ cell count and other haematological ***:Out of the 342 adult HIV positive subjects a total of 254 patients(74.3%) were found to have malaria *** incidence of malaria parasitemia increased with advancing clinical stage of HIV infection and this was statistically significant(P=0.002).There was no statistical significance when gender was compared with the HIV-malaria status(P>0.05).Of the 254 co-infected patients,134(52.8%) had high parasitemia (>1.25×10~9/L).Sixty patients were found to be hyperparasitemic(>2.5 parasites/L).There was a significant association between CD4~+ cell count and having significant parasitemia(P0.05).Conclusions:The prevalence of parasitemia is high among the HIV/AIDS infected patients.

关键词： HIV Malaria HAART CD4~+

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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong Wei Jin Liu Tao Zhu Cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

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Childhood malaria in the Niger delta area of Nigeria:mothers/care givers'perception,definition and treatment practices

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 52-58页

作者： Idogun E.Sylvester Airauhi L.U Department of Chemical Pathology University of Benin Teaching HospitalBenin City Department of Medical Microbiology Biology University of Benin Teaching HospitalBenin City

Objective:The objective of the study was to evaluate mothers/care givers perception of malaria,their treatment practices and the effects on the outcome of ***:Four hundred and sixty children were enrolled and their mothers/care givers *** children were screened for malaria parasitaemia and there after,blood specimens were obtained for biochemical and haematological evaluation from those children who met the criteria and tested positive to *** *** cell volume,electrolytes,urea, creatinine,plasma glucose,and serum bilirubin were ***:A total of 460 children were studied, 233(50.7%) males and 227(49.3%) *** malaria cases were 112(24.3%) and severe malaria 348(75.7%).Those who presented early 106(23.0%) and those who presented late 354(77.0%).Perception and definition of malaria as well as the treatment seeking behaviors vary significantly with the level of education of the mothers and care *** without formal education 68(51.9%) wrongly perceived that the etiology of malaria can only be diagnosed by native doctors compared to those with primary six education 61 (26.5%) and junior secondary education 10(10.1%).Only 43(9.3%) gave the correct dose of chloroquine syrup to their sick children,while 32(7.0%) gave at sub optimal ***:Wrong perception of malaria especially the complicated malaria and wrong treatment practices are major contributory factors to the high mortality and morbidity of malaria in *** is therefore a need for health education to correct the wrong ideas about the cause and treatment practices of malaria as part of malaria control programme.

关键词： Childhood malaria Mothers/Caregivers Perception and treatment practices Nigeria

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China Life Sciences 2025年第1期 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang Wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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Comparative Analysis of Indoor Levels of Suspended Particulates and Nitrogen Dioxide a Few Hours later after an Asthmatic Attack

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Chinese Journal of Chemistry 2007年第11期25卷 1669-1674页

作者： UKPEBOR, Emmanuel Ehiabhi OKUO, James Majebi EKANEM, Victor James UKPEBOR, Justina Ebehirieme Air Pollution Research Group Department of Chemistry University of Benin Benin City Nigeria Department of Pathology University of Benin/University of Benin Teaching Hospital PMB 1154 Benin City Nigeria

Suspended particulates （TSP） and nitrogen dioxide （NO2） are known respiratory irritants linked to asthma aggravation. This pilot study was designed to investigate the role of these pollutants on the frequency of asthmatic attack on two of the inhabitants of a household. The surveillance of TSP and NO2 in this household commenced a few hours later, after one of the occupants suffered an attack. The TSP load determination was done using a High Volume Gravimetric sampler and a light scattering method via a Haz-Dust 10 μm particulate monitor. Palmes Diffusion tubes for NO2 and a portable Crowcon Gasman toxic gas detector were utilized for NO2 screening. In the first day of monitoring in the living room, the in situ particulate sampler （Haz-Dust） recorded a mean TSP level of 26,000 μg·m^-3. A confirmatory test with the eight hour average Gravimetric sampler gave 25,833 μg·m^-3. With the use of the Gasman toxic gas detector for NO2, the NO2 concentration for the first few hours of sampling was lower than 188 μg·m^-3, the detection limit of this instrument. However, the exact NO2 concentrations for the 7 day monitoring after the attack were 27.50 μg·m^-3 （kitchen） and 12.03 μg·m^-3 （living room） as recorded by the Palmes diffusion tubes.

关键词： nitrogen dioxide total suspended particulate asthma

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Impact of the emigration of nurses on health care delivery system in selected hospitals,Benin‑city,Edo State,Nigeria

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Journal of Integrative Nursing 2020年第3期2卷 110-115页

作者： Olaolorunpo OLORUNFEMI David Idenyi AGBO Omotayo Mercy OLORUNFEMI Esther OdoghoOKUPAPAT Department of Medical Surgical Nursing School of NursingUniversity of Benin Teaching Hospital Department of Measurement and Evaluation University of Benin Teaching Hospital Staff School Department of Perioperative Nursing School of Postbasic Nursing StudiesUniversity of Benin Teaching HospitalBenin-cityEdo StateNigeria

Background:Globally,there is a high demand for nurses,resulting in migration from low‑to high‑income *** emigration of nurses is the act of leaving one's own country to settle permanently in another country,leading to a shortage in the number of nurses in their home ***,this study aims to assess the impact of the emigration of nurses on the health‑care delivery system in *** and Methods:A descriptive cross‑sectional survey was conducted with a stratified sampling technique to select 270 nurses from three selected hospitals in Benin‑city Edo state.A self‑structured questionnaire with open and Likert scale questions were used as an instrument to assess the Impact of the Emigration of nurses on the Health Care Delivery *** collected were analyzed using tables,percentages,means,standard deviation and t‑***:The result showed a mean score of 1.59±0.92 impacts of the emigration of nurses on health‑care delivery system and identified how to reduce *** study also showed that there is no significant difference between gender and reason for emigration among nurses(t=3.84,P≤0.001).Conclusion:The emigration of nurses is severely affecting the health care delivery system in the ***,the Nursing and Midwifery Council of Nigeria gave the directive for training schools to increase their training capacity and number of students’intake to cushion the effect,and this study shows that this palliative can only be a short time measure,and however will encourage more nurses traveling abroad on the long ***,the hospital managers and government should provide a conducive working environment,better remuneration,attractive retirement benefit,and other incentives as a push in factor for nurses to stay back in their home countries.

关键词： Emigration health‑care system migration Nigeria nurses

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Ki-67 immunohistochemical expression in mandibular ameloblastoma: A prognostic indicator for local recurrence

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Open Journal of Stomatology 2013年第9期3卷 520-526页

作者： Ayman Hegab Mohmmad Shuman Mohammed Abd El-Akher Delaram Arwlan medcal city teaching hospital Teaching Laboratory Baghdad Iraq Oral and Maxillofacial Surgery Faculty of Dental Medicine Al-Azhar University Assuit Egypt Oral and Maxillofacial Surgery Faculty of Dental Medicine Al-Azhar University Cairo Egypt

Objective: This study used Ki-67 to evaluate the proliferative activity of ameloblastoma in an attempt to provide a scientific basis for any differences in the biologic behaviour that exists between the different types of ameloblastoma and correlate the results with the recurrence rate. Study design: We assessed Ki-67 expression by immunohistochemistry in 32 cases of mandibular ameloblastoma. Formalin-fixed, paraffinembedded blocks were sectioned and used for Haematoxylin & Eosin (H&E) staining. H&E slides were used to re-evaluate the histological types of the ameloblastoma. Immunohistochemical analysis for Ki-67 with a labelled streptavidin-biotin-peroxidase complex technique was performed on tumour sections using Monoclonal Mouse Anti-Human Ki-67 Antigen (clones MIB1, code M7240, Dako Corporation). Lymph nodes (lymphoma) were used as positive control for Ki-67. Results: The specimens comprised 18 cases of Follicular ameloblastoma, 7 cases of Cystic ameloblastoma, 4 cases of plexiform ameloblastoma, and 3 cases of Acanthotic ameloblastoma. The results showed that cellular proliferative activity varied within the ameloblastoma types. There was no statistically significant difference in the Ki-67 Acanthotic, cystic and follicular types of ameloblastoma, while plexiform type showed statistically significantly higher levels than the other 3 types. The mean Ki-67 labelling index of plexiform ameloblastoma ranged from 13 to 30 with a mean of 19.75. The mean values of Ki-67 were statistically significantly higher in recurrent than?non-recurrent cases. Conclusion: The significant expression of Ki-67 could provide useful prognostic markers for proliferative activity and good prognostic indicators for recurrence rate of mandibular ameloblastoma.

关键词： Mandibular Ameloblastoma Recurrence Immunohistochemistry Ki-67

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