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Integrating multi-omics data of childhood asthma using a deep association model

Fundamental Research 2024年第4期4卷 738-751页

作者： Kai Wei Fang Qian Yixue Lia Tao Zeng Tao Huang Bio-Med Big Data Center CAS Key Laboratory of Computational BiologyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Guoke Ningbo Life Science and health Industry Research institute Ningbo 315000China Guangzhou National Laboratory Guangzhou 510000China GMU-GIBH joint School of Life Sciences The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and DiseasesGuangzhou LaboratoryGuangzhou Medical UniversityGuangzhou 510000China Key Laboratory of Systems health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Childhood asthma is one of the most common respiratory diseases with rising mortality and *** multi-omics data is providing a new chance to explore collaborative biomarkers and corresponding diagnostic models of childhood *** capture the nonlinear association of multi-omics data and improve interpretability of diagnostic model,we proposed a novel deep association model(DAM)and corresponding efficient analysis ***,the Deep Subspace Reconstruction was used to fuse the omics data and diagnostic information,thereby correcting the distribution of the original omics data and reducing the influence of unnecessary data ***,the joint Deep Semi-Negative Matrix Factorization was applied to identify different latent sample patterns and extract biomarkers from different omics data ***,our newly proposed Deep Orthogonal Canonical Correlation Analysis can rank features in the collaborative module,which are able to construct the diagnostic model considering nonlinear correlation between different omics data *** DAM,we deeply analyzed the transcriptome and methylation data of childhood *** effectiveness of DAM is verified from the perspectives of algorithm performance and biological significance on the independent test dataset,by ablation experiment and comparison with many baseline methods from clinical and biological *** DAM-induced diagnostic model can achieve a prediction AUC of o.912,which is higher than that of many other alternative ***,relevant pathways and biomarkers of childhood asthma are also recognized to be collectively altered on the gene expression and methylation *** an interpretable machine learning approach,DAM simultaneously considers the non-linear associations among samples and those among biological features,which should help explore interpretative biomarker candidates and efficient diagnostic models from multi-omics data analysis for human complexdiseases.

关键词： Deepsub space reconstruction Deepnon-negative matrix factorization Deepcanonical correlationanalysis Multi-omics Interpretable machine learning Childhood asthma

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bone Research 2024年第1期12卷 122-136页

作者： Nan-Yu Zou Ran Liu Mei Huang Yu-Rui Jiao Jie Wei Yangzi Jiang Wen-Zhen He Min Huang Yi-Li Xu Ling Liu Yu-Chen Sun Mi Yang Qi Guo Yan Huang Tian Su Ye Xiao Wei-Shan Wang Chao Zeng Guang-Hua Lei Xiang-Hang Luo Chang-Jun Li Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Epidemiology and health Statistics Xiangya School of Public HealthCentral South UniversityChangshaChina Hunan Key Laboratory of joint Degeneration and Injury ChangshaHunan 410008China Key Laboratory of Aging-related bone and joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina School of Biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShiheziXinjiangChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain *** this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture *** injection of human rGCA in young mice induced SSPC senescence and delayed fracture *** deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC ***,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular *** of Plxnb2 in SSPCs impaired fracture *** of GCA-neutralizing antibody enhanced fracture healing in aged ***,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.

关键词： healing union senescence

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Development of a Method to Determine the Environmental Burden of Diseases and an Application to Identify Factors Driving Changes in the Number of PM_(2.5)-Related Deaths in China between 2000 and 2010

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Environment & health 2024年第9期2卷 642-650页

作者： Ning Kang Pengfei Li Tao Xue Tong Zhu institute of Reproductive and Child health National Health Commission Key Laboratory of Reproductive Health/Department of Epidemiology and BiostatisticsMinistry of Education Key Laboratory of Epidemiology of Major Diseases(PKU)School of Public HealthPeking University Health Science CenterBeijing 100191China institute of Medical Technology Peking University Health Science CenterBeijing 100191China Advanced institute of Information Technology Peking UniversityHangzhou 311215China State Environmental Protection Key Laboratory of Atmospheric Exposure and Health Risk Management and Center for Environment and HealthPeking UniversityBeijing 100871China State Environmental Protection Key Laboratory of Atmospheric Exposure and Health Risk Management and Center for Environment and Health and State Key Joint Laboratory of Environment Simulation and Pollution ControlCollege of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China

The attributable burden is codetermined by the exposure level and nontarget ***,the conventional method of health impact assessment based on preestablished exposure−response functions includes only a few well-known characteristics and thus is insufficient to capture the comprehensive *** aimed to develop a method to fuse health impact assessment with epidemiological analysis and to identify factors driving baseline *** method was applied to identify the factors underlying the change in the number of fine particulate matter(PM_(2.5))related deaths in China between 2000 and *** the study period,the number of PM_(2.5)-related deaths across China's Mainland increased by 0.62(95%CI:0.57,0.69)million,with 0.65(95%CI:0.47,0.91)million,0.55(95%CI:0.39,0.79)million,and 0.11(95%CI:0.06,0.18)million deaths being associated with increased PM_(2.5)exposure,population aging,and growth in population size,***,economic growth,urbanization,improvement of welfare services,and improvement of hospital services resulted in 0.25(95%CI:0.15,0.40)million,0.16(95%CI:0.10,0.27)million,0.16(95%CI:0.09,0.26)million,and 0.09(95%CI:0.05,0.15)million fewer deaths,*** indicated that increased exposure was the major driver of the change in the number of PM_(2.5)-related deaths,and economic growth was the main driver of increased resilience to air pollution.

关键词： health burden decomposition analysis air pollution fine particulate matter premature deaths

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Surface iodine and pyrenyl-graphdiyne co-modified Bi catalysts for highly efficient CO_(2) electroreduction in acidic electrolyte

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Nano Research 2024年第4期17卷 2381-2387页

作者： Min Zhang Juan Wang Xin Rong Xiu-Li Lu Tong-Bu Lu MOE International joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

CO_(2) electroreduction to formic acid/formate would contribute to alleviating the energy and climate *** work reports a Bi-based catalyst derived from the in-situ electroreduction of Bi_(2)O_(2)CO_(3) modified with iodine and pyrenyl-graphdiyne(PGDY)on the surface for efficient electroreduction of CO_(2) in acidic electrolyte,with a high partial current density of 98.71 mA·cm^(-2) and high Faradaic efficiency(FE)>90%over the potential range from^(-1).2 to-1.5 V *** hydrogen electrode(RHE),as well as the long-term operational stability over 240 h without degradation in H-type *** results and density function theory calculations show that the synergistic effect of surface iodine and PGDY is responsible for this active and extremely stable process of CO_(2) electroreduction via lowering the energy barriers for formation of*OCHO intermediate,suppressing the competitive HER by enhancing the concentration of both K+and CO_(2) at reaction interface,as well as preventing the dissolution and re-deposition of active Bi atoms on surface during catalytic *** work provides new insight into designing highly active and stable electrocatalysts for CO_(2) reduction.

关键词： CO_(2) reduction electrocatalysis Bi-based catalysts acidic electrolyte

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Ultra-efficient and parameter-free computation of submicron thermal transport with phonon Boltzmann transport equation

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Fundamental Research 2024年第4期4卷 907-915页

作者： Yue Hu Yongxing Shen Hua Bao University of Michigan-Shanghai Jiao Tong University joint institute Shanghai Jiao Tong UniversityShanghai 200240China

Understanding thermal transport at the submicron scale is crucial for engineering applications,especially in the thermal management of electronics and tailoring the thermal conductivity of thermoelectric *** the submicron scale,the macroscopic heat diffusion equation is no longer valid and the phonon Boltzmann transport equation(BTE)becomes the governing equation for thermal ***,previous thermal simulations based on the phonon BTE have two main limitations:relying on empirical parameters and prohibitive computational ***,the phonon BTE is commonly used for qualitatively studying the non-Fourier thermal transport phenomena of toy *** this work,we demonstrate an ultra-efficient and parameter-free computational method of the phonon BTE to achieve quantitatively accurate thermal simulation for realistic materials and *** properly integrating the phonon properties from first-principles calculations,our method does not rely on empirical material properties *** can be generally applicable for different materials and the predicted results can match well with experimental ***,by developing a suitable ensemble of advanced numerical algorithms,our method exhibits superior numerical *** full-scale(from ballistic to diffusive)thermal simulation of a 3-dimensional fin field-effect transistor with 13 million degrees of freedom,which is prohibitive for existing phonon BTE solvers even on supercomputers,can now be completed within two hours on a single personal *** method makes it possible to achieve the predictive design of realistic nanostructures for the desired thermal *** also enables accurately resolving the temperature profiles at the transistor level,which helps in better understanding the self-heating effect of electronics.

关键词： Submicron thermal transport Boltzmann transport equation Deterministic numerical method Phonon transport Transistors Nanostructured materials

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Intertwined depressive and cognitive trajectories and the risk of dementia and death in older adults:a competing risk analysis

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General Psychiatry 2024年第2期37卷 207-215页

作者： Ziyang Ren Lirong Nie Yushan Du Jufen Liu institute of Reproductive and Child health/National health Commission Key Laboratory of Reproductive health Peking UniversityBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina

Background Depressive symptoms and cognitive impairment often interact,rendering their associations *** date,their joint trajectories and associations with dementia and death remain *** To explore the interactions between depressive symptoms and cognitive function,their developmental trajectories and the associations with all-cause dementia,Alzheimer’s disease(AD)and all-cause death in older *** Data were from the health and Retirement *** symptoms and cognitive function were measured using the 8-item Centre for Epidemiologic Studies Depression Scale and the Telephone Interview of Cognitive Status,***-cause dementia and AD were defined by self-reported or proxy-reported physician ***-cause death was determined by *** restricted cubic spline,group-based trajectory modelling and subdistribution hazard regression were *** Significant interactions between depressive symptoms and cognitive function in 2010 in their association with new-onset all-cause dementia and AD from 2010 to 2020 were found,especially in women(p for interactionjoint trajectories of depressive symptoms and cognitive function from 1996 to 2010 were determined,where rapidly decreased cognitive function was more common in those with no depressive *** with older adults with the trajectory of no depressive symptoms and very good cognitive function,those with the trajectory of no depressive symptoms but rapidly decreased cognitive function were much more likely to develop new-onset all-cause dementia and death,with subdistribution hazard ratios(95%confidence intervals)of 4.47(2.99 to 6.67)and 1.84(1.43 to 2.36),especially in wome

关键词： death analysis rendering

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Effect of ambient pressures on laser-induced breakdown spectroscopy signals

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Frontiers of physics 2024年第4期19卷 243-256页

作者： Kaifan Zhang Weiran Song Zongyu Hou Zhe Wang State Key Laboratory of Power System Operation and Control Tsinghua-Rio Tinto Joint Research Centre for ResourcesEnergy and Sustainable DevelopmentInternational Joint Laboratory on Low Carbon Clean Energy InnovationInstitute for Carbon NeutralityDepartment of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Shanxi Research institute for Clean Energy Tsinghua UniversityTaiyuan 030032China

Laser-induced breakdown spectroscopy(LIBS)is regarded as the future superstar for analytical chemistry and widely applied in various *** the quality of LIBS signal is fundamental to achieving accurate quantification and large-scale commercialization of *** propose control methods that improve LIBS signal quality,it is essential to have a comprehensive understanding of the influence of key parameters,such as ambient gas pressure,temperature,and sample temperature on LIBS *** date,extensive research has been carried ***,different researchers often yield significantly different experimental results for LIBS,preventing the formation of consistent *** greatly prevents the understanding of influencing laws of key parameters and the improvement of LIBS quantitative *** ambient gas pressure as an example,this paper compares the effects of ambient gas pressure under different optimization conditions,reveals the influence of spatiotemporal window caused by inherent characteristics of LIBS signal sources,i.e.,intense temporal changes and spatial non-uniformity of laser-induced plasmas,on the impact patterns of key *** the perspective of plasma spatiotemporal evolution,the paper elucidates the influence patterns of ambient gas pressure on LIBS signals,clarifying seemingly contradictory research results in the literature.

关键词： laser-induced breakdown spectroscopy spatiotemporal window pressure condition signal uncertainty plasma modulation

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Peroxidase-like nanozyme based microenvironment-responsive injectable hydrogel for bacteria-infected wound healing

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Science China Technological Sciences 2024年第10期67卷 3247-3260页

作者： ZHOU Wei LI XiaNan TANG MengCheng PAN LingFeng WANG BeiBei ZHANG Hao ZHANG Han WANG ShiBo KONG XiangDong institute of Smart Biomaterial Materials School of Materials Science and EngineeringZhejiang University of Science & Technology Zhejiang-Mauritius joint Research Center for Biomaterials and Tissue Engineering Zhejiang University of Science & Technology

Hydrogel stands out as one of the most attractive wound dressings due to its excellent moisturizing properties and capacity to absorb wound exudates. However, conventional hydrogel dressings often lack responsiveness to the microenvironment, merely acting as protective barriers for the wound. Consequently, they exhibit limited effectiveness in preventing infection and facilitating wound repair. To address these problems, we have developed a multifunctional injectable hydrogel, CF/MS@HG, based on peroxidase-like nanozymes, aiming at rapidly healing bacterial-infected wounds. The hydrogel is mainly composed of oxidized sodium alginate, aminated gelatin, and polylysine, encapsulating MIL-101(CuFe) NPs(CF) and manganese selenide nanoparticles(MnSe2NPs, or MS NPs). After injection, the complex rapidly gelatinizes at the infected wound site through a Schiff base reaction. In vitro experiments have demonstrated the hydrogel's strong adhesion and self-healing ***, CF exhibiting peroxidase(POD)-like activity, catalyzes in situ hydrogen peroxide(H2O2) to generate highly toxic hydroxyl radicals(·OH) within the wound microenvironment, inducing oxidative damage to bacteria. Meanwhile, MS decomposes into H2Se in the slightly acidic wound microenvironment, disrupting bacterial metabolism and inhibiting *** addition of polylysine further enhances the hydrogel's antibacterial properties. In vivo experiments have shown that the hydrogel exhibits excellent biological safety and significantly promotes wound healing. This multifunctional smart hydrogel holds great promise for the treatment of bacterial-infected wounds.

关键词： peroxidase-like nanozyme manganese selenide injectable hydrogel bacterial infection wound healing

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Sustainable development of electroencephalography materials and technology

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SusMat 2024年第2期4卷 125-144页

作者： Ling Xiong Nannan Li Yi Luo Lei Chen institutes for Breast health Medicine West China HospitalSichuan UniversityChengduChina Micro/Nano Fabrication Laboratory Microsystem and Terahertz Research CenterChina Academy of Engineering PhysicsChengduChina institute of Electronic Engineering China Academy of Engineering PhysicsMianyangChina Department of Neurology Joint Research Institution of Altitude HealthWest China HospitalSichuan UniversityChengduChina

Electroencephalogram(EEG)is one of the most important bioelectrical signals related to brain activity and plays a crucial role in clinical *** by continuously expanding applications,the development of EEG materials and technology has attracted considerable ***,systematic analysis of the sustainable development of EEG materials and technology is still *** review discusses the sustainable development of EEG materials and ***,the developing course of EEG is introduced to reveal its significance,particularly in clinical ***,the sustainability of the EEG materials and technology is discussed from two main aspects:integrated systems and EEG *** integrated systems,sustainability has been focused on the developing trend toward mobile EEG systems and big-data monitoring/analyzing of EEG *** is related to miniaturized,wireless,portable,and wearable systems that are integrated with big-data modeling *** EEG electrodes and materials,sustainability has been comprehensively analyzed from three perspectives:performance of different material/structural categories,sustainablematerials for EEGelectrodes,and sustainable manufacturing *** addition,sustainable applications of EEG have been ***,the sustainable development of EEG materials and technology in recent decades is summarized,revealing future possible research directions as well as urgent challenges.

关键词： clinical medicine electroencephalography technology limitations and future directions materials and electrodes sustainable development

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The future path to sutureless surgery:Self–adhesive tough hydrogel

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Science Bulletin 2024年第15期69卷 2307-2310页

作者： Lei Xiang Ding Zhao Yihan Li Qimanguli Saiding Wenguo Cui Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Surgical sutures serve as foundational elements in surgical procedures,facilitating wound closure,exudation minimization,infection prevention,structural support maintenance,and healing *** classification of traditional surgical suturing methods is intricate,and contingent upon variables such as tissue type,wound morphology,and desired healing outcomes.

关键词： healing wound prevention

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