检索结果-南通市图书馆

On the interaction of a donepezil-huprine hybrid with synthetic membrane models

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第2期18卷 333-334页

作者： Pablo Zambrano max planck institute of biochemistry Cellular and Molecular BiophysicsMunichGermany

Alzheimer's disease is the most prevalent type of dementia today,discovered and described by Alois Alzheimer in *** to the World Alzheimer Report 2021,75%of people with dementia worldwide are undiagnosed,equivalent to 41 million people(Gauthier et al.,2021).With each passing year,the number of people affected by these diseases is increasing,and the estimates of suffering from them in the future are growing.

关键词： Alzheimer diseases

Osteoporosis and fractures in liver disease: Relevance, pathogenesis and therapeutic implications

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第28期20卷 9427-9438页

作者： Inaam A Nakchbandi Translational Medicine University of Heidelberg max-planck institute of biochemistry

It is being increasingly recognized that patients with liver disease develop bone loss that can be severe enough to lead to atraumatic fractures and thus markedly diminish life quality and expectancy. The estimated prevalence for liver-related osteoporosis is between 20-420/100000 of the general population, and fractures between 60-880/100000. It should be kept in mind that up to 40% of patients with chronic liver disease may experience a fracture. The pathogenic mediators include fibronectin, insulin like growth factor-I, and various cytokines, but decreased vitamin D and/or treatment with corticosteroids contribute to worsening bone health. Despite the advances in bone biology that have shed some light on the pathogenesis of this bone loss, treatment options remain nonspecific and tightly linked to treatments of other forms of osteoporosis. Thus, treatment should include calcium and vitamin D supplementation in all patients with chronic liver disease. Therapy with bisphosphonates should be considered, especially in patients receiving corticosteroids. This review focuses on the prevalence of this entity as well as the evidence available with regard to the pathogenesis of bone loss in liver disease, the diagnostic steps required in all patients, and the therapeutic options available.

关键词： Osteoporosis Liver disease Fracture Prevalence Pathogenesis Fibronectin Insulin like growth factor-Ⅰ Therapy Vitamin D Calcium

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

A 'hot' oil sorbent for fast cleanup of viscous crude-oil spills

在线全文

学校读者我要写书评

暂无评论

National Science Review 2018年第4期5卷 445-446页

作者： Markus Antonietti max planck institute for Colloids and Interfaces

In 2010,the Gulf of Mexico oil spill created the largest environmental ocean accident in *** estimated number of 4.9 million barrels of crude oil were released into the ocean and brought severe damage to the marine ecosystems and fishing,and threatened the health of *** oil cleanup technologies,including skimmers,dispersants and controlled burning,were used to treat the

关键词： hot oil sorbent for fast cleanup of viscous crude-oil spills

The co-orbital restricted three-body problem and its application

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2010年第1期53卷 171-178页

作者： Gerhard HEINZEL Albrecht RDIGER max planck institute for Gravitational Physics

Based on large quantities of co-orbital phenomena in the motion of natural bodies and spacecraft, a model of the co-orbital restricted three-body problem is put forward. The fundamental results for the planar co-orbital circular restricted three-body problem are given, which include the selection of variables and equations of motion, a set of approximation formulas, and an approximate semi-analytical solution. They are applied to the motion of the barycenter of the planned gravitational observatory LISA constellation, which agrees very well with the solution of precise numerical integration.

关键词： co-orbital restricted three-body problem LISA

Balancing nutrients in a toxic environment: the challenge of eating

在线全文

学校读者我要写书评

暂无评论

Insect Science 2022年第1期29卷 289-303页

作者： Peng Wang Daniel G.Vassão Bettina Raguschke Michael J.Furlong Myron P.Zalucki School of Biological Sciences The University of QueenslandSt LuciaQueenslandAustralia Department of biochemistry Max Planck Institute for Chemical EcologyJenaGermany

Insect herbivores can regulate their food intake by mixing food sources with different nutrient content, but face the resulting challenge of ingesting various plant secondary metabolites. How insects deal with toxins in a complex nutrient environment is unclear. Here we investigated the influence of a classic plant secondary metabolite, allyl glucosinolate (sinigrin), and its hydrolyzed product allyl isothiocyanate (AITC), on the development of Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) when fed on diets with different protein-to-carbohydrate (p : c) ratios. We also examined the effects of these toxins on larval biochemistry, by chemically analyzing the frass produced by insects feeding on the different diets. As expected, AITC had a greater negative effect than sinigrin on H. armigera life-history traits. However, AITC at low concentration appeared to have a positive effect on some traits. Both sinigrin and AITC-induced detoxification activity in the gut, and the reaction was related to diet protein concentration. High-protein diets can provide the required free amino acid, especially cysteine, needed for the detoxification process. The nutrient content of the diet influences how plant secondary metabolites are handled, and the use of artificial diets in experiments investigating the metabolic fate of plant secondary compounds needs to be carefully evaluated.

关键词： diet protein glucosinolate gut metabolism Helicoverpa armigera isothiocyanate

Turning to myelin turnover

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第12期14卷 2063-2066页

作者： Tobias J.Buscham Maria A.Eichel Sophie B.Siems Hauke B.Werner Department of Neurogenetics Max Planck Institute of Experimental Medicine

Neural plasticity in the adult central nervous system involves the adaptation of myelination, including the formation of novel myelin sheaths by adult-born oligodendrocytes. Yet, mature oligodendrocytes slowly but constantly turn over their pre-existing myelin sheaths, thereby establishing an equilibrium of replenishment and degradation that may also be subject to adaptation with consequences for nerve conduction velocity. In this short review we highlight selected approaches to the normal turnover of adult myelin in vivo, from injecting radioactive precursors of myelin constituents in the 1960s to current strategies involving isotope labeling and tamoxifen-induced gene targeting.

关键词： oligodendrocyte myelin plasticity and turnover degradation tamoxifen metabolic labeling isotope labeling neural plasticity myelinoid bodies central nervous system

Silencing NOA1 Elevates Herbivory-Induced Jasmonic Acid Accumulation and Compromises Most of the Carbon-Based Defense Metabolites in Nicotiana attenuata

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2011年第8期53卷 619-631页

作者： Hendrik Wünsche Ian T. Baldwin Department of Molecular Ecology max planck institute for Chemical Ecology

Nitric oxide-associated protein 1 （NOA1） is involved in various abiotic stress responses and is required for plant resistance to pathogen infections. However, the role of NOA1 in plant-herbivore interactions has not been explored. We created NOA1-silenced Nicotiana attenuata plants （irNaNOA1）. Compared with wild-type （WT） plants, irNaNOA1 plants had highly decreased photosynthesis rates. We further examined various traits important for plant defense against its specialist herbivore Manduca sexta by treating WT and irNaNOA1 plants with mechanical wounding and M. sexta oral secretions （OS）. NOA1-silenced plants showed elevated levels of herbivory-induced jasmonic acid （JA）, but decreased JA-isoleucine conjugate （JA-Ile） levels. The decreased JA-Ile levels did not result from compromised JAR （jasmonic acid resistant） activity in irNOA1 plants. Moreover, nitrogen-rich defensive compounds, nicotine and trypsin proteinase inhibitors, did not differ between WT and irNaNOA1 plants. In contrast, concentrations of most carbon-based defensive compounds were lower in these plants than in WT plants, although the levels of chlorogenic acid were not changed. Therefore, silencing NOA1 alters the allocation of carbon resources within the phenylpropanoid pathway. These data suggest the involvement of NOA1 in N. attenuata’s defense against M. sexta attack, and highlight its role in photosynthesis, and biosynthesis of jasmonates and secondary metabolites.

关键词： NOA1 defense herbivory nitric oxide-associated protein 1 secondary metabolites.

Self-assembled vesicle–colloid hybrid swimmers:Non-reciprocal strokes with reciprocal actuation

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2020年第6期29卷 30-36页

作者： Jaime Agudo-Canalejo Babak Nasouri max planck institute for Dynamics and Self-Organization(MPIDS) 37077 GoettingenGermany

We consider a self-assembled hybrid system,composed of a bilayer vesicle to which a number of colloids are *** on known results of membrane curvature elasticity,we predict that,for sufficiently deflated prolate vesicles,the colloids can self-assemble into a ring at a finite distance away from the vesicle equator,thus breaking the up–down symmetry in the *** the relative variation of the position of the colloidal ring along the vesicle endows the system with an effective elasticity,periodic cycles of inflation and deflation can lead to non-reciprocal shape changes of the vesicle–colloid hybrid,allowing it to swim in a low Reynolds number environment under reciprocal *** design several actuation protocols that allow control over the swimming direction.

关键词： vesicles colloids microswimmers curvature