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Gut liver brain axis in diseases:the implications for therapeutic interventions

Signal Transduction and Targeted Therapy 2024年第1期9卷 79-104页

作者： Mengyao Yan Shuli Man Benyue Sun Long Ma Lanping Guo Luqi Huang Wenyuan Gao State Key lab.ratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&Technology300457 TianjinChina National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina Tianjin Key lab.ratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityWeijin Road300072 TianjinChina

Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract,liver,and nervous *** the past few decades,breakthrough progress has been made in the gut liver brain axis,mainly through understanding its formation mechanism and increasing treatment *** this review,we discuss various complex networks including barrier permeability,gut hormones,gut microbial metabolites,vagus nerve,neurotransmitters,immunity,brain toxic metabolites,β-amyloid(Aβ)metabolism,and epigenetic regulation in the gut-liver-brain *** therapies containing antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation(FMT),polyphenols,low FODMAP diet and nanotechnology application regulate the gut liver brain ***,some special treatments targeting gut-liver axis include farnesoid X receptor(FXR)agonists,takeda G protein-coupled receptor 5(TGR5)agonists,glucagon-like peptide-1(GLP-1)receptor antagonists and fibroblast growth factor 19(FGF19)*** gut-brain axis embraces cognitive behavioral therapy(CBT),antidepressants and tryptophan metabolism-related *** liver-brain axis contains epigenetic regulation and Aβmetabolism-related *** the future,a better understanding of gut-liver-brain axis interactions will promote the development of novel preventative strategies and the discovery of precise therapeutic targets in multiple diseases.

关键词： metabolism therapeutic immunity

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Breeding maize of ideal plant architecture for high-density planting tolerance through modulating shade avoidance response and beyond

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Journal of Integrative Plant Biology 2024年第5期66卷 849-864页

作者： Fereshteh Jafari Baobao Wang Haiyang Wang Junjie Zou biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China Graduate School of Chinese Academy of Agricultural Sciences Beijing 100081China National Nanfan Research Institute CAASSanya 572025China State Key lab.ratory for Conservation and Utilization of Subtropical Agro-Bioresources College of Life SciencesSouth China AgriculturalUniversityGuangzhou 510642China

Maize is a major staple crop widely used as food,animal feed,and raw materials in industrial ***-density planting is a major factor contributing to the continuous increase of maize ***,high planting density usually triggers a shade avoidance response and causes increased plant height and ear height,resulting in lodging and yield *** plant height and ear height,more erect leaf angle,reduced tassel branch number,earlier flowering,and strong root system architecture are five key morphological traits required for maize adaption to high-density *** this review,we summarize recent advances in deciphering the genetic and molecular mechanisms of maize involved in response to high-density *** also discuss some strategies for breeding advanced maize cultivars with superior performance under high-density planting conditions.

关键词： flowering time high-density planting leaf angle maize plant architecture plant height/ear height root architecture tasselbranch

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Copper naphthalocyanine-based hole-transport material for highperformance and thermally stable perovskite solar cells

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Science China Chemistry 2024年第8期67卷 2701-2709页

作者： Yue Qiang Huaiman Cao Yuzhen Pan Yi Chi Liangyu Zhao Yingguo Yang Hai-Bei Li Yan Gao Licheng Sun Ze Yu State Key lab.ratory of Fine Chemicals Frontier Science Center for Smart MaterialsDalian University of Technology(DUT).Dalian 116024China School of Chemistry Dalian University of Technology(DUT)Dalian 116024China School of Microelectronics Fudan UniversityShanghai 200433China Shanghai Synchrotron Radiation Facility(SSRF) Zhangjiang LabShanghai Advanced Research InstituteShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China School of Ocean Shandong UniversityWeihai 264209China Center of Artificial Photosynthesis for Solar Fuels and Department of Chemistry School of ScienceWestlake UniversityHangzhou 310024China Department of Chemistry School of Engineering Sciences in ChemistryBiotechnology and HealthKTH Royal Institute of Technology Stockholm 10044Sweden

Metal phthalocyanines(MPcs) have gained considerable research attention as hole-transport materials(HTMs) in perovskite solar cells(PSCs) because of their superb stability. However, the photovoltaic performance of MPc-based HTMs in PSCs is still lagging behind their small molecule and polymeric counterparts, largely due to their relatively low hole mobility. Here, we report for the first time the application of a copper naphthalocyanine derivative(namely t Bu-Cu Nc) as a hole-transport material(HTM)in perovskite solar cells(PSCs), and systematically study its optoelectronic and photovoltaic property compared with its Cu Pc analog(t Bu-Cu Pc). Combined experiments disclose that the extension of π-conjugation from Pc to Nc core leads to not only an enhanced hole-carrier mobility associated with a stronger intermolecular interaction, but also an elevated glass transition temperature(T_g) of 252 °C. The resultant PSCs employing t Bu-Cu Nc deliver an excellent power conversion efficiency of 24.03%, which is the record efficiency reported for metal complex-based HTMs in PSCs. More importantly, the encapsulated t Bu-Cu Nc-based devices also show dramatically improved thermal stability than the devices using the well-known SpiroOMe TAD, with a T_(80)lifetime for more than 1,000 h under damp-heat stress. This study unfolds a new avenue for developing efficient and stable HTMs in PSCs.

关键词： hole-transport materials perovskite solar cells copper naphthalocyanine extendedπ-conjugation thermal stability

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Enhancing Resistance to Bacterial Blight in Rice Using CRISPR-based Base Editing Technology

Enhancing Resistance to Bacterial Blight in Rice Using CRISP...

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中国植物病理学会2024年学术年会

作者： LI Chenhao LIU Bo DONG Hansong YANG Bing Division of Plant Sciences University of Missouri Department of Plant Pathology Nanjing Agricultural University Ministry of Agriculture Key lab.of Molecular Biology of Crop Pathogens and Insects Institute of BiotechnologyZhejiang University College of Plant Protection Shandong Agricultural University

Bacterial blight(BB),caused by Xanthomonas oryzae pathovar oryzae(Xoo),poses a significant threat to rice production,particularly in Asia and West *** resistance against BB in elite rice varieties is crucial to advancing rice breeding program and supporting smallholder *** Activator-Like effectors(TALes) are key virulence factors in Xoo,with some targeting the susceptibility(S) genes such as the sugar transporter SWEET genes in *** this,SWEET14 is an important S genes,with its promoter binding by the TALe TalC which exists across all sequenced African Xoo *** the present study,we utilized CRISPR/Cas9-based cytidine and adenine base editors to alter the effector binding element(EBE) of TalC in the promoter of SWEET14 in rice cultivars Kitaake,IR24,and Zhonghua *** introducing C to T changes in EBE led to reduced SWEET14 induction by TalC-containing Xoo strains,resulting in resistance to African Xoo isolates reliant on TalC for ***,A to G changes retained SWEET14 inducibility and susceptibility to Xoo in edited ***,no off-target mutations were detected at predicated sites,and the edited lines exhibited no obvious defects in major agronomictraits in *** results underscore the effectiveness of base editing systems for both molecular biology research and crop improvement endeavors.

关键词： Base editing base editors CBE and ABE rice improvement bacterial blight resistance

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Construction of wavelength-tunable DSE quinoline salt derivatives by regulating the hybridization form of the nitrogen atom and intramolecular torsion angle

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Chinese Chemical Letters 2024年第10期35卷 315-320页

作者： Kuan Deng Fei Yang Zhi-Qi Cheng Bi-Wen Ren Hua Liu Jiao Chen Meng-Yao She Le Yu Xiao-Gang Liu Hai-Tao Feng Jian-Li Li Key lab.ratory of Synthetic and Natural Functional Molecule of the Ministry of Education Shaanxi Key Laboratory for Carbon Neutral TechnologyCollege of Chemistry&Materials ScienceNorthwest UniversityXi'an710127China Key lab.ratory of Resource Biology and biotechnology in Western China Ministry of EducationBiomedicine Key Laboratory of Shaanxi ProvinceLab of Tissue Engineeringthe College of Life SciencesFaculty of Life Science&MedicineNorthwest UniversityXi'an 710069China Fluorescence Research Group Singapore University of Technology and DesignSingapore 487372Singapore Baoji AIE Research Center Shanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji721013China

Dual-state emission(DSE)molecules displayed conspicuous fluorescent performance both in solid and solution ***,the construction of DSE molecules and the regulation of their emission wavelengths remains a great *** on the structure-function relationship of quinolinonitrile-type fluorophores,this work proposed a feasible strategy for modulating their fluorescent properties into DSE via limiting the torsion angle between the quinoline ring and C=C bond in the range of 4.7°to 30°.Based on this strategy,53 compounds were obtained which displayed tunable emission wavelengths from^(3)97 nm to 740 nm in solid-state and from 360 nm to 672 nm in *** feasibility of the strategy was supported by a series of theoretical calculations,optical characterizations,and crystal analysis,suggesting the compounds have great potential in imaging living cells and tissues with desired wavelengths.

关键词： Fluorescence Dual-state emission Structure-function relationship Wavelength regulation Fluorescent imaging

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An Efficient Probe for Bacterial Nitroreductase Imaging and Detection Based on NanoLuc-Furimazine Bioluminescent Pair

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Chinese Journal of Chemistry 2024年第12期42卷 1373-1380页

作者： Ximeng Shi Yumeng Wang Jiaoyang Yu Yating Yang Zecheng Jin Hanghang Wang Dalei Wu Wei Chen Jianming Guo Yinan Zhang Jiangsu Key lab.ratoryforFunctional Substances of Chinese Medicine School of PharmacyNanjing Universityof Chinese MedicineNanjingJiangsu210023China Jiangsu Collab.rative Innovation Center of Chinese Medicinal Resources Industrialization School of PharmacyNanjing University of ChineseMedicineNanjingJiangsu210023China Clinical Research Center the Second Hospital of NanjingAffiliated Hospital to Nanjing University of Chinese MedicineNanjingJiangsu210003China Key lab.ratory of Resources Biology and biotechnology in Western China Ministry of EducationCollege of Life SciencesNorthwestUniversityXi'anShaanxi710069China Helmholtz International lab State Key Laboratoryof Microbial TechnologyShandong UniversityQingdaoShandong 266237China

Comprehensive SummaryThe detection of critical endogenous species, such as bacteria in microenvironments in the body, requires better imaging tools for visualization and monitoring of biological events. Bioluminescence imaging is the most popular strategy for obtaining real-time in living cells and organisms. Herein, we introduced a nitroaryl group on the C-3 position and a hydroxy group at the C-6 phenyl ring on furimazine to report the first bioluminescent probe (7) based on NanoLuc-furimazine bioluminescent pair for the detection of nitroreductase in bacteria. The probe, which possessed up to 560-fold intensity increase with a low detection limit of 16 ng/mL of nitroreductase, has the most efficient uncage efficiency in comparison with other bioluminescent congeners, thus enabling highly selective and sensitive visualization of NTR activity in a panel of clinical priority pathogens. Additionally, imaging of the recombinant strain as well as the NTR from mouse feces indicated the potential of this probe in the application of different mouse disease models.

关键词： Nitroreductase NanoLuc-furimazine Biosensors Analytical methods Luminescence Imaging agents

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Conservation genetics of a resident population of Greylag Goose(Anser anser) at the southernmost limit of the species' distribution in Europe

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Avian Research 2019年第1期10卷 53-62页

作者： Anastasios Bounas Giorgos Catsadorakis Annita Logotheti Berend Voslamber Antonios Magoulas Dimitris Tsaparis Molecular Ecology and Conservation Genetics lab Department of Biological Applications and TechnologyUniversity of Ioannina Society for the Protection of Prespa Sovon Dutch Centre for Field Ornithology Institute of marine Biology Biotechnology and Aquaculture(IMBBC)Hellenic Centre for Marine Research(HCMR)

Background:Conservation of small and isolated populations can be challenging since they are prone to loss of genetic diversity due to random genetic drift and ***,information from the assessment of genetic diversity and structure are needed for conservation programs to determine the appropriate management strategy for the *** investigated the levels of genetic variability in a resident Greylag Goose(Anser anser) population,the southernmost breeding population of the species in Europe and the sole viable population of any goose species in ***:A fragment of mtDNA Control Region and a panel of 11 microsatellite markers were used to search for any signs of genetic impoverishment and population substructure and to reveal the underlying processes through the identification of possible past demographic ***:The population was found to be monomorphic in the amplified fragment of the mitochondrial Control Region,with all individuals sharing a single private *** showed a lack of any population substructure indicating a panmictic *** the population seems to have experienced a strong and recent genetic bottleneck and exhibits a small effective population size,we did not find evidence of either extremely low levels of genetic diversity or inbreeding ***:The recent demographic decline we detected and the combined influence of residency and anthropogenic factors have probably shaped the current genetic *** study population does not need emergency conservation actions but should be regarded as a discrete management *** management strategies should focus on population and genetic monitoring and preventing further abundance declines that would increase the risk of genetic impoverishment.

关键词： Conservation Genetic variability Inbreeding Isolation Management units Microsatellites mtDNA Nonmigratory population

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Inkjet-Printing Controlled Phase Evolution Boosts the Efficiency of Hole Transport Material Free and Carbon-Based CsPbBr_(3) Perovskite Solar Cells Exceeding 9%

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Energy & Environmental Materials 2024年第2期7卷 209-220页

作者： Lihua Zhang Shi Chen Jie Zeng Zhengyan Jiang Qian Ai Xianfu Zhang Bihua Hu Xingzhu Wang Shihe Yang Baomin Xu Department of Materials Science and Engineering and Shenzhen Engineering Research and Development Center for Flexible Solar Cells Southern University of Science and TechnologyShenzhen 518055China Department of Chemistry The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Henan Key lab.ratory of Photovoltaic Materials Henan UniversityKaifeng 475004China Guangdong Key lab.of Nano-Micro Material Research School of Chemical Biology and BiotechnologyShenzhen Graduate SchoolPeking UniversityShenzhen 518055China Key University lab.ratory of Highly Efficient Utilization of Solar Energy and Sustainable Development of Guangdong Southern University of Science and TechnologyShenzhen 518055China Guangdong-Hong Kong-Macao Joint lab.ratory for Photonic-Thermal-Electrical Energy Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

Hole transport material free carbon-based all-inorganic CsPbBr_(3)perovskite solar cells(PSCs)are promising for commercialization due to its low-cost,high open-circuit voltage(V_(oc))and superior *** to the different solubility of PbBr_(2)and CsBr in conventional solvents,CsPbBr_(3)films are mainly obtained by multi-step spin-coating through the phase evolution from PbBr_(2)to CsPb_(2)Br_(5)and then to CsPbBr_(3).The scalab.e fabrication of high-quality CsPbBr_(3)films has been rarely ***,an inkjet-printing method is developed to prepare high-quality CsPbBr_(3)*** formation of long-range crystalline CsPb_(2)Br_(5)phase can effectively improve phase purity and promote regular crystal stacking of CsPbBr_(3).Consequently,the inkjet-printed CsPbBr_(3)C-PSCs realized PCEs up to 9.09%,8.59%and 7.81%with active areas of 0.09,0.25,and 1 cm^(2),respectively,demonstrating the upscaling potential of our fabrication method and *** high performance is mainly ascribed to the high purity,strong crystal orientation,reduced surface roughness and lower trap states density of the as-printed CsPbBr_(3)*** work provides insights into the relationship between the phase evolution mechanisms and crystal growth dynamics of cesium lead bromide halide films.

关键词： all-inorganic perovskite solar cells CsPbBr_(3) inkjet-printing phase evolution

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A preliminary investigation on the occurrence and distribution of antibiotic resistance genes in the Beijiang River, South China

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Journal of Environmental Sciences 2013年第8期25卷 1656-1661页

作者： Zhenhao Ling Ying Yang Yuanli Huang Shichun Zou Tiangang Luan School of marine Sciences Sun Yat-sen University Department of Civil and Environmental Engineering Hong Kong Polytechnic University Environmental biotechnology lab Department of Civil Engineering The University of Hong Kong Guangzhou Quality Supervision and Testing Institute

The occurrence of antibiotic resistance genes （ARGs） was investigated and quantified in 20 water samples collected in the Beijiang River, South China. Sulfonamide- and tetracycline-resistant bacteria were present in 17 and 14 of the collected 20 samples. For sulfonamide ARGs, sulI and sulII were frequently observed in the Beijiang River. The levels of sulI were higher than sulII （p 〈 0.05）, with the mean values of （1.41 ± 1.12） × 10-2 and （1.58 ± 1.71） × 10-3 copies/16S rDNA, respectively. For tetracycline ARGs, tetG had the highest frequency, 100%, followed by tetA （85%）, tetO （85%）, tetC （70%）, tetX （60%）, tetM （40%） and tetQ （20%）, while tetE and tetS were not detected in all the samples from the Beijiang River. On the other hand, tetC had the highest concentration, ranging from 8.30 × 10-2 to 13.20 copies/16S rDNA. The poor correlation between ARGs and antibiotic concentrations revealed that the self-amplification and persistence of ARGs were the reasons that made ARGs exist in the water environment even though the antibiotic selecting pressure was absent. Because so few field measurements have been conducted for investigating the levels of ARGs in rivers in South China, this study provides an important insight on better understanding the occurrence and spread of ARGs in such an ecosystem.

关键词： antibiotic resistant genes Beijiang River South China

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Biomarkers and Ultra Structural Evaluation of marine Pollution by Polycyclic Aromatic Hydrocarbons

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Journal of Environmental Protection 2016年第10期7卷 1283-1304页

作者： Nehad M. Abd El Moneam Nabila E. Abd El Maguid Amany M. El-Sikaily Marwa G. Zaki Mohamed A. Sheradah Biochemistry and Zoology Department Faculty of Science Alexandria University Alexandria Egypt marine Pollution Research lab. National Institute of Oceanography & Fisheries Alexandria Egypt marine biotechnology lab. National Institute of Oceanography & Fisheries Alexandria Egypt

The present study is endeavored to study the oxidative stress and antioxidant response as well as the ultrastructural change of both liver and muscle tissues of Siganus rivulatus collected from polluted region (El-Mex Bay) and control region (Marsa Matrouh) to identify the significance of biomarkers. The results revealed that, El-Mex Bay was polluted by different types of chemicals including hydrocarbons comparing with the reference area (Matrouh area). Where, the concentration range of total hydrocarbons in sediment samples collected from Matrouh coast was 409.24 - 521.26 ng/g, dry weight, where as this range in sediment samples collected from El-MexBay was 4159.77 - 4589.81 ng/g, dry weight. In this context, the induction of antioxidant systems in fish collected from polluted area in response to oxidative stress should be considered as a clear indication of the presence of pollution and environmental health degradation. Also, The increase in lipid peroxidation was a useful indicator of the pollution load in the present study. The results suggest that chemical pollution is capable of inducing morphological alteration in liver offish collected from polluted area. The present study indicated that ultra-structural changes serveas biomarker of stress in aquatic environment.

关键词： Biomarkers Ultra Structural Evaluation Polycyclic Aromatic Hydrocarbons (PAHs)

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