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Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第45期18卷 6657-6668页

作者： Jun-Jie Xiong Kiran Altaf Muhammad A Javed Wei Huang Rajarshi Mukherjee Gang Mai Robert Sutton Xu-Bao Liu Wei-Ming Hu Department of Hepato-Biliary-Pancreatic Surgery West China HospitalSichuan University Liverpool nihr Pancreas biomedical research Unit Royal Liverpool University HospitalUniversity of LiverpoolLiverpool L69 3GAUnited Kingdom Pancreatic Diseases research Group Department of Integrated Traditional and Western MedicineWest China HospitalSichuan University

AIM:To conduct a meta-analysis to determine the safety and efficacy of laparoscopic liver resection(LLR) and open liver resection(OLR) for hepatocellular carcinoma(HCC).METHODS:PubMed(Medline),EMBASE and Science Citation Index Expanded and Cochrane Central Register of Controlled Trials in the Cochrane Library were searched systematically to identify relevant comparative studies reporting outcomes for both LLR and OLR for HCC between January 1992 and February *** authors independently assessed the trials for inclusion and extracted the ***-analysis was performed using Review Manager Version 5.0 software(The Cochrane Collaboration,Oxford,United Kingdom).Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed effects(Mantel-Haenszel method) or random effects models(DerSimonian and Laird method).Evaluated endpoints were operative outcomes(operation time,intraoperative blood loss,blood transfusion requirement),postoperative outcomes(liver failure,cirrhotic decompensation/ascites,bile leakage,postoperative bleeding,pulmonary complications,intraabdominal abscess,mortality,hospital stay and oncologic outcomes(positive resection margins and tumor recurrence).RESULTS:Fifteen eligible non-randomized studies were identified,out of which,9 high-quality studies involving 550 patients were included,with 234 patients in the LLR group and 316 patients in the OLR *** was associated with significantly lower intraoperative blood loss,based on six studies with 333 patients [WMD:-129.48 mL;95%CI:-224.76-(-34.21) mL;P = 0.008].Seven studies involving 416 patients were included to assess blood transfusion requirement between the two *** LLR group had lower blood transfusion requirement(OR:0.49;95%CI:0.26-0.91;P = 0.02).While analyzing hospital stay,six studies with 333 patients were *** in the LLR group were found to have shorter hospital stay [WMD:-3.19 d;95%CI:-4.09-(-2.28) d;P < 0.00001] than their OLR

关键词： Hepatocellular carcinoma Laparoscopy Open liver resection Hepatectomy Meta-analysis

Chemo-dynamical modelling with Schwarzschild's method

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research in Astronomy and Astrophysics 2018年第12期18卷 1-8页

作者： Richard John Long Shude Mao National Astronomical Observatories Chinese Academy of Sciences Jodrell Bank centre for Astrophysics School of Physics and Astronomy The University of Manchester Physics Department and Tsinghua centre for Astrophysics Tsinghua University

We extend Schwarzschild’s dynamical modelling method to model absorption line strength data as well as the more usual luminosity and kinematic *** approach draws on earlier published work by the first author with the Syer & Tremaine made-to-measure(M2M) dynamical modelling method and uses similar ideas to create a chemo-Schwarzschild *** apply our extended Schwarzschild method to the same four early type galaxies(NGC 1248, NGC 3838, NGC 4452,NGC 4551) as the chemo-M2M work, and are able to recover successfully the 2D absorption line strength for the three lines we model(Hβ, Fe5015, Mg b).We believe that this is the first time Schwarzschild’s method has been used in this *** techniques developed can be applied to modelling other aspects of galaxies, for example age and metallicity data coming from stellar population modelling, and are not specific to absorption line strength data.

关键词： galaxies:abundances galaxies:formation galaxies:individual(NGC 1248,NGC 3838,NGC 4452,NGC 4551) galaxies:kinematics and dynamics galaxies:structure methods:numerical

Intensity of effort and momentary failure in resistance training:Are we asking a binary question for a continuous variable?

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Journal of Sport and Health Science 2022年第6期11卷 644-647页

作者： James P.Fisher James Steele Dave Smith School of Sport Health and Social ScienceSolent UniversitySouthamptonSO140YNUK research centre for Musculoskeletal and Sports Medicine Manchester Metropolitan UniversityManchesterM156BHUK

*** There is a growing body of research supporting the idea that a plethora of health benefits can result from resistance training using a low volume,high-effort approach(e.g.,increased metabolic rate and bone mineral density,a reduction in blood pressure,and improved muscle quality and insulin sensitivity,among ***,muscular strength and muscle massprimary goals and benefits of participation in resistance trainingare independently strong predictors of longevity and quality of life. Thus,many have sought to identify how the manipulation of resistance training variables might lead to“optimal”adaptations in such outcomes,as evidenced by repeated attempts over recent decades to review the literature and provide consensus statements on this topic.5-10 One variable that is often hotly debated within resistance training is training to failure.

关键词： resistance binary continuous

REVIEW ON research AND DEVELOPMENT OF MAGNESIUM ALLOYS

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Acta Metallurgica Sinica(English Letters) 2008年第5期21卷 313-328页

作者： Z. Yang J.P. Li J.X. Zhang G.W. Lorimer J. Robson Department of Materials Science and Engineering Xilan Jiaotong University Xilan 710049 China Department of Materials Science and Engineering Xi＇an Technological University Xi＇an 710032 China manchester Materials Science centre University of Manchester Manchester M 1 7HS UK

The current research and development of magnesium alloys is summarized. Several aspects of magnesium alloys are described： cast Mg alloy, wrought Mg alloy, and novel processing. The subjects are discussed individuall... 详细信息

关键词： Magnesium alloys Novel processing Grain refined

Trust beyond Technology Algorithms: A Theoretical Exploration of Consumer Trust and Behavior in Technological Consumption and AI Projects

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Journal of Computer and Communications 2024年第6期12卷 72-102页

作者： David Oyekunle Ugochukwu Okwudili Matthew David Preston David Boohene Salford Business School University of Salford Manchester UK Computer Science Department Federal University (UFLA) Lavras Brazil Department of Entrepreneurship and Business Science University of Energy and Natural Resources Sunyani Ghana

In an era dominated by artificial intelligence (AI), establishing customer confidence is crucial for the integration and acceptance of AI technologies. This interdisciplinary study examines factors influencing customer trust in AI systems through a mixed-methods approach, blending quantitative analysis with qualitative insights to create a comprehensive conceptual framework. Quantitatively, the study analyzes responses from 1248 participants using structural equation modeling (SEM), exploring interactions between technological factors like perceived usefulness and transparency, psychological factors including perceived risk and domain expertise, and organizational factors such as leadership support and ethical accountability. The results confirm the model, showing significant impacts of these factors on consumer trust and AI adoption attitudes. Qualitatively, the study includes 35 semi-structured interviews and five case studies, providing deeper insight into the dynamics shaping trust. Key themes identified include the necessity of explainability, domain competence, corporate culture, and stakeholder engagement in fostering trust. The qualitative findings complement the quantitative data, highlighting the complex interplay between technology capabilities, human perceptions, and organizational practices in establishing trust in AI. By integrating these findings, the study proposes a novel conceptual model that elucidates how various elements collectively influence consumer trust in AI. This model not only advances theoretical understanding but also offers practical implications for businesses and policymakers. The research contributes to the discourse on trust creation and decision-making in technology, emphasizing the need for interdisciplinary efforts to address societal challenges associated with technological advancements. It lays the groundwork for future research, including longitudinal, cross-cultural, and industry-specific studies, to further explore consume

关键词： Consumer Trust AI-Driven Projects Transparency Ethical Accountability Structural Equation Modeling (SEM) Technology Acceptance Model (TAM) Interdisciplinary Study Organizational Factors Psychological Factors Behavioral Intention

TDP-43 and amyloid precursor protein processing: implications for Alzheimer's disease

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Neural Regeneration research 2021年第7期16卷 1402-1403页

作者： David A.Hicks Division of Neuroscience and Experimental Psychology School of Biological SciencesFaculty of BiologyMedicine and HealthUniversity of ManchesterManchester Academic Health Science CentreManchesterUK RBMOnline Bourn HallBournCambridgeUK

In this perspective article,I will discuss our recent publication(Hicks et al.,2020),specifically its major findings and integration with the published ***'s disease(AD)is a progressive neurodegenerative disease of predominantly unknown *** neuropathological hallmarks are extracellular plaques formed of the amyloid beta(Aβ)peptide and neurofibrillary tangles of tau protein.

关键词： Alzheimer Aβ tau

Astrocytes in Post-traumatic Stress Disorder

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Neuroscience Bulletin 2022年第8期38卷 953-965页

作者： Baoman Li Dianjun Zhang Alexei Verkhratsky Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyang 110122China Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PTUK Department of Stem Cell Biology State Research Institute Centre for Innovative Medicine01102 VilniusLithuania

Although posttraumatic stress disorder(PTSD)is on the rise,traumatic events and their consequences are often hidden or minimized by patients for reasons linked to PTSD *** experiences can be broadly classified into mental stress(MS)and traumatic brain injury(TBI),but the cellular mechanisms of MS-or TBI-induced PTSD remain *** evidence has shown that the morphological remodeling of astrocytes accompanies and arguably contributes to fearful memories and stressrelated *** this review,we summarize the roles of astrocytes in the pathogenesis of MS-PTSD and *** synthesize and secrete neurotrophic,proand anti-inflammatory factors and regulate the microenvironment of the nervous tissue through metabolic pathways,ionostatic control,and homeostatic clearance of *** or trauma-associated impairment of these vital astrocytic functions contribute to the pathophysiological evolution of PTSD and may present therapeutic targets.

关键词： Astrocytes Traumatic brain injury Traumatic events Neurotrophic factors Serotonin

Synthetic biology in the UK-An outline of plans and progress

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Synthetic and Systems Biotechnology 2016年第4期1卷 243-257页

作者： L.J.Clarke R.I.Kitney UK Synthetic Biology Leadership Council UK Department of BioEngineering Imperial CollegeUK Faculty of Life Sciences University of ManchesterUK BionerG UK EPSRC National centre for Synthetic Biology and Innovation UK Institute of Systems and Synthetic Biology UK biomedical Systems Engineering Imperial CollegeUK BioMedical Systems EngineeringImperial CollegeUK

Synthetic biology is capable of delivering new solutions to key challenges spanning the bioeconomy,both nationally and *** this significant potential and the associated need to facilitate its translation and commercialisation the UK government commissioned the production of a national Synthetic Biology Roadmap in 2011,and subsequently provided crucial support to assist its *** infrastructural investments have been made,and important strides made towards the development of an effectively connected community of practitioners and interest groups.A number of Synthetic Biology research centres,DNA Synthesis Foundries,a centre for Doctoral Training,and an Innovation Knowledge centre have been established,creating a nationally distributed and integrated network of complementary facilities and *** UK Synthetic Biology Leadership Council published a UK Synthetic Biology Strategic Plan in 2016,increasing focus on the processes of translation and *** 50 start-ups,SMEs and larger companies are actively engaged in synthetic biology in the UK,and inward investments are starting to *** these initiatives provide an important foundation for stimulating innovation,actively contributing to international research and development partnerships,and helping deliver useful benefits from synthetic biology in response to local and global needs and challenges.

关键词： Synthetic biology Engineering biology Biodesign Roadmap Responsible research and Innovation(RRI) Innovation and Knowledge centre(IKC) Synthetic Biology Leadership Council(SBLC) Bioeconomy

Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important?

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Eye and Vision 2016年第1期3卷 141-146页

作者： FangJun Bao Brendan Geraghty QinMei Wang Ahmed Elsheikh The Affiliated Eye Hospital of Wenzhou Medical University Wenzhou City 325027China The Institution of Ocular Biomechanics Wenzhou Medical UniversityWenzhou City 325027China School of Engineering University of LiverpoolLiverpool City L693GHUK nihr biomedical research centre for Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondon CityUK

Keratoconus is a bilateral,non-inflammatory,degenerative corneal *** occurrence and development of keratoconus is associated with corneal thinning and conical protrusion,which causes irregular *** the disruption of the collagen organization,the cornea loses its shape and function resulting in progressive visual ***,corneal topography is the most important tool for the diagnosis of keratoconus,which may lead to false negatives among the patient population in the subclinical ***,it is now hypothesised that biomechanical destabilisation of the cornea may take place ahead of the topographic evidence of keratoconus,hence possibly assisting with disease diagnosis and *** article provides a review of the definition,diagnosis,and management strategies for keratoconus based on corneal biomechanics.

关键词： Keratoconus In vivo Corneal biomechanics Corneal collagen cross-linking