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PET imaging in ischemic cerebrovascular disease:current status and future directions

Neuroscience Bulletin 2014年第5期30卷 713-732页

作者： Wolf-Dieter Heiss max planck Institute for Neurological research

Cerebrovascular diseases are caused by interruption or significant impairment of the blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphological damage. These pathophysiological changes can be assessed by positron emission tomography （PET）, which permits the regional measurement of physiological parameters and imaging of the distribution of molecular markers. PET has broadened our understanding of the flow and metabolic thresholds critical for the maintenance of brain function and morphology： in this application, PET has been essential in the transfer of the concept of the penumbra （tissue with perfusion below the functional threshold but above the threshold for the preservation of morphology） to clinical stroke and thereby has had great impact on developing treatment strategies. Radioligands for receptors can be used as early markers of irreversible neuronal damage and thereby can predict the size of the final infarcts; this is also important for decisions concerning invasive therapy in large （＂malignant＂） infarctions. With PET investigations, the reserve capacity of blood supply to the brain can be tested in obstructive arteriosclerosis of the supplying arteries, and this again is essential for planning interventions. The effect of a stroke on the surrounding and contralateral primarily unaffected tissue can be investigated, and these results help to understand the symptoms caused by disturbances in functional networks. Chronic cerebrovascular disease causes vascular cognitive disorders, including vascular dementia. PET permits the detection of the metabolic disturbances responsible for cognitive impairment and dementia, and can differentiate vascular dementia from degenerative diseases. It may also help to understand the importance of neuroinflammation after stroke and its interaction with amyloid deposition in the development of dementia. Although the clinical application of PET

关键词： stroke dementia PET brain metabolism brain ischemia

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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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Imprinted Zac1 in neural stem cells

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World Journal of Stem Cells 2015年第2期7卷 300-314页

作者： Guillaume Daniel Udo Schmidt-Edelkraut Dietmar Spengler Anke Hoffmann max planck Institute of Psychiatry Translational Research

Neural stem cells(NSCs) and imprinted genes play an important role in brain development. On historical grounds, these two determinants have been largely studied independently of each other. Recent evidence suggests, however, that NSCs can reset select genomic imprints to prevent precocious depletion of the stem cell reservoir. Moreover, imprinted genes like the transcriptional regulator Zac1 can fine tune neuronal vs astroglial differentiation of NSCs. Zac1 binds in a sequence-specific manner to pro-neuronal and imprinted genes to confer transcriptional regulation and furthermore coregulates members of the p53-family in NSCs. At the genome scale, Zac1 is a central hub of an imprinted gene network comprising genes with animportant role for NSC quiescence, proliferation and differentiation. Overall, transcriptional, epigenomic, and genomic mechanisms seem to coordinate the functional relationships of NSCs and imprinted genes from development to maturation, and possibly aging.

关键词： Zac1 Cell fate decisions Neural stem cells Genomic imprinting Igf2-H19 Dlk1 p57 Kip2 Necdin Differentiation Imprinted gene networks

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University max planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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Super rigid tris-spirobifluorenes:Syntheses and properties

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Chinese Chemical Letters 2021年第1期32卷 397-400页

作者： Luyao Zhao Chunbo Duan Dongxue Ding Shihui Liu Debin Xia Ying Guo Hui Xu Martin Baumgartend College of Chemical and Environmental Engineering.Horbin Universty of Science and Tetenologo Herbin 150040 China MIT Key Laboratory'of Crtcal Materials Technology for New Energy Conversion and Storge School of Chemisty and Chermical Engineering Harbin Instiute of Technology.Harbin 150001 China Key Laboratory of Functional lnorganic Material Chemistry Ministy of EducarionSchool of Chermistry and Materiol ScienceHeilongjiang UniversiyHarbin 150080China max planck istitute for pobymer research Mainz 55128Cermpay

In this work,a blue emitter with a 3 D rigid structure composed of multiple spirobifluorene(3-Spiro) has been synthesized and *** a detailed study of the electrochemical and photophysical properties of 3-Spiro,we have evidenced that 3-Spiro can be applied as an active component of organic light-emitting diodes(OLEDs).The device with 5% doping rate of 4 CzPNPh exhibits high external quantum efficiency(EQE) of 11%,which proves the potential of 3 D rigid structure emitters for OLEDs.

关键词： OLEDs Spirobifluorene Blue emitter Rigid structure Three dimensional

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An Impulsive Heating Model for the Evolution of Coronal Loops

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Chinese Journal of Astronomy and Astrophysics 2006年第5期6卷 608-616页

作者： Li Feng Wei-Qun Gan Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 max planck Institute for Solar System research Max-Planck-Str. 2 37191 Katlenburg-LindauGermany

It was suggested by Parker that the solar corona is heated by many small energy release events generally called microflares or nanoflares. More and more observations showed flows and intensity variations in nonflaring loops. Both theories and observations have indicated that the heating of coronal loops should actually be unsteady. Using SOLFTM （Solar Flux Tube Model）, we investigate the hydrodynamics of coronal loops undergoing different manners of impulsive heating with the same total energy deposition. The half length of the loops is 110 Mm, a typical length of active region loops. We divide the loops into two categories： loops that experience catastrophic cooling and loops that do not. It is found that when the nanoflare heating sources are in the coronal part, the loops are in non-catastrophic-cooling state and their evolutions are similar. When the heating is localized below the transition region, the loops evolve in quite different ways. It is shown that with increasing number of heating pulses and inter-pulse time, the catastrophic cooling is weakened, delayed, or even disappears altogether.

关键词： hydrodynamics -- Sun corona -- Sun transition region

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An Extended Chaboche's Viscoplastic Law at Finite Strains: Theoretical and Numerical Aspects

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Journal of Materials Science & Technology 2005年第2期21卷 145-147页

作者： R.C.Lin W.Brocks Institute for Materials research GKSS research Centre Max-Planck-Street D-21502 Geesthacht GermanyInstitute for Materials Research GKSS Research Centre Max-Planck-Street D-21502 Geesthacht Germany

This paper presents a newly extended Chaboche’s viscoplastic law at finite strains, so that the classical Chaboche’s theories can be applied to the physical and numerical simulation of metals processing and behavior description of spatial metal structures. The extension is based on a new dissipation inequality at finite strains. The evolution equations are formulated in terms of the corotational rates of the logarithmic elastic strain and the strain-like internal variable conjugate to the back stress as well as the material time derivative of the accumulated plastic strain. The stress equation is expressed on the hyperelastic theory. Therefore, the possible inconsistency with elasticity, caused by the hypoelastic equations, is completely removed. A set of numerical examples with finite deformations are presented to prove the effectivities of the new model and numerical algorithms.

关键词： Viscoplastic law Dissipation inequality Finite strain

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Recycling of magnesium drive train components

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Science China(Technological Sciences) 2009年第1期52卷 148-154页

作者： Daniel FECHNER Carsten BLAWERT Norbert HORT Karl Ulrich KAINER MagIC-Magnesium Innovation Centre GKSS Research Centre Max-Planck-Straβe 1

With the development of new heat resistant magnesium alloys, the automotive industry has introduced several parts to the drive train. The rising number of large magnesium components will result in a higher quantity of automotive post consumer scrap. It was the aim of this work to find a reasonable alloy system for the recycling of these magnesium drive train components. A matrix of potential recy-cling alloys based on the magnesium alloy AM50 was prepared via permanent mould casting. The materials were investigated via tensile testing, creep tests and salt spray tests. Three alloys were selected for processing via high pressure die casting and the tests were repeated on the new materials. A promising system for recycling has been isolated and will be investigated more deeply for the influence of impurities.

关键词： magnesium recycling end-of-life vehicles recycling alloy post consumer scrap

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i2dash:Creation of Flexible,Interactive,and Web-based Dashboards for Visualization of Omics Data

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 568-577页

作者： Arsenij Ustjanzew Jens Preussner Mette Bentsen Carsten Kuenne Mario Looso max planck Institute for Heart and Lung research Bioinformatics UnitD-61231 Bad NauheimGermany

Data visualization and interactive data exploration are important aspects of illustrating complex concepts and results from analyses of omics data.A suitable visualization has to be intuitive and ***-based dashboards have become popular tools for the arrangement,consolidation,and display of such ***,the combination of automated data processing pipelines handling omics data and dynamically generated,interactive dashboards is poorly ***,we present i2dash,an R package intended to encapsulate functionality for the programmatic creation of customized *** supports interactive and responsive(linked)visualizations across a set of predefined graphical layouts.i2dash addresses the needs of data analysts/software developers for a tool that is compatible and attachable to any R-based analysis pipeline,thereby fostering the separation of data visualization on one hand and data analysis tasks on the other *** addition,the generic design of i2dash enables the development of modular extensions for specific *** a proof of principle,we provide an extension of i2dash optimized for single-cell RNA sequencing analysis,supporting the creation of dashboards for the visualization needs of such *** with these features,i2dash is suitable for extensive use in large-scale sequencing/bioinformatics *** this line,we provide i2dash as a containerized solution,enabling a straightforward large-scale deployment and sharing of dashboards using cloud services.i2dash is freely available via the R package archive CRAN(https://***/package=i2dash).

关键词： Data visualization Dashboard Cloud Data analysis Automation

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Alloying effect of silver in magnesium on the development of microstructure and mechanical properties by indirect extrusion

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Journal of Magnesium and Alloys 2021年第1期9卷 112-122页

作者： Bjorn Wiese Regine Willumeit-Römer Dietmar Letzig Jan Bohlen Division Metallic Biomaterials Institute of Materials ResearchHelmholtz-Zentrum GeesthachtMax-Planck-Str.1Geesthacht 21502Germany Magnesium Innovation Center(MagIC) Institute of Materials ResearchHelmholtz-Zentrum GeesthachtMax-Planck-Str.1Geesthacht 21502Germany

The effect of Ag in solid solution on the microstructure,texture and the deformation behaviour of indirectly extruded Mg was *** as a solid solution strengthener affects the behaviour during extrusion,resulting in enhanced deformation related heating and corresponding coarser grained *** substantial effect on the texture development is *** mechanical properties simultaneously increase in stress and strain levels with increasing Ag content,especially in tension as a result of the changing impact of the slip modes which can be associated with a decrease of the lattice parameters as well as the c/a ratio of the hcp lattice *** compression tests with twin dominated flow,the impact is much smaller on the compressive yield stress but higher with respect to the twinning related strain hardening *** solution strength functions for Fleischer and Labusch were determined,also confirming the anisotropic behaviour of the extruded Mg alloys.

关键词： Mg-Ag-alloys Lattice parameters Indirect extrusion Microstructure Mechanical properties

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