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Effects of lifestyle modification on liver enzyme and Fibroscan in Indian patients with non-alcoholic fatty liver disease

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Gastroenterology Report 2018年第1期6卷 49-53,I0002页

作者： Jayanta Paul Raj Vigna Venugopal Lorance Peter Shihaz Hussain Kula Naresh Kumar Shetty Mohit P.Shetti Department of Gastroenterology Manipal HospitalBangaloreIndia

Background and aims:Non-alcoholic fatty liver disease(NAFLD)is remarkably increasing in developing countries like India,in parallel with the increasing incidence of *** modification is a recommended treatment for *** most of the previous studies,improvement after lifestyle modification was assessed by liver fibrosis through liver biopsy,but we cannot do a serial liver biopsy in every NAFLD *** fibrosis can also be assessed by fibroscan non-invasively in *** study was designed to evaluate the effect of lifestyle modification on liver enzymes and Fibroscan values in a population with ***:Initially,50 NAFLD patients were included in this prospective follow-up study;however,after 6 months of lifestyle modification,only 39 participants were *** both the first and second consultations,Fibroscan was carried *** participants underwent a careful interview,anthropometry measurements and radiological and biochemical tests during every ***:After 6 months of lifestyle modification,Fibroscan values improved significantly(8.3160.11kPa vs 7.8760.12kPa,p¼0.009).Alanine aminotransferase(ALT)values also showed improvement during the second consultation(97.2562.62 U/L vs 66.6963.95 U/L,p<0.001).Conclusion:Measured by Fibroscan and liver enzymes,it has been found that lifestyle modification is an effective therapy to downgrade hepatic injury in NAFLD *** Fibroscan can be used to assess the treatment response in NAFLD patients due to its non-invasive nature.

关键词： non-alcoholic fatty liver disease lifestyle modification alanine aminotransferase Fibroscan

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Polymyositis-like syndrome with rhabdomyolysis in association with brucellosis

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Asian Pacific Journal of Tropical Medicine 2012年第9期5卷 755-756页

作者： Kushal Naha Suman Karanth Sowjanya Dasari Mukhyaprana Prabhu Department of Medicine Kasturba HospitalManipal-576 104Manipal UniversityKarnatakaIndia

Diffuse myositis with progression to rhabdomynlysis has been reported in association with wide range of viral *** report a case of polvmvosilis-like svndrome complicated by rhabdomyolysis secondary to *** case report ... 详细信息

关键词： Polymyositis Rhabdomyolysis Brucellosis Atypical presentation

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Pitfalls and optimal approaches to diagnose melioidosis

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 501-510页

作者： Paul Vijay Kingsley Govindakarnavar Arunkumar Meghan Tipre Mark Leader Nalini Sathiakumar Sultan Ismail hospital manipal Center for Virus Research Manipal University School of Public Health University of Alabama at Birmingham

Melioidosis is a severe and fatal infectious disease in the tropics and subtropics. It presents as a febrile illness with protean manifestation ranging from chronic localized infection to acute fulminant septicemia with dissemination of infection to multiple organs characterized by abscesses. Pneumonia is the most common clinical presentation. Because of the wide range of clinical presentations, physicians may often misdiagnose and mistreat the disease for tuberculosis, pneumonia or other pyogenic infections. The purpose of this paper is to present common pitfalls in diagnosis and provide optimal approaches to enable early diagnosis and prompt treatment of melidoidosis. Melioidosis may occur beyond the boundaries of endemic areas. There is no pathognomonic feature specific to a diagnosis of melioidosis. In endemic areas, physicians need to expand the diagnostic work-up to include melioidosis when confronted with clinical scenarios of pyrexia of unknown origin, progressive pneumonia or sepsis. Radiological imaging is an integral part of the diagnostic workup. Knowledge of the modes of transmission and risk factors will add support in clinically suspected cases to initiate therapy. In situations of clinically highly probable or possible cases where laboratory bacteriological confirmation is not possible, applying evidence-based criteria and empirical treatment with antimicrobials is recommended. It is of prime importance that patients undergo the full course of antimicrobial therapy to avoid relapse and recurrence. Early diagnosis and appropriate management is crucial in reducing serious complications leading to high mortality, and in preventing recurrences of the disease. Thus, there is a crucial need for promoting awareness among physicians at all levels and for improved diagnostic microbiology services. Further, the need for making the disease notifiable and/or initiating melioidosis registries in endemic countries appears to be compelling.

关键词： Melioidosis pseudomallei Review Diagnosis Treatment Pitfalls Approaches route of infection

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A review on assessment and treatment of the trunk in stroke A need or luxury

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Neural Regeneration Research 2012年第25期7卷 1974-1977页

作者： Suruliraj Karthikbabu Mahabala Chakrapani Sailakshmi Ganeshan Kedambadi C Rakshith Syed Nafeez Venkatesan Prem Department of Physiotherapy Manipal College of Allied Health SciencesManipal HospitalBangalore 560017KarnatakaIndia Department of Medicine Kasturba Medical CollegeManipal UniversityMangalore 575003KarnatakaIndia Doctoral Advisory Committee Manipal UniversityManipal 576104KarnatakaIndia Department of Neurology Kasturba Medical CollegeManipal UniversityMangalore 575003KarnatakaIndia

Trunk function has been identified as an important early predictor of functional outcome after stroke and the same deteriorates on both contralateral and ipsilateral sides of the body following stroke. The primary contribution of the trunk muscles is to allow the body to remain upright, adjust weight shifts, and control movements against constant pull of gravity and is considered central key point of the body. Proximal stability of the trunk is a pre-requisite for distal limb mobility, balance, gait and functional activities and its positive correlation in hemiplegia has been demonstrated in a cross- sectional study. Both isokinetic and handheld dynamometer muscle strength testing demonstrated the weakness of bilateral trunk flexors, extensors and rotator muscles in both acute and chronic hemiplegic patients. This was confirmed by electromyography analysis which identified poor bilateral trunk muscles activity in patients with stroke. Trunk impairment scale is sensitive to evaluate the selective muscle control of upper and lower trunk, and it has been reported that lateral flexion of the trunk is easier than rotation of the trunk and the clinical observation concurs to the difficulty in lower trunk rotation of stroke patients. However, trunk exercises given early after stroke could produce enhanced balance performance post- stroke. This review attempts to report the evidence supporting the involvement of the trunk and its influence on balance and functional performance in post-stroke hemiplegia.

关键词： stroke hemiplegia trunk control balance function electromyography trunk muscle activity strength trunk impairment scale review

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Effectiveness of craniosacral therapy,Bowen therapy,static touch and standard exercise program on sleep quality in fibromyalgia syndrome:A randomized controlled trial

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Journal of Integrative Medicine 2024年第4期22卷 473-483页

作者： Reepa Avichal Ughreja Prem Venkatesan Dharmanand Balebail Gopalakrishna Yogesh Preet Singh Vani Lakshmi R Department of Physiotherapy Manipal College of Health ProfessionsManipal Academy of Higher EducationManipal 576104KarnatakaIndia Department of Rheumatology Manipal HospitalBengaluru 560052KarnatakaIndia Department of Clinical Immunology and Rheumatology All India Institute of Medical SciencesBilaspur 174001Himachal PradeshIndia Department of Data Science Prasanna School of Public HealthManipal Academy of Higher EducationManipal 576104KarnatakaIndia

Background:Sleep disturbance is commonly seen in fibromyalgia syndrome (FMS);however,high quality studies involving manual therapies that target FMS-linked poor sleep quality are lacking for the Indian ***:Craniosacral therapy (CST),Bowen therapy and exercises have been found to influence the autonomic nervous system,which plays a crucial role in sleep *** the paucity of evidence concerning these effects in individuals with FMS,our study tests the effectiveness of CST,Bowen therapy and a standard exercise program against static touch (the manual placebo group) on sleep quality in ***,setting,participants and intervention:A placebo-controlled randomized trial was conducted on132 FMS participants with poor sleep at a hospital in *** participants were randomly allocated to one of the four study groups,including CST,Bowen therapy,standard exercise program,and a manual placebo control group that received static ***,Bowen therapy and static touch treatments were administered in once-weekly 45-minute sessions for 12 weeks;the standard exercise group received weekly supervised exercises for 6 weeks with home exercises until 12 *** 12 weeks,all study participants performed the standard exercises at home for another 12 *** outcome measures:Sleep quality,pressure pain threshold (PPT),quality of life and fibromyalgia impact,physical function,fatigue,pain catastrophizing,kinesiophobia,and positive–negative affect were recorded at baseline,and at weeks 12 and 24 of the ***:At the end of 12 weeks,the sleep quality improved significantly in the CST group (P=0.037) and Bowen therapy group (P=0.023),and the PPT improved significantly in the Bowen therapy group(P=0.002) and the standard exercise group (P<0.001),compared to the static touch *** improvements were maintained at 24 *** between-group differences were observed for other secondary ***:CST and Bowen therapy improv

关键词： Chronic pain Complementary therapies Exercise Fibromyalgia Musculoskeletal manipulations Sleep

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