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International Journal of Ophthalmology(English edition) 2018年第1期11卷 83-88页

作者： Maedbh Rhatigan Elizabeth Mc Elnea Patrick Murtagh Kirk Stephenson Elaine Harris Paul Connell David Keegan Department of Ophthalmology Mater Misericordiae University Hospital

AIM： To report anatomic and visual outcomes following silicone oil removal in a cohort of patients with complex retinal detachment, to determine association between duration of tamponade and outcomes and to compare patients with oil removed and those with oil in situ in terms of demographic, surgical and visual factors. METHODS： We reported a four years retrospective case series of 143 patients with complex retinal detachments who underwent intraocular silicone oil tamponade. Analysis between anatomic and visual outcomes, baseline demographics, duration of tamponade and number of surgical procedures were carried out using Fisher＇s exact test and unpaired two-tailed t-test. RESULTS： One hundred and six patients（76.2%） had undergone silicone oil removal at the time of review with 96 patients（90.6%） showing retinal reattachment following oil removal. Duration of tamponade was not associated with final reattachment rate or with a deterioration in best corrected visual acuity（BCVA）. Patients with oil removed had a significantly better baseline and final BCVA compared to those under oil tamponade（P=0.0001, 〈0.0001 respectively）. CONCLUSION： Anatomic and visual outcomes in this cohort are in keeping with those reported in the literature. Favorable outcomes were seen with oil removal but duration of oil tamponade does not affect final attachment rate with modern surgical techniques and should be managed on a case by case basis.

关键词： silicone oil tamponade proliferative vitreoretinopathy retinal detachment

Non-surgical factors influencing lymph node yield in colon cancer

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World Journal of Gastrointestinal Oncology 2016年第5期8卷 466-473页

作者： Patrick Wood Colin Peirce Jurgen Mulsow Department of Colorectal Surgery Mater Misericordiae University Hospital

There are numerous factors which can affect the lymph node(LN) yield in colon cancer *** aim of this paper was to identify both modifiable and nonmodifiable factors that have been demonstrated toaffect colonic resection specimen LN yield and to summarise the pertinent literature on these topics.A literature review of Pub Med was performed to identify the potential factors which may influence the LN yield in colon cancer resection *** terms used for the search were:LN,lymphadenectomy,LN yield,LN harvest,LN number,colon cancer and colorectal *** nonmodifiable and modifiable factors were *** review identified fifteen non-surgical factors:(13 nonmodifiable,2 modifiable) which may influence LN *** yield is frequently reduced in older,obese patients and those with male sex and increased in patients with right sided,large,and poorly differentiated *** ethnicity and lower socioeconomic class may negatively influence LN ***-operative tumour tattooing appears to increase LN *** are many factors that potentially influence the LN yield,although the strength of the association between the two varies *** oncological resection and pathological analysis remain the cornerstones to achieving good quality and quantity LN yields in patients with colon cancer.

关键词： Lymph node Number Factors Yield Colon cancer

Outcome following incomplete surgical cytoreduction combined with intraperitoneal chemotherapy for colorectal peritoneal metastases

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 445-454页

作者： Roisin Mary Heaney Conor Shields Jurgen Mulsow Peritoneal Malignancy Institute Mater Misericordiae University Hospital

Cytoreductive surgery combined with intraperitoneal chemotherapy can improve survival in appropriately selected patients with colorectal peritoneal metastases. Outcomes are best in those patients in whom a complete cytoreduction can be achieved. Unresectabledisease is however encountered in approximately one-quarter of patients at laparotomy. The merits, or otherwise, of proceeding with an incomplete cytoreduction in this setting are unclear. We performed a review of published outcomes following incomplete cytoreduction for colorectal peritoneal metastases. Using the electronic databases, Pub Med and MEDLINE, a systematic search of available literature published during the period January 1997 to September 2014 was conducted. Following application of exclusion criteria, 19 papers were identified and included in this review. These comprised fifteen case series, 3 case control studies and one randomised control trial. In the nineteen studies included in this review, 2790 patients underwent cytoreductive surgery with or without intraperitoneal chemotherapy for peritoneal metastases of colorectal origin. Of these, 1732(62%) underwent a complete cytoreduction while 986(35%) patients underwent an incomplete cytoreduction. Median survival in the complete cytoreduction group ranged from 11 to 62 mo while survival in the latter group ranged from 2.4 to 32 mo. Of the 986 patients with an incomplete cytoreduction, 331 patients received intraperitoneal chemotherapy and survival in this cohort ranged from 4.5 to 32 mo. An incomplete cytoreduction, with or without intraperitoneal chemotherapy, does not appear to confer a survival benefit. The limited available data points to a palliative benefit in a subset of patients. In the absence of high quality data, the decision as to whether or not to proceed with surgery should be made on an individual patient basis.

关键词： Colorectal carcinoma Peritoneal metastases Carcino

Surgical management of non-syndromic ectopia lentis

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1156-1160页

作者： Kirk AJ Stephenson Michael O’Keefe David J Keegan Retinal Research Group Mater Misericordiae University Hospital&Mater Private HospitalDublin 7Ireland

AIM:To compare whether aphakic contact lenses or secondary iris-claw intraocular lenses are superior in the refractive management post-pars plana vitreolensectomy in a pedigree with an FBN1 mutation causing non-syndromic ectopia lentis(NSEL)with retinal detachment(RD).METHODS:Eight affected individuals had pars plana vitreolensectomy for bilateral ectopia lentis(EL).Twelve eyes of 6 patients had secondary iris-claw intraocular lenses inserted and 4 eyes of 2 patients were managed with contact *** retinal detachment(RRD)was treated when ***-and post-operative assessment included visual acuity,endothelial cell count and dilated fundal ***:Macula-on RRD was present in all individuals>18 y,64%(7/11 eyes)presenting post-vitreolensectomy with 57%having bilateral non-synchronous *** aphakia was managed with iris-fixated intraocular lenses(IOL group,n=6),or contact lenses(CL group,n=2).Visual acuity≥0.3 log MAR(driving standard)was achieved in 75%of IOL group eyes and 25%of the CL group *** loss of corneal endothelial cell count in the IOL group was 4%at 2 y ***:In this cohort,refractive management with iris-claw IOLs provided superior outcomes to contact lenses and the authors recommend this as the optimal refractive correction in EL patients.

关键词： FBN1 isolated ectopia lentis retinal detachment iris-claw intraocular lenses

Single access laparoscopic total colectomy for severe refractory ulcerative colitis

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World Journal of Gastroenterology 2020年第39期26卷 6015-6026页

作者： John Burke Des Toomey Frank Reilly Ronan Cahill Department of Colorectal Surgery Beaumont HospitalDublin D09Ireland Department of Surgery Mater Misericordiae University HospitalDublin D07Ireland

BACKGROUND Single port laparoscopic surgery allows total colectomy and end ileostomy for medically uncontrolled ulcerative colitis solely via the stoma site *** intuitively appealing,there is sparse evidence for its use beyond *** To examine the usefulness of single access laparoscopy(SAL)in a general series experience of patients sick with ulcerative *** All patients presenting electively,urgently or emergently over a three-year period under a colorectal specialist team were *** was performed via the stoma site on a near-consecutive basis by one surgical team using a“surgical glove port”allowing group-comparative and case-control analysis with a contemporary cohort undergoing conventional multiport ***,straight rigid laparoscopic instrumentation were used without additional *** Of 46 consecutive patients requiring surgery,39(85%)had their procedure begun laparoscopically.27(69%)of these were commenced by single port access with an 89%completion rate thereafter(three were concluded by multi-trocar laparoscopy).SAL proved effective in comparison to multiport access regardless of disease severity providing significantly reduced operative access costs(>100€case)and postoperative hospital stay(median 5 d vs 7.5 d,P=0.045)without increasing operative *** proved especially efficient in those with preoperative albumin>30 g/dL(n=20).Its comparative advantages were further confirmed in ten pairs case-matched for gender,body mass index and preoperative *** outcomes proved durable in the intermediate term(median follow-up=20 mo).CONCLUSION Single port total colectomy proved useful in planned and acute settings for patients with medically refractory *** regarding duration and cost should not be barriers to its implementation.

关键词： Single incision laparoscopy Minimal access surgery Inflammatory bowel disease Ulcerative colitis Total colectomy and end ileostomy Case match analysis

Paediatric retinal detachment:aetiology,characteristics and outcomes

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 262-266页

作者： Elizabeth McElnea Kirk Stephenson Sarah Gilmore Michael O'Keefe David Keegan Department of Ophthalmology Mater Misericordiae University HospitalDublin 7Ireland Department of Ophthalmology Temple Street Children's University HospitalDublin 1Ireland

AIM： To provide contemporary data on the aetiology, clinical features and outcomes of paediatric retinal ***： A retrospective review of all those under 16 y who underwent surgical repair for retinal detachment at a single centre between the years 2008 and 2015 inclusive was performed. In each case the cause of retinal detachment, the type of detachment, the presence or absence of macular involvement, the number and form of reparative surgeries undertaken, and the surgical outcome achieved was ***： Twenty-eight eyes of 24 patients, 15（62.5%） of whom were male and 9（37.5%） of whom were female, their mean age being 11.6 y and range 2-16y developed retinal detachment over the eight year period studied. Trauma featured in the development of retinal detachment in 14（50.0%） cases. Retinal detachment was associated with other ocular and/or systemic conditions in 11（39.3%） cases. A mean of 3.0 procedures with a range of 1-9 procedures per patient were undertaken in the management of retinal detachment. Complex vitrectomy combined with scleral buckling or complex vitrectomy alone were those most frequently performed. Mean postoperative visual acuity was 1.2 log MAR with range 0.0-3.0 log MAR. In 22 of 26（84.6%） cases which underwent surgical repair the retina was attached at last ***： Aggressive management of paediatric retinal detachment including re-operation increases the likelihood of anatomical success. In cases where the retinal detachment can be repaired by an external approach alone there is a more favourable visual outcome.

关键词： paediatric retinal detachment vitrectomy scleral buckle

Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

Imaging of bone metastasis: An update

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World Journal of Radiology 2015年第8期7卷 202-211页

作者： Gerard J O'Sullivan Fiona L Carty Carmel G Cronin Department of Radiology Mater Misericordiae University Hospital

Early detection of skeletal metastasis is critical for accurate staging and optimal treatment. This paper briefly reviews our current understanding of the biological mechanisms through which tumours metastasise to bone and describes the available imaging methods to diagnose bone metastasis and monitor response to treatment. Among the various imaging modalities currently available for imaging skeletal metastasis, hybrid techniques whichfuse morphological and functional data are the most sensitive and specific, and positron emission tomography(PET)/computed tomography and PET/magnetic resonance imaging will almost certainly continue to evolve and become increasingly important in this regard.

关键词： Neoplasm metastasis Radionuclide imaging Magnetic resonance imaging Computed tomography Bone and bones

MicroRNAs and liver cancer associated with iron overload:Therapeutic targets unravelled

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World Journal of Gastroenterology 2013年第32期19卷 5212-5226页

作者： Catherine M Greene Robert B Varley Matthew W Lawless Respiratory Research Division Department of MedicineEducation and Research CentreRoyal College of Surgeons In IrelandBeaumont Hospital Experimental Medicine UCD School of Medicine and Medical ScienceMater Misericordiae University Hospital

Primary liver cancer is a global disease that is on the *** carcinoma(HCC)accounts for most primary liver cancers and has a notably low survival rate,largely attributable to late diagnosis,resistance to treatment,tumour recurrence and ***(miRNAs/miRs)are regulatory RNAs that modulate protein *** are involved in several biological and pathological processes including the development and progression of *** the poor outcomes with current HCC treatments,miRNAs represent an important new target for therapeutic *** studies have demonstrated their role in HCC development and *** many risk factors underlie the development of HCC,one process commonly altered is iron *** overload occurs in several liver diseases associated with the development of HCC including Hepatitis C infection and the importance of miRNAs in iron homeostasis and hepatic iron overload is well *** miRNA expression in hepatic fibrosis and injury response have been reported,as have dysregulated miRNA expression patterns affecting cell cycle progression,evasion of apoptosis,invasion and ***2009,miR-26a delivery was shown to prevent HCC progression,highlighting its therapeutic *** studies have since investigated the clinical potential of other miRNAs with one drug,Miravirsen,currently in phaseⅡclinical *** also have potential as biomarkers for the diagnosis of HCC and to evaluate treatment *** studies and clinical trials suggest miRNA-based treatments and diagnostic methods will have novel clinical applications for HCC in the coming years,yielding improved HCC survival rates and patient outcomes.

关键词： MicroRNAs Liver cancer Iron regulation Hepatitis C Therapeutic targets

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration