检索结果-南通市图书馆

Signal Transduction and Targeted Therapy 2023年第1期8卷 10-12页

作者： Rayhane Nchioua Federica Diofano Sabrina Noettger Pascal von Maltitz Steffen Stenger Fabian Zech Jan Münch Konstantin M.J.Sparrer Steffen Just Frank Kirchhoff institute of Molecular Virology Ulm University Medical CenterUlmGermany Molecular Cardiology Department of Internal Medicine IIUlm UniversityUlmGermany institute of medical microbiology and hygiene Ulm University Medical CenterUlmGermany

Dear Editor,Since its first description in South Africa in November 2021,the SARS-CoV-2 Omicron variant rapidly outcompeted the previously dominating Delta *** is the fifth variant of concern(VOC).It contains an unusually high number of mutations compared to previous VOCs,especially in the viral Spike protein,and shows high transmissibility and efficient escape of neutralizing antibodies.

关键词： Strong neutral Omi

Good and bad outcomes of respiratory viral infections—influenza A virus trains sustained antitumor immunity of macrophages in the lung

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2023年第8期20卷 861-863页

作者： Sabine Stegemann-Koniszewski Sarah Frentzel Dunja Bruder Experimental Pneumology Department of PneumologyUniversity Hospital Magdeburg/Medical FacultyHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke University MagdeburgMagdeburgGermany institute of medical microbiology and Hospital hygiene Infection Immunology GroupHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke University MagdeburgMagdeburgGermany Immune Regulation Group Helmholtz Centre for Infection ResearchBraunschweigGermany

In their recent article in Nature Immunology, Wang et al. showed that influenza A virus (IAV) infection trained alveolar macrophages (AMs) for sustained antitumor immunity in the lung [1], extending the concept of trained immunity and pointing out benefits of viral respiratory infection in the context of pulmonary antitumor immune surveillance.

关键词： immunity sustained respiratory

Macrophage’s little helper: vitamin A directs alternatively activated monocyte-derived macrophages to tissue-resident macrophages

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2017年第10期14卷 805-808页

作者： Dirk Schlüter Florian H Heidel institute of medical microbiology and Hospital hygiene Otto-von-Guericke University MagdeburgMagdeburg 39120Germany Organ-Specific Immune Regulation Helmholtz-Center for Infection ResearchBraunschweig 38124Germany Innere Medizin II Hämatologie und OnkologieUniversitätsklinikum JenaJena 07745Germany Leibniz-institute on Aging Fritz-Lipmann-InstituteJenaGermany

Tissue-resident macrophages originate from the yolk sac in a Myb-independent manner and populate all organs during *** macrophages are a heterogeneous self-renewing population that adapt to the organ-specific local environment to contribute to tissue *** on the age,organ and inflammatory conditions,macrophages that are derived from hematopoietic stem cells(HSCs)in a Myb-dependent manner may also infiltrate organs and develop into tissueresident macrophages.

关键词： organs vitamin homeostasis

Analysis of the microbial communities in soils of different ages following volcanic eruptions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2020年第1期30卷 126-134页

作者： Marcela HERNáNDEZ Marcela CALABI Ralf CONRAD Marc G.DUMONT max Planck institute for Terrestrial microbiology Karl-von-Frisch-Str.10Marburg 35043(Germany) Scientific and Technological Bioresource Nucleus Universidad de La FronteraTemuco(Chile) School of Biological Sciences University of SouthamptonSouthampton SO171BJ(UK)

Volcanism is a primary process of land *** provides a model for understanding soil-forming processes and the role of pioneer bacteria and/or archaea as early colonizers in those new *** objective of this study was to identify the microbial communities involved in soil *** was extracted from soil samples from the Llaima volcano in Chile at sites destroyed by lava in different centuries(1640,1751,and 1957).Bacterial and archaeal 16 S r RNA genes were analyzed using quantitative polymerase chain reaction(q PCR)and Illumina Mi Seq *** showed that microbial diversity increased with soil age,particularly between the 1751 and 1640 *** archaeal communities,Thaumarchaeota was detected in similar abundances in all soils,but Euryarchaeota was rare in the older *** analysis of bacterial 16 S r RNA genes showed high abundances of Chloroflexi(37%),Planctomycetes(18%),and Verrucomicrobia(10%)in the youngest *** and Acidobacteria were highly abundant in the older soils(16%in 1640 and 15%in 1751 for Acidobacteria;38%in 1640 and 27%in 1751 for Proteobacteria).The microbial profiles in the youngest soils were unusual,with a high abundance of bacteria belonging to the order Ktedonobacterales(Chloroflexi)in the 1957 soil(37%)compared with the 1751(18%)and 1640(7%)*** this study,we show that there is a gradual establishment of the microbial community in volcanic soils following an eruption and that specific microbial groups can colonize during the early stages of recovery.

关键词： 16S rRNA gene extreme environment high-throughput sequencing Ktedonobacterales microbial diversity pioneer microbe recolonization soil formation volcanic deposit

A Major Role of the MEKK1-MKK1/2-MPK4 Pathway in ROS Signalling

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2009年第1期2卷 120-137页

作者： Andrea Pitzschke Armin Djamei Frederique Bitton Heribert Hirt Department of Plant Molecular Biology Max F. Perutz Laboratories University of Vienna Dr.-Bohr-Gasse 9 1030 Vienna Austria Present address: max-Planck-lnstitute for Terrestrial microbiology Karl-von-Frisch-Strasse 35043 Marburg Germany URGV Plant Genomics Laboratory 2 Rue Gaston Cremieux 91057 Evry France

Over the last few years, it has become evident that reactive oxygen species （ROS） signalling plays an important role in various physiological responses, including pathogen defense and stomatal opening/closure. On the other hand, ROS overproduction is detrimental for proper plant growth and development, indicating that the regulation of an appropriate redox balance is essential for plants. ROS homeostasis in plants involves the mitogen-activated protein kinase （MAPK） pathway consisting of the MAPK kinase kinase MEKK1 and the MAPK MPK4. Phenotypic and molecular analysis revealed that the MAPK kinases MKK1 and MKK2 are part of a cascade, regulating ROS and salicylic acid （SA） accumulation. Gene expression analysis shows that of 32 transcription factors reported to be highly responsive to multiple ROS-inducing conditions, 20 are regulated by the MEKK1, predominantly via the MEKK1-MKK1/2-MPK4 pathway. However, MEKK1 also functions on other as yet unknown pathways and part of the MEKK1-dependent MPK4 responses are regulated independently of MKK1 and MKK2. Overall, this analysis emphasizes the central role of this MAPK cascade in oxidative stress signalling, but also indicates the high level of complexity revealed by this signalling network.

关键词： Mitogen-activated protein kinases MEKK1 MKK1 MKK2 MPK4 reactive oxygen species redox homeostasis stress signalling differential gene expression.

In Vivo Function of Tic22, a Protein Import Component of the Intermembrane Space of Chloroplasts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2013年第3期6卷 817-829页

作者： Mareike Rudolf Anu B. Machettira Lucia E. Groβ Katrin L. Weber Kathrin Bolte Tihana Bionda Maik S. Sommer Uwe G. Maier Andreas RM. Weber Enrico Schleiff Joanna Tripp Department of Biosciences Molecular Cell Biology of Plants Center of Membrane Proteomics and Cluster of Excellence Frankfurt Goethe University Max-von-Laue Str. 9 D-60438 Frankfurt Germany institute of Plant Biochemistry Heinrich-Heine-University Universitatsstr. 1 D-40225 Dusseldorf Germany Cell Biology Philipps University Marburg Karl-von-Frisch-Str. 8 D-35032 Marburg Germany LOEWE Center for Synthetic microbiology (SYNMIKRO) Hans-Meerwein-Str. D-35032 Marburg Germany

Preprotein import into chloroplasts depends on macromolecular machineries in the outer and inner chloroplast envelope membrane （TOC and TIC）. It was suggested that both machineries are interconnected by components of the intermembrane space （IMS）. That is, amongst others, Tic22, of which two closely related isoforms exist in Arabidopsis thaliana, namely atTic22-III and atTic22-IV. We investigated the function of Tic22 in vivo by analyzing T-DNA insertion lines of the corresponding genes. While the T-DNA insertion in the individual genes caused only slight defects, a double mutant of both isoforms showed retarded growth, a pale phenotype under high-light conditions, a reduced import rate, and a reduction in the photosynthetic performance of the plants. The latter is supported by changes in the metabolite content of mutant plants when compared to wild-type. Thus, our results support the notion that Tic22 is directly involved in chloroplast preprotein import and might point to a particular importance of Tic22 in chloroplast biogenesis at times of high import rates.

关键词： protein translocation TOC and TIC intermembrane space translocon chloroplast biogenesis metabolitecontent.

Moorella thermoacetica:A promising cytochrome-and quinone-containing acetogenic bacterium as platform for a CO_(2)-based bioeconomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Carbon 2023年第1期1卷 2-13页

作者： Florian P.Rosenbaum Volker Müller Molecular microbiology&Bioenergetics Institute of Molecular BiosciencesJohann Wolfgang Goethe UniversityMax-von-Laue-Str.960438 FrankfurtGermany

The negative effect of fossil-based industrial processes on the environment,especially the contribution to global warming by emitting greenhouse gases such as CO_(2) causes a global threat to ***,technologies are demanded by the society for a sustainable and environmentally friendly *** biotechnological use of sugar-based feedstocks to produce valuable products are in conflict with,for example,food *** order to overcome this issue,waste products such as syngas(H_(2),CO and CO_(2))or CO_(2) taken from the atmosphere are of increasing interest for biotechnological *** bacteria are already used at industrial scale to produce sustainable and environmentally friendly biofuels from syngas.A promising candidate due to its physiological flexibility is the thermophilic acetogen Moorella *** contrast to most acetogens *** is not restricted to one energy conserving *** addition to the Ech complex,cytochromes and quinones may be involved in energy conservation by,for example,DMSO *** extra energy con-served can be used to form highly valuable but energy demanding *** this review we give insights into the physiology of this acetogen,the current state of the art of *** as a platform for biotechnological applications and discuss future perspectives.

关键词： Anaerobes Synthesis gas Bioenergetics Thermophiles Wood-Ljungdahl pathway

Modelling air change rate of naturally ventilated dairy buildings using response surface methodology and numerical simulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2021年第3期14卷 827-839页

作者： Qianying Yi Guoqiang Zhang Barbara Amon Sabrina Hempel David Janke Chayan Kumer Saha Thomas Amon Department of Engineering Aarhus UniversitySkejby Nordlandsvej 3018200 AarhusDenmark Department of Engineering for Livestock Management Leibniz Institute for Agricultural Engineering and Bioeconomy(ATB)Max-Eyth-Allee 70014469 PotsdamGermany Department of Technology Assessment and Substance Cycles Leibniz Institute for Agricultural Engineering and Bioeconomy(ATB)Max-Eyth-Allee 10014469 PotsdamGermany Faculty of Civil Engineering Architecture and Environmental EngineeringUniversity ofZielona GoraLicealna 9/965-417 Zielona GoraPoland Department of Farm Power and Machinery Bangladesh Agricultural UniversityBAU Main Road2202 MymensinghBangladesh institute of Animal hygiene and Environmental Health Department of Veterinary MedicineFree University BerlinRobert-von-Ostertag-Str.7-1314163 BerlinGermany

The air change rate(ACR)of naturally ventilated dairy buildings(NVDBs)plays an important part in the design and control of the ventilation system,as well as in the estimation of the gaseous emission *** objectives of this research were to model the ACR based on a quantitative investigation of the relationship between the ACR and its potential influencing factors,including the opening ratio(r),the building length to width ratio(a),the wind speed(U),and the wind direction(0).The investigations were performed using the response surface methodology integrated with the Box-Behnken design and Computational Fluid Dynamics(CFD)*** response surface models of the ACR of NVDBs were established for three opening ratio ranges of 5%-42.5%,42.5%-80%,and 5%-80%,*** was found that the selection of the opening ratio range had almost no effect on the developed response surface *** results showed that the ACR of NVDBs was not influenced by a,but was significantly affected by r,U,6,and interaction effects between every two of the three *** highest ACR was 6.7 s^(-1),6.0 s^(-1),and 4.0 s^(-1)when 0,U,and r was at their respective medium value while the rest parameters were at the highest values,indicating that the r played an important role in the value of *** was concluded that in the prediction of the ACR of a building,the influences of both individual and interactional effects of 0,U,and r should be considered.

关键词： emission estimation computational fluid dynamics Box-Behnken design response surface model

Soil biodiversity in a rapidly changing world

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2020年第1期30卷 1-4页

作者： Zhongjun JIA David D.MYROLD Ralf CONRAD State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China) Department of Crop and Soil Science Oregon State UniversityCorvallis OR 97331(USA) max Planck institute for Terrestrial microbiology Karl-von-Frisch-Str.1035043 Marburg(Germany)

Microbes are simple single-cell organisms,but have an enormous practical significance for human *** microbes make our planet habitable,and the planet's rapidly changing environments in turn have a profound impact on the soil microbial communities,both positively and *** is thus crucial to better understand how abiotic and biotic factors interact to assemble microbiomes under the given environmental conditions,and how they modulate the intrinsic link between microbial diversity and ecosystem *** a functional viewpoint.

关键词： soil planet environments

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2022年第2期19卷 234-244页

作者： Yeonsu Kim Xiaoyan Zheng Kathrin Eschke M.Zeeshan Chaudhry Federico Bertoglio Adriana Tomić Astrid Krmpotić Markus Hoffmann Yotam Bar-On Julia Boehme Dunja Bruder Thomas Ebensen Linda Brunotte Stephan Ludwig Martin Messerle Carlos Guzman Ofer Mandelboim Michael Hust Stefan Pöhlmann Stipan Jonjić LukaČičin-Šain Department of Viral Immunology Helmholtz Centre for Infection Research(HZI)BraunschweigGermany Department of Biotechnology Institut für BiochemieBiotechnologie und BioinformatikTechnischen Universität BraunschweigBraunschweigGermany Oxford Vaccine Group University of OxfordOxfordUK Center for Proteomics University of RijekaFaculty of MedicineRijekaCroatia Infection Biology Unit German Primate CenterGöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenGöttingenGermany Department of Immunology Rappaport Faculty of MedicineTechnion-Israel Institute of TechnologyHaifaIsrael Infection Immunology Institute for Medical Microbiology and Hospital HygieneHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke-University MagdeburgMagdeburgGermanyImmune RegulationHelmholtz Centre for Infection ResearchBraunschweigGermany Department of Vaccinology and Applied microbiology Helmholtz Centre for Infection ResearchBraunschweigGermany institute of Virology Medical University MünsterMünsterGermany institute of Virology Hannover Medical School(MHH)HannoverGermany German Centre for Infection Research(DZIF) Hannover-Braunschweig SiteHannoverGermany Centre for Individualized Infection medicine(CiiM) a joint venture of HZI and MHHHannoverGermany

Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and *** remains a medical need for vaccines against these ***(cytomegalovirus)is aβ-herpesvirus that induces uniquely robust immune responses in which remarkably large populations of antigen-specific CD8+T cells are maintained for a ***,CMV has been proposed and investigated as a novel vaccine vector for expressing antigenic peptides or proteins to elicit protective cellular immune responses against numerous *** generated two recombinant murine CMV(MCMV)vaccine vectors expressing hemagglutinin(HA)of influenza A virus(MCMV^(HA))or the spike protein of severe acute respiratory syndrome coronavirus 2(MCMV^(S)).A single injection of MCMVs expressing either viral protein induced potent neutralizing antibody responses,which strengthened over ***,MCMV^(HA)-vaccinated mice were protected from illness following challenge with the influenza virus,and we excluded that this protection was due to the effects of memory T ***,we show here that MCMV vectors induce not only long-term cellular immunity but also humoral responses that provide long-term immune protection against clinically relevant respiratory pathogens.

关键词： Vaccine vector SARS-CoV-2 Influenza Cytomegalovirus humoral imunity