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Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 1-3页

作者： van Dyck, Leonard E. Bremmer, Frank Dobs, Katharina Justus Liebig Univ Giessen Dept Psychol Giessen Germany max planck inst human cognit & brain sci Leipzig Germany Univ Marburg Ctr Mind Brain & Behav Darmstadt Marburg Germany Philipps Univ Marburg Dept Neurophys Marburg Germany

In a recent study published in Cell,Marin Vargas and Bisi et al.1 present an innovative approach to unravel the computational principles underlying proprioceptive processing in non-human *** findings showcase the utility of task-driven modeling in advancing neuroscience and offer translational potential by providing seminal insights into the goals and mechanisms by which the brain encodes body position and movements.

关键词： networks neural principles

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Origin and evolution of new exons in the rodent zinc fingerprotein 39 gene

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Chinese science Bulletin 2005年第11期50卷 1126-1130页

作者： PENG Lixin ZHENG Hongkun LI Xin YANG Shuang CHEN Hong WANG Wen College of Animal science and Technology Northwest Sci-Tech Uni-versity of Agriculture and ForestryYangling 712100China CAS-max planck Junior scientist Group Key Laboratory of Cellular and Molecular EvolutionKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Beijing institute of Genomics Chinese Academy of SciencesBeijing 101300China Graduate School of the Chinese Academy of sciences Beijing 100039 China institute of Cellular and Molecular Biology Xuzhou Normal Univer-sityXuzhou 221116China

The origin of new structures and functions is an important process in evolution. In the past decades, we have obtained some preliminary knowledge of the origin and evo- lution of new genes. However, as the basic unit of genes, the origin and evolution of exons remain unclear. Because young exons retain the footprints of origination, they can be good materials for studying origin and evolution of new exons. In this paper, we report two young exons in a zinc finger protein gene of rodents. Since they are unique sequences in mouse and rat genome and no homologous sequences were found in the orthologous genes of human and pig, the young exons might originate after the divergence of primates and rodents through exonization of intronic sequences. Strong positive selection was detected in the new exons between mouse and rat, suggesting that these exons have undergone significant functional divergence after the separation of the two species. On the other hand, population genetics data of mouse dem- onstrate that the new exons have been subject to functional constraint, indicating an important function of the new exons in mouse. Functional analyses suggest that these new exons encode a nuclear localization signal peptide, which may me- diate new ways of nuclear protein transport. To our knowl- edge, this is the first example of the origin and evolution of young exons.

关键词：核苷酸序列啮齿动物动物起源动物进化蛋白质因子

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