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Circulating Th17 and Tc17 Cells and Their Imbalance with Regulatory T Cells Is Associated with Myocardial Infarction in Young Indian Patients

引用

World Journal of Cardiovascular Diseases 2015年第12期5卷 373-387页

作者： Thiruvelselvan Ponnusamy Komarlu Venkatachala Srikanth Ramanjappa Manjunatha Vijay V. Kakkar Lakshmi Mundkur Research Scholar Manipal University at Thrombosis Research Institute Bangalore India Narayana Institute of Cardiac Sciences Bangalore India Clinical Research unit Thrombosis Research Institute Bangalore India mary and gary western and tata molecular immunology unit Thrombosis Research Institute Bangalore India molecular immunology unit Thrombosis Research Institute London United Kingdom

Background: Activated inflammatory cells are found in coronary plaques as well as peripheral circulation in patients with acute coronary syndrome. We explored the circulating T cell profile, their reactivity to self-antigens and plasma cytokine levels in Indian patients with Myocardial Infarction. Methods and Results: Intracellular expression of interferon-γ Interleukin (IL)-4, IL-17, IL-10 and Foxp3 were determined in CD4+ and CD8+ T cells using flow cytometry in patients with ST elevated myocardial infarction (STEMI) (N = 79) and controls (N = 80). Cytokines were measured using Milliplex kit and T cell reactivity was studied by CFSE dilution. Statistical analysis was performed using SPSS software. Patients with myocardial infarction showed higher proportion of IL-17 expressing CD4+ and CD8+ T cells (Th17 and Tc17) and elevated levels of IL-6 and IL-17 in plasma with significant reduction in circulating Tregs. Th1, Th2 and CD4+CD28null cells were not significantly different in patients compared to healthy individuals. The ratio of Th17 and Tc17 to Tregs showed an independent association with STEMI with an adjusted odds ratio of 2.92 (95% CI: 1.73 - 4.92), P + and CD8+ T cells secreting IL-17 and Tregs is associated with acute myocardial infarction. HSP60 and Ox-LDL may contribute to this response and pathogenesis of AMI in Indian population.

关键词： T Lymphocytes Adaptive Immunity Coronary Artery Disease Myocardial Infarction Cytokines Auto-Antigens

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