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Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development

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Neural Regeneration Research 2016年第9期11卷 1394-1395页

作者： Misako Okumura Takahiro Chihara Department for Evolutionary biology Max-Planck Institute for Developmental Biology Department of Biological Science Graduate School of ScienceHiroshima University

Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila （larman et al., 1993, 1994）. Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs （Jar- man et al., 1993）. Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors （R1-R7） directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells （Jarman et al., 1994）.

关键词： ORN Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development

GmNF-YC4 delays soybean flowering and maturation by directly repressing GmFT2a and GmFT5a expression

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Journal of Integrative Plant biology 2024年第7期66卷 1370-1384页

作者： Yupeng Cai Li Chen Xiaoqian Liu Weiwei Yao Wensheng Hou State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Ministry of Agriculture Key Laboratory of Soybean biology(Beijing) Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Flowering time and growth period are key agronomic traits which directly affect soybean(Glycine max(L.)Merr.)adaptation to diverse latitudes and farming *** FLOWERING LOCUS T(FT)homologs GmFT2a and GmFT5a integrate multiple flowering regulation pathways and significantly advance flowering and maturity in *** the genes responsible for regulating GmFT2a and GmFT5a will improve our understanding of the molecular mechanisms governing growth period in *** this study,we identified the Nuclear Factor Y-C(NFY-C)protein GmNF-YC4 as a novel flowering suppressor in soybean under long-day(LD)***-YC4 delays flowering and maturation by directly repressing the expression of GmFT2a and *** addition,we found that a strong selective sweep event occurred in the chromosomal region harboring the GmNF-YC4 gene during soybean *** GmNF-YC4Hap3 allele was mainly found in wild soybean(Glycine soja Siebold&Zucc.)and has been eliminated from *** landraces and improved cultivars,which predominantly contain the GmNF-YC4Hap1 ***,the Gmnf-yc4 mutants displayed notably accelerated flowering and maturation under LD *** alleles may prove to be valuable genetic resources for enhancing soybean adaptability to higher latitudes.

关键词： CRISPR/Cas9 early flowering and maturity GmNF-YC4 regional adaptability soybean

The RNA binding protein EHD6 recruits the m^(6)A reader YTH07 and sequesters OsCOL4 mRNA into phase-separated ribonucleoprotein condensates to promote rice flowering

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Molecular Plant 2024年第6期17卷 935-954页

作者： Song Cui Peizhe Song Chaolong Wang Saihua Chen Benyuan Hao Zhuang Xu Liang Cai Xu Chen Shanshan Zhu Xiangchao Gan Hui Dong Yuan Hu Liang Zhou Haigang Hou Yunlu Tian Xi Liu Liangming Chen Shijia Liu Ling Jiang Haiyang Wang Guifang Jia Shirong Zhou Jianmin Wan State Key Laboratory for Crop Genetics&Germplasm Enhancement and Utilization Zhongshan Biological Breeding LaboratoryNational Observation and Research Station of Rice Germplasm ResourcesNanjing Agricultural UniversityNanjing 210095China State Key Laboratory for Crop Gene Resources and Breeding Institute of Crop ScienceChinese Academy of Agricultural SciencesBeijing 100081China Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular SciencesKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking-Tsinghua Center for Life SciencesBeijing Advanced Center of RNA BiologyPeking UniversityBeijingChina Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding Agricultural College of Yangzhou UniversityYangzhou 225009China max planck institute for Plant Breeding Research Carl-von-Linne´-Weg 1050829 KolnGermany

N6-Methyladenosine(m^(6)A)is one of the most abundant modifications of eukaryotic mRNA,but its comprehensive biological functionality remains further *** this study,we identified and characterized a new flowering-promoting gene,EARLY HEADING DATE6(EHD6),in ***6 encodes an RNA recognition motif(RRM)-containing RNA binding protein that is localized in the non-membranous cytoplasm ribonucleoprotein(RNP)granules and can bind both m^(6)A-modified RNA and unmodified RNA *** found that EHD6 can physically interact with YTH07,a YTH(YT521-B homology)domain-containing m^(6)A *** showed that their interaction enhances the binding of an m^(6)A-modified RNA and triggers relocation of a portion of YTH07 from the cytoplasm into RNP granules through phase-separated *** these condensates,the mRNA of a rice flowering repressor,CONSTANS-like 4(OsCOL4),becomes sequestered,leading to a reduction in its protein abundance and thus accelerated flowering through the Early heading date 1 *** together,these results not only shed new light on the molecular mechanism of efficient m^(6)A recognition by the collaboration between an RNA binding protein and YTH family m^(6)A reader,but also uncover the potential for m^(6)A-mediated translation regulation through phaseseparated ribonucleoprotein condensation in rice.

关键词： N6-methyladenosine m^(6)A EHD6 YTH domain-containing protein phase separation heading date

Pressure-Tunable Large Anomalous Hall Effect in Ferromagnetic Metal LiMn_(6)Sn_(6)

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Chinese Physics Letters 2024年第5期41卷 69-76页

作者：高玲玲赖俊文陈栋裴翠颖王琦赵毅李昌华曹渭征吴珏霏陈宇林陈星秋孙岩 Claudia Felser 齐彦鹏 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China max planck institute for Chemical Physics of Solids Dresden 01187Germany College of Physics Qingdao UniversityQingdao 266071China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUK School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shanghai Key Laboratory of High-resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210China

Recently, giant intrinsic anomalous Hall effect(AHE) has been observed in the materials with kagome ***, we systematically investigate the influence of high pressure on the AHE in the ferromagnet LiMn_(6)Sn_(6) with clean Mn kagome lattice. Our in situ high-pressure Raman spectroscopy indicates that the crystal structure of LiMn_(6)Sn_(6) maintains a hexagonal phase under high pressures up to 8.51 GPa. The anomalous Hall conductivity(AHC) σ_(xy)^(A) remains around 150 Ω^(-1)·cm^(-1), dominated by the intrinsic mechanism. Combined with theoretical calculations, our results indicate that the stable AHE under pressure in Li Mn_(6)Sn_(6) originates from the robust electronic and magnetic structure.

关键词： structure mechanism intrinsic

Heatwave exacerbates air pollution in China through intertwined climate-energy-environment interactions

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Science Bulletin 2024年第17期69卷 2765-2775页

作者： Tianshu Chen Tao Wang Likun Xue Guy Brasseur Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China Environment Research institute Shandong UniversityQingdao 266237China Big Data Research Center for Ecology and Environment Shandong UniversityQingdao 266237China Environmental Modelling Group Max Planck Institute for MeteorologyHamburg 20146Germany National Center for Atmospheric Research BoulderCO 80307USA

Climate change is increasing the frequency and intensity of heatwaves, raising concerns about their detrimental effects on air quality. However, a role for heatwave-human-environment interactions in air pollution exacerbation has not been established. In the summer of 2022, record-breaking heatwaves struck China and Europe. In this study, we use integrated observational data and machine learning to elucidate the formation mechanism underlying one of the most severe ozone pollution seasons on record in central eastern China, an area that encompasses approximately half of China's total population and sown *** findings reveal that the worsened ozone and nitrogen dioxide pollution resulted from a mismatch between energy demand and supply, which was driven by both heatwaves and energy policy-related factors. The observed adverse heatwave-energy-environment feedback loop highlights the need for the diversification of clean energy sources, more resilient energy structures and power policies, and further emission control to confront the escalating climate challenge in the future.

关键词： Heatwaves Air pollution Ozone Energy Machine learning

Small Ubiquitin-Like Modifier Conjugating Enzyme with Active Site Mutation Acts as Dominant Negative Inhibitor of SUMO Conjugation in Arabidopsis

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Journal of Integrative Plant biology 2013年第1期55卷 75-82页

作者： Konstantin Tomanov Christian Hardtke Ruchika Budhiraja Rebecca Hermkes George Coupland Andreas Bachmair Department of Biochemistry and Cell biology Max F. Perutz Laboratories Center for Molecular Biology University of Vienna Department of Plant Molecular biology University of Lausanne Department of Plant developmental biology Max Planck Institute for Plant Breeding Research

Small ubiquitin-like modifier （SUMO） conjugation affects a broad range of processes in plants, including growth, flower initiation, pathogen defense, and responses to abiotic stress. Here, we investigate in vivo and in vitro a SUMO conjugating enzyme with a Cys to Ser change in the active site, and show that it has a dominant negative effect. In planta expression significantly perturbs normal development, leading to growth retardation, early flowering and gene expression changes. We suggest that the mutant protein can serve as a probe to investigate sumoylation, also in plants for which poor genetic infrastructure precludes analysis via loss-of-function mutants.

关键词： Agroinfection conjugating enzyme dominant-negative active site mutation small ubiquitin-like modifier conjugation small ubiquitin-like modifier.

Explainability and Interpretability in Electric Load Forecasting Using Machine Learning Techniques–A Review

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Energy and AI 2024年第2期16卷 483-496页

作者： Lukas Baur Konstantin Ditschuneit maximilian Schambach Can Kaymakci Thomas Wollmann Alexander Sauer Fraunhofer institute for Manufacturing Engineering and Automation IPA Nobelstraße 12Stuttgart70569Germany institute for Energy Efficiency in Production(EEP) University of StuttgartNobelstraße 12Stuttgart70569Germany Merantix Momentum GmbH Max-Urich-Straße 3Berlin13355Germany

Electric Load Forecasting(ELF)is the central instrument for planning and controlling demand response programs,electricity trading,and consumption *** to the increasing automation of these processes,meaningful and transparent forecasts become more and more ***,at the same time,the complexity of the used machine learning models and architectures *** there is an increasing interest in interpretable and explainable load forecasting methods,this work conducts a literature review to present already applied approaches regarding explainability and interpretability for load forecasts using Machine *** on extensive literature research covering eight publication portals,recurring modeling approaches,trends,and modeling techniques are identified and clustered by properties to achieve more interpretable and explainable load *** results on interpretability show an increase in the use of probabilistic models,methods for time series decomposition and the use of fuzzy logic in addition to classically interpretable *** explainable approaches are Feature Importance and Attention *** discussion shows that a lot of knowledge from the related field of time series forecasting still needs to be adapted to the problems in *** to other applications of explainable and interpretable methods such as clustering,there are currently relatively few research results,but with an increasing trend.

关键词： Electric load forecasting Explainability InterpretabilityStructured review

Data-driven Simulations of Magnetic Field Evolution in Active Region 11429:Magneto-frictional Method Using PENCIL CODE

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Research in Astronomy and Astrophysics 2024年第2期24卷 74-82页

作者： P.Vemareddy Jorn Warnecke Ph.A.Bourdin Indian institute of Astrophysics Sarjapur roadII BlockKoramangalaBengaluru-560034India max-planck-Institut für Sonnensystemforschung Justus-von-Liebig-Weg 3D-37077 GöttingenGermany institute of Physics University of GrazUniversitätsplatz 5A-8010 GrazAustria

Coronal magnetic fields evolve quasi-statically over long timescales and dynamically over short *** of now there exist no regular measurements of coronal magnetic fields,and therefore generating the coronal magnetic field evolution using observations of the magnetic field at the photosphere is a fundamental requirement to understanding the origin of transient phenomena from solar active regions(ARs).Using the magneto-friction(MF)approach,we aim to simulate the coronal field evolution in the solar AR *** MF method is implemented in the open source PENCIL CODE along with a driver module to drive the initial field with different boundary conditions prescribed from observed vector magnetic fields at the *** order to work with vector potential and the observations,we prescribe three types of bottom boundary drivers with varying free-magnetic *** MF simulation reproduces the magnetic structure,which better matches the sigmoidal morphology exhibited by Atmospheric Imaging Assembly(AIA)images at the pre-eruptive *** found that the already sheared field further driven by the sheared magnetic field will maintain and further build the highly sheared coronal magnetic configuration,as seen in AR ***-driven MF simulation is a viable tool to generate the coronal magnetic field evolution,capturing the formation of the twisted flux rope and its eruption.

关键词： Sun corona-Sun evolution-Sun magnetic fields-Sun photosphere

Assessing structure of Mg_(3)Bi_(2-x)Sb_(x)(0≤x≤2)at pressures below 40 GPa

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Journal of Materiomics 2024年第4期10卷 837-844页

作者： Weiwei Dong Wei Xu Zhiying Guo Weishu Liu Yu Pan Satishkumar Kulkarni Xiaodong Li Konstantin Glazyrin Beijing Synchrotron Radiation Facility(BSRF) Institute of High Energy PhysicsChinese Academy of Sciences100049BeijingChina Deutsches Elektronen-Synchrotron DESY Notkestr.8522607HamburgGermany International Centre for Material Science Superstripes RICMASSVia dei Sabelli 119A00185RomeItaly Department of Materials Science and Engineering Southern University of Science and Technology518055ShenzhenChina max-planck-institute for Chemical Physics of Solids Nöthnitzer Straße 4001187DresdenGermany Centre for X-ray and Nanoscience CXNS Deutsches Elektronen Synchrotron DESYNotkestr.8522607HamburgGermany

Mg_(3)Bi_(2-x)Sb_(x)(0≤x≤2)have gained significant attention due to their potential in thermoelectric(TE)***,there has been much debating regarding their structural properties and phase diagram as a function of pressure,which is crucial for understanding of their TE ***,we investigate a unified phase diagram of Mg_(3)(Bi,Sb)_(2) materials up to 40 GPa at room temperature using high-pressure X-ray *** high-pressure phases with the structural transition succession of P3m1→C2/m→P21/n are observed,which is valid for all Mg_(3)Bi_(2-x)Sb_(x)(0≤x≤2)*** further explore the low-pressure phase P3m1 and report that alloying does not change the quasi-isotropic compression of the unit lattice parameters nor has effect on the anisotropic bond compressibility,as recently reported for the *** study presents a comprehensive picture of Mg3Bi2–xSbx as a function of pressure and chemical composition providing a solid foundation for the future experimental and theoretical studies searching for the most efficient TE compound in Mg_(3)(Bi,Sb)_(2).

关键词： Mg_(3)Bi_(2-x)Sb_(x)(0≤x≤2) Thermoelectric High-pressure Structural evolution